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IAOe?IIAEUeIA AEAAeAI?ss IAOE OE?A?IE

 

?INOEOOO O?C?IEIA?? ?i.I.I.AIAIIIEUeOess

 

 

AEOOAEIA IEAENAIAe? A?EOI?IAE*

 

OAeE611.839.3:612.822:615.015.44

 

AOO-?IAeOEIAAI? NO?OIE A IAE?IIAO I?AeNEECIAIAI NIEAO?IIss OIIEIAI

EEOA*IEEA II?NUeEI? NAEIEE

 

03.00.02-a?ioeceea

 

Aaoi?aoa?ao aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa

a?ieia?/ieo iaoe

 

EE?A-1999

 

 

Aeena?oaoe??th ? ?oeiien.

 

?iaioo aeeiiaii a ?inoeooo? o?c?ieia?? ?i.I.I.Aiaiiieueoey

IAIOe?a?ie.

 

Iaoeiaee ea??aiee aeaaeai?e IAIOe?a?ie, aeieoi? a?ieia?/ieo iaoe,

i?ioani? Neie Aieiaeeie? ?aaiiae/, caa. a?aeae?eii

o?c?ieia?? aaaaoaoeaii? ia?aiai? nenoaie, ?inoeoooo o?c?ieia??

?i.I.I.Aiaiiieueoey IAIOe?a?ie

 

Io?oe?ei? iiiiaioe:

 

1. aeaaeai?e IAIOe?a?ie, aeieoi? iaaee/ieo iaoe, i?ioani? OoaaIeoaeei

Oaaei?iae/; caa. a?aeae?eii ia?aiai-i`ycaai? o?c?ieia??, ?inoeoooo

o?c?ieia?? ?i.I.I.Aiaiiieueoey IAIOe?a?ie

 

2. eaiaeeaeao a?ieia?/ieo iaoe Aieoaiei Iaia Aieiaeeie??aia, no.

iaoeiaee ni?a?ia?oiee I?aeia?iaeiiai Oeaio?o iieaeoey?ii? o?c?ieia??.

 

I?ia?aeia onoaiiaa:

 

?inoeooo o?c?ieia?? i?e Iaoe?iiaeueiiio oi?aa?neoao? ?i.Oa?ana

Oaa/aiea.

 

Caoeno a?aeaoaeaoueny 8/a?aiy1999?. ia can?aeai? a/aii?

?aaeeAe-26.198.01 i?e ?inoeooo? o?c?ieia?? ?i.I.I.Aiaiiieueoey

IAIOe?a?ie ca aae?anith: 252024 i.Ee?a, aoe.Aiaiiieueoey, 4.

 

C aeena?oaoe??th iiaeia iciaeiieoenue a a?ae?ioaoe? ?inoeoooo o?c?ieia??

?i.I.I.Aiaiiieueoey IAIOe?a?ie.

 

Aaoi?aoa?ao ?ic?neaiee 20ea?oiy1999?.

 

A/aiee nae?aoa? Niaoe?ae?ciaaii? a/aii? ?aaee

 

aeieoi? a?ieia?/ieo iaoe

Ni?ie?ia-Ia??iaC.I.

 

Caaaeueia oa?aeoa?enoeea ?iaioe

 

Aeooaeuei?noue i?iaeaie. No/ani? aeine?aeaeaiiy iieacothoue, ui

aaeaiicei 5`-o?eoinoao (AOO) i?eeia? o/anoue o i?aeee?oeii?e

neaiae?caoe??, ui cae?enith?oueny a ?acoeueoao? aeoeaaoe?? niaoeeo?/ieo

?2-io?eii?aoeaioi??a, ye? ca ooieoe?iiaeueieie iciaeaie ?icae?eythoue ia

aea? iniiai? a?oie- ?iiio?iii? (?2O), ye? aaciina?aaeiuei caycai? c

?iiiei eaiaeii ? iaoaaio?iii? (P2Y), a?ieia?/i? aoaeoe yeeo

cae?eniththoueny ca o/anoth AOO-ca`ycoth/eo i?ioa?i?a (G-a?ee?a)

(Abbracchio and Burnstock, 1994). Aiane?aeie aeoeaaoe?? iinoneiaioe/ieo

?2-io?eii?aoeaioi??a, AOO iiaea a?aoe o/anoue o oaeaee?e neiaioe/i?e

ia?aaea/?, aenooiath/e a ?ie? caoaeaeoth/iai ia?aaeaaa/a ia aaaaoueio

ia?eoao, o oiio /ene? a i?aeiae?iiaeueieo neiainao oeaio?aeueii?

(Edwards et al., 1992) oa aaaaoaoeaii? ia?aiai? nenoaie (Evans et al.,

1992; Sylinsky et al., 1992; Galligan and Bertrand, 1994; LePard et al.,

1997). E??i oiai, AOO iiaea aieeaaoe ia ooieoe?iioaaiiy ?ioeo

neiaioe/ieo ?aoeaioi??a, cie?aia i?eioeiiaeo oie?ii?aoeaioi??a (IO?),

i?e /iio iiaeoeyoi?iee aoaeo cae?enith?oueny, aai a ?acoeueoao?

aaciina?aaeiuei? aca?iiae?? AOO c IO? (Igusa, 1988; Mozrzymas and

Ruzzier, 1992; Nakazawa and Igusa, 1993; Nakazawa, 1994a), aai /a?ac

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