Реферат на тему:
Diphtheria and Tetanus Toxoids and Pertussis Vaccine
Adsorbed. For Active Immunization against Diphtheria,
Tetanus and Whooping Cough.
Description. Diphtheria and Tetanus Toxoids and Pertussis Vaccine
Adsorbed (DPT Vaccine Adsorbed) as supplied by Connaught Laboratories
Limited, is sterile, cloudy, uniform suspension of diphtheria and
tetanus toxoids and pertussis vaccine adsorbed on aluminium phosphate
and suspended in isotonic sodium chloride solution.
This vaccine fulfils the WHO requirements Diphtheria Toxoid, Tetanus
Toxoid and Pertussis Vaccine.
Indications. DPT Vaccine Adsorbed is indicated for the primary
immunization of infants at or above the age of two months, and of
children through 6 years of age against diphtheria, tetanus and whooping
Contraindications. DPT Vaccine Adsorbed should not be administered to
infants or children with fever, or other evidence of acute illness or
infection. The presence of an evolving or changing neurologic disorder
is a contraindication to receipt of this vaccine. A second or third DPT
injection should not be given to a child who has suffered a severe
adverse reaction to the previous dose. The pertussis component should be
omitted and diphtheria and tetanus immunization completed.
Elective immunization of individuals over б months of age should be
deferred during an outbreak of poliomyelitis.
DPT Vaccine Adsorbed should not be administered to children over б years
of age or to adults because of the danger of reactions to diphtheria
toxoid or to pertussis vaccine and because pertussis is less severe in
these age groups than in infants and young children.
Dosage. For primary immunization of infants and pre-school children
through 6 years of age, it is recommended that three intramuscular
injections of 0.5 ml be administered with an interval of four to eight
weeks between doses. For a lasting immunization effect, a fourth
injection of 0.5 ml is essential approximately one year following the
Administration. The vaccine should be administered by intramuscular
injection. The musculus vastus lateralis (mid-thigh laterally) is the
preferred injection site for infants. The site of injection shoud be
prepared with a suitable antiseptic. Do not inject intravenously. Each
injection of the primary immunization series should be made into a
different area (site). If sterile disposable syringes and needles are
not used, syringes and needles should be sterilized in an autoclave at
121°С for 30 minutes. Failing that, they should be boiled for at least
20 minutes. Care should be taken to maintain sterility until used.
Storage. Diphtheria and Tetanus Toxoids and Pertussis Vaccine Adsorbed
shouls be stored and transported at a temperature between 2° and 8°C
(35° and 46°F). Do not freeze. Product which has been exposed to
freezing should not be used. When using a multi-dose vial, it is
recommended that partially used vials be discarded at the end of the
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