I?I?NOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE
OE?A?INUeEEE IAe? IAAeE*II? ?AAA?E?OAOe?? OA EO?I?OIEIA??
A?EAN Aieiaeeie?a ?iiai?aia
OAeE 615.327:553,715]:616-092.19-001.28
Aaeueiaiaeoeai?noue i?aai?/ieo ?a/iaei
aiaee ”Iaooony” oa i?aeoiaee aei iiaeaethaaiiy ?o
iioiaeaeaiiy
14.01.33 – eo?i?oieia?y oa o?c?ioa?ai?y
Aaoi?aoa?ao
aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy
eaiaeeaeaoa iaaee/ieo iaoe
Iaeana – 1998
Aeena?oaoe??th ? ?oeiien
?iaioa aeeiiaia a ?inoeooo? o?c?ieia?? ?i. I.I. Aiaiiieueoey IAI
Oe?a?ie.
Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe ?aan?aea Noaiai Aaneeueiae/,
?inoeooo o?c?ieia?? ?i. I.I. Aiaiiieueoey IAI Oe?a?ie, caa?aeoaa/
a?aeae?eii aenia?eiaioaeueii? aaeueiaieia??.
Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, noa?oee iaoeiaee
ni?a?ia?oiee Ae?aaiie?aoeueea Iaoae?y Aieiaeeie??aia, Oe?a?inueeee IAe?
iaaee/ii? ?aaa?e?oaoe?? oa eo?i?oieia??, aieiaiee iaoeiaee ni?a?ia?oiee
a?aeae?eaiiy a?aeiiaiiai e?eoaaiiy oai?eo oa?aiaaoe/iiai i?io?eth;
aeieoi? iaaee/ieo iaoe, noa?oee iaoeiaee ni?a?ia?oiee Ee?oe/ Ethaeieea
I?ieii?aia, iaoeiai-i?aeoe/ia ia’?aeiaiiy “?aaa?e?oaoe?y”, caa?aeoaa/
aano?iaioa?ieia?/iei a?aeae?eaiyi.
I?ia?aeia onoaiiaa: E?einueeee ?anioae?eainueeee IAe? o?ce/ieo iaoiae?a
e?eoaaiiy oa iaaee/ii? ee?iaoieia?? ?i. ?.I. Na/aiiaa IIC Oe?a?ie,
ee?i?/iee a?aeae?e
Caoeno a?aeaoaeaoueny “ 25 “ a?oaeiy 1998 ?. i 14 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 41.608.01 i?e Oe?a?inueeiio
iaoeiai-aeine?aeiiio ?inoeooo? iaaee/ii? ?aaa?e?oaoe?? oa eo?i?oieia??
IIC Oe?a?ie (270014, Iaeana, Ea?iiioianueeee i?ia., 6).
C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? Oe?a?inueeiai IAe?
iaaee/ii? ?aaa?e?oaoe?? oa eo?i?oieia?? (270014, Iaeana, Ea?iiioianueeee
i?ia., 6).
Aaoi?aoa?ao ?ic?neaiee “ 10 ” eenoiiaaea 1998 ?ieo.
A/aiee nae?aoa? niaoe?ae?ciaaii? ?aaee,
eaiaeeaeao iaaee/ieo iaoe,
noa?oee iaoieaee ni?a?ia?oiee
A.I. Aeieo???aa
CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE
Aeooaeuei?noue oaie. Aaeeaaiiy oa?i?io “e?eoaaeueia i?ia?aeueia aiaea
Iaooony” i?aaii??ia eeoa /anoeiai, yeui aeoiaeeoe c oi?iaeueii? oiiae,
ui aei i?ia?aeueieo iaeaaeaoue aiaee, eio?? i?noyoue a naieiio neeaae?
nieae ia iaioa 2 a/e (A.A. Eaaiia, A.A. Iaa?aaa, 1964; I.A. Oea?oen,
TH.A. Aeaieeia, 1975). ?? iecueea i?ia?ae?caoe?y (0,7-0,8 a/e, oiaoi ia
??ai? i??nii? aiaee) nea?oaaea iiooe aaeueiaiaeoeaieo /eiiee?a a noi?iio
i?aai?/ieo neeaaeiee?a. Aaea a ia?o?e ienueiia?e caaaeoe? i?i Iaooonth
ii?yae c eiinoaoaoe??th ?? e?eoaaeueieo aeanoeainoae caa?oa?oueny oaaaa
ia eiia??iee oaeoi? oeeo aeanoeainoae: “… naeyie O?oneaaoey oa ?ioeo
n?e Aae?oe?? i’thoue aiaeo c aeii?oeaie iaooe aeey e?eoaaiiy aaaaoueio
caoai?thaaiue” (G. Rzaczynski, 1721). A ia?o?e iaoeia?e i?aoe?,
i?enay/ai?e Iaooon?, oaae neacaii i?i iaooo ye “ia iicaaaeaio cia/eiino?
neeaaeiao /anoeio” (T. Torosiewicz, 1836). A, aeania, caeiaaaeea i?i
ae?th/a ia/aei aiaee a?aeia?aaeaia ? o ?? iaca?. Iieiaeaiiy i?i
coiiaeai?noue e?eoaaeueii? ae?? Iaooon? ?? iaooiaeie neeaaeieeaie
?icaeiaia a ?iaioao M. Koch (1842), A. Unger (1843), A.N. Ao?ena?a e
I.A. Oaaea?iaie (1950). Ii?yae c oei, ai?iaeiaae a?eueo noie?oiueiai
ia??iaeo aeine?aeaeaiue, ye aieiai? e?eoaaeuei? /eiieee, ?icaeyaeaeeny:
niieiiiae?ai? ?a/iaeie (B. Radziszewski, 1881; T. Praschil, 1904; K.
Gerus, 1911); eaoe? n??/eno? aoaeaaiaee (G. Flaschen, 1931; Z. Orlowski,
1936; E.A. Aathi, O.O. Eaa/aiei, 1957; I.A. A?eee, 1975; ss.I. Eea/ae ?
?i., 1962; A.E. Aueiaa, A.A. Aieaaa, 1968); oaiiee (N.A. Oaie?i, 1951);
aae?aiae?iiiiae?ai? neiiaoii?iaoe/i? ?a/iaeie (O.A. Eo?eoaeui, 1963,
1965, 1968). I?ioa oe? oaa?aeaeaiiy /e i?eiouaiiy iiaoaeiaai? ia ia
i?yieo aeieacao, a ia caaaeueieo oyaeaiiyo i?i aoaeoe oeo /e ?ioeo
neeaaeiee?a Iaooon?, oiio iathoue eeoa ?noi?e/io oe?ii?noue.
Aaeueiaioa?aiaaoe/io ae?th Iaooon? ? ?? i?aai?/ieo neeaaeiee?a
ioe?ithaaee ca?aeii ci?i aiaeii-nieueiaiai iai?io (A.A. Aneiaiei, 1978,
1981), oiea?aco ? ae?o?aco (E.I. Aeaieeiaa e ae?., 1977), ia?oe?aeueii?
ooieoe?? ie?ie (A.E. Eaineay, I.Ae. Aanea, 1980), aeia/iooai?aiiy (I.E.
Aaai? e ae?., 1974; C.A. Aaa?eethe, 1980), i?ioean?a oeaieiiiai aeeoaiiy
oa oinoi?eethaaiiy a ia/?ioe? (E.E. AEaeeei, 1975). Canoinoaaiiy
nenoaiiiai i?aeoiaeo aeicaieeei io?eiaoe aaaaoi iiaeo aeaieo, eio??,
iaeiae, aeyaeeeny iaiaeiicia/ieie ? noia?a/eeaeie.
Aeine?aeaeaiiy I.N. ss?aiaiei ? ?i. (1983-1989) ?aaeoe??
aano?i-aioa?aeueii? iaie?aaoe/ii? aiaeie?eiii? nenoaie ia iaeii?aciaa ?
aeiaaio?eaaea aaaaeaiiy i?ia?aeueii? aiaee Iaooony aeicaieeei ei?aeoii
ioe?ieoe aaeueiaiaeoeaio ae?th ?? a?iiiniiey?iiai /eiieea, i?ioa, a
iiaeaeueoiio, aenia?eiaioaeueii anoaiiaeaii, ui aea?eueiaiiy
aano?i?ioanoeiaeueieo ai?iii?a coiiaeaia a?aae??ioieie iioieaie aiaee c
ii?iaeieie oeoieiai-eeoeiaiai o?aeoo a oeaieie aioo??oiueiai na?aaeiaeua
(N.A.?aan?aea, 1994), oiaoi a?iiiniiey?i?noue ? ianiaoeeo?/iei
aaeueiaiaeoeaiei /eiieeii i?ia?aeueii? aiaee Iaooony.
Ioaea, i?iaeaia aeyniaiiy ?ie? i?aai?/ieo neeaaeiee?a aiaee Iaooony a ??
aaeueiaiaeoeaiino? caeeoa?oueny aeooaeueiith. Ia nueiaiaei? anoaiiaeaii,
ui aaoiooiii? i?e?ii?aai?cie aiaee Iaooony caeaoi? ?oeioaaoe ??
i?aai?/i? ?a/iaeie, iaeiae ooai?aiiy a?ieia?/ii aeoeaieo ?a/iaei (AA?)
oeyoii i?e?iaii? a?io?ainoi?iaoe?? eeoa ia?aaeaa/aeiny (N.A.
E?aoaieiieeiaa, 1962; A.E. Eaanieeia e ae?., 1978, 1981; A.A. Aneiaiei,
1981).
Caycie ?iaioe c iaoeiaeie oaiaie. Iaoeiai-aeine?aeia ?iaioa
aeeiioaaeanue a ieaiiaiio ii?yaeeo o a?aeae?e? ii aea/aiith iaoai?ci?a
o?c?ieia?/ii? ae?? i?ia?aeueieo aiae oa eaai?aoi??? aenia?eiaioaeueii?
aaeueiaieia?? a?aeae?eo o?c?ieia?? aiaeii-nieueiaiai iai?io ?inoeoooo
o?c?ieia?? ?i. I.I.Aiaiiieueoey IAI Oe?a?ie ? ca”caia c oaiaie:
”Eco/aiea ?iee ioaeaeueieo eiiiiiaioia aiae oeia Iaooony, iaoaieciu eo
oeceieiae/aneiai e ea/aaiiai aeaenoaey” , N ain. ?aaeno?aoeee
01850003843, oeo? oaiu 2.35.7.7.,”Eco/aiea aeieiae/aneie aeoeaiinoe e
oeceieiae/aneiai aeaenoaey i?aaie/aneeo aauanoa aiaeu Iaooony”, N ain.
?aaeno?aoeee 01880009978, oeo? oaiu 2.36.1.1.,”Eco/eoue
oeceieiae/aneoth aeoeaiinoue ?yaea ieia?aeueieo aiae iiauo enoi/ieeia
n oeaeueth yenia?eiaioaeueiiai iainiiaaiey eo ea/aaiiai aeaenoaey” ii
i?ia?aiia AEIO N 348 io 30. 07.86, N ain. ?aaeno?aoeee
01870026029, oeo? oaiu 2.36.5.3.
Iaoa aeine?aeaeaiiy. ?icoe?aiiy niaeo?o iaoiae?a ioe?iee
aaeueiaiaeoeaiino? i?aai?/ieo ?a/iaei aiae oeio Iaooony, ?ic?iaea
i?aeoiae?a aei iiaeaethaaiiy ?o iioiaeaeaiiy c iaoith ooi/iaiiy aeayeeo
noi??i iaoai?cio ?oiuei? ae?? oa ?aeaioeo?eaoe?? aiae iiaia?aee?eoeo
?iaeiaeu oa naa?aeeiaei ia i?aaeiao i?eiaeaaeiino? aei oeio Iaooony.
Caaea/? aeine?aeaeaiiy. O a?aeiia?aeiino? c iaoith aeine?aeaeaiiy aoee
iinoaaeai? ianooii? caaaeaiiy.
1. Aeyaeoe niaoeeo?/i? oa?iaioaoeai? a?i?iaeeeaoi?e aeey aiae oeio
Iaooony. Aea/eoe caeaaei?noue i?ae ??aiyie oa?iaioaoeaii? aeoeaiino?
aiae ??cieo naa?aeeiaei oa e?euee?noth i?e?ii?aai?ci?a ??cieo
o?c?ieia?/ieo a?oi oeeo aiae.
2. Aea/eoe aieea aiae oeio Iaooony ia aeoeai?noue a?ae?ie?oe/ieo
oa?iaio?a oeoieiai-eeoeiaiai o?aeoo aeciaaiiiai oa iaia?aiiiai
iioiaeaeaiiy. C”ynoaaoe aieea ie?aieo a?oi i?aai?/ieo ?a/iaei
e?eoaaeueieo aiae oeueiai oeio ia eaoae?oe/io aeoeai?noue a?ae?ieac.
3. Ioe?ieoe aieea i?e?iaeieo oa aio?iiiaaiieo oaeoi??a ia
aaeueiaiaeoeai?noue aiaee Iaooony naa?aeeiaei O?oneaaaoeueeiai
?iaeiaeua c aeiiiiiaith niaoeeo?/ieo a?inaini??a.
4. Aea/eoe aieea aiaee Iaooony i?e o?eaaeiio iaiithaaii?
oaa?ei ia oaaioeeoa?io aeoeai?noue a?aioeioeeo?a oa ?aaeoeai?noue
i?aai?a ?ioiii? nenoaie. I?iaanoe ii??aiyeueio ioe?ieo
?ioiiiiaeoethth/i? ae?? a?ae?ioiaii? oa a?ae?io?eueii? o?aeoe?e
e?io?e?caoo e?eoaaeueii? aiaee ia oaaioeeoa?io aeoeai?noue
a?aioeioeeo?a aenia?eiaioaeueieo oaa?ei.
5. ?ic?iaeoe caaaeuei? i?eioeeie io?eiaiiy a?oie aaeueiaiaeoeaieo
?a/iaei , i?eoaiaiieo aiaeai oeio Iaooony, oeyoii i?e?iaii?
a?ioaoiieia?? ae?iuoaaiiy anioe?eiaaii? eoeueoo?e
aoaeaaiaeaiueieenethth/eo i?e?ii?aai?ci?a ia aoaeaaiaeiaa?e ne?iaei?.
6. I?iaanoe ii??aiyeueio ioe?ieo aieeao i?iaeoeo?a a?io?ainoi?iaoe??
iciea?eoo ia iaia?aii? ?iio?ainii?oi? AOOace aioa?ioeeo?a oa ia
nenoaio ianiaoeeo?/iiai ?ioiiiai caoenoo c ae??th iaoeaii? aiaee
Iaooony.
7. Iaa?oiooaaoe ? c”ynoaaoe cia/aiiy i?e?iaiiai oeaiico a iaoai?ci?
ae?? i?ia?aeueieo aiae oeio Iaooony , aeaoe ioe?ieo io?eiaiei
?acoeueoaoai aeey aaeueiaieia?? .
Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Ia iniia?
ee?i?ei-a?io?i?/ieo oa i?e?ia?ieia?/ieo iaoiae?a aia?oa ?ic?iaeaii
a?inaini?i? iaoiaee ioe?iee aaeueiaiaeoeaiino? i?ia?aeueii? aiaee
Iaooony in vitro . ?icoe?aii iaa?? a?ioano?a aeey ioe?iee
aaeueiaiaeoeaii? ae?? aiae oeueiai oeio.
Aia?oa anoaiiaeaii, ui i?e?iaia eaeoaoaeaa?ae?iaaiacia aeoeai?noue ?
a?ieia?/iei ?iaeeeaoi?ii aiaee Iaooony, coiiaeaia aeeoo?ae?yeuei?noth
noeueoao?aaeoeoth/eo aaeoa??e, cie?aia Desulfovibrio desulfuricans.
Aia?oa c”yniaaiee iaoai?ci ae?? ie?aieo a?oi i?aai?/iiai eiiieaeno
e?eoaaeueieo i?ia?aeueieo aiae ia aeoeai?noue a?ae?ie?oe/ieo oa?iaio?a
oiieiai eeoa/ieea (aeueoa-ai?eace oa iaia?aiii? Na,K-AOOace).
Aia?oa anoaiiaeiii iiaeoethth/o ae?th aiaee Iaooony ia oaaioeeoa?io
caeaoi?noue a?aioeioeeo?a o ee?i?oe? oa aenia?eiaio?.
Aia?oa a?aeoai?aii iaeei ?c eeth/iaeo aaeueiaiaoaeo?a i?ia?aeueii?
aiaee – aaeueioaaiiy aeoeaiino? ?iio?ainii?oieo AOOac ea?aiiiaeie
eeneioaie, io?eiaieie oeyoii i?e?iaii? a?io?ainoi?iaoe??..
Iaoiaeii a?ioaoiieia?/iiai iaa?iiaaeaeaiiy iaoaaie?o?a anioe?eiaaii?
eoeueoo?e aoaeaaiaeaiueieenethth/eo i?e?ii?aai?ci?a aiaee Iaooony
io?eiaii aaeueiaiaeoeai? ?a/iaeie oa a?aeoai?aii aaeueiaiaoaeoe ia
oa?iaioieo a?inaini?ao oa i?e aaaaoi?aciaiio iaaeoiaeaeaii? a
i?aai?ci in vivo.
I?aeoe/ia cia/aiiy. Io?eiai? ?acoeueoaoe ? iniiaith a?ieia?/ii?
?aeaioeo?eaoe?? i?ia?aeueieo aiae oeio Iaooony ca?aeii ?o aeanii?
oa?iaioaoeaii? aeoeaiino?. ?ic?iaeaii iaoiaee oa?iaioaoeaiiai
a?ioanooaaiiy i?aai?/ieo ?a/iaei e?eoaaeueieo i?ia?aeueieo aiae c iaoith
?icoe?aiiy niaeo?o ?o ?aeaioeo?eaoe?eieo oa?aeoa?enoee.
Cai?iiiiiaai? a?inaini?i? iaoiaee iiaeooue aooe aeei?enoai? aeey
aea/aiiy a?ieia?/ii? aeoeaiino? neeaaeieo i?aai?/ieo noi?oae,
a?iiiaeaeae, aiiaiiaoe/ieo cania?a oa i?ia?ioee?a, a oaeiae aeey ioe?iee
aieeao aio?iiiaaiieo oa i?e?iaeieo /eiiee?a ia ??aaiue
aaeueiaiaeoeaiino? e?eoaaeueieo neaaii?ia?ae?ciaaieo aiae . C ?o
aeiiiiiaith ei?aeoii i?iaaaeaii iii?oi??ia ci?i e?eoaaeueii? ae??
i?ia?aeueii? aiaee Iaooony ??cieo naa?aeeiaei O?oneaaaoeueeiai
?iaeiaeua oa ?aeaioeo?eiaaii aiaee oeio Iaooony na?aae iiaeo
naa?aeeiaei.
A?ioaoiieia?/ii iaea?aeaii a?oio aaeueiaiaeoeaieo i?aai?/ieo ?a/iaei
i?ia?aeueii? aiaee Iaooony, ui aeicaiey? caaacia/eoe oe?eani?yiiaaio
iiaeeo?eaoe?th aaeueiaioa?aiaaoe/ii? oe?iiino? oe??? oi?eaeueii?
e?eoaaeueii? aiaee.
Cai?iiiiiaaii oa ai?iaaaeaeaii a i?aeoeeo ?aeiiaiaeaoe?? uiaei uaaey/eo
iaoiae?a i/enoee e?eoaaeueieo aiae c iaoith caa?aaeaiiy aaeueiaiaeoeaieo
i?aai?/ieo ?a/iaei oa aaiaoe/iiai oiiaeo i?e?iaiiai oeaiico
O?oneaaaoeueeiai ?iaeiaeua.
Iniaenoee aianie caeiaoaa/a. Aaoi?ii naiino?eii aecia/aia iaoa oeueiai
aeine?aeaeaiiy, i?iaiae?ciaaia iaoeiaa e?oa?aoo?a c aea/aii? i?iaeaie.
?ic?iaeaii a?inaini?i? iaoiaee, iaoai?cie ae?? oa i?e/eii? oaeoi?e ?o
iiaeeo?eaoe?? a?oiaie i?aai?/ieo ?a/iaei aiaee Iaooony c”yniaai?
naiino?eii. Ia?aaaaeia a?eueo?noue aenia?eiaio?a, i?enay/aia aea/aiith
?ioiiiiaeoethth/i? ae?? aiaee Iaooony i?iaaaeaia iniaenoi. Aaoi?
naiino?eii ?ic?iaeea i?aeoiaee oa ciiaeaethaaea a?ioaoiieia?th
iaea?aeaiiy a?ieia?/ii aeoeaieo ?a/iaei aeine?aeaeoaaii? aiaee.
?acii ?c N.A.?aan?aeith aeae?eaii i?iaeoeoe i?e?iaii? a?io?aini?iaoe??
iciea?eoo iaoiaeii e?io?eueii? nooee oa a?aeoai?aii iniiai?
aaeueiaiaoaeoe aiaee Iaooony a aeine?aeao in vivo.Aeine?aee c
?a?no?aoe??th aeoeaiino? aeaaeaiueeeo i’yc?a i?iaaaeai? ?acii c A.I.
Caai?iaeitheii oa ?.ss. Aa?aei. Noaoenoe/ia ia?iaea ?acoeueoao?a, ?o
ocaaaeueiaiiy, ?ioa?i?aoaoe?y oa aeniiaee cae?eniai? naiino?eii.
Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy ?iaioe
ii?eethaeiaii ia: XXIX
Ananithci?e ia?aae?, i?enay/ai?e noaio ? ia?niaeoeaai ?icaeoeo
iaoiaee/ieo iniia o?i?/iiai ? a?ieia?/iiai iii?oi?eiao iiaa?oiaaeo aiae
noo? (?inoia-ia-Aeiio, aeiaoaiue 1987); Ananithci?e eiioa?aioe??
?inoeoooo aaieia?? AI O?N? (Ee?a, /a?aaiue 1988 ); ?anioae?eainuee?e
iaoe.-i?aeo. eiio. “Oeyoe ciaioaiiy aio?iiiaaiiiai aieeao ia i?e?iaei?
?ano?ne” (Iaeana, aeiaoaiue 1990); ?aa?iiaeuei?e iaoe.-i?aeo. eiio.
“Aeooaeueiua aii?inu naiaoi?ii-eo?i?oiiai ea/aiey” (Oaeai?iae, eenoiiaae
1990); II ?anioae?eainuee?e iaoe.-i?aeo. eiio. aea?iaoieia?a ?
eo?i?oieia?a “Eo?i?oi? oaeoi?e I?eea?iaooy a iaaee/i?e ? nioe?aeuei?e
?aaa?e?oaoe?? oai?eo aea?iaoicaie” (Euea?a, aa?anaiue 1991 );
iaoe.-i?aeo. eiio. “Iia? i?aeoiaee aei i?aai?caoe?? ? i?iaaaeaiiy
e?eoaaiiy, ?aaa?e?oaoe?? ? ?ae?aaoe?? a oiiaao eo?i?oo”(O?oneaaaoeue,
aeiaoaiue 1995); iaoe.-i?aeo. eiio. “Iaaee/ia ?aaa?e?oaoe?y iioa?i?eeo
aiane?aeie *i?iiaeeuenueei? eaoano?ioe” (O?oneaaaoeue, o?aaaiue 1996);
?icoe?aiiio can?aeaii? eaai?aoi??? aenia?eiaioaeueii? aaeueiaieia??
a?aeae?eo o?c?ieia?? aiaeii-nieueiaiai iai?io ?inoeoooo o?c?ieia?? ?i.
I.I. Aiaiiieueoey IAI(O?oneaaaoeue, aa?anaiue 1997); can?aeaii? naeoi?o
a?noea?aeueieo nenoai ?inoeoooo o?c?ieia?? ?i. I.I. Aiaiiieueoey IAI
(Ee?a, eenoiiaae 1997 ).
Ioae?eaoe??. ?acoeueoaoe aeena?oaoe?? iioae?eiaai? a iiiia?ao??, 8
noaooyo o iaoeiaeo aeaeaiiyo, 9 oacao c’?cae?a oa eiioa?aioe?e.
No?oeoo?a oa ianya ?iaioe. Aeena?oaoe?y aeeeaaeaia ia 163 noi??ieao
iaoeiiieniiai oaenoo, neeaaea?oueny ?c anooio, aiae?oe/iiai iaeyaeo
e?oa?aoo?e, iieno iaoiaeee aeine?aeaeaiue, 5 ?icae?e?a ?acoeueoao?a
aeanieo aeine?aeaeaiue, ?o iaaiai?aiiy oa aeniiae?a, nieneo 317
aeei?enoaieo e?oa?aoo?ieo aeaea?ae. Aeena?oaoe?y i?noeoue 34
oaaeeoe? oa 12 ?enoie?a.
CI?NO ?IAIOE
Aeine?aeaeoaaee i?ia?aeueio aiaeo Iaooony (IAI) naa?aeeiaei (na) 1- II,
8-II, 16-II, 21-I O?oneaaaoeueeiai ?iaeiaeua, a oaeiae
neaaii?ia?ae?ciaai? aiaee oeueiai oeio na. 18-EAe No?aeieoeueeiai
?iaeiaeua, na. 123 (Iii??ee), na. N 2 ? N 3 (Aooa), oa aeaea?aea N 11
(THcy). A?aea?? i?ia aiaee i?iaiaeeee a noa?eeuei? oeaeiie ia’?iii 0,3
e, ye? aeine?aeaeoaaee ia i?ci?oa 3 aiaeei c iiiaioo a?aeai?o. A ie?aieo
na??yo aeei?enoiaoaaee IAI i?ney 3-30-aeaiiiai caa??aaiiy a aa?iaieo /e
aiaa?iaieo oiiaao. Ai?no eenith eiio?iethaaee iioaioe?iiao?e/ii
aiae?caoi?ii “Tlenomierz” (Iieueua). A /anoei? aeine?ae?a c aiaee
iiia?aaeiuei aeaeaeyee i?e?ioei?o c aeiiiiiaith aaeoa??aeueiiai o?eueo?o
OII2-1000 oa iaia?aie “??ii?-4”. I?iae caa??aaee a aa?iaoe/ieo ?ieinoyo
i?e 9iN ai?iaeiaae 30 ae?a.
Iaoiaee aeine?aeaeaiiy. Aea/aiiy aaoiooiiii? i?e?ioei?e IAI oa ??
niaoeeo?/ieo o?c?ieia?/ieo a?oi i?iaiaeeee ca?aeii iaoiaee/ieo
?aeiiaiaeaoe?e. Aecia/aiiy caaaeueii? e?eueeino? aaeoa??e i?iaiaeeeinue
iaoiaeii i?yii? i?e?ineii?? o oaciai-eiio?aniiio cia?aaeaii?. Aeyaeaiiy
e?eueeino? i?e?ii?aai?ci?a o?ueio niaoeeo?/ieo o?c?ieia?/ieo a?oi
i?iaiaeeeinue iaoiaeii oeo??a ia aeaeoeaieo aeeaeeueieo na?aaeiaeuao. A,
naia, aoaeaaiaeaiueieeneth/? i?e?iae (AII) aeae?eyee ia na?aaeiaeu?
Oaoniia, noeueoao?aaeoeoth/? i?e?iae (N?I) – ia na?aaeiaeu? Ooo?i, a
o?iiiaieene? – ia na?aaeiaeu? Aae???iea. Ioe?iea aeeoo?ae?yeueiino?
i?e?ii?aai?ci?a cae?enithaaeanue ii ciai?oi?o iciaeao ?inoo,
eoeueoo?aeueieo oa oa?iaioaoeaieo aeanoeainoyo.
Aeey iiaeaethaaiiy aaiaco a?ae?io?eueieo niieoe aiaee Iaooony AII
eoeueoeaoaaee c aoaeaaiaeiaaith ne?iaeiith iaooiaiai iioiaeaeaiiy:
aiaeiai?nii? ii?iaee o?oneaaaoeueeiai ?iaeiaeua IAI, aeeeueiiai
iciea?eoo Ai?eneaanueeiai ?oaeiiai oi?aae?iiy, ai?eneaanueei? iaooe ?
o?i?/ii /enoiai ia?ao?iiaiai ianea. Caaaa/aio eoeueoo?o AII io?eioaaee
oeyoii aaaaoi?aciaeo ia?an?a?a ia na?aaeiaeua Oaoniia c aoaeaaiaeiyie.
Eoeueoo?aeueio ??aeeio (E?) e?io?e?coaaee ia onoaiiaoe? LZ- 9,2.?c
nooiai caeeoeo i?ia?aeueieo oa i?aai?/ieo eiiiiiaio?a aiaeiith
aeno?aeoe??th aeae?eyee a?ae?io?euei? i?aai?/i? ?a/iaeie (I?).
A IAI, E? ? aiaeieo aeoyaeeao aoaeaaiaei?a aecia/aee ai?no aaeoa??e,
eiioeaio?aoe?th i?aai?/iiai aoaeaoeth (Ni?a), a?ooi?a, ai?i?a,
ea?aiiiaeo eeneio, eenith, aaee/eio Eh-iioaioe?aeo ? pH.
Oanooaaiiy aaeueiaiaeoeaiino? IAI, E? ? aiaeieo aeoyaeie aoaeaaiaei?a
cae?enithaaee in vitro oa in vivo. In vitro aeine?aeaeoaaee
eaeoaoaeaa?ae?iaaiacio (EAeA) aeoeai?noue iaoiaeii Aa?aiae??a,
aeoeai?noue aaeoa??aeueii? aeueoa-ai?eace iaoiaeii Ni?oa ? ?iy,
aeoeai?noue Na,K-AOOace aioa?ioeeo?a uo?a iaoiaeii Cortas a
iiaeeo?eaoe?? I.I. Oa?eaiiai?, a oaeiae nei?ioeeao oa aeaeo?e/io
aeoeai?noue ?cieueiaaieo aeaaeaiueeeo i’yc?a (AI), (I.N. ss?aiaiei e
ae?., 1989). A aeine?aeao ia uo?ao ?n vivo aeine?aeaeoaaee aeoeai?noue
o?e?aeeii? caoenii? nenoaie i?aai?cio: ?ioiii?, i?e?iniiaeueii?
iiiiieneaaiacii? (IIN) ia/?iee oa eaiaeueoeaai? nae?aoi?ii-o?ainii?oii?
(ENON) ie?ie. Noai ?ioiii? nenoaie ioe?ithaaee ii ai?noo eaeeioeeo?a o
e?ia?, oaaioeeoa?i?e aeoeaiino? iaeo?io?e?a, ian? naeac?iee, iieacieeao
eaeei-, oa nieaiia?aie (I.A. Aaca?iiaa, 1982). I?i aeoeai?noue IIN
noaeeee ii o?eaaeino? aa?a?oo?aoiiai nio; ??aaiue ENON ioe?ithaaee ii
oaeaeeino? aene?aoe?? oaiie?ioo c na/ath, aaaaeaiiai aioo??oiueii’yciai
(N.A. ?aan?aea, 1994).
Aaeue-o?iiaoia?ao?th a?ae?io?eueieo I? IAI, E? oa aiaeieo aeoyaeie
aoaeaaiaei?a cae?enithaaee ia iaeo?aeueiiio naoaaeaen? G-10 (N.A.
?aan?aea, 1994).
AEe?i? eeneioe (AEE) c IAI ? E? aeae?eyee iaoiaeii aeno?aeoe??
oei?ioi?iii i?e ?I 3,0-4,0. ?o noia?iee ai?no aecia/aee ii
eiioeaio?aoe?? NIII-a?oi. Aeey ?aeaioeo?eaoe?? ?iaeea?aeoaeueieo AEE
o?aeoe?th AEE c E? aiae?coaaee ia aaci-??aeeiiiio o?iiaoia?ao? (EOI-
8IAe) c iieoi’yii-?ii?caoe?eiei aeaoaeoi?ii. A?ieia?/io aeoeai?noue AEE,
aeeo/aieo c IAI ? E?, a oaeiae i??enoeiiai? eeneioe (N14), ye
i?aaenoaaieea ea?aiiiaeo (aee?ieo) eeneio IAI, aea/aee ii ae?? ia
Na,K-AOOaco ? i?aia?ao AI.
Noaoenoe/ia ia?iaea oeeo?iaiai iaoa??aeo i?iaaaeaia ca e?eoa??yie t
Student, T Wilcocson, U Wilcocson-Mann-Witney. Ei?aeyoe?eii-?aa?aneaiee
aiae?c cae?eniaii ia eiii’thoa?? ca i?ia?aiith Costat.
?acoeueoaoe aeine?aeaeaiiy. 1. I?e?iaia eaeoaoaeaa?ae?iaaiacia
aeoeai?noue – ?iaeeeaoi? aiae oeio Iaooony. Anoaiiaeaii, ui ??aaiue
EAeA o an?o aeine?aeaeoaaieo aiaeao ei?aethaaa ?c /enaeuei?noth
noeueoao?aaeoeoth/eo i?e?ii?aai?ci?a. Caaaeueia aeoeai?noue EAeA
(iiieue/e*aiae) o aiae? na. 18-EAe neeaaeaea 16512, o aiae? Iaooony
(O?oneaaaoeue) – 12410, o aiae? na. 123 – 855, oiae? ye o iiaa?oiaaeo
aiaeao – 202. *enaeuei?noue niaoeeo?/ieo i?e?ii?aai?ci?a-
aoaeaaiaeaiueieenethth/eo oa noeueoao?aaeoeoth/eo (oen/e), aen?yieo c
aiaee na. 18-EAe, neeaaeaea 4,3, aiaee Iaooony (O?oneaaaoeue) – 0,96,
aiaee na. 123 – 0,34. I?e oeueiio anoaiiaeaii, ui iaeaeua aeoeai?noue
EAeA i?eoaiaiia a?oi? aiaa?iaieo noeueoao?aaeoeoth/eo aaeoa??e, a
naia, Desulfovibrio desulfuricans.
Anoaiiaeaii, ui ai?no N?I oa AII o IAI na. 21-I na. 1-II nooo?ai
ciaiooaaany o aaniyii-in?ii?e ia??iae, aeinyaath/e i?i?ioio ia ii/aoeo
aa?aniy c iinooiiaei i?aeaeuaiiyi aei n?/iy. Oey ae oaiaeaioe?y aeyaeaia
aeey caaaeueii? EAeA-aeoeaiino? i?ia?aeueii? aiaee, eio?a cieaeoaaeanue
a oeae ia??iae o aiae? na. 21-I c 14011 aei 10510 (p0,4).
Oaeei /eiii, I? e?eoaaeueieo aiae oeio Iaooony aeoeaothoue IIN ia/?iee,
ENON ie?ie oa nenoaie ee?oeiiiai ?ioi?oaoo e?ioi?aeieo i?aai?a o e?ia?
uo??a, ui noeioeth? caaaeueio ?acenoaioi?noue i?aai?cio.
5. Ci?ie i?aai?/ieo ?a/iaei oa aaeueiaiaeoeaiino? aiaee Iaooony i?ae
aieeaii aaoiooiiieo i?e?ii?aai?ci?a. Caa??aaiiy IAI i?e oaiia?aoo??
ieanoa, a i?enooiino? eenith, /e aac iueiai, aeicaiey? aea??eiai
i?inoaaeeoe a?io?ainoi?iaoe?th i?aai?/ieo ?a/iaei ?? aa?iaieie oa
aiaa?iaieie aaoiooiiieie i?e?ii?aai?ciaie. Anoaiiaeaii, ui caa??aaiiy
IAI i?e ai?no? eenith 2 ia/e, ai?iaeiaae 30 ae?a, noi?iaiaeaeoaaeinue
ca?eueoaiiyi caaaeueii? /enaeueiino? i?e?ii?aai?ci?a a 2,3 ?. ai?iaeiaae
7 ae?a, i?ney /iai a?aeaoaaeinue iinooiiaa ciaioaiiy i?e?iaiiai /enea
aei 0,8 iei/ie ia 30 aeiao. I?e oeueiio, ??no AII o 8 ?. cao?eniaaiee ia
7 aeiao, i?ioa, iaaeae?, ?o /enaeuei?noue iinooiiai ciaiooaaeanue aei
85% aeo?aeiiai ??aiy. E?euee?noue o?iiiaieeneeo aaeoa??e ci?ithaaeanue
aiaeia?/ii, eeoa ia oae ??cei, aeinyaath/e iaeneiaeueieo cia/aiue (450
ee/ie, oiaoi 120%) ia 7 aeiao, ?c iinooiiaei ciaioaiiyi aei 300 ee/ie ia
30 aeiao caa??aaiiy. Iaaiaee, /enaeuei?noue N?I neeaaeaea eeoa 230 ee/ie
ia 7 aeiao, oa i?ney 14 ae?a caa??aaiiy aiie, ae?eni? aiaa?iae, ia
aen?aaeeny cian?i.
Aaeiaee ai?no Ni?a ciaiooaaanue ianooo?ai ai?iaeiaae 14 ae?a aa?iaiiai
caa??aaiiy IAI, a iiaeaeueoiio e?euee?noue cieceeanue ia 50% a?ae
aeo?aeiiai ??aiy aei 30 aeiae. Aiaeii/an ai?no a?ooi?a caciaa
aeano?oeoe?? (ia 90%) ai?iaeiaae 14 aei?a caa??aaiiy, oiae? ye
eiioeaio?aoe?y ai?i?a ciaiooaaeanue ??aiii??ii, i?ioa iaooeeueii,
ai?iaeiaae i?nyoey, aei 16%. ?, iaaiaee, ai?no ea?aiiiaeo eeneio
ciaiooaaanue ia 20% eeoa a ia?o? 7 ae?a, a, iio?i, aei e?ioey i?nyoey,
c?inoaa ia 30% aeua aeo?aeieo oeeo?.
Oaeei /eiii, i?inoaaeaii ?ioaineaio aeeoo?ae?yeuei?noue AII, cieaeaiiy
ai?noo a?ooi?a, iaeiie/aiiy ea?aiiiaeo eeneio i?e aa?iaiiio caa??aaii?
IAI.
Caa??aaiiy aiaee a aiaa?iaieo oiiaao noi?iaiaeaeoaaeinue ??aiii??iei oa
iaeiicia/iei ciaioaiiyi i?e?iaiiai /enea c 2,6 aei 0,5 iei/ie ai?iaeiaae
30 ae?a. I?e oeueiio, iaeneiaeueiee ??no (o 4,2 ?ace)
noeueoao?aaeoeoth/eo aaeoa??e, ye ae?enieo aiaa?ia?a, aeyaeaii ia 7
aeiao. A iiaeaeueoiio ?o /enaeuei?noue iinooiiai ciaiooaaeany, i?ioa, ua
ia 21 aeiao neeaaeaea 123% a?ae aeo?aeiiai ??aiy. Iaeneiaeueiee ??no AII
(150% a?ae aeo?aeiiai ??aiy) niinoa??aaee ia 3 aeiao, c iinooiiaei
ciaioaiiyi ?o /enaeueiino? aei 88% /a?ac 30 ae?a caa??aaiiy. Iaaiaee,
/enaeuei?noue o?iiiaeo aaeoa??e, ye ae?enieo aa?ia?a, i?ney iacia/iiai
?inoo (11%) ia 3 aeiao, iaooeeueii ciaiooaaeany, aeinyaath/e 30,9% a?ae
aeo?aeiiai ??aiy ia 17 aeiao caa??aaiiy.
Anoaiiaeaii iinooiiaa i?aeaeuaiiy ai?noo Ni?a i?e caa??aaii? IAI a
aiaa?iaieo oiiaao. Oae, ai?no Ni?a aeinyaaa iaeneioio (121% i?e?inoo) ia
24 aeiao caa??aaiiy ? caeeoaany ia 18% aeua aeo?aeiiai ??aiy ia 30
aeiao.Ai?no a?ooi?a iinooiiai ciaiooaaany ia 10% a?ae aeo?aeiiai ??aiy.
I?ioa aeyaeaii iaeiini?yiiaaia ca?eueoaiiy ai?i?a (o 2 ?ace) oa
ea?aiiiaeo eeneio (o 1,5 ?ace.) ia 30 aeiao caa??aaiiy.
Aiae?coth/e ci?ie i?aai?/ieo ?a/iaei oa aaoiooiiieo i?e?ii?aai?ci?a
i?e aa?iaiiio ? aiaa?iaiiio caa??aaii? IAI, eiinoaoiaaii ??cea ciaioaiiy
a?ooi?iicieo niieoe (ia 45%) c iaeii/aniei ca?eueoaiiyi /enaeueiino? AII
o 8 ?ac ia 7 aeiao aa?iaiiai caa??aaiiy.I?ioa i?e aaceeniaaiio
caa??aaii? anoaiiaeaii ??no ea?aiiiaeo eeneio (ia 203, 6%), iacia/io
aeano?oeoe?th a?ooi?a oa ca?eueoaiiy AII ia 150% a oeae ia??iae.
Eiinoaoiaaii a?iaaiia iaa?iiaaeaeaiiy ea?aiiiaeo eeneio, ai?i?a oa
Ni?a.
Oaeei /eiii, i?ia?aeia ?ieue o aeano?oeoe?? a?ooi?iicieo niieoe oa
iaa?iiaaeaeaii? aiaei?ic/eiieo I? (ea?aiiiaeo eeneio) iaeaaeeoue
aaoiooiiiei AII aiaee Iaooony. Cie?aia, ?ioaineai?noue anei?eyoe??
a?ae?ioiaieo I? a aa?iaieo oiiaao o 5 ?ac?a aeua, i?ae a oiiaao aac
aeinooio eenith.
Anoaiiaeaii, ui aaeueiaieia?/ia aeoeai?noue IAI ii caeaoiino?
aaeueioaaoe Na,K-AOOaco aioa?ioeeo?a uo?a oaeiae ci?ithaaeinue a
i?ioean? caa??aaiiy. Oae, IAI caa??aaea aaeueioth/o caeaoi?noue
ai?iaeiaae 14 ae?a i?e a?aenooiino? eenith. Iaaiaee, iaoeaia ? iane/aia
eeniai (17 ia/e) IAI ao?a/aea ?ia?aoth/o caeaoi?noue aaea /a?ac 24 aiae
caa??aaiiy, oiae? ye aa?iaaia aaci?e?iaia IAI – /a?ac 3 aeiae. A
ianooii? aei? i?iyaeyee ae?th aeoeaaoi?e Na,K-AOOace, iaeneioiaeueii
noeioethaaee oa?iaio ia 7 aeiao (107%). I?ioa, aaea ia 10 aeiao
e?euee?noue aeoeaaoi??a oaeaeei ciaiooaaeanue. Aiaea,eio?a i?noeoue 2
ia/e eenith, ao?a/aea aaeuei?aiee aieea ia oa?iaio aeaui i?ci?oa (ia 3
aeiao) oa i?iyaeyea cia/ii neaaoee aeoeaoth/ee aoaeo (50%) ia 7 aeiao
caa??aaiiy. Iiae?ai? ?acoeueoaoe io?eiai? i?e oanooaaii? aa?iaaii? aiaee
ia ?cieueiaaieo i?aia?aoao AI oa na?oey oa ia i?ioeane eeneioiooai?aiiy
a oeoieo niaae (I.N. ss?aiaiei e ae?., 1989).
Oaeei /eiii, a?io?ainoi?iaoe?y AA? IAI aaoiooiiieie i?e?ii?aai?ciaie
no?iai caeaaeaea a?ae e?eueeino? ?ic/eiaiiai o aiae? eenith. Iieacaii,
ui ?iaea?oi?e ?ii-o?ainii?oii? AOOace oa AI ia?aaaaeaee o aiae? Iaooony
i?e a?aenooiino? eenith, ?, iaaiaee, ?o aeoeaaoi?e aeii?ioaaee a
aa?iaieo oiiaao. Noia?iee aoaeo IAI aecia/aany e?euee?niei
ni?aa?aeiioaiiyi ?iaea?oi??a oa aeoeaaoi??a, ui caeaaeaei a?ae
?ioaineaiino? canai?iiy a?ooi?iicieo niieoe ?? AII. Anoaiiaeaii, ui IAI
ao?a/aea aaeueiaiaeoeai?noue ia 10-20 aeiao caa??aaiiy a aa?iaieo
oiiaao.
Aeyniaiiy o?i?/ii? i?e?iaee aeyaeaieo AA? oa ?ie? ie?aieo a?oi
i?e?ii?aai?ci?a o ?o aaiac? noaei caaaeaiiyi ianooiieo aeine?aeaeaiue.
6. Iiaeaethaaiiy aaiaco aee?ieo eeneio oa aeine?aeaeaiiy ?o ?ie? a
aaeueiaiaeoeaiino? aiaee Iaooony. Anoaiiaeaii, ui /ioe?ueiooeaeiaaa
?ieoaaoe?y aaoiooiiieo i?e?ii?aai?ci?a IAI c eiia?oe?eiei iciea?eoii
noi?iaiaeaeoaaeanue ooai?aiiyi aiaei?ic/eiieo AA? (?aan?aea N.A., 1994),
i?e?iaea eio?eo caeeoa?oueny iaa?aeiiith. Ea?oth/enue e?oa?aoo?ieie
aeaieie, ui aee?i? eeneioe ? iino?eieie neeaaeiaeie IAI o eiioeaio?aoe??
0,01-0,1 iIieue/e (A.I. ssnaae/, 1982; A.N. Aaaoiiaa, 1986) oa
?acoeueoaoaie aeanieo aeine?aeaeaiue, ui AII caaacia/othoue aea??eiaa
iaeiie/aiiy AEE i?e aa?iaiiio caa??aaii? IAI, aaaaeaee ca aeioe?eueia
aeine?aeeoe iiaeeea?noue ooai?aiiy AEE oeyoii i?e?iaii?
a?io?ainoi?iaoe?? aoaeaaiaeiaai? ne?iaeie: aiaeiai?nii? ii?iaee
O?oneaaaoeueeiai ?iaeiaeua Iaooon?, ai?eneaanueeiai iciea?eoo, iaooe,
ia?ao?iiaiai ianea.
Iaoiaeii aaeue-o?iiaoia?ao?? c?aeaioeo?eiaaii 7 aiaei?ic/eiieo niieoe
AII-iaoaaie?o?a, 4 c eio?eo ?aeaioe/i? a?ae?io?eueiei I? IAI.
Anoaiiaeaii, ui eoeueoo?aeueia ??aeeia (E?) caeaoia aaeueioaaoe
Na,K-AOOaco a ?icaaaeaii? 1-0,01% aei ia’?io ?ieoaaoe?eiiai na?aaeiaeua
ia 6-12 aeiao eoeueoeaoaaiiy AII. Aeacaiee aoaeo ia caeaaeaa a?ae
aeei?enoaii? aoaeaaiaeiaai? ne?iaeie. Aiaeii/an, aaeuei?aia caeaoi?noue
E? /?oei ei?aethaaea ?c ai?noii AEE a i?e, /a?ac oea i?aaii??ii
aeiionoeoe, ui naia AEE ? ?iaea?oi?aie Na,K-AOOace. Aeey
i?aeoaa?aeaeaiiy oeueiai aeiiouaiiy i?iaaaeaii na??th aenia?eiaio?a c
aeine?aeaeaiiy ae?? AEE, aeae?eaieo c aiaee Iaooony oa eoeueoo?aeueii?
??aeeie. Iieacaii, ui AEE aiaee Iaooony (N16-N24) ? E? (N9-N18), a aeic?
0,1 ieIieue/e, a??ia?aeii aaeueioaaee aeoeai?noue oa?iaioa, a
na?aaeiueiio, ia 26,51,5% (p
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