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EE?ANUeEEE IAOEIAI-AeINE?AeIEE ?INOEOOO

AAIAOIEIA?? OA IA?AEEAAIIss E?IA?

IIC OE?A?IE

EA?IEUe TH??e Noaiaiiae/

OAeE 616-006.441+616.155.392.2]:612.017.01-085/-089

AIEEA E?EOAAIIss IA OAIIOEI?*IO OA?AEOA?ENOEEO E?IOI?AeIEO EE?OEI OAI?EO
IA O?II?*I? E?IOII?IE?OA?AOEAI? CAOAI?THAAIIss C ?IOIIEIE OeEOIIAI?ssIE

14.01.31 — aaiaoieia?y oa o?ainooc?ieia?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a — 1998

1

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia o Euea?anueeiio o?e?ae? Ee?anueeiai iaoeiai-aeine?aeiiai
?inoeoooo aaiaoieia?? oa ia?aeeaaiiy e?ia? IIC Oe?a?ie.

Iaoeia? ea??aieee — aeieoi? iaaee/ieo iaoe, i?ioani?

AEAIANUeEA ss?ineaaa ?ee?aia,

caa?aeoaa/ a?aeae?eaiiy aaiaoieia?? Euea?anueeiai o?e?aeo

Ee?anueeiai iaoeiai-aeine?aeiiai ?inoeoooo aaiaoieia??

oa ia?aeeaaiiy e?ia?

— aeieoi? iaaee/ieo iaoe, i?ioani?

EIA?INUeEEE Aieiaeeie? Inoaiiae/,

caa?aeoaa/ eaai?aoi??? ?ioiieia?? Euea?anueeiai o?e?aeo

Ee?anueeiai iaoeiai-aeine?aeiiai ?inoeoooo aaiaoieia??

oa ia?aeeaaiiy e?ia?

Io?oe?ei? iiiiaioe — aeieoi? iaaee/ieo iaoe, i?ioani?

AAEAeOEIAA Na?oeaia Ieoaee?aia,

caa?aeoaa/ eaoaae?e aaiaoieia?? Ee?anueei? iaaee/ii? aeaaeai??

i?neyaeeieiiii? ina?oe IIC Oe?a?ie

— aeieoi? iaaee/ieo iaoe, i?ioani?

CA??EIAA Aeea Naiai?aia,

i?ia?aeiee iaoeiaee ni?a?ia?oiee eaai?aoi??? oeeoieia??

oa ?ioiieia?? Ee?anueeiai IAe? aaiaoieia?? oa ia?aeeaaiiy e?ia?

I?ia?aeia onoaiiaa — ?inoeooo aenia?eiaioaeueii? iaoieia??,
iieieia?? oa ?aae?ia?ieia?? ?i. ?.?. Eaaaoeueeiai IAI Oe?a?ie,

a?aeae?e ?ioiioeeoio?i??, i. Ee?a

Caoeno aeena?oaoe?? a?aeaoaeaoueny “…11..” .eenoiiaaea. 1998 ?. i
.14:30… aiaeei? ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae
26.612.01 a Ee?anueeiio IAe? aaiaoieia?? oa ia?aeeaaiiy e?ia? (254060,
i.Ee?a, aoe.I.Aa?e?inueeiai, 12).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Ee?anueeiai IAe?
aaiaoieia?? oa ia?aeeaaiiy e?ia?.

Aaoi?aoa?ao ?ic?neaiee “..01..” ..aeiaoiy 1998 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee EII?NA?AIEI A.A.

AEOOAEUeI?NOUe OAIE

O?ii?/iei e?ioii?ie?oa?aoeaiei caoai?thaaiiyi (OEIC) i?eoaiaiiee
?icaeoie oneeaaeiaiue ?ioiiiai aaiaco. Ca?aeii c aeaieie ??cieo aaoi??a,
?ioii? oeeoiiai?? oneeaaeiththoue ia?aa?a OEIC o 5-25% iaoe??io?a
(Z.M.Sthoeger ? ni?aaao., 1993; K.Gronbek ? ni?aaao., 1996). Iae/ano?oa
oea ?ioiia aaiie?oe/ia aiai?y (?AA) oa ?ioiia o?iiaioeeoiiai?/ia io?io?a
(?OI).

Iacaaaeath/e ia oa, ui aeieeiaiiy aiai?? /e o?iiaioeeoiiai?? ? iniiaith
aeey ae?aaiinooaaiiy i?ci?o noaae?e (III, IV ca Rai) o?ii?/ii?
e?ioi?aeii? eaeeai?? (OEE), i?iaiic caoai?thaaiiy a?aeiinii o?eaaeino?
aeeooy naia i?e ?ioiieo oeeoiiai?yo ? cia/ii ni?eyoeea?oei, i?ae i?e
oeeoiiai?yo iaoaieanoe/iiai aaiaco (ss.E.Auaianeay ? ni?aaao., 1996;
A.Haubenstock, R.Zalucky, 1985; G.Majumdar ? ni?aaao., 1993). Ie??i
oiai, e?eoaaeueia oaeoeea i?e aeieeiaii? ?ioiieo oeeoiiai?e
a?ae??ciy?oueny a?ae o?aaeeoe?eii? oa?ai?? OEE ? caeeoa?oueny aeaeaeith
a?ae ae??oaiiy, ia aeeaey/enue ia cia/iee a?naiae e?eoaaeueieo cania?a
(ei?oeeinoa?i?aei? ai?iiie, aee?eoth/? i?aia?aoe, eaeeaieaciaoa?ac,
nieaiaeoii?y oa ?io?).

Aeine?aeaeaiiy inoaii?o ?ie?a iieacaee, ui iaoai?cie ae??
o?i?ioa?aiaaoe/ieo cania?a oa a?ieia?/ii aeoeaieo ?a/iaei, ui
canoiniaothoueny a e?eoaaii? ceiye?nieo caoai?thaaiue, neeaaei? ? aei
e?ioey ia aeyniai? (J.E.Wertz, M.R.Haenley, 1996). A?aeiii, ui an?
e?eoaaeuei? caniae caioneathoue caaaeuei? iaoai?cie aiiioico, ye?
?aaoeththoueny ?yaeii iieiaai?a (J.L.Binet ? ni?aaao., 1996; I.Korner ?
ni?aaao., 1997). Nooi?iue aiiioico A-ee?oei i?e OEE ? aeici- ?
/anicaeaaeiei. Aieea e?eoaaeueieo i?aia?ao?a ia ceiye?ni? ? e?ioi?aei?
ee?oeie caeaaeeoue a?ae yaeu aeoeaaoe?? /e ?ai?an?? a aaiii?, ye? ia
iiaeooue ia noi?iaiaeaeoaaoenue ci?iaie oaiioeio ee?oeie. Naia oiio
aea/aiiy ci?i oaiioei?/ii? oa?aeoa?enoeee iaia?aie ceiye?nieo ee?oei o
oai?eo ia A-OEE c ?ioiieie oneeaaeiaiiyie a i?ioean? e?eoaaiiy c
o?aooaaiiyi eiai aoaeoeaiino? ? ia?niaeoeaiei a ieai? aeai?o ?
iaa?oiooaaiiy iaea?eueo ?aoe?iiaeueieo i?ia?ai oa?ai??, ui aeicaieeoue
oaeineiiaeeoe e?eoaaeueio oaeoeeo i?e oe?e iaoieia??.

CA’ssCIE ?IAIOE C IAOEIAEIE I?IA?AIAIE, IEAIAIE, OAIAIE

Ia?aiee iai?yiie aeine?aeaeaiiy aaciina?aaeiuei iia’ycaiee c
iaoeiai-aeine?aeieie ?iaioaie Euea?anueeiai o?e?aeo Ee?anueeiai IAe?AIE
(?? Aea?ae?a?no?aoe?? 0194U022112 oa UA 01012649?).

IAOA AeINE?AeAEAIIss

Aaeineiiaeaiiy e?eoaaeueii? oaeoeee o oai?eo o?ii?/ieie
e?ioii?ie?oa?aoeaieie caoai?thaaiiyie c ?ioiieie oneeaaeiaiiyie ia
iniia? aeyniaiiy ci?i oaiioei?/ii? oa?aeoa?enoeee e?ioi?aeieo ee?oei
ia?eoa?e/ii? e?ia? a i?ioean? ??cieo noai oa?ai?? c a?aooaaiiyi ??
aoaeoeaiino?.

CAAeA*? AeINE?AeAEAIIss

1. Aeynieoe iniaeeaino? ?ioiieia?/iiai oaiioeio e?ioi?aeieo ee?oei
ia?eoa?e/ii? e?ia? oai?eo ia A-OEIC c ?ioiieie oneeaaeiaiiyie.

2. Aea/eoe ci?ie ?ioiioaiioei?/ii? oa?aeoa?enoeee eaeeai?/ieo A-ee?oei
oa nenoaie O-e?ioioeeo?a ia?eoa?e/ii? e?ia? oai?eo ia A-OEE c ?ioiieie
oneeaaeiaiiyie i?ae ae??th ??cieo noai e?eoaaiiy.

3. Aeynieoe aeni?an?th A-, O- oa aeoeaaoe?eieo aioeaai?a ia e?ioioeeoao
ia?eoa?e/ii? e?ia? i?ney nieaiaeoii?? o oai?eo ia iaaiaeaee?inueeo
e?ioiio (A-IAE) c ?ioiieie oneeaaeiaiiyie oa aac oneeaaeiaiue.

4. O oai?eo ia A-OEE c ?ioiieie oneeaaeiaiiyie ni?anoaaeoe /anoioo ?
o?eaae?noue ?ai?n?? i?ney ??cieo iaoiae?a e?eoaaiiy c? ci?iaie
?ioiioaiioei?/ii? oa?aeoa?enoeee e?ioioeeo?a ia?eoa?e/ii? e?ia? ? ia
oe?e iniia? iaa?oiooaaoe oa aaeineiiaeeoe e?eoaaeueio oaeoeeo.

IAOEIAA IIAECIA IAeA?AEAIEO ?ACOEUeOAO?A

Aia?oa aeyaeai? a?aei?iiino? ?ioiioaiioei?/ii? oa?aeoa?enoeee
e?ioioeeo?a ia?eoa?e/ii? e?ia? oai?eo ia OEE c ?ioiieie oneeaaeiaiiyie
i?ae aieeaii ??cieo noai oa?ai??. Iieacaii, ui aiane?aeie e?eoaaiiy
a?aeaoaathoueny e?euee?ni? ? ye?ni? ci?ie oaiioei?/ii? oa?aeoa?enoeee
eaeeai?/ieo A-ee?oei. E?euee?ni? ci?ie i?iyaeythoueny cieaeaiiyi ??aiy
aeni?an?? A-ee?oeiieo ia?ea??a, a ?o ae?aaeai?noue ei?aeth? c
aoaeoeai?noth oa?ai??. sse?ni? ci?ie — oea c?inoaiiy aeni?an??
aeoeaaoe?eieo aioeaai?a; iae/ano?oa ca?eueoo?oueny aeni?an?y CD25R,
?aoeaioi?a IL-2. Aia?oa iieacaii, ui aaaeeeaei oaeoi?ii aoaeoeaiino?
oa?ai?? i?e OEE ? i?aeaeuaiiy ??aiy aeni?an?? ia eaeeai?/ieo ee?oeiao
Fas-?aoeaioi?a (CD95), e?aoaaiiy yeiai oaeoi?ii iae?ico iooeei caionea?
i?ia?aio aiiioico. Aeyaeaii, ui c?inoaiiy e?eueeino? CD95+-ee?oei ianoa?
i?ney i?ia?ai e?eoaaiiy, ui a?aecia/athoueny nooo?aith aoaeoeai?noth,
oiaoi i?ney eo?no oa?ai?? a?ie?enoeiii c i?aaei?cieiiii oa i?ney noaie
NI? o oai?eo ia OEE c ?ioiieie oneeaaeiaiiyie ?, iniaeeai, i?ney
nieaiaeoii?? o oai?eo ia OEE oa IAE. Aeiaaaeaii o?niee ei?aeyoe?eiee
ca’ycie i?ae i?e?inoii ??aiy CD95+-ee?oei i?ae /an eo?no e?eoaaiiy ?
na?aaeiueith o?eaae?noth ?ai?n??. Iieacaii, ui ?acoeueoaoeaia e?eoaaiiy
oai?eo ia OEE c ?ioiieie oneeaaeiaiiyie i?ecaiaeeoue aei c?inoaiiy
iiioeyoe?? O-e?ioioeeo?a ? a?aeiiaeaiiy O-ee?oeiii? ?ioii?aaoeyoe??.
Aeyaeai? a?aei?iiino? ?ioiioaiioei?/ii? oa?aeoa?enoeee e?ioioeeo?a
ia?eoa?e/ii? e?ia? oai?eo ia OEIC c ?ioiieie oneeaaeiaiiyie a i?ioean?
??cieo noai oa?ai?? iiaeooue neoaoaaoe iniiaith aeey ?icoi?iiy iaoai?cio
ae?? ie?aieo e?eoaaeueieo caoiae?a.

I?AEOE*IA CIA*AIIss IAeA?AEAIEO ?ACOEUeOAO?A

Ia iniia? ni?anoaaeaiiy aoaeoeaiino? ie?aieo iaoiae?a e?eoaaiiy ?ioiieo
oneeaaeiaiue OEE oa ci?i oaiioei?/ii? oa?aeoa?enoeee e?ioioeeo?a
ia?eoa?e/ii? e?ia? oai?eo iaa?oioiaaia e?eoaaeueia oaeoeea i?e aeai?e
iaoieia??. ?ic?iaeaii i?aeoe/i? ?aeiiaiaeaoe?? uiaei canoinoaaiiy
ie?aieo noai oa?ai?? o oai?eo ia OEE c ?ioiieie oneeaaeiaiiyie c
o?aooaaiiyi ee?i?/ieo i?iya?a caoai?thaaiiy oa ci?iaie ?ioiioaiioei?/ii?
oa?aeoa?enoeee e?ioioeeo?a. Iaa?oioiaaii aeioe?euei?noue i?iaaaeaiiy
nieaiaeoii?? o oai?eo ia OEIC, ui i?io?eathoue c ?ioiieie
oneeaaeiaiiyie.

INIAENOEE AIANIE CAeIAOAA*A

Aaoi?ii naiino?eii i?iaaaeai? aiae?c aeooaeueiino? ? nooiaiy aea/aiiy
oaie ?iaioe, oa?aeoa?enoeea ianoaaeaieo oai?eo, aea?? ? ii?aoethaaiiy
iaoiaeee aeine?aeaeaiiy, ?ioiioaiioei?/i? aeine?aeaeaiiy ee?oei
ia?eoa?e/ii? e?ia?, noaoenoe/iee aiae?c iaoa??aeo. Aeyaeai?
caeiiii??iino? noi?ioeueiaaii o aeniiaeao.

AI?IAAOe?ss ?ACOEUeOAO?A AeENA?OAOe??

?acoeueoaoe aeine?aeaeaiue iieeaaeai? a iniiao ?ioi?iaoe?eiiai eenoea
“Aeeoa?aioe?eia ae?aaiinoeea aooi?ioiieo ? iaoaieanoe/ieo aaiioeeoiiai?e
o oai?eo o?ii?/iith e?ioi?aeiith eaeeai??th” (Ee?a, 1995),
aeiiia?aeaeenue ia Y eiia?an? na?oiai? oaaea?aoe?? Oe?a?inueeeo
e?ea?nueeeo oiaa?enoa (Aei?i?iiao?ianuee, 1994 ?.), 3 Oe?a?inueeiio
c’?cae? aaiaoieia?a ? o?ainooc?ieia?a (Noie, 1995), XIII Meeting Intern.
Soc. Haematology (European & African Division) (Istanbul, Turkiye,
1995), YI eiia?an? na?oiai? oaaea?aoe?? Oe?a?inueeeo e?ea?nueeeo
oiaa?enoa (Iaeana, 1996), 40th Annual Meeting of the GTH (Gesellschaft
fr Thrombose- und Hmostaseforschung) (Basel, 1996), I I?aeia?iaeiiio
eiia?an? iieiaeeo a/aieo (Oa?iii?eue, 1997), XIV Meeting of the Int.
Soc. Haematology (Stockholm, 1997), 4th Int. Symp. on Clinical
Immunology (Amsterdam, 1997), XVII Zjazd Polskiego Towarzystwa
Hematologow i Transfuzjologow (Krakow, 1997), Conf. “B-cell
Lymphoproliferative Disorders: contributions of molecular and cell
biology to understanding and treatment” (New York, 1998),
iaoeiai-i?aeoe/i?e eiioa?aioe?? iieiaeeo a/aieo oa oao?aoe?a “No/ani?
i?iaeaie aaiaoieia?? oa o?ainooc?ieia??” (Ee?a, 1998), Frhjahrstagung
1998 der sterreichischen Gesellschaft fr Hmatologie und Oncology (Baden
bei Wien, Austria, 1998), III Scientific and Educational Conf. “Chronic
Lymphocytic Leukaemias“ (Pu?awy, Poland, 1998). Iniiai? iieiaeaiiy
aeena?oaoe?? ai?iaaaeaeaii a i?aeoeeo aaiaoieia?/iiai a?aeae?eaiiy 5-i?
ee?i?/ii? e?ea?i? i.Eueaiaa, eiinoeueoaoeaii? iie?ee?i?ee Euea?anueeiai
o?e?aeo Ee?anueeiai IAe? aaiaoieia?? oa ia?aeeaaiiy e?ia?,
aaiaoieia?/iiai eaa?iaoo eiinoeueoaoeaii? iie?ee?i?ee Euea?anueei?
iaeanii? ee?i?/ii? e?ea?i?.

IOAE?EAOe??

?acoeueoaoe aeena?oaoe?? iioae?eiaaii o 4 noaooyo o iaoeiaeo aeo?iaeao,
13 oacao c’?cae?a ? eiioa?aioe?e oa a ?ioi?iaoe?eiiio eenoeo.

IANssA ? NO?OEOO?A AeENA?OAOe??

Aeena?oaoe?y aeeeaaeaia ia 174 noi??ieao iaoeiiieno, c ieo 112 noi??iie
oaenoo, 15 noi??iie caeiathoue oaaeeoe?, 7 noi??iie – ?ethno?aoe??, 40
noi??iie – nienie e?oa?aoo?e. ?iaioa neeaaea?oueny c? anooio, iaeyaeo
e?oa?aoo?e, i’yoe ?icae?e?a aeanieo aeine?aeaeaiue, aeniiae?a, nieneo
aeei?enoaieo aeaea?ae, yeee i?noeoue 369 aeaea?ae. ?iaioa ?ethno?iaaia
28 oaaeeoeyie oa 7 ?enoieaie.

CI?NO ?IAIOE

IAOA??AE ? IAOIAeE AeINE?AeAEAIIss

I?iaaaeaii ?ioiioaiioei?/ia ianoaaeaiiy 67 oai?eo o?ii?/ieie
e?ioii?ie?oa?aoeaieie caoai?thaaiiyie, ia?aa?a yeeo oneeaaeieany
?ioiieie oeeoiiai?yie. An? oai?? ia?aaoaaee ia noaoe?iia?iiio e?eoaaii?
a aaiaoieia?/iiio a?aeae?eaii? 5-i? ee?i?/ii? e?ea?i? i.Eueaiaa,
ee?i?/ii? aace Euea?anueeiai o?e?aeo Ee?anueeiai iaoeiai-aeine?aeiiai
?inoeoooo.

Na?aaei?e a?e oai?eo aeiinea 57,6±1,0 ?ie?a. Na?aae ianoaaeaieo
iaoe??io?a 53 (c ieo 36 /ieia?e?a ? 17 ae?iie) no?aaeaeaee ia A-OEE ? o
14 iaoe??io?a (10 /ieia?e?a ? 4 ae?iee) aoea ae?aaiinoiaaia
iaaiaeaee?inueea e?ioiia (IAE). O an?o oai?eo aeine?aeaeoaaany
?ioiieia?/iee oaiioei e?ioi?aeieo ee?oei ia?eoa?e/ii? e?ia? a i?ioean?
e?eoaaiiy (aei ii/aoeo ? i?ney cae?i/aiiy oa?ai??). O 9 oai?eo
ianoaaeaiiy i?iaaaeaii aea?/? — a i?ioean? ??cieo iaoiae?a e?eoaaiiy.
Aeey ii??aiyiiy io?eiaieo aeaieo i?iaaaeaii ?ioiioaiioei?/ia ianoaaeaiiy
12 oai?eo ia OEE aac ?ioiieo oneeaaeiaiue (I-II no. caoai?thaaiiy ca
Rai) oa aeine?aeaeaiiy aoii?aeueiiai ?ioi?oaoo o 34 caei?iaeo in?a. A
caaaeueiiio i?iaaaeaii 164 ?ioiioaiioei?/i? aeine?aeaeaiiy.

A caeaaeiino? a?ae i?ecia/aii? oa?ai?? aeae?eaii 7 a?oi oai?eo ia OEE:

1) 13 oai?eo iaea?aeoaaee i?aaei?cieii (Pr) a na?aaei?e aeic? 1-2 ia/ea
iane/aeiao;

2) 11 oai?ei iaeii/anii c i?aaei?cieiiii o noaiaea?oi?e aeic? aaiaeeee
a?ie?enoei (Vr) 2 ia iaeei ?ac ia oeaeaeaiue i?e eo?nia?e aeic? 6 ia;

3) 8 oai?eo io?eioaaee oei?aiaooeee (Chl) a aeic? 0,15-0,2 ia/ea
iane/aeiao aei 200-300 ia ia eo?n e?eoaaiiy a eiia?iaoe?? c
i?aaei?cieiiii;

4) 8 oai?ei e?eoaaiiy i?ecia/aeinue ca noaiith NI? (2 ia a?ie?enoeio
aioo??oiueiaaiii 1-ee aeaiue, oeeeeioinoai 750 ia/i2 aioo??oiueiaaiii
1-e aeaiue, i?aaei?cieii 40 ia/i2 per os i?ioyaii 5 aei?a);

5) 9 oai?ei ia oii? e?eoaaiiy i?aaei?cieiiii i?ecia/aeenue aeoeaaoi?e
O-nenoaie ?ioi?oaoo (Thy) (O-aeoea?i, oeiae?i) a aeic? 1,0 ie i?aia?aoo
aioo??oiueii’ycaai (10 ?i’?eoe?e ia eo?n);

6) eaeeaieaciaoa?ac (LPF) ia oii? e?eoaaiiy i?aaei?cieiiii i?iaiaeeany o
7 oai?eo. Eo?n e?eoaaiiy neeaaeaany ?c 2-7 naain?a eaeeaieaciaoa?aco c
aeaeaeaiiyi a na?aaeiueiio 800-1200 ie ieacie ? 50-140 ie eaeeiiane;

7) nieaiaeoii?y (Spl) i?iaaaeaia o 7 oai?eo ia OEE. Aei iia?aoe?? ? a
i?neyiia?aoe?eiiio ia??iae? oai?? iaea?aeoaaee i?aaei?cieii a aeic? 1-3
ia/ea iane a caeaaeiino? a?ae aaiiaeeiai?ee.

Oai?ei ia IAE (7 oai?eo c ?ioiieie oneeaaeiaiiyie ? 7 oai?eo aac ?ioiieo
oneeaaeiaiue) i?iaaaeaia nieaiaeoii?y. Iieacaie aei nieaiaeoii?? aoee
cia/ia nieaiiiaaae?y, ?cieueiaaia o?aaeaiiy naeac?iee, iaaoaeoeai?noue
eiina?aaoeaiiai aai oeeoinoaoe/iiai e?eoaaiiy, iino?eii ?aoeeaeeaoth/ee
ia?aa?a ?ioiieo oneeaaeiaiue.

O ?iaio? aeei?enoiaoaaeenue caaaeueiiee?i?/i?, aaiaoieia?/i?,
a?io?i?/i?, na?ieia?/i? oa ?ioiieia?/i? iaoiaee aeine?aeaeaiiy.

O a?oio ?ioiieia?/ieo iaoiae?a aoiaeeee:

1. Aecia/aiiy aeeoa?aioe?eieo aioeaai?a ia iaia?ai? e?ioi?aeieo ee?oei
ca aeiiiiiaith iiiieeiiaeueieo aioeo?e (IEAO) na??? ?II (io?eiaieo
N.I.Neaei?aiei ? ni?aaao. a ?inoeooo? aenia?eiaioaeueii? iaoieia??,
iieieia?? oa ?aae?ia?ieia?? ?i.?.?.Eaaaoeueeiai IAI Oe?a?ie), na??? ?EI
(io?eiaieo A.TH.Aa?eoi?eiaei ? ni?aaao. a ?inoeooo? ee?i?/ii? iieieia??
?IIOe AI ?in??), na??? EO (io?eiaieo I.A.O?eaoiaei ? ni?aaao. a
?inoeooo? ?ioiieia?? IIC ?in??) oa na??? ANA (io?eiaieo O.?.Aoee/iaith ?
ni?aaao. a ?in?enueeiio aaiaoieia?/iiio iaoeiaiio oeaio??). Iaiaeue
aeeth/aea 29 IEAO.

Aeine?aeaeaiiy ?ioiioaiioeio e?ioi?aeieo ee?oei i?iaiaeeeinue iai?yiei
?ioiioethi?anoeaioiei iaoiaeii a iiiioa?? ee?oei, i?ee??ieaieo aei neea
ca aeiiiiiaith iie?-L-e?ceio (o??ia “Sigma”). sse aoi?eiia ne?iaaoea
canoiniaoaaeenue F(ab)2-o?aaiaioe aioeo?e aei ?ioiiaeiaoe?i?a a?ei?
ieo?, iii?/ai? oethi?i?cio?ioe?aiaoii, io?eiai? a IAI “I?aia?ao” i?e
Ieaeiuei-Iiaai?iaenueeiio IAe?A?I.

E?ioi?aei? ee?oeie iaea?aeoaaee c aaia?ei?ciaaii? aaiicii? e?ia? ca
iaoiaeii aeeoa?aioe?eiaaiiai oeaio?eooaoaaiiy a a?aae??io? u?eueiino?
aa?ia?ao?io-o?eieo (d=1,077) (E.A.Oaeoaoe, A.A.Aaaeaeei, 1973).
A?aeiinio e?euee?noue aioeaaiiiceoeaieo iiiiioeeaa??a i?ae?aoiaoaaee ia
100-200 ee?oei, aeei?enoiaoth/e ethi?ianoeaioiee i?e?ineii “Ethiai ?-8”.

2. Aecia/aiiy eiioeaio?aoe?? ne?iaaoeiaeo ?ioiiaeiaoe?i?a eean?a G, A, M
iaoiaeii ?aae?aeueii? ?ioiiaeeooc??.

3. Aecia/aiiy ??aiy oee?eoethth/eo ?ioiieo eiiieaen?a o ne?iaaooe?
e?ia?.

Io?eiai? ?acoeueoaoe ioe?ithaaee iaoiaeii aa??aoe?eii? noaoenoeee
(I.I.Aea?ea/, 1963).

?ACOEUeOAOE AeINE?AeAEAIUe OA ?O IAAIAI?AIIss.

A i?ioean? e?eoaaiiy i?aaei?cieiiii (Pr) ?ai?n?y ?ioiiiai oneeaaeiaiiy
?icaeioeanue o 54% oai?eo ia OEE, a ?? o?eaae?noue a na?aaeiueiio
aeiineea (5,4±0,9) i?n. I?ae ae??th i?aaei?cieiio ia A-ee?oeiao
ciaiooaaeanue aeni?an?y ia?ea??a aeic??eeo ee?oei CD20, CD72 (oaae.1).
Iaeii/anii c?inoaa ??aaiue aeni?an?? aeoeaaoe?eieo ia?ea??a CD25R i
CD11b (oaae.2).

Ia oii? ?noioiiai cieaeaiiy /enea aeic??eeo CD3+ O-ee?oei aeyaeaii
i?aeaeuaiiy ??aiy CD4+ O-aaeia??a ? a?eueo cia/iee ??no CD8+-ee?oei.
Ni?aa?aeiioaiiy CD4+/CD8+ i?e oeueiio aeinoia??ii ciaiooaaeinue. ??aaiue
CD16+-ee?oei (NK-ee?oei) i?ney e?eoaaiiy i?aaei?cieiiii cia/ii
i?aeaeuoaaany.

E?eoaaiiy ?ioiieo oneeaaeiaiue OEE a?ie?enoeiii (Vr) ? i?aaei?cieiiii
i?eaiaeeei aei ?ai?n?? o 73% oai?eo o?eaae?noth (13,5±3,0) i?n.
Iieacieeii iiceoeaiiai oa?aiaaoe/iiai aieeao a?ie?enoeio ia eaeeai?/i?
A-ee?oeie aoei aeinoia??ia cieaeaiiy eeiiaeueiiai aenoeano. Aaaeeeaei
oaeoi?ii aoaeoeaiino? a?ie?enoeio i?e OEE ? i?aeaeuaiiy ??aiy aeni?an??
ia eaeeai?/ieo ee?oeiao Fas-?aoeaioi?a (CD95) ye iane?aeie aeoeaaoe??,
/a?ac ui aiie noathoue a?eueo /ooeeaeie aei ?iaeoeoe?? aiiioico
oeeoie?iaie.

I?ney e?eoaaiiy a?ie?enoeiii c i?aaei?cieiiii aeyaeaii c?inoaiiy
e?eueeino? CD3+-ee?oei oa nooo?aa ca?eueoaiiy e?eueeino? CD4+-ee?oei, o
ca’yceo c /ei ni?aa?aeiioaiiy Th/Ts ii?iae?coaaeinue. Eo?n e?eoaaiiy
i?aia?aoii aee?eoth/i? ae?? c a?oie acioenoeo ?i?eo?a — oei?aiaooeeeii
(Chl) — oa i?aaei?cieiiii coiiaea aeieeiaiiy ?ai?n?? ?ioiiiai
oneeaaeiaiiy o 75% oai?eo, iaeiae o?eaae?noue ?? aoea ei?ioeith —
(6,1±1,3) i?n. ?ioiioaiioei?/ii aeyaeaii cieaeaiiy ??aiy aeni?an??
A-ee?oeiieo aioeaai?a CD20, CD37 i CD72. ?noioii i?aeaeuoaaany ??aaiue
aeni?an?? o?eueee CD11b, a a?aenioie ee?oei, ye? ?aaaoaaee c IEAO
?II-38, eio?a aeyaey? aioeaai i?ie?oa?oth/eo ee?oei Ki67, cieaeoaaany.
Oei?aiaooeee i?eai?/o? i?ie?oa?aoeaio ? i?oioe/io aeoeai?noue
eaeeai?/ieo ee?oei (C.I.Aoeeeia, 1991), ui ie i?aeoaa?aeeee
?ioiioaiioei?/ieie aeine?aeaeaiiyie.

Eo?n e?eoaaiiy oei?aiaooeeeii oa i?aaei?cieiiii i?ecaiaeea aei c?inoaiiy
noaiiioeyoe?e O-aaeia??a oa O-noi?ani??a i?eaeecii a iaeiaeia?e i???,
oae ui ni?aa?aeiioaiiy CD4+/CD8+ ?noioii ia ci?ithaaeinue. I?aeaeuoaaany
??aaiue CD16+ NK-ee?oei.

I?ney eo?no iie?o?i?ioa?ai?? ca noaiith NI? iiaia ?ai?n?y ?ioiiiai
oneeaaeiaiiy ?icaeioeanue o 75% oai?eo, a na?aaeiy o?eaae?noue ?ai?n??
?ioiiiai oneeaaeiaiiy aoea (10,4±3,2) i?n. Aeia?ee ee?i?/iee aoaeo
i?ia?aie NI? noi?iaiaeaeoaaany ae?aaeaieie ci?iaie a aeni?an??
A-ee?oeiieo ia?ea??a oa cieaeaiiyi aaniethoii? e?eueeino? e?ioioeeo?a ia
15,2%. A?aecia/aii ae?aaeaia cieaeaiiy a?aenioea HLA-Dr+-, CD20+-,
CD21+-, CD22+-, sIgM+-, CD37+-, ?II-10+-, CD72+- oa CD76+-ee?oei.
Iaeii/anii anoaiiaeaii ae?aaeai? iciaee aeoeaaoe?? eaeeai?/ieo A-ee?oei,
ia iaia?ai? yeeo c??n ??aaiue aeni?an?? a?eueoino? aeine?aeaeaieo
aeoeaaoe?eieo ia?ea??a: CD25R, CD11b, CD95 i ia?ea?a A-aeano?a
aioeaaicaeaaeii? noaae?? aeic??aaiiy (i?ie?oa?oth/eo ee?oei), yeee
?aaao? c IEAO ?II-3.

I?ney e?eoaaiiy ca noaiith NI? aeni?an?y iaeaea an?o O-ee?oeiieo
aioeaai?a (CD2, CD7, CD3, CD4) ia?inoaea, ie??i CD8, caaaeyee /iio
ni?aa?aeiioaiiy CD4+/CD8+ oaae ca?eueooaaeinue, aeinyaath/e ii?iaeueieo
aaee/ei.

Oaaeeoey 1

Aeni?an?y iniiaieo A-ee?oeiieo aioeaai?a ia iaia?ai? e?ioi?aeieo ee?oei
ia?eoa?e/ii? e?ia? oai?eo ia OEIC i?e ??cieo iaoiaeao e?eoaaiiy

Aioeaai HLADR CD20 CD21 CD22 CD5 CD37 CD72 ?II10 Pr aei73,5±2,8
43,3±5,6 49,2±2,5 51,0±5,4 69,5±2,3 58,3±8,4 48,1±5,4 38,3±3,1
i?ney74,0±1,9 28,7±4,6*44,9±3,2 50,8±5,6 69,2±2,8 51,6±8,2
30,0±4,8*41,7±2,9 Vr+Pr aei75,8±3,2 52,2±7,5 58,7±5,7 72,6±3,4 71,3±3,7
72,7±9,5 60,1±5,3 44,1±6,9 i?ney61,9±5,3*46,2±9,4 41,0±6,0*59,9±7,9
63,5±3,9 64,9±6,0 53,5±6,7 41,3±6,9 Chl+Praei65,8±2,3 56,4±3,3 52,3±3,4
59,2±2,5 64,0±1,2 75,8±1,5 59,3±2,6 55,3±3,3 Oai?? ia OEE i?ney68,3±2,5
43,7±3,5*49,4±3,8 56,2±3,8 66,3±1,8 64,0±4,4*49,8±2,0*50,7±3,2 c
?ioiieieCOP aei78,9±1,4 50,7±1,6 52,2±1,9 60,0±3,0 61,6±1,9 51,3±1,8
52,1±1,7 48,2±1,2

oneeaaeiaiiyie i?ney68,8±1,9*44,3±1,9*46,6±1,1*50,8±2,0*65,9±2,1
45,5±1,3*45,8±1,9*42,2±1,2*Thy+Praei81,5±2,2 57,8±8,0 47,3±7,7 75,6±4,3
59,8±0,8 83,3±4,2 55,3±8,0 44,7±0,3 i?ney71,3±6,3 55,0±6,0
29,7±2,9*51,4±0,5*61,3±8,5 82,4±3,7 45,3±4,1 48,5±8,6 LPF+Praei67,6±3,0
55,2±3,9 49,3±6,1 60,2±5,3 65,3±3,6 67,2±5,6 46,0±5,5 33,5±5,5
i?ney57,6±4,9 49,0±4,7 42,3±4,6 58,4±8,4 54,3±8,5 43,8±8,1*46,0±2,0
43,5±1,5 Spl+Praei79,2±1,8 58,1±3,7 52,8±3,0 63,8±3,5 67,0±3,4 74,7±4,8
61,4±3,8 58,8±5,5 i?ney72,6±2,2*40,8±5,4*40,6±2,8*56,5±2,5
54,2±1,6*61,6±2,6*49,5±2,9*43,4±3,5*Oai?? ia IAESpl+Praei65,4±2,5
56,3±2,6 39,9±3,1 57,6±4,4 — 72,4±4,1 46,0±1,2 40,1±7,0 aac
oneeaaeiaiuei?ney65,9±4,8 51,0±3,7 31,7±2,6*56,3±4,4 — 63,0±3,2
40,3±1,6*39,0±5,3

Spl+Praei70,4±4,6 65,4±3,8 33,6±5,5 62,6±8,3 — 73,4±4,6 49,8±2,1
41,6±4,0 i?ney66,2±7,6 49,7±4,7*28,0±4,1 58,4±2,1 — 58,8±8,7
41,7±1,7*28,6±2,7*

I?ei?oea. * — noaoenoe/ii aeinoia??ia ??cieoey i?ae iieacieeaie aei oa
i?ney e?eoaaiiy (p0,05), i?ioa ni?aa?aeiioaiiy CD4+/CD8+ i?aeaeuoaaeinue.

O oai?eo ia IAE c ?ioiieie oneeaaeiaiiyie i?ney iia?aoe?? c?inoaei /enei
O-ee?oei, ia yeeo aeyaeyeenue CD2 oa CD4 aioeaaie (p

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