I?I?NOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE
IAOe?IIAEUeIEE IAAeE*IEE OI?AA?NEOAO
?i.I.I.AIAIIIEUeOess
IO?EOE?IA Ienaia Aeieo??aia
OAeE 616.521-022.7:548:615.849.112
AEA*AIIss CI?I IIEACIEE?A OACEA?AO?? NE?IAAOEE E?IA?
O OAI?EO IA AECAIO A AeEIAI?Oe? EIIIEAENIIAI
E?EOAAIIss AECAIE ?C CANOINOAAIIssI
I?E?IOAEEUeIAI? ?ACIIAINII? OA?AI??
14.01.20 – oe??i? oa aaia?e/i? oai?iae
A a o i ? a o a ? a o
aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy
eaiaeeaeaoa iaaee/ieo iaoe
E e ? a – 1 9 9 9
Aeena?oaoe??th ? ?oeiien.
?iaioa aeeiiaia a Iaoe?iiaeueiiio iaaee/iiio oi?aa?neoao?
?i. I.I.Aiaiiieueoey
Iaoeiaee ea??aiee – aeieoi? iaaee/ieo iaoe, i?ioani?
Noaiaiaiei A?eoi? ?aaiiae/, Iaoe?iiaeueiee iaaee/iee oi?aa?neoao
?i.I.I.Aiaiiieueoey, i?ioani? eaoaae?e oe??ieo oa aaia?e/ieo oai?ia c
eo?nii NI?Aeo.
Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani?
Eyoaiei ?aai Ieeeoi?iae/, A?iieoeueeee iaaee/iee oi?aa?neoao, i?ioani?
eaoaae?e oe??ieo oa aaia?e/ieo oai?ia;
eaiaeeaeao iaaee/ieo iaoe,
Ei?ieueiaa AEaiiaoa Aaeaioei?aia,
Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?i. I.E.Ooi?ea,
aeioeaio eaoaae?e oe??ieo oa aaia?e/ieo oai?ia.
I?ia?aeia onoaiiaa:. Aei?i?iiao?ianueea aea?aeaaia iaaee/ia aeaaeai?y
IIC Oe?a?ie, eaoaae?a oe??ieo oa aaia?e/ieo oai?ia, i.
Aei?i?iiao?ianuee.
Caoeno a?aeaoaeaoueny “20 ” “o?aaiy” 1999?. i 1330 aiae. ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.003.02 Iaoe?iiaeueiiai iaaee/iiai
oi?aa?neoaoo ?i.I.I.Aiaiiieueoey ca aae?anith: 252004, i.Ee?a-4,
aoeueaa? Oaa/aiea, 17, aoaeeoi??y oa?aiaaoe/ii? ee?i?ee.
C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Iaoe?iiaeueiiai
iaaee/iiai oi?aa?neoaoo ?i.I.I.Aiaiiieueoey ca aae?anith: i.Ee?a, aoe.
Ciieia?/ia, 3, noiiaoieia?/iee ei?ion.
Aaoi?aoa?ao ?ic?neaii “17” ea?oiy 1999 ?ieo.
A/aiee nae?aoa?
niaoe?ae?ciaaii? a/aii? ?aaee,
aeieoi? iaaee/ieo iaoe
N.A.Nae?eae
CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE
Aeooaeuei?noue oaie aeine?aeaeaiiy. Aecaia – aea?a?/ia caiaeueia
caoai?thaaiiy oe??e – caeeoa?oueny iaei??th c aeooaeueieo oa
iaaeinoaoiuei aea/aieo i?iaeai no/anii? aea?iaoieia??.
?iciianthaeaeai?noue aecaie, ca?aeii aeaieo e?oa?aoo?e, neeaaea? a?ae 10
aei 40 a?aenioe?a na?aae on??? iaoieia?? oe??e. I?e oeueiio a inoaii?
aeanyoee?ooy a?aecia/a?oueny iaooeeueia oaiaeaioe?y aei c?inoaiiy
caoai?thaaiino? oeei aea?iaoicii oa a?eueo oyaeeiai eiai ee?i?/iiai
ia?aa?ao.
Ia aeoieo a?eueoino? aeine?aeiee?a, a ao?iiaoiaaiac? aecaie aaaeeeao
?ieue a?ae?a?athoue i?ioeane aooiaioeaaiiino?, ia ?icaeoie yeeo aieeaa?
noai ia?aiai? nenoaie, ?ioiieia?/ii? ?aaeoeaiino?, aiaeie?eiii?
ooieoe??.
Aei oaia??oiueiai /ano i?e aecai? iaaeinoaoiuei aea/ai? ? c’yniaai?
aeaye? eaiee ao?iiaoiaaiaco, cie?aia e?i?aeii? ia?ieneaeaoe??, a oaeiae
?ioiieia?/ia oa e?enoae?coth/a ooieoe?? ne?iaaoee e?ia?.
A inoaii? aeanyoee?ooy aeey ooi/iaiiy aea?a?/iiai eiiiiiaioa i?e ?yae?
caoai?thaaiue iaaea?oueny ia?aaaaa oacea?ao?/iiio iaoiaeo, yeee
a?oioo?oueny ia e?enoae?caoe?? ?ic/eio oei?ii? i?ae? (II) a i?enooiino?
noi?oae. Canoinoaaiiy oeueiai iaoiaeo, ca aeaieie aeine?aeaeaiue (Ia?eia
I.E., 1986) aea? ciiao ae?aaiinooaaoe ?icaeoie aea?a?? ia ?aii?o aoaiao
caoai?thaaiiy. Oea iineoaeeei iai i?aenoaaith aeey aeei?enoaiiy oeueiai
iaoiaeo a eiiieaeniiio ianoaaeaii? oai?eo ia aecaio.
Caeeoa?oueny aeooaeueiith i?iaeaia e?eoaaiiy aecaie. O?eaaea
aeei?enoaiiy ?yaeo e?ea?nueeeo i?aia?ao?a ia??aeei ni?ey? ?icaeoeo ?o
iaia?aiiniino? e /anoiio caaino?aiith oeueiai aea?iaoico. Oiio
aeooaeueiith ? ?ic?iaea iiaeo oa aaeineiiaeaieo iaoiae?a e?eoaaiiy
aecaie, cie?aia aaciaaeeeaiaioicieo.
O aea?iaoieia?/i?e i?aeoeoe? a inoaii? ?iee ciaeoia iioe?aiiy iaoiae
i?e?ioaeeueiai? ?aciiainii? oa?ai?? (I?O), canoinoaaiiy yeiai ni?ey?
ii?iae?caoe?? ii?ooaieo ooieoe?e i?aai?cio ? aeicaiey? ciaioeoe
e?euee?noue iaaeeeaiaioicieo i?aia?ao?a.
I?aeoe/ii ia aea/aiei ? ciai?oi? canoinoaaiiy i?aia?ao?a noeueoaaeeaceio
n??aea i?e e?eoaaii? aecaie, eio?? iathoue aioei?e?iaiee ?
i?ioecaiaeueiee aoaeoe oa ni?eythoue i?enei?ai?e ?aaaia?aoe?? oe??e a
ciiao o?aaeaiiy.
Aeena?oaoe?y aeeiiaia o a?aeiia?aeiino? c iniiaiei iaoeiaei iai?yiii
eaoaae?e oe??ieo ? aaia?e/ieo oai?ia c eo?nii NI?Aeo Iaoe?iiaeueiiai
iaaee/iiai oi?aa?neoaoo ?i.I.I.Aiaiiieueoey ? ? o?aaiaioii eiiieaenii?
oaie “?ic?iaea iiaeo iaoiae?a ae?aaiinoeee oa e?eoaaiiy o?ii?/ieo
aea?iaoic?a ? aaia?e/ieo caoai?thaaiue” (Aea?aeaaiee ?a?no?aoe?eiee
iiia? I195 O 00390).
Iaoa aeine?aeaeaiiy. ?ic?iaea iaoiaaiaoe/ii iaa?oioiaaiiai eiiieaeniiai
iaoiaeo e?eoaaiiy i?e?iaii? oa ni?aaaeiuei? aecaie ?c canoinoaaiiyi
i?e?ioaeeueiai? ?aciiainii? oa?ai??, ui aaco?oueny ia ?acoeueoaoao
oacea?ao?/iiai, aacio?iiaoia?ao?/iiai aiae?co e?i?ae?a (aee?iieeneioiee
niaeo? ne?iaaoee e?ia?) e ?ioiieia?/iiai iaoiae?a aeine?aeaeaiiy.
Aeey aeinyaiaiiy iinoaaeaii? iaoe ae??ooaaeeny oae? caaaeaiiy:
1. Aecia/aiiy iieaciee?a e?enoae?caoe?? ne?iaaoee e?ia? o oai?eo ia
ni?aaaeith e i?e?iaio aecaio.
2. I?iaaaeaiiy aeine?aeaeaiue ?yaeo iieaciee?a ?ioiieia?/ii?
?aaeoeaiino? i?aai?cio i?e oeueiio aea?iaoic?.
3. Aeine?aeaeaiiy noaio e?i?aeii? ia?ieneaeaoe?? i?e aecai? oa ci?ie
aee?iieeneioiiai niaeo?o e?ia? i?e canoinoaaii? I?O.
4. Aea/aiiy aieeao I?O ia iieacieee e?enoae?caoe?? ne?iaaoee e?ia?,
e?iiia?ieneaeaoe?? oa ci?ie ?ioiieia?/iiai noaio a aeeiai?oe? e?eoaaiiy
oai?eo.
5. I?iaanoe iaoeiaa iaa?oiooaaiiy ? aea/eoe ee?i?/io aoaeoeai?noue
i?noeaaiai canoinoaaiiy i?aia?ao?a nieae n??aea a oa?ai?? aecaie.
6. ?ic?iaeoe ?aeiiaiaeaoe?? ii canoinoaaiith I?O ? i?aia?ao?a nieae
n??aea a eiiieaeniiio e?eoaaii? aecaie.
Iaoeiaa iiaecia. Oia?oa i?iaaaeaii eiiieaenia aea/aiiy oacea?ao?/ieo,
e?i?aeieo oa ?ioiieia?/ieo iieaciee?a ? aea/aii ?o aieea ia ia?aa?a
aecaie.
Oia?oa iaoeiai iaa?oioiaaii e aeieacaii aeineoue aenieo ee?i?/io
aoaeoeai?noue canoinoaaiiy i?e?ioaeeueiai? ?aciiainii? oa?ai?? a
ii?aeiaii? c i?noeaaith oa?ai??th aecaie i?aia?aoaie, ye? ai?uothoue
nie? noeueoaaeeaceio n??aea.
I?aeoe/ia cia/ei?noue aeena?oaoe?eiiai aeine?aeaeaiiy a oiio, ui iaoeiai
iaa?oioiaaia iaiao?aei?noue eiiieaenii? oa?ai?? aecaie ?c canoinoaaiiyi
I?O ? i?noeaai nieae noeueoaaeeaceio n??aea. Oaea oa?ai?y ni?ey?
i?enei?aiith ?aa?ano ee?i?/ieo i?iya?a caoai?thaaiiy aiane?aeie
ii?iae?coth/iai aieeao I?O ia ?ioiiee noaoon, i?ioeane e?i?aeii?
ia?ieneaeaoe?? oa e?enoae?coth/o ooieoe?th e?ia? e ?io? ii?ooaiiy
iaoaaie?cio.
Ai?iaaaeaeaiiy a e?eoaaeueio i?aeoeeo i?io?eueieo aea?iaoieia?/ieo
caeeaae?a I?O ? i?aia?ao?a noeueoaaeeaceio n??aea ni?eyoeia a?eueo
oni?oiiio e?eoaaiith oai?eo ia aecaio ? iiaeiaaeaiith oa?i?io ?ai?n?e.
Canoinoaaiiy oacea?ao?/iiai iaoiaeo aeicaieeoue oia?aaeaeaii
ae?aaiinooaaoe iiaeeea?noue ?aoeeaeeao caoai?thaaiiy, nai?/anii
i?ecia/aoe ei?eaoth/o oa?ai?th, a oaeiae i?aeaeueoue aoaeoeai?noue
aeeniaina?ecaoe?? oai?eo ia aecaio.
Cai?iaaaeaeaiiy ?acoeueoao?a aeine?aeaeaiiy a i?aeoeeo. ?acoeueoaoe
i?aoe? ai?iaaaeaeaii a i?aeoeeo oe??iiai a?aeae?eaiiy Oeaio?aeueii?
i?nueei? ee?i?/ii? e?ea?i? i.Ee?aa, Ee?anueeiai iaeaniiai
oe??ii-aaia?ieia?/iiai aeeniaina?o, OAAe ?1 i.Ee?aa, a oaeiae a
iaa/aeueiee i?ioean i?e aeeeaaeaii? eo?no aea?iaoieia?? ia eaoaae??
oe??ieo ? aaia?e/ieo oai?ia c eo?nii NI?Aeo Iaoe?iiaeueiiai iaaee/iiai
oi?aa?neoaoo.
Iniaenoee aianie caeiaoaa/a. Aaoi?ii naiino?eii i?iaaaeai?
aenia?eiaioaeuei?, ee?i?/i? e eaai?aoi?i? aeine?aeaeaiiy, noaoenoe/i?
ia/eneaiiy oa ?o aiae?c ? ?acii c iaoeiaei ea??aieeii aeena?oaoe?eii?
?iaioe aoee c?iaeai? a?aeiia?aei? caeeth/aiiy oa aeniiaee.
Ai?iaaoe?y ?acoeueoao?a i?aoe?. Iaoa??aee aeena?oaoe?? iaaiai?ai? ia
can?aeaiiyo eaoaae?e oe??ieo ? aaia?e/ieo oai?ia IIO o 1997-1998??.,
can?aeaii? Ee?anueeiai iaeaniiai e i?nueeiai oiaa?enoaa
aea?iaoi-aaia?i-eia?a a 1997 ?. Ia?oiio iaoe?iiaeueiiio c’?cae?
oa?iaeieia?a Oe?a?ie (Iieoaaa, aa?anaiue 1995 ?.).
Ioae?eaoe?y iaoa??ae?a aeine?aeaeaiiy. Ca iaoa??aeaie aeena?oaoe??
iioae?eiaaii 10 iaoeiaeo i?aoeue, cie?aia – 3 aeo?iaeuei? noaoo? – o
aeaeaiiyo, ?aeiiaiaeiaaieo AAE Oe?a?ie.
Ia’?i ? no?oeoo?a aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 192 noi??ieao
iaoeiiieniiai oaenoo ? neeaaea?oueny c? anooio, iaeyaeo e?oa?aoo?e, 8
?icae?e?a aeanieo aeine?aeaeaiue, caeeth/aiiy, aeniiae?a, nieneo
aeei?enoaieo aeaea?ae, yeee aeeth/a? 380 aeaea?ae (a oiio /ene? 301
a?o/eciyieo aaoi??a ? aeecueeiai ca?oa?aeaey oa 79 aaoi??a aeaeaeiai
ca?oa?aeaey).
Oaeno ?ethno?iaaii 29 oaaeeoeyie, 27 ?enoieaie, aeieneaie c ?noi??e
oai?iae.
IAOA??AEE OA IAOIAeE AeINE?AeAEAIIss
I?iaaaeaii eiiieaenia ee?i?ei-eaai?aoi?ia ianoaaeaiiy 120 oai?eo ia
aecaio a noaae?? caaino?aiiy, c yeeo o 95 iaoe??io?a aoea ae?aaiinoiaaia
i?e?iaia, a a 25 – ni?aaaeiy oi?ia aecaie.
An? oai?? ia?aaoaaee ia noaoe?iia?iiio e?eoaaii? a oe??ieo a?aeae?eaiiyo
OeIEE i.Eeaaa oa Ee?anueeiai iaeaniiai OAAe. Eiio?ieueio a?oio noaiiaeee
30 caei?iaeo in?a.
Ca noaooth na?aae ianoaaeaieo aoei – 84 /ieia?ea (70%) ? 36 ae?iie
(30%), o a?oe? a?ae 18 aei 68 ?ie?a. Oa?i?i ia?aa?ao caoai?thaaiiy
noaiiaea a?ae 7 i?nyoe?a aei 5 ?ie?a, na?aaeiy o?eaae?noue – 4,3 ?iee.
?aoeeaeeaoth/ee oa?aeoa? caoai?thaaiiy aoa o 55% in?a, iiaeiaaeai?noue
?ai?n?? a ianoaaeaieo oai?eo a na?aaeiueiio noaiiaeea 5,7 i?nyoey.
I?e ee?i?/iiio ianoaaeaii? o 60,8% oai?eo aoee aeyaeai? noiooi?
caoai?thaaiiy. Iae/ano?oa ?a?no?oaaany i?eic nooiai?a – 30% oai?eo,
o?ii?/iee oieaoeenoiaia?ioie?o a noaae?? ?ai?n?? – 7,5%,
aoa?ineea?ioe/iee ea?ae?ineea?ic – 6,7%, oeoe?iaee ae?aaao – 2,5%. O 15%
oai?eo a?aecia/aii aeaa e a?eueoa noiooi?o caoai?thaaiiy.
Aeyaeai? noiooi? oai?iae ia iiaee nooo?ai aieeiooe ia aiae?c
?acoeueoao?a noaoenoe/ii? ia?iaee iaea?aeaieo aeaieo.
I?e aeine?aeaeaii? e?ia? o 16,7% oai?eo aoa aeyaeaiee eaeeioeeoic, o
33,3% – i?enei?aia OCA, o 5,8% oai?eo a eaeeioeeoa?i?e oi?ioe?
a?aecia/aeany aiceiio?e?y. Ii?ooaiiy a?io?i?/ieo iieaciee?a e?ia?
(i?aeaeuaiiy AeO, AnO, oeiieiai? i?iae) iaee 10% oai?eo.
Ii?yae ?c caaaeueiii?eeiyoeie ee?i?ei-eaai?aoi?ieie aeine?aeaeaiiyie a
aeeiai?oe? e?eoaaiiy aecia/aeeny iieacieee ?ioiiiai noaoono, nenoaie
e?i?aeii? ia?ieneaeaoe?? (EI) oa oacea?ao?/iiai aeine?aeaeaiiy e?ia?.
?ioiieia?/i? aeine?aeaeaiiy i?iaiaeeeeny a eaai?aoi??? aano?iaioa?ieia??
IAeEOe Iaoe?iiaeueiiai iaaee/iiai oi?aa?neoaoo ? aeeth/aee e?euee?nio
ioe?ieo O- ? A-nenoai ?ioi?oaoo oa ?o ooieoe?iiaeueio aeoeai?noue,
?aeaioeo?eaoe?th O- ? A-e?ioioeeo?a oa ?o noaiiioeyoe?e ca aeiiiiiaith
iiiieeiiaeueieo aioeo?e, aecia/aiiy ??aiy oee?eoethth/eo ?ioiieo
eiiieaen?a. Aecia/aiiy e?eueeino? A- oa AAN-?OE (O- oa A-e?ioioeeo?a)
i?iaiaeeeiny ca aeiiiiiaith i?e?iiaoiaeo Ae/eiai? I.A. (1981),
i?ae?aooiie aeoeaieo AAN-?OE ca iaoiaeii S.Horowitz et al (1975),
aeyaeaiiy noaiiioeyoe?e A-?OE (O-oaeia??a oa O-noi?ani??a) ca iai?yiei
?ioiioeoi?anoeaioiei oanoii c ieoa/eie iiiieeiiaeueieie aioeo?eaie o??ie
“Ortho” (NOA). Aecia/aiiy noaiiioeyoe?e A-e?ioioeeo?a i?iaiaeeeiny
i?yiei ?ioiioeoi?anoeaioiei iaoiaeii ca?aeii ?aeiiaiaeaoe?e
A.O.Oaa?iniia oa ni?aaao. (1989). Aeei?enoiaoaaee iiiiniaoeeo?/i?
ne?iaaoee ae?iaieoeoaa o??ie “Sevac”, *aoineiaae?y oa a?o/eciyi?
(“A?iiaae” ?i. ?.?. Ia/ieeiaa).
Oacea?ao?/ia aeine?aeaeaiiy ne?iaaoee e?ia? i?iaiaeeee ca iaoiaeeeith
E.A.Ii?ic ? ni?aaao. (1986).
Aeine?aeaeaiiy aee?iieeneioiiai niaeo?a e?i?ae?a i?iaiaeeeeny a
eaai?aoi??? aacio?iiaoia?ao?/iiai aiae?co e?i?ae?a IAeEOe
Iaoe?iiaeueiiai iaaee/iiai oi?aa?neoaoo ia aaciaeo o?iiaoia?aoao na???
“Oeaao-500” ca iaoiaeii Folch J. at al. (1957). A?ae?ie?c ? iaoeethaaiiy
aeueo aee?ieo eeneio e?i?ae?a cae?enithaaee ca iaoiaeii E.I.Neiye
(1976).
?acoeueoaoe eaai?aoi?ieo aeine?aeaeaiue ia?iaeyee iaoiaeii aa??aoe?eii?
noaoenoeee.
??aaiue aeinoia??iino? ae?aoiaoaaee ca oaaeeoeath No’thaeaioa-O?oa?a,
aecia/ath/e eiao?oe??io aeinoia??iino? ?. Noaoenoe/ii aeinoia??iith
aaaaeaee ??cieoeth i?e ciaeaeaiiio ?0,05.
Ianoaaeai? iaie oai?? aoee ?icae?eai? ia o?e oa?aiaaoe/i? a?oie. Ia?oa
a?oia (45 oai?eo) ia?aeaeueii c o?aaeeoe?eiith iaaeeeaiaioiciith
oa?ai??th io?eioaaea eo?n I?O. Ae?oaa (45 iaoe??io?a) io?eioaaea I?O ?
i?noeaai e?ai “Aea?iacei”, yeee ai?uo? 1% noeueoaaeeaceio n??aea. O?aoy
-eiio?ieueia a?oia (30 oai?eo) – e?eoaaeany eeoa aaceniith oa?ai??th.
E?eoaaiiy aeaeo?iiaai?oiei aei?ii?ithaaiiyi (AIA) ii-ae?aiaciio
i?iaiaeeee ca aeiiiiiaith aia?aoa “Iieeoii” (aaaa 200 a, aeeaeaiiy – 220
A, 50 Aoe, iiooaei?noue – aei 0,5 Ao; nioaa /anoio aei?ii?ithaaiiy
aeaeo?i-iaai?oieo eieeaaiue – 5o1010 – 5o1014, niaeo?aeueia u?euei?noue
aei?ii?ithaaiiy a EA*-ae?aiacii? – 3o10-18 Ao/Aoe). Ae?yee ia
a?ieia?/ii-aeoeai? oi/ee caaaeueii? ae?? A 56, G 14, V 61 ?
neiioiiaoe/i?, ye? iathoue ni?eyoeeaee aieea ia ia?aa?a aecaie. Eo?n
e?eoaaiiy aeeth/aa 6-10 naain?a. Ii?ii?ithaaee 2-4 ia?i? oi/ee
oi?iaeiaae 10-15 oa.
?ACOEUeOAOE AEANIEO AeINE?AeAEAIUe OA ?O IAAIAI?AIIss
Iaie aoei aea/aii oa?aeoa? i?ioean?a e?enoae?caoe?? ne?iaaoee e?ia? i?ae
aieeaii oei?ii? i?ae? (oacea?ao??) o oai?eo ia aecaio c iaoith
aeei?enoaiiy io?eiaieo ?acoeueoao?a a yeino? aeiaeaoeiaiai
ae?aaiinoe/iiai oa i?iaiinoe/iiai oanoo. O oai?eo ia aecaio i?ioeane
e?enoae?caoe?? aoee ii?ooai?, cie?aia a noaae?? caaino?aiiy caiaeueiiai
i?ioeano oeaio?e e?enoae?caoe?? /ano?oa ooai?thaaeeny a?aeaeaeaii a?ae
i?ai?/iiai i?e?iaeiiai iaai?oiiai iiethna, e?enoaeia?ao?/iee iaethiie
iaa aeaeyae iiaeiaaeaieo ia?aeaeueieo i?iiai?a c iaeiei aai aac oeaio??a
e?enoae?caoe??. ?acii c oei, o eiio?ie? a?aecia/aeiny a?ae 20 aei 40
oeaio??a e?enoae?caoe??, ?icoaoiaaieo ii an?e iiaa?oi? /aoee Iao??. O
oai?eo ia aecaio aeyaeaii ca?eueoaiiy e?eueeino? e?enoae?/ieo i?iiai?a
oei?ii? i?ae?, iineeaiiy e?enoae?caoe?? iaaeieeoiueiai oiio, iooi?noue
oa caoeaeiaai?noue i?iiai?a e?enoae?a, ia a?aei?io a?ae
e?enoaeiooai?aiiy o caei?iaeo in?a.
E?enoaeia?ao?/iee iaethiie a?ae??ciyany oaeiae o oai?eo ia i?e?iaio e
ni?aaaeith aecaie ? caeaaeaa a?ae aino?ioe i?iyao caiaeueiiai i?ioeano.
Oae, o oai?eo ia ni?aaaeith aecaio, i?e iayaiino? iieiaiiy, oeaio?e
e?enoae?caoe?? /ano?oa aoee a?aenooi?ie. E?enoaeia?ao?/iee iaethiie o
oai?eo a noaae?? caaino?aiiy aecaie ia caeaaeaa a?ae a?eo, noao? oai?eo,
o?eaaeino? caoai?thaaiiy ? noiooi?o oai?ia.
E?enoaeia?ao?/iee iaethiie ci?ithaaany i?ae aieeaii AIA ii-ae?aia-ciio
in vitro. Oae, i?iiai? e?enoae?a ci?ithaaee iai?yi ?inoo, ca?aath/enue o
oi/oe? aieeao AIA. Aenia?eiaioaeueii aecia/aii, ui ii?ii?iaiiy ??aeeie
ai?iaeiaae 20-30 oa., aei iiyae ia?oiai e?enoaea, ? aeinoaoi?i aeey
ianooiieo ci?i e?enoae?caoe??.
Aeey ia’?eoea?caoe?? ee?i?/ii? ea?oeie aecaie iaie aoa cai?iiiiiaaiee
iaoiae aecia/aiiy iieaciee?a e?enoae?caoe?? ne?iaaoee e?ia?. Cie?aia
aeine?aeaeoaaeenue oa?i?ie ii/aoeo e cae?i/aiiy e?enoae?caoe?? (t1 ?
tcaa.) oa ei?o?oe?aio e?enoae?caoe?? – Ee?. (a?aeiioaiiy tcaa. aei t1).
Aeyaeaii, ui i?e aecai? t1 ca?eueoo?oueny aei 205-215 oa., a Ee?.
cieaeo?oueny aei 1,45-1,55 a?aeiinii aiaeia?/ieo iieaciee?a o caei?iaeo
in?a (t1 – 140-150 oa., Ee?. – 2,1-2,3) (?0,05). I?e ae?? AIA
ii-ae?aiaciio in vitro ye i?e aecai?, oae ? a eiio?ie? tcaa.
ciaioo?oueny ia 20%, ci?iththoueny t1 ? t2 (/an a?ae iiyae ia?oiai
e?enoaea aei cae?i/aiiy e?enoae?caoe??), a ?acoeueoao? /iai eiao?oe??io
e?enoae?caoe?? cia/ii cieaeo?oueny a eiio?ie?, a na?aaeiueiio aei 1,5 ?
ca?eueoo?oueny o oai?eo ia aecaio – a na?aaeiueiio aei 1,7. Oea aeaco?
ia oa, ui AIA ii-ae?aiaciio ni?ey? ii?iae?caoe?? oacea?ao?/ieo
iieaciee?a ne?iaaoee e?ia? o oai?eo ia aecaio ? i?aeoaa?aeaeo? aenieo
/ooeea?noue e?ia? aei ae?? AIA ii-ae?aiaciio.
I?e aea/aii? aieeao ia a?ieia?/i? ??aeeie iino?eiiai iaai?oiiai iiey
(III) ? AIA ii-ae?aiaciio aeyaeaii, ui a?eueo ae?aaeaio ae?th ia
e?enoae?caoe?th na?icii? ??aeeie ia? III ((610)o10-3Oe). I?e
e?enoae?caoe?? na?icii? ??aeeie o oai?eo ia aecaio ciaioo?oueny t1 ia
20-25 oa. ? t2 ia 20-25 oa., ii??aiyii c eiio?ieai. Ci?ith?oueny
e?enoaeia?ao?/ia ea?oeia. E?enoaee caa??aathoue e?i?eia ?icoaooaaiiy ?
?inoooue aei oeaio?o. Ia ne?iaaoeo e?ia? a?eueoo ae?th aeyaey? AIA
ii-ae?aiaciio.
I?e e?enoae?caoe?? a?ieia?/ieo ??aeei (ne?iaaoea e?ia?, neeia, na?icia
??aeeia) a oiiaao ??cieo oaiia?aoo? (a?ae 28 aei 42iN) aeyaeaii, ui
e?enoae?caoe?y i?enei?th?oueny i?e ii?aeiaii? iecueei? oaiia?aoo?e ?
iaai?oiiai iiey, oi aeaco? ia i?aeaeuaiiy /ooeeaino? a?ieia?/ieo ??aeei
i?e aecai? aei iaai?oieo iie?a i?e cieaeaii? oaiia?aoo?e.
Aeine?aeaeaiiy inoaii?o ?ie?a na?ae/aoue, ui a iaoiaaiac? aecaie iathoue
cia/aiiy ?ioii? ii?ooaiiy, oiaoi ci?ie ee?oeiiiai e aoii?aeueiiai
?ioi?oaoo. O ianoaaeaieo iaie oai?eo ia ni?aaaeith e i?e?iaio aecaio
aoee aeyaeai? nooo?a? ii?ooaiiy iieaciee?a ee?oeiiiai e aoii?aeueiiai
?ioi?oaoo (oaae.1).
Oaaeeoey 1
Iieacieee ee?oeiiiai e aoii?aeueiiai ?ioi?oaoo o oai?eo ia aecaio
Iieacieee (%)Oai?? ia aecaio,
i=60I?e?iaia oi?ia,
i=44Ni?aaaeiy oi?ia,
i=16Eiio?ieue,
i=30O-e?ioioeeoe34,5wmetafile8? ???????????????
???????????yyy????.????1?????????????
?`???&??yyyy?????Ayyyaeyyy ??f?????&??MathType??
????u?th??????I?aaenoaaeai? a oaae. 1 aeai? na?ae/aoue i?i aeao?oeeo
O-oaeia??a ? O-noi?ani??a i?e a?eueo ae?aaeai?e aeai?an?? O-oaeia??a, ui
aeyaeyeiny a cieaeaii? ?ioii?aaoeyoi?iiai ?iaeaeno, ciaioaiiy e?eueeino?
O-aeoeaieo.
Aiaeii/an niinoa??aaeeny ci?ie a aoii?aeueiiio ?ioi?oao?, a naia
a?aecia/aeeny aeoeaaoe?y A-e?ioioeeo?a, aeao?oeeo Ig I ? ca?eueoaiiy
??aiy Oe?E. Aeeaeia ci?i ? ee?oeiiiai, ? aoii?aeueiiai ?ioi?oaoo
c?inoaea c o?eaae?noth caoai?thaaiiy oa a?eii oai?eo. Aeao?oeeo O-e oa
O-o niinoa??aaany i?e ni?aaaei?e oi?i? aecaie, i?e i?e?iai?e a?eueoei
aoa aeao?oeeo O-a. I?e ni?aaaei?e oi?i? aecaie ??aaiue Oe?E ? Ig I aoa
aeinoia??ii aeuei, i?ae i?e i?e?iai?e aecai?, a ??aaiue Ig A – iaioei.
Oeacai? ci?ie ee?oeiiiai e aoii?aeueiiai ?ioi?oaoo niinoa??aaeeny a
a?eueoino? oai?eo ia aecaio.
Oaeei /eiii, iayai?noue cia/ieo ii?ooaiue iieaciee?a ?ioi?oaoo i?e
aecai? a noaae?? caaino?aiiy aeeeeea? ?ioiiaeao?oeeoiee noai. C naiai
aieo, ?ioii? ii?ooaiiy ni?eythoue o?eaaeiio ia?aa?ao caiaeueiiai
i?ioeano e iiya? ?aoeeaeea?a.
Ie oaeiae aeine?aeeee ai?no aeueo aee?ieo eeneio (AAEE), ui ?
noano?aoaie i?ioean?a e?iiia?ieneaeaoe?? (EI) a ne?iaaooe? e ieaci?
e?ia? (oaae.2).
Oaaeeoey 2
Ai?no AAEE a ne?iaaooe? e?ia? o oai?eo ia aecaio
AEe?ia eeneioaOai?? ia aecaioI?e?iaia oi?iaNi?aaaeiy oi?iaEiio?ieue
N:16:0 – iaeuei?oeiiaa42,1wmetafile8? ???????????????
???????????yyy????.????1?????????????
?`???&??yyyy?????Ayyyaeyyy ??f?????&??MathType??
????u?th??????I?iaaaeai? aeine?aeaeaiiy iieacaee, ui i?e aecai?
aeoea?cothoueny i?ioeane EI, i?i ui na?ae/eoue i?aeaeuaiiy noie
iaiane/aieo AEE ? iie?-iaiane/aieo AEE (IIAEE) oa cieaeaiiy noie
iane/aieo AEE a ne?iaaooe? e?ia?. I?e oeueiio, iaea?eueo oa?aeoa?ieie
aoea iiaia a?aenooi?noue a?ao?aeiiiai? AEE ? nooo?aa cieaeaiiy ai?noo
noaa?eiiai?, iea?iiai? AEE. A?aecia/aeiny noaoenoe/ii aeinoia??ia
i?aeaeuaiiy ai?noo aeeicio?e?iiai? ? aeieiciaaenaiiai? IIAEE (? 0,05).
Anoaiiaeaia caeaaei?noue ci?i AEE niaeo?a e?ia? a?ae o?eaaeino?
caoai?thaaiiy. I?e o?eaaeino? caoai?thaaiiy iiiaae 5 ?ie?a
niinoa??aaeiny cia/ia i?aeaeuaiiy noie iaiane/aieo aei 57,4+2,4% ?
cieaeaiiy noie iane/aieo aei 42,6+1,1% AEE.
Iieacieee AEE-niaeo?a ieacie e?ia? a ianoaaeaieo iaie oai?eo iaee
i?ioeeaaeio caeaaei?noue, i?ae o ne?iaaooe? e?ia?. Oae, ai?no iane/aieo
AEEN ca?eueooaaany aei 58,9+2,1%, a ai?no iaiane/aieo AEE ciaiooaaany
aei 41,1+2,1%, noaoenoe/ia aeinoia??ii a?ae??ciyth/enue a?ae eiio?ieth
(? 0,05), ui iiaeia iiynieoe i?aeaeuaiiyi a’yceino? e?ia?. O
caeaaeiino? a?ae a?eo oai?eo eiioeaio?aoe?y noano?ao?a EI c?inoaea,
iaaoaath/e iaeneiaeueieo iieaciee?a o a?oe? a?ae 40 aei 50 ?ie?a ?
noaa?e?coaaeany o oai?eo iioeeiai a?eo.
Oaeei /eiii, io?eiai? aeai? na?ae/aoue, ui caiaeueiee i?ioean o oe???
i?e aecai? ?aae?co?oueny a oiiaao i?aeaeuaii? EI ? ciaioaiiy ?ioiii?
?aaeoeaiino?, ui i?ecaiaeeoue aei o?ceei-o?i?/ieo ci?i e?ia?.
Ca?eueoaiiy iaiane/aiino? oa iie?iaiane/aiino? AEE cieaeo? a’yce?noue
e?ia? ? ni?ey? ?? ieoaeaiith, a a ?acoeueoao? a?aenooiino? a?ao?aeiiiai?
eeneioe ia neioaco?oueny ?yae a?ieia?/ii-aeoeaieo ?a/iaei, ui /anoi
ii?aeio?oueny c ii?ooaiiyi nae?aoi?ii? ooieoe?? i?aeoeoieiai? caeice oa
iai?io a ia/?ioe?. Iayai?noue ?ioiiaeao?oeeoiiai noaio ni?ey? cieaeaiith
caoenieo aeanoeainoae e?ia?, a ?acoeueoao? /iai iaeiie/o?oueny aaeeea
e?euee?noue ??ciiiai?oieo iaoaaie?o?a, ui i?ecaiaeeoue aei cieaeaiiy ??
e?enoae?caoe?eii? iiaeeeaino?.
Ca?aeii aeaieo e?oa?aoo?e, ooai?aiiy e?enoae?/ieo ca?iaee?a ?
aia?aaoe/iei i?ioeanii, oiio ??cea ciaioaiiy e?eueeino? oeaio??a
e?enoae?caoe?? ? ca?eueoaiiy /ano ?o ooai?aiiy iiaea na?ae/eoe i?i
cieaeaiiy aia?aaoe/ieo, iai?iieo i?ioean?a, noano?aoaie /iai ? e?i?aee,
cie?aia AAEE iie?iaiane/aiiai ?yaeo. Iieacieee oacea?ao?? ? AAEE
iiaeooue aeei?enoiaoaaoeny aeey ioe?iee nooiaiy aeoeaiino? aecaiaoiciiai
i?ioeano, a oaeiae ye i?iaiinoe/i? iieacieee aoaeoeaiino? oa?ai??
caoai?thaaiiy.
I?e i?iaaaeaii? ei?aeyoe?eiiai aiae?co i?ae aeine?aeaeoaaieie
iieacieeaie iaie aoei anoaiiaeaii iayai?noue i?yiiai ei?aeyoe?eiiai
ca’yceo ia?aaaaeii na?aaeiuei? neee i?ae iieacieeii noie IIAEE ? t1 oa
noie iaiane/aieo AEEN ? t1. Iieacaiee i?yiee o?niee ei?aeyoe?eiee
ca’ycie i?ae ai?noii O-e ? t1 (r =+0,85, ? 0,05), O-o ? t1 (r =+0,81, ?
0,05), O-a ? t1 (r =+0,72, ? 0,05) oa Oe?E (r = +0,78, ? 0,05),
na?aaeiuei? neee i?ae Ig A ? t1 (r =+0,36, ? 0,05), e iai?ioi?e
ei?aeyoe?eiee ca’ycie i?ae Ig M ? t1 (r = -0,91, ? 0,05).
Aca?iica’ycie i?ae ??aiai ?ioiieo ee?oei ? ii/aoeii e?enoae?caoe??
na?ae/eoue i?i cia/io ?ieue ?ioiii? ?aaeoeaiino? a i?ioean? ii?ooaiiy
e?enoae?caoe?eii? aeanoeaino? e?ia?.
Iaie aoa oaeiae i?iaaaeaiee aiae?c ei?aeyoe?eiiai ca’yceo eiioeaio?aoe?e
noi iaiane/aieo ? iie?iaiane/aieo AEE ?c iieacieeaie ee?oeiiiai e
aoii?aeueiiai ?ioi?oaoo. Aeyaeaiee i?yiee ei?aeyoe?eiee ca’ycie i?ae
noiith iaiane/aieo AEE ? O-a (r = +0,45, ? 0,05) oa cai?ioi?e c /eneii
O-e (r = -0,28, ? 0,05) ? i?ae noiith IIAEE ? Oo – i?yiee ca’ycie (r =
+0,39, ? 0,05) ? cai?ioi?e c /eneii O-e (r = -0,12, ? 0,05), O-a (r =
-0,37, ? 0,05), Oe?E (r = -0,3, ? 0,05), Ig A (r = -0,34, ? 0,05) ?
Ig M (r = -0,74, ? 0,05), ui aeaco? ia oa, ui aeoea?caoe?y i?ioean?a EI
ca ?aooiie i?aeaeuaiiy noie iaiane/aieo ? IIAEE noi?iaiaeaeo?oueny
i?eai?/aiiyi aeoeaiino? ?ioiieiiiaoaioieo ee?oei.
?acoeueoaoe i?iaaaeaiiy eiiieaenii? oa?ai?? c aeei?enoaiiyi I?O
A?aoiaoth/e iiiaeeii?noue iaoiaaiaoe/ieo eaiie aecaie e iaoai?cio ae??
I?O, iaie aoea i?iaaaeaia iae?iea oa?aiaaoe/ii? aoaeoeaiino? AIA
ii-ae?aiaciio oaeeue oa i?noeaaiai canoinoaaiiy e?aio “Aea?iac?i” (1%
noeueoaaeeaceio n??aea) ia iniia? aea/aiiy aeeiai?ee ee?i?/ieo,
eaai?aoi?ieo aeaieo, iieaciee?a ?ioi?oaoo, EI oa oacea?ao??.
Aeey ae??oaiiy iinoaaeaieo caaaeaiue iaie aoei noi?iiaaii o?e a?oie
oai?eo, ??aiioe?iieo i?ae niaith ca a?eii, noaooth, o?eaae?noth
caoai?thaaiiy, a oaeiae aeo?aeieie ee?i?ei-eaai?aoi?ieie aeaieie.
Ia?oo a?oio noaiiaeee 45 iaoe??io?a, a eiiieaenio oa?ai?th yeeo aoea
aeeth/aia I?O. Ae?oaa a?oia (45 oai?eo), e??i eiiieaenii? oa?ai?? c I?O,
canoiniaoaaea i?noeaai e?ai “Aea?iacei”. O o?aoth a?oio aa?eoei 30
iaoe??io?a, ye? io?eioaaee eeoa o?aaeeoe?eio iaaeeeaiaioicio oa?ai?th.
Aeeth/aiiy a eiiieaenia e?eoaaiiy aecaie I?O iieacaei, oi i?ae ??
aieeaii niinoa??aaany a?eueo i?enei?aiee ?aa?an ee?i?/ieo i?iya?a
aea?iaoico (ciaiooaaeeny a?ae/oooy naa?a?aeo, ia/??, aieth, iieiaiiy oa
?io.).
Eaai?aoi?i? aeine?aeaeaiiy o i?ioean e?eoaaiiy aeacoaaee, ui o oai?eo
ia?oi? ? ae?oai? a?oi ca eio?ioeee oa?i?i ii?iae?coaaeeny iieacieee
eaeeioeeoico, OCA, AeO, AnO, oeiieiai? i?iae. O ia?aaaaeii? a?eueoino?
oai?eo, yeei i?iaiaeeeanue eiiieaenia oa?ai?y ?c canoinoaaiiyi e?aio
“Aea?iacei”, aaeaeiny nooo?ai ciaioeoe e?euee?noue cania?a i?noeaai?
oa?ai??.
I?e aiae?c? aoaeoeaiino? e?eoaaiiy caeaaeii a?ae ee?i?/ii? oi?ie
caoai?thaaiiy aoei aeyaeaii, ui I?O ? aeineoue aoaeoeaiith ye i?e
i?e?iai?e, oae ? i?e ni?aaaei?e aecai?, a i?noeaaa canoinoaaiiy
“Aea?iaceio” aoaeoeaiyoa i?e e?eoaaii? i?e?iaii? aecaie.
Iaee?au? oa?aiaaoe/i? ?acoeueoaoe aoee aeinyaioo? a ae?oa?e a?oi?
oai?eo, ye? io?eioaaee I?O ? e?ai “Aea?iacei”. I?i oea na?ae/eoue
aeinyaiooa ee?i?/ia ?ai?n?y aei 2-o ?ie??a o 91,2% oai?eo i?e nooo?aiio
nei?i/aii? no?ie?a noaoe?iia?iiai e?eoaaiiy (16+1,4 aei?a) ii??aiyii c
eiio?ieueiith a?oiith (26+1,6 aei?a) ? a?oiith, aea i?iaiaeeeanue
o?eueee I?O (18,8+1,6 aei?a).
O oai?eo, eio?? io?eioaaee I?O, niinoa??aaeany iaenooo?a?oa aeeiai?ea
ii?iae?caoe?? ye ee?oeiiiai, oae ? aoii?aeueiiai ?ioi?oaoo, ui
i?iyaeyeiny o ca?eueoaii? ??aiy caaaeueii? e?eueeino? O-e aei 36,5+
0,7%, ?ioii?aaoeyoi?iiai ?iaeaeno aei 1,4+0,01 oa Ig G aei 13,65+1,5
a/e. Cieceany ai?no A-e aei 26,7+1,1%, Ig I aei 0,66+0,01 a/e, ciaioeany
??aaiue Oe?E aei 47,6+1,8 oi.iae. A?eueo ae?aaeaiith aoea aeeiai?ea
ii?iae?caoe?? iieaciee?a ?ioiii? ?aaeoeaiino? o oai?eo c oa?i?iii
caoai?thaaiiy aei 5 ?ie?a.
O oai?eo ae?oai? a?oie oaeiae nooo?ai ii?iae?coaaeeny iieacieee
?ioi?oaoo. I?e oeueiio o oai?eo eiio?ieueii? a?oie aoea cao?eniaaia iaio
ae?aaeaia oaiaeaioe?y aei ii?iae?caoe?? iieaciee?a ee?oeiiiai e
aoii?aeueiiai ?ioi?oaoo.
O an?o iaoe??io?a, a e?eoaaii? yeeo canoiniaoaaee I?O, a?aeaoeany
i?aeoe/ii iiaia ii?iae?caoe?y i?ioean?a EI. Aiaeii/an o oai?eo
eiio?ieueii? a?oie, ye? io?eioaaee eeoa o?aaeeoe?eio iaaeeeaiaioicio
oa?ai?th, aeeiai?ea ii?iae?caoe?? iieaciee?a niaeo?a AAEE aoea iaio
ae?aaeaiith.
Aecia/aiiy e?enoae?caoe?eieo iieaciee?a ne?iaaoee e?ia? iieacaei, ui
aeeth/aiiy a eiiieaen oa?aiaaoe/ieo caoiae?a I?O ni?eyei ciaioaiith t1
(a na?aaeiueiio aei 210 oa.) oa i?aeaeuaiith Ee?. (a na?aaeiueiio aei
2,1). O e?enoaeia?ao?/iiio iaethieo a?aecia/aeiny ca?eueoaiiy oeaio??a
e?enoae?caoe??, ciaioaiiy e?eueeino? e?i?eieo e?enoae?a, a i?e?ineii?/ii
– i?ici??noue e?enoae?a. O oai?eo eiio?ieueii? a?oie e?enoaeia?ao?/i?
ci?ie aoee iaio ae?aaeai?. Aeeiai?ea ci?i e?enoae?caoe?? ne?iaaoee e?ia?
ei?aethaaea c ?aa?anii ee?i?/ieo i?iya?a caoai?thaaiiy.
?acoeueoaoe a?aeaeaeaiiiai niinoa?aaeaiiy (aei aeaio ?ie?a) iieacaee, ui
o oai?eo ia aecaio, yeei aoea i?iaaaeaia eiiieaenia oa?ai?y c
aeei?enoaiiyi I?O, cia/ii ??aeoa niinoa??aaeiny caaino?aiiy aea?iaoico.
?aoeeaeea caoai?thaaiiy ia i?ioyc? aeaio ?ie?a na?aae oai?eo, ye?
io?eioaaee I?O, aoei ca?a?no?iaaii o 8,8% aeiaaee?a, a a oeo, eio??
io?eioaaee o?aaeeoe?eia e?eoaaiiy – o 20,3% aeiaaee?a, ui na?ae/eoue i?i
ia?aaaao a oa?aiaaoe/i?e aoaeoeaiino? ?ic?iaeaiiai iaie eiiieaeniiai
iaoiaeo e?eoaaiiy aecaie.
AENIIAEE
1. Aeyaeai? i?e aecai? ci?ie iieaciee?a oacea?ao?? caeaaeaoue a?ae
ee?i?/ii? oi?ie oa oyaeeino? ia?aa?ao aea?iaoico ? iiaeooue yaeyoeny
aeiaeaoeiaei ae?aaiinoe/iei oanoii.
2. O oai?eo ia aecaio aeyaeaii cai?ioiee ei?aeyoe?eiee ca’ycie
ia?aaaaeii na?aaeiuei? neee i?ae iieacieeaie oacea?ao?? oa ai?noii AAEE.
Aeiaaaeaii, ui c?inoaiiy ??aiy iaiane/aieo ? IIAEE aieeaa? ia
o?ceei-o?i?/iee noai ne?iaaoee e?ia? ? eeiaoeeo e?enoae?caoe?eii?
oanoiai? nenoaie, ui aeiiiaith? aeai? i?i iaoiaaiac aecaie.
3. Aeyaeai? i?e aecai? ci?ie a niaeo?? AAEE (a?aenooi?noue a?ao?aeiiiai?
eeneioe, i?aeaeuaiiy ai?noo iaiane/aieo AEE) aeacothoue ia
iaiao?aei?noue o?aooaaiiy oeeo a?io?i?/ieo ii?ooaiue i?e i?ecia/aii?
eiiieaenii? oa?ai?? aea?iaoico.
4. O oai?eo ia aecaio aeyaeai? ii?ooaiiy ee?oeiiiai e aoii?aeueiiai
?ioi?oaoo, ye? i?iyaeythoueny ciaioaiiyi caaaeueii? e?eueeino? A-?OE,
ii?ooaiiyi ni?aa?aeiioaiiy i?ae ?ioii?aaoeyoi?ieie ee?oeiaie,
ca?eueoaiiyi ai?noo AAN-?OE ? Oe?E. Iaenooo?a?o? ?o ii?ooaiiy oa?aeoa?i?
a noaae?? caaino?aiiy aea?iaoico ? eiai iiaeiaaeaiiio ia?aa?ao, a oaeiae
o oai?eo iioeeiai a?eo.
5. Canoinoaaiiy I?O a eiiieaeniiio e?eoaaii? oai?eo ia aecaio ni?ey?
?aa?ano ee?i?/ieo i?iya?a caoai?thaaiiy, a oaeiae ii?iae?caoe??
?ioiieia?/ieo, a?io?i?/ieo ? oacea?ao?/ieo iieaciee?a.
6. I?noeaaa canoinoaaiiy e?aio “Aea?iacei”, yeee ai?uo? noeueoaaeeacei
n??aea oa i?e?ioaeeueiai? ?aciiainii? oa?ai?? a eiiieaeni?e oa?ai??
aecaie aeicaiey? nei?ioeoe o?eaae?noue noaoe?iia?iiai e?eoaaiiy oai?eo,
ciaioeoe aeei?enoaiiy ciai?oieo e?ea?nueeeo i?aia?ao?a, a oaeiae
caiia?aaoe iiaeeeaino? ?icaeoeo ?aoeeaeeao aea?iaoico.
NIENIE IAOEIAEO I?AOeUe, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe??
1. Io?uoeeia I.Ae. Iiaua aeaiiua i aicaeaenoaee yeaeo?iiaaieoiiai
eceo/aiey i?e aecaia // AEo?iae aea?iaoieiaee e aaia?ieiaee. – 1998.
-?2. – N.61-63.
2. Aieia/aiei Ae.ss., Io?eoe?ia I.Ae., Ia?aa?a oa ?ioiieia?/iee noai
oai?eo ia aecaio ae?iie a ia??iae? iinoiaiiiaoce // Iaae?ao??y,
aeooa?noai oa a?iaeieia?y. – 1998. – ?1. – N. 91-92.
3. Io?eoe?ia I.Ae. Aieea i?e?ioaeeueiai? ?aciiainii? oa?ai?? ia
aee?iieeneioiee niaeo? ne?iaaoee e?ia? oai?eo ia aecaio // I?iaeaiu,
aeinoeaeaiey e ia?niaeoeau ?acaeoey iaaeeei-aeieiae/aneeo iaoe e i?iaeai
cae?aaiio?aiaiey. – Neioa?iiieue. – 1998. – Oii 134, /.1. – N. 199-202.
4. Eieyaeaiei A.A., Aieia/aiei Ae.E., Io?eoe?ia I.Ae. Canoinoaaiiy
aeiii?i?eo a eiiieaeni?e oa?ai?? aea?iaoieia?/ieo oai?eo // E?ee
Oe?a?ie. – 1998. – ?3. – N.38-39.
5. Io?uoeeia I.Ae. Iee?i-?aciiainiay oa?aiey (I?O) e iieacaoaee
e?enoaeeia?aoee nuai?ioee e?iae aieueiuo a oa?aiee yecaiu // Aeooaeueiua
i?iaeaiu iaaeeoeeiu e aeieiaee. – E.: I-ai cae?aaiio?aiaiey Oe?aeiu,
Oe?. ain. iaae. ei-o. – 1997. – Oii 1. – N.130-133.
6. Io?uoeeia I.Ae. Niinia ea/aiey yecaiu // Aeooaeueiua aii?inu
aea?iaoi-aaia?ieiaee. – Aeiai?iiao?iane-Oiaeueieoeeee. – 1997. – Aui.
10. – N.108.
7. Io?uoeeia I.Ae. Aeeyiea iee?iaieiiaie ?aciiainiie oa?aiee ia
eiioiieiae/aneoth ?aaeoeaiinoue o aieueiuo yecaiie // Aeooaeueiua
aii?inu aea?iaoi-aaia?ieiaee. – Aeiai?iiao?iane-Oiaeueieoeeee. -1997. –
Aui. 10. – N. 107.
8. Io?eoe?ia I.Ae. Iaai?oi?aciiainia oa?ai?y a e?eoaaii? aecaie //
Ieoaiiy ae?aaiinoeee oa e?eoaaiiy. – Ee?a: IIC Oe?a?ie. – 1995. –
N.163-164.
9. Io?uoeeia I.Ae., Eieyaeaiei A.A. Aea?iacei i?e ea/aiee eiaeieo
caaieaaaiee // Oac. aeii. I iaoe. c’?caeo oa?iaeieia?a Oe?a?ie “No/ani?
i?iaeaie oa?iaeieia??”. – 27-29 aa?aniy 1995, i.Iieoaaa. – 1995. –
N.140-141.
10. Io?uoeeia I.Ae., Eieyaeaiei A.A. Eniieueciaaiea iace Eiaeoeii a
aea?iaoieiae/aneie i?aeoeea // Oac. aeii. I iaoe. c’?caeo oa?iaeieia?a
Oe?a?ie “No/ani? i?iaeaie oa?iaeieia??”. – 27-29 aa?aniy 1996,
i.Iieoaaa. – 1995. – N. 141.
AIIOAOe?ss
Io?eoe?ia I.Ae. Aea/aiiy ci?i iieaciee?a oacea?ao?? ne?iaaoee e?ia? o
oai?eo ia aecaio a aeeiai?oe? eiiieaeniiai e?eoaaiiy aecaie ?c
canoinoaaiiyi i?e?ioaeeueiai? ?aciiainii? oa?ai??. – ?oeiien.
Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe
ca niaoe?aeuei?noth 14.01.20 – oe??i? oa aaia?e/i? oai?iae.
Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i.I.I.Aiaiiieueoey. Ee?a, 1999.
I?iaaaeaia eiiieaenia ee?i?ei-eaai?aoi?ia ianoaaeaiiy 120 oai?eo ia
ni?aaaeith e i?e?iaio aecaio ?c canoinoaaiiyi oacea?ao?/iiai,
aacio?iiaoia?ao?/iiai aecia/aiiy e?i?ae?a e ?ioiieia?/iiai iaoiae?a.
Iieacaii, ui o oai?eo ia aecaio niinoa??aa?oueny ae?aaeaia ii?ooaiiy
iieaciee?a oacea?ao?? ne?iaaoee e?ia?, iayai?noue ?ioiiaeao?oeeoiiai
noaio c i?aeaeuaiiyi ??aiy Oe?E, a oaeiae ci?ie aee?iieeneioiiai niaeo?a
ne?iaaoee ? ieacie e?ia?. Aeyaeai? ei?aeyoe?ei? ca’ycee, ia?aaaaeii
na?aaeiuei? neee, i?ae aeine?aeaeaieie iieacieeaie. ?acoeueoaoe
i?iaaaeaieo aeine?aeaeaiue ia?aeiiothoue, ui oacea?ao?/iee iaoiae iiaea
aooe canoiniaaiei o yeino? aeiiii?aeiiai ae?aaiinoe/iiai oanoo i?e
aecai?, a oaeiae ye i?iaiinoe/iiai – a aeeiai?oe? oa?ai?? aea?iaoico.
?ic?iaeaii iiaee eiiieaeniee iaoiae e?eoaaiiy aecaie ?c canoinoaaiiyi
I?O ? i?noeaai e?aio “Aea?iacei”, ai?uoth/ee noeueoaaeeacei n??aea, yeee
nooo?ai i?aeaeuo? aoaeoeai?noue e?eoaaiiy ? iiaeiaaeo? no?iee ?ai?n??
aea?iaoico.
Eeth/ia? neiaa: aecaia, oacea?ao?y, aee?iieeneioiee niaeo?,
?ioiiaeao?oeeo, I?O, Aea?iacei, noeueoaaeeacei n??aea.
AIIIOAOeEss
Io?uoeeia I.Ae. Eco/aiea eciaiaiee iieacaoaeae oacea?aoee nuai?ioee
e?iae aieueiuo yecaiie a aeeiaieea eiiieaeniiai ea/aiey yecaiu n
i?eiaiaieai iee?iaieiiaie ?aciiainiie oa?aiee. – ?oeiienue.
Aeenna?oaoeey ia nieneaiea iao/iie noaiaie eaiaeeaeaoa iaaeeoeeineeo
iaoe ii niaoeeaeueiinoe 14.01.20 – eiaeiua e aaia?e/aneea aieacie.
Iaoeeiiaeueiue iaaeeoeeineee oieaa?neoao ei.A.A.Aiaiiieueoea, Eeaa,
1999.
Yecaia yaeyaony aeooaeueiie e iaaeinoaoi/ii eco/aiiie i?iaeaiie
nia?aiaiiie aea?iaoieiaee. ?ani?ino?aiaiiinoue yecaiu ninoaaeyao io 10
aei 40% n?aaee anae iaoieiaee eiaee. A iineaaeiea aeanyoeeaoey
ioia/aaony iaoeeiiiay oaiaeaioeey e ?inoo caaieaaaaiinoe yoei
aea?iaoicii e aieaa oyaeaeia aai eeeie/aneia oa/aiea.
I?e yoii caaieaaaiee iaaeinoaoi/ii eco/aiu iaeioi?ua caaiuey aai
iaoiaaiaca, a /anoiinoe eeieaeiay ia?ieneaeaoeey, a oaeaea
eiioiieiae/aneay e e?enoaeeecothuay ooieoeee nuai?ioee e?iae.
Aeooaeueiie yaeyaony ?ac?aaioea iiauo e oniaa?oainoaiaaiiuo iaoiaeia
ea/aiey yecaiu, a /anoiinoe aaciaaeeeaiaioiciuo.
N oeaeueth ?ac?aaioee iaoiaaiaoe/anee iainiiaaiiiai eiiieaeniiai iaoiaea
ea/aiey iee?iaiie e enoeiiie yecaiu n i?eiaiaieai iee?iaieiiaie
?aciiainiie oa?aiee i?iaaaeaii eiiieaeniia eeeieei-eaai?aoi?iia
ianeaaeiaaiea 120 aieueiuo enoeiiie e iee?iaiie yecaiie n i?eiaiaieai
oacea?aoe/aneiai, eiioiieiae/aneiai iaoiaeia e aacio?iiaoia?aoe/aneiai
ii?aaeaeaiey eeieaeia.
N?aaee ianeaaeiaaiiuo auei 84 ioae/eiu e 36 aeaiuei a aic?anea io 18 aei
68 eao ni n?aaeiae aeeeoaeueiinoueth caaieaaaiey 4,3 aiaea.
?aoeeaeeae?othuee oa?aeoa? caaieaaaiey ioia/aaony o 55% aieueiuo.
Niioonoaothuea caaieaaaiey auyaeythony o 60,8 aieueiuo.
Iaia?oaeaii, /oi o aieueiuo yecaiie iaaethaeaaony au?aaeaiiia ia?ooaiea
iieacaoaeae oacea?aoee nuai?ioee e?iae – oaaee/aiea a?aiaie ia/aea
e?enoaeeecaoeee aei 205-215 iei. e nieaeaiea eiyooeoeeaioa
e?en-oaeecaoeee aei 1,45-1,5 ioiineoaeueii aiaeiae/iuo iieacaoaeae o
caei?iauo eeoe (140-150 iei. e 2,1-2,3 – niioaaonoaaiii).
E?enoaeeia?aoe/aneay ea?oeia nuai?ioee e?iae oa?aeoa?ecoaony
oiaiueoaieai eiee/anoaa oeaio?ia e?enoaeeecaoeee aei 0-6 (a eiio?iea
20-40), oaaee/aieai eiee/anoaa eeiaeiuo e?enoaeeia, oneeaieai
e?enoaeeecaoeee ie?oaeathuaai oiia, iooiinoueth e caoeaeiaaiiinoueth
e?enoaeeia, a ioee/ea io e?enoaeeiia?aciaaiey o caei?iauo eeoe.
E?enoaeeia?aoe/aneay ea?oeia ioee/a-aony o aieueiuo enoeiiie e iee?iaiie
yecaiie e caaeneo io au?aaeaiinoe ainiaeeoaeueiiai i?ioeanna.
I?e aeaenoaee YIE ii-aeeaiaciia in vitro i?e yecaia e a eiio?iea iauaa
a?aiy e?enoaeeecaoeee oiaiueoaaony ia 20%, eiyooeoeeaio e?enoaeeecaoeee
oaaee/eaaaony i?e yecaia a n?aaeiai aei 1,7, /oi oeacuaaao ia
ii?iaeecaoeeth oacea?aoe/aneeo iieacaoaeae nuai?ioee e?iae o aieueiuo
yecaiie iiae aeaenoaeai YIE ii-aeeaiaciia.
Iieacaii, /oi a noaaeee iaino?aiey yecaiu eiaaony eiioiiaeaoeoeeo-iia
ninoiyiea n au?aaeaiiui oiaiueoaieai i?ioeaioiiai niaea?aeaiey
O-eeioioeeoia e eo noaiiioeyoeee, aeaoeoeeoii Ig I, aeoeaaoeeae
A-eeioioeeoia e iiauoaieai o?iaiy OeEE. Aeoaeia eciaiaiee e eeaoi/iiai e
aoii?aeueiiai eiioieoaoa oaaee/eaaaony n aeeeoaeueiinoueth caaieaaaiey e
aic?anoii aieueiuo. Iaia?oaeaiu ioee/ey a eiioiiii noaoona i?e enoeiiie
e iee?iaiie oi?iao yecaiu.
Auyaeaii eciaiaiea aee?iieeneioiiai niaeo?a nuai?ioee e ieaciu e?iae o
aieueiuo. I?e yecaia aeoeaece?othony i?ioeannu eeieaeiie
ia?ie-neaeaoeee, i /ai naeaeaoaeuenoaoao iiauoaiea noiiu iaianuuaiiuo e
IIAEE e nieaeaiea noiiu ianuuaiiuo aee?iuo eeneio a nuai?ioea e?iae.
Aeaiiua eciaiaiey aieaa au?aaeaiu i?e aeeeoaeueiinoe caaieaaaiey aieaa 5
eao e a aic?anoa io 40 aei 50 eao.
Iaia?oaeaiu ei?aeyoeeiiiua nayce, i?aeiouanoaaiii n?aaeiae neeu, iaaeaeo
enneaaeiaaiiuie iieacaoaeyie. Acaeiinaycue iaaeaeo o?iaiai eiioiiuo
eeaoie e ia/aeii e?enoaeeecaoeee naeaeaoaeuenoaoao i cia/eoaeueiie aeiee
eiioiiie ?aaeoeaiinoe a i?ioeanna ia?ooaiey e?enoaeeecothuae niiniaiinoe
e?iae. A aeoeaecaoeey i?ioeannia eeieaeiie ia?ieneaeaaeee ca n/ao
iiauoaiey noiiu iaianuuaiiuo e IIAEE nii?iaiaeaeaaony oaiaoaieai
aeoeaiinoe eiioiieiiiaoaioiuo eeaoie.
?acoeueoaou i?iaaaeaiiuo enneaaeiaaiee iieacaee, /oi oacea?aoe/aneee
iaoiae enneaaeiaaiey iiaeao eniieueciaaoueny a ea/anoaa
aeiiieieoaeueiiai aeeaaiinoe/aneiai oanoa i?e yecaia, a oaeaea eae
i?iaiinoe/aneiai – a aeeiaieea oa?aiee aea?iaoica.
Ia iniiaa n?aaieoaeueiie ioeaiee eeeie/aneeo aeaiiuo, eiioiiiai noaoona,
iieacaoaeae eeieaeiie ia?ieneaeaoeee e e?enoaeeecothuae ooieoeee e?iae
iieacaiu i?aeiouanoaa ?ac?aaioaiiiai iiaiai eiiieaeniiai iaoiaea ea/aiey
yecaiu n i?eiaiaieai I?O e ianoii e?aia “Aea?iacei” (i?iecaiaenoai oe?iu
“LEK”, Neiaaiey), niaea?aeauaai 1% noeueoaaeeaceia na?aa?a.
Oaeei ia?acii, ?ac?aaioaiiue eiiieaeniue iaoiae ni/aoaiiiai i?eiaiaiey
I?O e e?aia “Aea?iacei” iiauoaao yooaeoeaiinoue ea/aiey yecaiu e
oaeeeiyao n?iee ?aiennee aea?iaoica.
Eeth/aaua neiaa: yecaia, oacea?aoey, aee?iieeneioiue niaeo?,
eiioiiaeaoeoeeo, I?O, Aea?iacei, noeueoaaeeacei na?aa?a.
SUMMARY
Puryshkina O.D. Studing of changes of indicators for blood serum
thesography with eczema patiens in dynamics of complex eczema treatment
using microwave reasonance therapy.- Manuscript.
Dissertation for candidate of medical sciences searching,
specialization 14.01.20 skin and venerological ilness. 0.0. Bohomolet’s
National Medical University. Kyiv, 1999.
Complex clinics and laborattory investigation of 120 patiens with real
and microbal eczema using thezographical, immunological and
gas-chromatology methods for lipids indification was perfomed.
It is indicated that patients with eczema have clear distruction of
blood serum thezagraphy indicators, presence of immunodeficitus with CIK
level increasing and also changes of fatty acidic spectrum of serum and
plasma blood. Correlated connections, especially of medium force,
between investigated indicators were revealed.
Data of the investigations have revealed that thezographical method may
be used as a subsidiary diagnostic test with eczema and also as
prognozed one in dermatose therapy dinamics.
A new complex method for eczema treatment with MRT and “Dermazine” creme
localy is developed. The creme containing silver sulphadiasine increases
the effectiveness of treatment and enlarges the period of dermatosis
remision.
Key words: eczema, thezography, fatty-acidic spectrum, immunodeficitus,
MRT, Dermazine, silver sulphadiasine.
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