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Вплив антиоксидантів та омепразолу на протизапальну активність, побічну дію та фармакокінетику індометацину (експериментально-клінічне дослідження): А

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AEAAeAI?ss IAAeE*IEO IAOE OE?A?IE

?INOEOOO OA?IAEIEIA?? OA OIENEEIEIA??

INOAI*OE Ieaia ?aai?aia

OAeE: 615.356:615.24-02:615.262

AIEEA AIOEIENEAeAIO?A OA IIAI?ACIEO IA I?IOECAIAEUeIO AEOEAI?NOUe,
IIA?*IO Ae?TH OA OA?IAEIE?IAOEEO ?IAeIIAOAOeEIO

(aenia?eiaioaeueii-ee?i?/ia aeine?aeaeaiiy)

14.03.05 – oa?iaeieia?y

Aaoi?aoa?aoaeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiyeaiaeeaeaoa
iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a A?iieoeueeiio aea?aeaaiiio iaaee/iiiooi?aa?neoao?
?i.I.?.Ie?iaiaa

Iaoeiaee ea??aiee

aeieoi? iaaee/ieo iaoe NOAI?NEAA*OE Ieeiea Aaeaiiae/

aeioeaio eaoaae?e oaeoeueoaonueei? oa?ai?? A?iieoeueeiai aea?aeaaiiai

iaaee/iiai oi?aa?neoaoo ?i.I.?.Ie?iaiaa

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, /eai-ei?aniiiaeaio IAI oa AII Oe?a?ie, i?ioani?
O?EION Oaae?? Iao?iae/caa?aeoaa/ a?aeae?eo oa?iaeieia?? i?ioecaiaeueieo
oa aiaeueaaoe/ieo cania?a ?inoeoooo oa?iaeieia?? oa oieneeieia?? AII
Oe?a?ie

aeieoi? iaaee/ieo iaoe i?ioani? EENAIEI A?eai??e ?aaiiae/caa?aeoaa/
eaoaae?e n?iaeii? iaaeeoeeie, ee?i?/ii? ?ioiieia?? ? aea?aieia??
Ee?anueei? iaaee/ii? aeaaeai?? i?neyaeeieiiii? ina?oe ?i. I.E.Ooi?ea

I?ia?aeia onoaiiaa: Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. ae.
I.I.Aiaiiieueoey, eaoaae?a oa?iaeieia??

Caoeno aeena?oaoe?? a?aeaoaeaoueny 19 o?aaiy 1999 ?ieo i 13 aiae ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.550.01 i?e ?inoeooo?
oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie (252057, Ee?a, aoe. A.Iioue?,
14)

C aeena?oaoe??th iiaeia iciaeiieoenue a a?ae?ioaoe? ?inoeoooo
oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie

Aaoi?aoa?ao ?ic?neaii ” 17 ” ea?oiy 1999 ?.

O/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.550.01, eaiaeeaeao a?ieia?/ieo
iaoe ?.A.Aeaiiaa

18

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie. Iioei?caoe?y oa?iaeioa?ai?? caiaeueiiai oa
aieueiaiai neiae?ii?a ? iaei??th c aaaeeeaeo i?iaeai no/anii?
oa?iaeieia??. Aeooaeuei?noue i?iaeaie iaoiiaeaia ye iioe?ai?noth
caoai?thaaiue, ui noi?iaiaeaeothoueny oeeie neiae?iiaie, oae ? /anoioith
oneeaaeiaiue, ui aeieeathoue i?e canoinoaaii? i?ioecaiaeueieo oa
aiaeueaaoe/ieo cania?a. Iacaaaeath/e ia aenieo /anoioo oa aaaee?noue
oneeaaeiaiue (A.I.Aeeoi?ia e niaao., 1991; 1996; Massimo Claar et al.,
1998; Lanas Arbeloa et al., 1998), ianoa?i?aei? i?ioecaiaeuei? i?aia?aoe
i?iaeiaaeothoue caeeoaoenue iaeoaeeaai?oeie e?ea?nueeeie caniaaie
[Peretz A., 1998]. Oiio i?iaeaia iioei?caoe?? oa?iaeioa?ai?? oeeie
i?aia?aoaie ? aeooaeueiith i?iaeaiith no/anii? oa?iaeieia??.

?ica’ycaiiy oeueiai aaaeeeaiai caaaeaiiy iiaeeeaa ye caaaeyee neioaco
iiaeo e?ea?nueeeo ?a/iaei, oae ? oeyoii a?eueo ?aoe?iiaeueiiai
aeei?enoaiiy aaea ?nioth/eo e?ea?nueeeo cania?a (I.A.Iioi?o, 1995).

Ca inoaii? ?iee a ee?i?/io i?aeoeeo ai?iaaaeaeaii aeanyoee iiaeo
e?ea?nueeeo cania?a c i?ioecaiaeueieie oa aiaeueaaoe/ieie aeanoeainoyie,
iaeiae i?ney o?eaaeeo ee?i?/ieo aeine?aeaeaiue c’yniaoaaeinue, ui aiie
ca aoaeoeai?noth oa aacia/i?noth iaei a?ae??ciythoueny a?ae ?nioth/eo
(I.A.Aoi/oe, 1994; A.A.Ianiiiaa, 1994; N.Ethoo, 1994; W.Blackburn et
al., 1995). Aeaui iaeiiin?aii noiyoue naeaeoeai? aeieaoi?e ae?oai?
?cioi?ie oeeeeiieneaaiace (Vane J.R., Botting R.M., 1998). Iaeiae /a?ac
aenieo aa?o?noue oa?ai?? oe? i?aia?aoe ua ia iaaoee oe?ieiai
canoinoaaiiy o ian, iniaeeai c iaeyaeo ia iaiao?aei?noue o?eaaeiai
(i?ioyaii e?eueeio i?nyoe?a) i?eeiio. Oiio iaeiei c ia?niaeoeaieo
iai?yie?a iioei?caoe?? i?ioecaiaeueii? oa?ai?? iiaea aooe ?ic?iaea
niinia?a i?aeaeuaiiy aoaeoeaiino? oa aacia/iino? canoinoaaiiy ?nioth/eo
ianoa?i?aeieo i?ioecaiaeueieo i?aia?ao?a.

Iniaeeai aeooaeueiith i?iaeaia aacia/iino? canoinoaaiiy i?ioecaiaeueieo
cania?a ? aeey ?aaiaoieia?/ieo oai?eo, aea ?nio? iano?eia iaiao?aei?noue
o?eaaeiai, a oi e iino?eiiai ?o i?eeiio. Cie?aia, aeey oai?eo ia
?aaiaoi?aeiee a?o?eo (?A) i?ioecaiaeuei? caniae ?acii c aacenieie
i?aia?aoaie ? eiiiiiaioaie iino?eii? i?aeo?eioth/i? oa?ai??
(A.I.Eiaaeaiei oa ni?aaao., 1995; ?.I.Aaiaeaea oa ni?aaao., 1996;
A.A.Ianiiiaa, ss.A.Neaeaeei 1996; Wolfe F., Hawley D., 1998).

C a?oie i?ioecaiaeueieo cania?a, ye i?aia?ao?a ia?oiai ?yaeo a e?eoaaii?
?A, iaeiei c iaeaoaeoeai?oeo caeeoa?oueny ?iaeiiaoaoeei. A iniia?
aaeuei?aiiai aieeao ?iaeiiaoaoeeio ia caiaeueiee i?ioean eaaeeoue
i?eai?/aiiy neioaco i?inoaaeaiaeei?a. I?aia?ao ? iaeiei c iaeiiooaei?oeo
?ia?a?oi??a i?inoaaeaiaeeineioaoace (oeeeeiieneaaiace), ui ? iaoiiaeth?
eiai i?ioecaiaeueio aeoeai?noue. Ianiaoeeo?/i?noue i?ioecaiaeueii? ae??
?iaeiiaoaoeeio ni?eyea oe?ieiio canoinoaaiith i?aia?aoo a ee?i?/i?e
i?aeoeoe? i?e aaaaoueio caoai?thaaiiyo, ye? noi?iaiaeaeothoueny
caiaeueiei /e aieueiaei neiae?iiaie.

Iaeiae ?iaeiiaoaoeei, ye ? ?io? IICI, ia iicaaaeaiee iaaeie?e?a, iaeiei
c iae?noioi?oeo c ieo ? iia?/i? aoaeoe, iaoiiaeai? ianaeaeoeai?noth
aaeuei?aiiai aieeao ia oeeeeiieneaaiaciee eiiieaen (I.I.A?eoi?ia oa
ni?aaao., 1996; Bianchi Porro G. et al., 1998; Griffin M.R., 1998). E??i
oeueiai oa?iaeioa?ai?y ?iaeiiaoaoeeiii ia caaaeaee oa?aeoa?eco?oueny
aeinoaoiueith aoaeoeai?noth, ui iiynith?oueny, i/aaeaeii,
iaa?aeiia?aei?noth i?ae aocueeei niaeo?ii iaoai?cio ae?? i?aia?aoo oa
neeaaeiei, aaaaoieiiiiiaioiei iaoiaaiacii caiaeaiiy. Oea aeicaiey?
niiae?aaoenue ia iioei?caoe?th e?eoaaiiy ?iaeiiaoaoeeiii oeyoii
ii?aeiaiiy eiai c i?aia?aoaie ?ioeo oa?iaeieia?/ieo a?oi,
oa?iaeiaeeiai?/iee aoaeo yeeo ?aae?co?oueny /a?ac o? eaiee iaoiaaiaco
caiaeaiiy, ia ye? ?iaeiiaoaoeei ia aieeaa?, aai ae oeae aieea
iaaeinoaoi?e.

Iaeieie c iaea?eueo ia?niaeoeaieo ii?aeiaiue a oeueiio ieai? iiaeooue
aooe ii?aeiaiiy ?iaeiiaoaoeeio c aioeieneaeaioaie ?, a ia?oo /a?ao,
i?e?iaei?ie – ?aoeiieii oa oieioa?ieii. Oe? i?aia?aoe ii?yae c
aioeieneaeaioiith aeoeai?noth i?iyaeythoue iaia?aiinoaa?e?coth/? oa
oeeoii?ioaeoeai? aeanoeaino?, ui ? aaaeeeaei a e?eoaaii? caiaeueiiai
i?ioeano c iaeyaeo ia aeac?ioaa?aoeai? i?ioeane a niieo/i?e oeaiei?
(Edmonds S. et al., 1997). Ia iaio iaa?oioiaaiei aeaea?oueny aeeth/aiiy
aei eiiieaeno e?eoaaiiy naeaie, i?aia?aoo ui i?noeoue i?e?iaeaiaio
naeai, ??aaiue yeiai i?e o?ii?/iiio caiaeaii?, ca e?oa?aoo?ieie aeaieie,
/anoi aeyaey?oueny cieaeaiei (V.E.Honkanen, 1991; U.Tarp, 1994; Heinle
K. et al., 1997).

Ine?eueee ?iaeiiaoaoeei iaeaaeeoue aei i?aia?ao?a c ei?ioeei ia??iaeii
iai?aaeaaaeaiiy (M.L.Orme, 1982; Taylor P.J. et al., 1998) ? a i?aai?ci?
oaeaeei iaoaaie?co?oueny aei oa?iaeieia?/ii iaaeoeaieo iaoaaie?o?a
(A.I.Eiaaeaiei e niaao., 1995), oi aeineoue aeooaeueiei aeey e?eoaaiiy
iei ? i?aeo?eiaiiy eiioeaio?aoe?? iaci?iaii? oi?ie i?aia?aoo a ieaci?
e?ia? ia oa?aiaaoe/ii aoaeoeaiiio ??ai?. Ca?eueoaiiy c oe??th iaoith
aeice /e /anoioe i?eeiio ?iaeiiaoaoeeio iaiaaeo?oueny aeieeiaiiyi
iia?/ieo aoaeo?a. Oiio aeaea?oueny ia?niaeoeaiei ii?aeiaiiy
?iaeiiaoaoeeio c i?aia?aoaie, ni?iiiaeieie caaaeueioaaoe
a?io?ainoi?iaoe?th ? oiia?eueieoe ia?aoai?aiiy aei iaaeoeaieo
iaoaaie?o?a. Caniaii ei?aeoe?? oaeaeeino? iaoaaie?/ii? ?iaeoeaaoe??
?iaeiiaoaoeeio iiaea noaoe aeieaoi? i?ioiiii? “iiiie” iiai?acie,
a?aeiiee ye aoaeoeaiee aioenae?aoi?iee i?aia?ao, ui oe?iei
canoiniao?oueny a e?eoaaii? ae?aceiai? oai?iae. Caeaoi?noue iiai?acieo
oiia?eueithaaoe ae?i?iaoe?th ?iaeiiaoaoeeio a ii?aeiaii? c a?aeiieie
aioeoeueoea?iaaiieie aeanoeainoyie ?iaeoue oaea ii?aeiaiiy iniaeeai
i?eaaaeeaei, ine?eueee a?aee?eaa? ia?niaeoeae i?aeaeuaiiy oa?aiaaoe/ii?
aeoeaiino? c iaeii/aniei ciaioaiiyi ooeiaeaeoth/iai aieeao ia
oeoieiai-eeoeiaee o?aeo.

Aeine?aeaeaiiy aeeiiaii a a?aeiia?aeiino? c Aea?aeathaeaeaoiith IAe?
A?iieoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. I.?.Ie?iaiaa NI
15.02.0001.86; ? Aea?ae?a?no?aoe?? – 01. 86.0.33161. “?ic?iaeoe niiniae
oe?eani?yiiaaii? ei?aeoe?? a?oai?iaie oa eioa?iaioaie aeoeaiino?
oa?iaio?a iaoaaie?cio enaiia?ioee?a, oa?iaeieia?/iiai ? oiene/iiai
aoaeo?a aeayeeo e?ea?nueeeo i?aia?ao?a oa o?i?/ieo niieoe”.

Iaoa ?iaioe. Ee?i?ei-aenia?eiaioaeueia iaa?oiooaaiiy aeioe?eueiino?
aeei?enoaiiy aioeieneaeaio?a (?aoeiieo aoeaoaoo, oieioa?ieo aoeaoaoo,
aaa?oo, naeaie) oa iiai?acieo ye cania?a iioei?caoe?? oa?iaeioa?ai??
ianoa?i?aeiei i?ioecaiaeueiei i?aia?aoii – ?iaeiiaoaoeeiii.

Caaea/? aeine?aeaeaiiy

1. Aea/eoe aieea aioeieneaeaio?a (aaa?oo, naeaie, aeeaoiieo, oieioa?ieo
oa ?aoeiieo) ia i?ioecaiaeueiee oa oeueoea?iaaiiee aoaeoe ?iaeiiaoaoeeio
o uo??a c aae’thaaioiei a?o?eoii oa a?ae?a?aoe iaeia?niaeoeai?o? c ieo
aeey ai?iaaaeaeaiiy a ee?i?eo.

2. Aea/eoe aieea iiai?acieo ia oa?iaeie?iaoeeo, i?ioecaiaeueiee oa
oeueoea?iaaiiee aoaeoe ?iaeiiaoaoeeio o uo??a c aae’thaaioiei a?o?eoii.

3. Aea/eoe oa?iaeie?iaoe/io aca?iiae?th i?ae iiai?acieii oa
?iaeiiaoaoeeiii o oai?eo ia ?aaiaoi?aeiee a?o?eo.

4. ?ic?iaeoe /ooeeaee oa aeinooiiee iaoiae aecia/aiiy ?iaeiiaoaoeeio a
a?ieia?/ieo ??aeeiao ? c eiai aeiiiiiaith aea/eoe oa?iaeie?iaoeeo
?iaeiiaoaoeeio o uo??a c aae’thaaioiei a?o?eoii oa oai?eo ia
?aaiaoi?aeiee a?o?eo.

5. Aea/eoe noai caaacia/aiino? oai?eo ia ?aaiaoi?aeiee a?o?eo
i?e?iaeaiaioii naeaiii a caeaaeiino? a?ae aeoeaiino? caiaeueiiai
i?ioeano oa ioe?ieoe iaiao?aei?noue oa aoaeoeai?noue eiai aeeth/aiiy aei
eiiieaeniiai e?eoaaiiy oai?eo ia ?A.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a

Aia?oa a aenia?eiaio? ia iiaeae? aae’thaaioiiai a?o?eoo uo??a ioe?iaii
aieea aeiaeaoeiaiai i?ecia/aiiy aioeieneaeaioieo i?aia?ao?a: aaa?oo,
naeaie, ?aoeiieo, oieioa?ieo oa aeeaoiieo ia i?ioecaiaeueio oa
oeueoea?iaaiio ae?th ?iaeiiaoaoeeio.

Iieacaii, ui aeiaeaoeiaa i?ecia/aiiy a?oai?i?a c aioeieneaeaioieie
aeanoeainoyie, ye ? naeaie oa aeeaoiieo, iiaeoeth? i?ioecaiaeueiee oa
aiaeueaaoe/iee aoaeoe ?iaeiiaoaoeeio. Aaa?o, i?iyaeyth/e aeanio
i?ioecaiaeueio aeoeai?noue, i?aeneeth? i?ioecaiaeueio ae?th
?iaeiiaoaoeeio ca ?aooiie iaiiaii? noiaoe?? aoaeo?a i?aia?ao?a.
Iacia/iee aaeuei?aiee aieea ia ia?aa?a aae’thaaioiiai a?o?eoo aeyaeaii ?
a naeaie oa aeeaoiieo, ii?aeiaiiy yeeo c ?iaeiiaoaoeeiii i?aeneeth?
aoaeo inoaiiueiai. Aeiaeaoeiaa i?ecia/aiiy aaa?oo, ?aoeiieo oa
oieioa?ieo cia/ii ciaioo? oeueoea?iaaiio ae?th ?iaeiiaoaoeeio.

Aeyaeaii, ui oi?ioaaiiy aae’thaaioiiai a?o?eoo uo??a aeeeeea? cieaeaiiy
??aiy ?aoeiieo oa oieioa?ieo a ieaci? e?ia?, a oa?iaeioa?ai?y
?iaeiiaoaoeeiii iineeth? aeao?oeeo aeacaieo a?oai?i?a.

Aia?oa aea/aia oa?iaeie?iaoe/ia ?ioa?oa?aioe?y ?iaeiiaoaoeeio c
iiai?acieii ? anoaiiaeaii, ui iiai?acie aaeueio? ae?i?iaoe?th
?iaeiiaoaoeeio c i?aai?cio aenia?eiaioaeueieo oaa?ei oa oai?eo ia
?aaiaoi?aeiee a?o?eo ? i?aeaeuo? eiioeaio?aoe?th iaci?iaii?,
oa?iaeieia?/ii aeoeaii? oi?ie i?aia?aoo a ieaci? e?ia?.

Aia?oa aenia?eiaioaeueii iieacaii, ui i?ecia/aiiy iiai?acieo ?noioii
i?aeaeuo? i?ioecaiaeueio ae?th ?iaeiiaoaoeeio ? iineaaeth? eiai
ooeiaeaeoth/o ae?th ia oeoieiai-eeoeiaee o?aeo.

Io?eiai? aeai? nooo?ai ?icoe?ththoue a?aeiiino? i?i oa?iaeie?iaoe/io oa
oa?iaeiaeeiai?/io aca?iiae?th ianoa?i?aeiiai i?ioecaiaeueiiai i?aia?aoa
?iaeiiaoaoeeio c e?ea?nueeeie caniaaie ?ioeo oa?iaeieia?/ieo a?oi.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a

1. Aenia?eiaioaeueii aeiaaaeaii ? ee?i?/ii i?aeoaa?aeaeaii iayai?noue
oa?iaeie?iaoe/ii? ?ioa?oa?aioe?? i?ae aeieaoi?ii i?ioiiii? “iiiie”
iiai?acieii ? ianoa?i?aeiei i?ioecaiaeueiei i?aia?aoii ?iaeiiaoaoeeiii,
yea iaoiiaeaia caeaoi?noth iiai?acieo aaeueioaaoe iaoaaie?/io
?iaeoeaaoe?th ?iaeiiaoaoeeio a i?ioean? a?io?ainoi?iaoe??, i?aeaeuoaaoe
??aaiue iaci?iaii? oi?ie i?aia?aoa a ieaci? e?ia? ? oeei i?aeneethaaoe
eiai oa?iaeieia?/io aeoeai?noue.

2. Aia?oa aenia?eiaioaeueii iaa?oioiaaii ? i?aeoaa?aeaeaii a ee?i?oe?
iaiao?aei?noue aeeth/aiiy aei eiiieaeno e?eoaaiiy oai?eo ia
?aaiaoi?aeiee a?o?eo i?aia?aoo naeaie, ?ic?iaeaii iieacaiiy aei eiai
canoinoaaiiy c aeei?enoaiiyi ia?aiao??a aeooao?iiiai? aioeia?aeenii?
nenoaie a?eo?ioeeo?a (aeoeai?noue naeai-caeaaeii?
aeooao?iiia?ieneaeace).

3. Ia iniia? aeaieo, io?eiaieo a aenia?eiaio? oa ee?i?oe?, iaoiaaiaoe/ii
iaa?oioiaaii noaie e?eoaaiiy oai?eo ia ?aaiaoi?aeiee a?o?eo
?iaeiiaoaoeeiii oa eiai ii?aeiaiiyie c aioeieneaeaioaie. Iieacaii, ui
i?ecia/aiiy naeaie, aaa?oo, ?aoeiieo oa oieioa?ieo ?noioii i?aeneeth?
i?ioecaiaeueio ae?th ?iaeiiaoaoeeio ? aeicaiey? ciaioeoe ?ecee
aeieeiaiiy iia?/ieo aoaeo?a.

4. ?ic?iaeaiee iaoiae aecia/aiiy ?iaeiiaoaoeeio a a?ieia?/ieo ??aeeiao
aeinooiiee aeey a?io?i?/ieo eaai?aoi??e e?eoaaeueieo caeeaae?a,
aeicaiey? eiio?iethaaoe ??aaiue oa?iaeieia?/ii aeoeaii? oi?ie i?aia?aoo
a ieaci? e?ia? a i?ioean? oa?iaeioa?ai??.

Ai?iaaaeaeaiiy ?acoeueoao?a aeine?aeaeaiiy a i?aeoeeo

?acoeueoaoe aeine?aeaeaiue ai?iaaaeaeaii a iaa/aeueiee i?ioean eaoaae?
oa?iaeieia??, oaeoeueoaonueei? oa?ai?? oa a?io?i?? A?iieoeueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo oa eaoaae?e oa?iaeieia??
Oa?iii?euenueei? aea?aeaaii? iaaee/ii? aeaaeai??. Iaoa??aee
aeena?oaoe?eii? ?iaioe ai?iaaaeaeaii a ee?i?/io i?aeoeeo
?aaiaoieia?/iiai a?aeae?eaiiy A?iieoeueei? iaeanii? ee?i?/ii? e?ea?i?
?i. I.?.Ie?iaiaa, ?aaiaoieia?/ieo a?aeae?eaiue Oiaeueieoeueei? oa
AEeoiie?nueei? iaeanieo e?ea?aiue.

Iniaenoee aianie caeiaoaa/a

Iniiai? ?acoeueoaoe aeine?aeaeaiiy, aeeeaaeai? a aeena?oaoe??, io?eiai?
iniaenoi caeiaoaa/ai. Ieaioaaiiy aoai?a aeine?aeaeaiiy, iae?e, aiae?c
ia?aeiiiai iaoa??aeo, noaoenoe/ia ia?iaea ?acoeueoao?a, ?ic?iaea
iniiaieo iieiaeaiue, aeniiae?a oa i?aeoe/ieo ?aeiiaiaeaoe?e ?iaioe
aeeiiai? aeena?oaioii iniaenoi. A iaoiae? aecia/aiiy ?iaeiiaoaoeeio a
a?ieia?/iiio iaoa??ae? aeena?oaioii ?ic?iaeaii niin?a aeno?aeoe??
?iaeiiaoaoeeio c ieacie e?ia? oa niin?a onoiaiiy niioai?thth/iai aieeao
aaiiaeia?io ia oi/i?noue aecia/aiiy.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??

Iniiaii iaoa?iaee aeena?oaoei? aeiiiaiaeaeenue ia I Oe?a?inueeie
iaoeiaie eiioa?aioei? ca o/anoth e?a?i NIAe “Aeooaeueii i?iaeaie
eeiii/ii? oa?iaeieiai?” (Aiiieoey, 1993), ia ?anioae?eainueeiio
neiiic?oi? “Aeooaeuei? i?iaeaie ?aaiaoieia??” (Iaeana, 1995), ieaioi?
anioe?aoe?? oa oiaa?enoaa ?aaiaoieia?a Oe?a?ie “Aeooaeuei? ieoaiiy
?aaiaoecio, aeeoocieo oai?ia niieo/ii? oeaieie oa ?aaiaoi?aeiiai
a?o?eoo” (Ee?a, 1995) ia iaoeiai-i?aeoe/i?e eiioa?aioe?? “Aoa?aioi?
iaoiaee e?eoaaiiy a ee?i?oe?” (A?iieoey, 1996), ??-io eiia?an?
?aaiaoieia?a Oe?a?ie (Ee?a, 1997), ??-e Anaoe?a?inuee?e eiioa?aioe?? c
ee?i?/ii? oa?iaeieia?? (A?iieoey, 1998), ia caniaeaiiyo iaeanieo
iaoeiaeo oiaa?enoa oa?iaeieia?a, ?aaiaoieia?a oa oa?aiaaoia.

Ioae?eaoe??

?acoeueoaoe ?iaioe iioae?eiaaii o 5 noaooyo a iaoeiaeo aeo?iaeao, a 1
ca??ieeo iaoeiaeo i?aoeue ? 6 iaoa??aeao oa oacao iaoeiaeo c’?cae?a oa
eiioa?aioe?e ??ciiai ??aiy.

No?oeoo?a oa ianya aeena?oaoei?. Aeena?oaoeiy neeaaea?oueny ci anooio,
iaeyaeo eioa?aoo?e, ?icae?eo “Iaoa?iaee, iiaeae?, iaoiaee aeine?aeaeaiiy
oa ee?i?/ia oa?aeoa?enoeea ianoaaeaieo oai?eo”, 3 ?icae?e?a aeanieo
aeineiaeaeaiue, iaaiai?aiiy, aeniiaeia, i?aeoe/ieo ?aeiiaiaeaoe?e oa
iieaae/eea oeeoiaaii? eioa?aoo?e, yeee iinoeoue 286 aeaea?ae aio/eciyieo
oa ca?oaiaeieo ioaeieaoeie. Aeena?oaoeiy aeeeaaeaia ia 17 noi?iieao
iaoeiiieniiai oaenoo, i?noeoue 40 oaaeeoeue oa 19 ?enoie?a.

CIINO ?IAIOE

Iaoa??ae, iiaeae? oa iaoiaee aeine?aeaeaiiy. Aenia?eiaioaeueia /anoeia
aeineiaeaeaiiy aeeiiaia ia 273 uo?ao-naioeyo iiioeyoei? Ainoa? ianith
120-250 a, yeeo oo?eioaaee ia noaiaea?oiiio ?aoeiiii aiaa?ith.

Iiaeaeue ?aaiaoi?aeiiai a?o?eoo – aae’thaaioiee a?o?eo (AA) uo?ia
aiaeoai?thaaee aaaaeaiiyi iiaiiai aae’thaaioa O?aeiaea (2 /anoeie
aacaeiio, 1 /anoeia eaiieiio oa aaeoa aaeoeeia AOeAE c ?ic?aooieo 5
ia/ie) iiae ieaioa?iee aiiiaa?ic caaeiuei? eaie uo?a a ia’?ii 0,1 ie. AA
?icaeaaany o 80-90% oaa?ei /a?ac 10-14 aeiia iiney aaaaeaiiy i
i?iyaeyany o aeaeyaei ?aaeoeaiiai caiaeueiiai i?ioeano noaeia?a
eiioeiaie oa oainoa.

Iiaeaeyie iioeeoeaioeaii? ?aaeoei? neoaeeee oanoe oa?ii/iiai oa
iaoaii/iiai iiae?aciaiiy o uo?ia. A ?iei oa?ii/iiai iiae?acieea
aeei?enoiaoaaee aiaeyio aaith c oaiia?aoo?ith 58i N, ii?ia iioeeoeaioe??
ioeiithaaee ca o?eaaeinoth eaoaioiiai ia?iiaeo aiaenieeoaaiiy oainoa. O
aiaeiiaiaeue ia iaoaii/ia iiae?aciaiiy ii?ia iioeeoeaioe?? aea/aee ia
noaeiaao, o?aaeaieo aae’thaaioiei a?o?eoii (O.I.O?eion oa ni?aaao.,
1987).

Oeueoea?iaaiio aeith ?iaeiiaoaoeeio ioeiithaaee ia uo?ao c aae’thaaioiei
a?o?eoii i?ney aioo??oiueioeoieiaiai aaaaeaiiy i?aia?aoo a aeic? 5 ia/ea
5 aei?a. Aaaeeinoue iioeiaeaeaiiy neeciai? iaieiiee ioeiithaaee
aicoaeueii. Aeaoaeoe aeiaiao?ii 1-2 ii aiaeiineee aei ae?acie ia?oiai
nooiaiy aaaeeinoi, 2-3 ii – aei ae?oaiai, a aieueoa 3 ii – aei o?aoueiai
nooiaiy. Ia?oi?aoeaii oa iaiao?oth/i ae?acee aiaeiineee aei
iioeiaeaeaiue /aoaa?oiai nooiaiy aaaeeinoi.

Iiai?acie oaa?eiai aaiaeeee ia?i?aeueii a aeici 50 ia/ea iaeei ?ac ia
aeaiue i?ioyaii 5 aeiia. A aeineiae oaa?ei a?aee ia i?ci?oa 3 aiae iiney
inoaiiueiai aaaaeaiiy iiaiaioi?a.

I?e i?iaaaeaii? oa?iaeie?iaoe/ieo aeine?aeaeaiue ?iaeiiaoaoeei oaa?eiai
aaiaeeee a aeic? 30 ia/ea. Eiioeaio?aoeith iiaeiiaoaoeeio a ieacii e?iai
aecia/aee ?ic?iaeaiei iaie iaoiaeii (I.A.Noaieneaa/oe e niaao., 1998).
Ia?aiao?e oa?iaeieiiaoeee ?ic?aoiaoaaee ca aeai/anoeiiith iiaeaeeth c
o?aooaaiiyi aniieooaaiiy (A.I.Nieiaueaa e niaao., 1980; A.A.Oe?nia,
1981; A.E.Ieio?ianeee, I.Aaen, 1988).

Aiino aieueiiai oieioa?ieo a ieacii e?iai aecia/aee ii ?aaeoei?
Aia?i-Aiaaey c aaoi-oaiaio?iea?iii (TH.I.Ino?ianueeee, 1979), a ?aoeiieo
– ca ?aaeoei?th c o?eooi?ioeoiaith eeneioith (N.Wang et al., 1978).

Aiino aiaeiiaeaiiai aeooaoiiio (A-SH) a ia/iioei aecia/aee a
aeooaoiiio?ainoa?aciie ?aaeoei? (K.Asaoka, K.Takahashi, 1981).
Oinoieiiiaee a neeciaie iaieiioei oeoiea oa aiiiaaiaoi ia/iiee aecia/aee
ca iaoiaeii, yeee a?oioo?oueny ia ooai?aiii aiae?ioiaiiai eiiieaeno
oinoieiiiaeia c aiiiith oa?ioiioeeaiaoii (I.I.Iaiothe oa niiaaao. 1987).
Eiioeaio?aoeith caaaeueieo eiiiaeia a aiiiaaiaoi neeciai? iaieiiee oa
ia/iiee uo?ia ioeiithaaee ca ?aaeoei?th c oinoi?iiaaiieiiiaei ?aaeoeaii.
Aiaeiiaeaiee aeooaoiii a aaiieicaoi a?eo?ioeeoia oai?eo aecia/aee ii
A.Aaoea? oa niiaaao. (1963) ca ?aaeoei?th c 5,5-aeeoii-2-iio?iaaicieiith
eeneioith (E.I.Aaaeceaaa, 1982). Aeoeaiinoue
aaia-aeooaiieo?ainiaioeaeace a aiiiaaiaoi neeciai? iaieiiee oeoiea uo?ia
(EO 2.3.2.2) ioeiithaaee ii aeaieueiaiith 4-iio?iaiieiio c
aaia-aeooaiieiio?iaiieiaeo (Ceriotti, De Nadai-Frank, 1972, 1973).
Aeoeaiinoue aeooaoiii?aaeoeoace (A?) (EO 1.6.4.2) ioeiithaaee ca
oaeaeeinoth ieeneaiiy NADPH a aeooaoiii?aaeoeoaciie ?aaeoei? (R.?into,
W.Bartley, 1969) a iiaeeo?eaoe?? R.Olinescu oa ni?aaao. (1994).
Aeoeaiinoue aeooaoiiiia?ieneaeace (AII) (EO 1.11.1.9) a a?eo?ioeeoao
e?iai oai?eo aecia/aee ye iienaii (E.I.Aaaeceaaa, 1982).
Noia?ieneaeaeeniooacio (EO 1.15.1.1) aeoeai?noue (NIAe) a a?eo?ioeeoao
oai?eo aecia/aee ca caeaoi?noth oa?iaioo i?eaii/oaaoe ooai?aiiy
oi?iacaio c iio?ioao?acieith oei?enoiai (A.I.*oiaeia e niaao., 1977).
??aaiue naeaio a ieaci? e?ia? aecia/aee e?iaoe/iei iaoiaeii
(I.A.Ao?aiaiei e niaao., 1985). Aiino i?iaeoeoia, ui ?aaaothoue c
oiiaa?aioo?iaith eeneioith (I?-OAE) aecia/aee ye iienaii
(TH.A.Aeaaeeie?ia, A.E.A?/aeia, 1972) ? ia?a?aoiaoaaee ia iaeiiiaee
aeeaeueaeaaiae ca iiey?iei eiaoioei?ioii aenoeioei? 1,56105.
Eii’thaiaai? aei?ie (AeEii) oa aei?ieaoiie (AeEao) a ne?iaaooei e?iai
oai?eo aecia/aee ca iaoiaeii, iienaiei Aaa?eeiaei A.A. oa Iioei?oaeiith
I.I. (1988).

Noaoenoe/io ia?iaeo ?acoeueoaoia aeineiaeaeaiiy aeeiioaaee iaoiaeaie
aiiiao?i? (A.A.Aoaea?, 1978, A.I.Iineia, 1990).

A ee?i?oe? ianoaaeaii 134 iniae. C ieo aoei 104 oai?eo ia ?aaiaoi?aeiee
a?o?eo oa 30 i?aeoe/ii caei?iaeo ethaeae, yei neeaee eiio?ieueio a?oio.
Aeiaaiic ?aaiaoi?aeiiai a?o?eoo anoaiiaethaaee ia iniiai e?eoa?i?a
Aia?eeainueei? ?aaiaoieiai/ii? anioeiaoei? (A?A, 1987) i oi?ioethaaee
caiaeii eeaneoieaoei? I.A.Anoaiaiei (1982).

?ACOEUeOAOE ?IAIOE OA ?O IAAIAI?AIIss

Ia ia?oiio aoai? a aenia?eiaioaeuei?e /anoei? aeine?aeaeaiiy ia iiaeae?
aae’thaaioiiai a?o?eoo uo??a aoei aea/aii aoaeoeai?noue ii?aeiaiiy
?iaeiiaoaoeeio c aioeieneaeaioaie. Aeey aeine?aeaeaiiy aoei acyoi
eeane/i? i?e?iaei? aioeieneaeaioe oieioa?ie oa ?aoeiie o aeaeyae?
eiia?iiaaiiai i?aia?aoo aaa?oo. Aeey ii??aiyiiy ioe?iaii aoaeoeai?noue
neioaoe/iiai aioeieneaeaioa aeeaoiieo oa naeaio – i?e?iaeaiaioa, yeee
aoiaeeoue aei neeaaeo i?inoaoe/ii? a?oie iniiaiiai aioeieneaeaioiiai
oa?iaioa aeooao?iiiai? aioeia?aeenii? nenoaie aeooao?iiia?ieneaeace.
Naeai canoiniaoaaany o aeaeyae? i?aia?aoo naeaia.

Aoei anoaiiaeaii, ui e?eoaaiiy ?iaeiiaoaoeeiii coieiy? i?ia?anoaaiiy
aae’thaaioiiai a?o?eoo uo??a ? aeeeeea? iaa?oue aeayeee eiai cai?ioi?e
?icaeoie, i?i ui na?ae/eoue ciaioaiiy ia’?io caiaeaieo noaeia?a oa
i?aeaeuaiiy ii?iao iioeeoeaioeaii? ?aaeoe?? (oaae. 1). Aeaye?
i?ioecaiaeuei? ?, iiina?aaeeiaaii, aioeiioeeoeaioeai? aeanoeaino?
aeyaeaii o aaa?oo, aeeaoiieo oa naeaie, i?e/iio iaeneiaeueiee
i?ioecaiaeueiee aoaeo na?aae aioeieneaeaio?a ni?aaeya aaa?o. Ca
aaee/eiith i?ioecaiaeueii? ae?? aoaeo aaa?oo iaaeeaeaany aei oaeiai o
?iaeiiaoaoeeio.

Ii?aeiaiiy aioeieneaeaio?a c ?iaeiiaoaoeeiii ni?eyei i?enei?aiith
cai?ioiueiai ?icaeoeo aae’thaaioiiai a?o?eoo. A on?o aeiaaeeao
oa?iaeieia?/iee aoaeo ii?aeiaiue ia?aaeuoaaa ae?th iaeiiai
?iaeiiaoaoeeio ? iinea iaiiaiee aaeaeeoeaiee oa?aeoa?. Iaeneiaeueiee
i?ioecaiaeueiee aoaeo ca?a?no?iaaii i?e iaeii/aniiio canoinoaaii?
?iaeiiaoaoeeio c aaa?oii oa naeaiith.

Oaaeeoey 1

Aieea aioeieneaeaio?a oa iiai?acieo ia aoaeoeai?noue e?eoaaiiy
aae’thaaioiiai a?o?eoo ?iaeiiaoaoeeiii (M ± m; n = 7)

Aeeiai?ea o a?aenioeao Niin?a e?eoaaiiyIaa?yeo coaeia?a Ii?iao
iioeeoeaioe??AA aac e?eoaaiiy119,7 ± 2,780,4 ± 2,7?iaeiiaoaoeei93,8 ±
2,5*109,4 ± 2,7Aeeaoiie100,3 ± 2,0*94,8 ± 2,1**Naeaia109,9 ± 2,7*92,0 ±
3,0**Aaa?o97,1 ± 1,5*105,0 ± 2,4**Iiai?acie116,1 ± 2,785,8 ±
3,8?iaeiiaoaoeei+Aeeaoiie85,3 ± 3,8*114,0 ± 3,4?iaeiiaoaoeei+Naeaia88,9
± 2,3*118,0 ± 2,2*?iaeiiaoaoeei+Aaa?o85,3 ± 3,5*119,1 ±
3,1*?iaeiiaoaoeei+Iiai?acie88,3 ± 2,5*120,1 ±
5,0?iaeiiaoaoeei+Aaa?o+Naeaia83,0 ± 3,6**123,0 ± 4,0*I?ei?oea: 1. “*” –
aeinoia??ia a?aei?ii?noue uiaei a?oie “AA aac e?eoaaiiy”; 2. “**” –
aeinoia??ia a?aei?ii?noue uiaei a?oie “?iaeiiaoaoeei”.3. Ii??a
iioeeoeaioe?? oa ia’?i noaeia?a aei e?eoaaiiy i?eeiyoi ca 100%

Iiai?acie, ia i?iyaeyth/e aeanii? i?ioecaiaeueii? ae?? ?noioii
iioaioe?thaaa oa?iaeieia?/iee aoaeo ?iaeiiaoaoeeio.

Io?eiai? ?acoeueoaoe aeaiiino?othoue iiaeeea?noue i?aeaeuaiiy
aoaeoeaiino? i?ioecaiaeueii? oa?ai?? ?iaeiiaoaoeeiii oeyoii ii?aeiaiiy c
aioeieneaeaioaie oa iiai?acieii.

C iaeyaeo ia a?aenooi?noue aeanii? i?ioecaiaeueii? ae?? o iiai?acieo ?
?noioi? iioaioe?thaaiiy iei i?ioecaiaeueiiai aoaeoo ?iaeiiaoaoeeio, iaie
i?eiouaii, ui iiai?acie iiaea ao?o/aoenue a oa?iaeie?iaoeeo
?iaeiiaoaoeeio, iniaeeai c o?aooaaiiyi a?aeiiinoae e?oa?aoo?e i?i
caeaoi?noue iiai?acieo aaeueioaaoe aeoeai?noue i?e?iniiaeueieo
iiiiieneaaiac. O ca’yceo c oeei iaie a aenia?eiaio? ioe?iaii iayai?noue
oa?iaeie?iaoe/ii? ?ioa?oa?aioe?? i?ae ?iaeiiaoaoeeiii oa iiai?acieii.

C’ynoaaeinue (?en.), ui ?iaeiiaoaoeei oaeaeei aniieoo?oueny c
oeoieiai-eeoeiaiai o?aeoo ? /a?ac 30 oa ?a?no?o?oueny a ieaci? e?ia? a
aeineoue aenie?e eiioeaio?aoe?? (a?eueoa 50 iea/ie). Iaeneiaeueia
eiioeaio?aoe?y cao?eniaaia /a?ac 1 aiae ? neeaaea? a na?aaeiueiio 74
iea/ie. I?ae /an -oace ca?a?no?iaaii ae?oaee i?e i?ae’eiio
eiioeaio?aoe??, ui, i/aaeaeii, iia’ycaii c yaeuai eeoa/ii-ia/?ieiai?
?aoee?eoeyoe??.

wmetafile8? ??e???-???????? ???????yyy????????????
Iiai?acie ?noioii oiia?eueithaaa ae?i?iaoe?th c i?aai?cio iaci?iaii?
oi?ie ?iaeiiaoaoeeio. ??cieoey c eiio?ieai noaaaea iii?oiith c /aoaa?oi?
aiaeeie aeine?aeo ? ia?inoaea aei e?ioey niinoa?aaeaiiy. *a?ac 12 aiae
eiioeaio?aoe?y ?iaeiiaoaoeeio a a?oi? “Iiai?acie” aoea a?eueo i?ae o 3
?ace aeuith i?ae o eiio?ie?. Oiia?eueiaiiy ae?i?iaoe?? ?iaeiiaoaoeeio c
i?aai?cio i?ae aieeaii iiai?acieo iaoiiaeaii, i/aaeaeii, ciaioaiiyi
oaeaeeino? eiai iaoaaie?/ii? ?iaeoeaaoe??, ine?eueee iiai?acie ia
ni?aaey? ?aaoeyoi?iiai aieeao ia ie?eiao aene?aoe?th e?ea?nueeeo
cania?a. A oie aea /an iienaia aca?iiae?y iiai?acieo c e?ea?nueeeie
i?aia?aoaie ia ??ai? a?io?ainoi?iaoe??.

Ine?eueee ee?i?/ia oe?ii?noue aoaeue-yeiai i?aia?aoo aecia/a?oueny
ni?aa?aeiioaiiyi aoaeoeaiino? oa aacia/iino? canoinoaaiiy, iaie aoei
ioe?iaii oeueoea?iaaiio aeoeai?noue ?iaeiiaoaoeeio oa eiai ii?aeiaiue c
aioeieneaeaioaie oa iiai?acieii.

Aoei anoaiiaeaii, ui i?ney i’yoeaeaiiiai eo?no e?eoaaiiy ?iaeiiaoaoeeiii
o an?o oaa?ei a neecia?e iaieiioe? oeoiea oa 12-iaei? eeoee
aeyaeythoueny ae?acee ??cieo nooiai?a aaaeeino?. Canoinoaaiiy ?acii c
?iaeiiaoaoeeiii aioeieneaeaio?a a on?o aeiaaeeao noi?iaiaeaeoaaeinue
ciaioaiiyi /anoioe oa aaaeeino? iia?/ieo aoaeo?a (oaae. 2). Na?aae
aioeieneaeaio?a iaeneiaeuei? aano?ii?ioaeoi?i? aeanoeaino? aeyaeaii o
?aoeiieo oa oieioa?ieo. Iaee?aua caoeuaei neeciao iaieiieo oeoieo oaa?ei
ii?aeiaiiy naeaie c aaa?oii, oiae? ye i?e canoinoaaii? eeoa naeaie
niinoa??aaee o?eueee oaiaeaioe?th aei ciaioaiiy e?eueeino? ae?acie.
I?ecia/aiiy iiai?acieo caaacia/eei cieaeaiiy oeueoea?iaaiii? ae??
?iaeiiaoaoeeio i?eaeecii aei 3,3 ae?acie ia 1 oaa?eio, i?e/iio
ia?aaaaeii ca ?aooiie aaaeeeo nooiai?a o?aaeaiiy.

Oaaeeoey 2

Aeeiai?ea oeueoea?iaaiiiai aoaeoo ?iaeiiaoaoeeio o oaa?ei c
aae’thaaioiei a?o?eoii i?e ii?aeiaii? c aioeieneaeaioaie oa iiai?acieii
(M±m; n=7)

A?oia oaa?ei a caeaaeiino? a?ae e?eoaaiiyE?euee?noue ae?acie ca
nooiaiyie aaaeeino?? nooi?iue?? nooi?iue??? nooi?iue?V nooi?iue
?iaeiiaoaoeei2,57±0,604,86±0,453,57±0,450,57±0,30?iaeiiaoaoeei+Aeeaoiie1
,57±0,453,14±0,452,29±0,450,29±0,15?iaeiiaoaoeei+Naeaia2,00±0,603,71±0,6
02,86±0,300,57±0,30?iaeiiaoaoeei+?aoeiie2,80±0,302,21±0,45*0,4±0,15*0*?i
aeii.+Oieioa?ie2,80±0,302,20±0,45*0,4±0,15*0*?iaeiiaoaoeei+Aaa?o1,71±0,4
52,71±0,3*2,0±0,30*0,14±0,15?iaeii.+Aaa?o+Naeaia1,00±0,3*2,0±0,45*1,7±0,
15*0*?iaeii.+Iiai?acie1,00±0,3*1,29±0,3*1,0±0,30*0*I?ei?oea: ciaeii “*”
iicia/aii aeinoia??io a?aei?ii?noue uiaei a?oie “?iaeiiaoaoeei”.

I?i caeaoi?noue oieioa?ieo oa naeaio ciaiooaaoe aenia?eiaioaeuei?
ae?acee iia?aeiieythoue ? al-Moutairy A.R oa Tariq M. (1996), ye?
iieacaee, ui iaeii/ania canoinoaaiiy naeaio ?acii c a?oai?iii A iineeth?
aano?ii?ioaeoeaiee aoaeo ye noiniaii no?aniaeo ae?acie, oae ? noiniaii
ae?acie, iaoiiaeaieo aaaaeaiiyi ianoa?i?aeieo i?ioecaiaeueieo
i?aia?ao?a.

C’ynoaaeinue, ui oa?iaeioa?ai?y ?iaeiiaoaoeeiii i?ecaiaeeea aei
cieaeaiiy a neecia?e iaieiioe? ai?noo caaaeueieo e?i?ae?a ia?aaaaeii ca
?aooiie oinoie?i?ae?a. Ai?no inoaii?o ciaiooaaany aei 30%, i/aaeaeii
/a?ac aeoeaaoe?th eiiiaeii? ia?ieneaeaoei? a neeciaie iaieiioei oeoieo,
i?i ui naiae/eei iiaeaeuaiiy aiinoo a iie iaeiiiaiai aeeaeueaeaaiaeo.
I?ecia/aiiy aaa?oo ni?eyei ca?eueoaiith ai?noo oinoie?i?ae?a a neecia?e
iaieiioe? i?e iaeii/aniiio c?inoaii? eiioeaio?aoe?? caaaeueieo e?i?ae?a.
Iaeneiaeueiee ii?iae?coth/ee aieea ia iaoaaie?ci e?i?ae?a ni?aaeyei
canoinoaaiiy aaa?oo ?acii c naeaiith.

A aenia?eiaio? ca?a?no?iaaii ua iaeei iia?/iee aoaeo ?iaeiiaoaoeeio.
Aoei aeyaeaii, ui oa?iaeioa?ai?y ?iaeiiaoaoeeiii iiaeeaeth? aeeeeeaiee
o?ii?/iei aaoi?ioiiei caoai?thaaiiyi aeao?oeeo ?aoeiieo oa oieioa?ieo a
ieaci? e?ia? uo??a c AA. Aeiaeaoeiaa aaaaeaiiy oeeo a?oai?i?a o aeaeyae?
aaa?oo caaacia/oaaei iiaia a?aeiiaeaiiy ai?noo aeacaieo a?oai?i?a a
ieaci? e?ia?.

Oaeei /eiii, a aenia?eiaioaeuei?e /anoei? aeine?aeaeaiiy iaa?oioiaaii
aeioe?euei?noue ii?aeiaiiy ?iaeiiaoaoeeio c aioeieneaeaioieie a?oai?iaie
oa naeaiith, ye? i?iyaeythoue aeanio i?ioecaiaeueio oa aano?ii?ioaeoeaio
aeoeai?noue caaacia/othoue iaeneiaeueiee oa?iaeieia?/iee aoaeo oaeeo
ii?aeiaiue oa i?i?iaeueiee ooeiaeaeoth/ee aieea ia oeoieiai-eeoeiaee
o?aeo ? iiia?aaeaeathoue a?iia?oai?i?coth/ee aoaeo ?iaeiiaoaoeeio oa
o?ii?/iiai aaoi?ioiiiai caiaeaiiy. Iaeia?niaeoeai?oeie aeey
ai?iaaaeaeaiiy a ee?i?eo aeaeathoueny ii?aeiaiiy ?iaeiiaoaoeeio c
?aoeiieii, oieioa?ieii oa aaa?oii ?acii c naeaiith. Aoaeoeai?noue oeeo
eiia?iaoe?e ? aoea aeine?aeaeaia o oai?eo ia ?A a ee?i?/i?e /anoei?
?iaioe.

C oe??th iaoith ianoaaeai? oai?? (104) aoee ?iciiae?eai? ia 4
?ai?acaioaoeai? a?oie a caeaaeiino? a?ae io?eiaii? oa?ai??
(?iaeiiaoaoeeiii, eiai ii?aeiaiiyie c ?aoeiieii, oieioa?ieii, aaa?oii oa
naeaiith). O /anoeie oai?eo aeine?aeaeaii aieea iiai?acieo ia
oa?iaeie?iaoeeo ?iaeiiaoaoeeio. I?i aoaeoeaiinoue e?eoaaiiy noaeeee ca
caaaeueiii?eeiyoeie noa’?eoeaieie oa ia’?eoeaieie eeiii/ieie iciaeaie,
aeeiaiieith ?ooeiieo aiioiii/ieo iieacieeia aeoeaiinoi caiaeueiiai
i?ioeano, iieacieeia noaio IIE oa aioeieneaeaioii? nenoaie, yei
ioeiithaaee ia ii/aoeo eiio?ieueiaaiiai eieoaaiiy i /a?ac 2 oeaeii
oa?ai??.

Aeine?aeaeaiiy iieacaee, ui o oai?eo ia ?A ia? i?noea aeoeaaoeiy IIE c
iaeiie/aiiyi a ieacii e?iai ia?aeiieo oa aoi?eiieo eiai i?iaeoeo?a oa
cieaeaiiyi iieaciee?a aioeieneaeaioii? nenoaie a?aeiia?aeii aeoeaiino?
?aaiaoi?aeiiai caiaeaiiy.

Aeine?aeaeaiiy ??aiy caaaeueiiai naeaio a ieaci? e?ia? oai?eo ia ?A
aeyaeei ?noioia eiai cieaeaiiy. sseui o caei?iaeo oeae iieaciee noaiiaea
77,88±3,77 ia/ie, oi o oai?eo ia ?aaiaoi?aeiee a?o?eo a?i aoa ia ??ai?
51,49±2,6 ia/ie, oiaoi aoa cieaeaiei ia 33%. I?i?iaeueiee ??aaiue
naeaio niinoa??aaee o oai?eo c iaeneiaeueiith aeoeai?noth caiaeueiiai
i?ioeano. O oaeeo iaoe??io?a eiioeaio?aoe?y caaaeueiiai naeaio a ieaci?
e?ia? noaiiaeea 38,13±4,6 ia/ie. Ia ca?a?no?iaaii ?noioii? a?aei?iiino?
i?ae ??aiai naeaio o oai?eo c i?i?iaeueiei oa na?aaei?i nooiaiai
aeoeaiino? ?A. Oi/a iaea i?noea oaiaeaioe?y cieaeaiiy oeueiai iieacieea
o iaoe??io?a c na?aaei?i nooiaiai aeoeaiino? caiaeueiiai i?ioeano.
Io?eiai? ?acoeueoaoe aeacothoue ia iiaeeeao i?e/aoi?noue naeaio aei
iaoiaaiaoe/ieo iaoai?ci?a oi?ioaaiiy o?ii?/iiai aaoi?ioiiiai caiaeueiiai
i?ioeano ? i?i iaiao?aei?noue aeeth/aiiy aei eiiieaeno e?eoaaiiy oaeeo
oai?eo i?aia?ao?a, aei neeaaeo yeeo aoiaeeoue i?e?iaeaiaio naeai.

A oiae? aeaioeaeiaaiai eo?no e?eoaaiiy ?iaeiiaoaoeeiii aoei aeinyaiooi
iaaii? iiceoeaii? aeeiai?ee iniiaieo ee?i?/ieo neiioii?a caoai?thaaiiy.
Ciaioeeanue ?ioaineai?noue aieueiaiai neiae?iio, o?eaae?noue a?ai?oiuei?
neooino?, ca?eueoeeanue ooieoe?iiaeueia aeoeai?noue noaeia?a.

Canoinoaaiiy iaeii/anii c ?iaeiiaoaoeeiii ?aoeiieo oa oieioa?ieo ?acii c
naeaiith ni?eyei i?enei?aiith cai?ioiueiai ?icaeoeo ee?i?/ieo iciae
caoai?thaaiiy (oaae. 3). Cia/ii oaeaeoa eoi??oaaany aieueiaee neiae?ii,
i?i ui na?ae/eei ciaioaiiy aaee/eie noaeiaiaiai oa aieueiaiai ?iaeaen?a.
Aeacai? ii?aeiaiiy caaacia/eee a?eueoo i?ioecaiaeueio aeoeai?noue ?, ye
iane?aeie, ciaioaiiy ?iaeaeno iaa?yeaiiy noaeia?a. Ca noia?iith
aoaeoeai?noth oa?ai?? iaeaeaa ii?aeiaiiy aoee iaeiaeia?. Aeiaeaoeiaa
canoinoaaiiy ?acii c ?iaeiiaoaoeeiii aaa?oo oa naeaie oaeiae
i?enei?thaaei ?aa?an ee?i?ee a?o?eoo. Iaeaeeiai?/i?oeie aoee iaa?yeiaee
?iaeaen oa noaeiaiaee ?aooiie – ia’?eoeai? e?eoa??? aoaeoeaiino?
i?ioecaiaeueii? oa?ai??.

Oaaeeoey 3

Aeeiai?ea ee?i?/ieo neiioii?a o oai?eo ia ?A i?ae aieeaii e?eoaaiiy
(M±m)

IIEACIEEEOa?i?i
ianoaaeaiiy?iaeiiaoaoeei?iae.+Oieioa?ie+Naeaia?iae.+?aoeiie+Naeaia?iae.+
Aaa?o+NaeaiaAieueiaee Aei
e?eoaaiiy16,9±1,220,5±3,416,7±1,923,72±2,88?iaeaenI?ney
12,0±0,912,2±2,69,9±1,6212,56±1,38(aaee)Aeeiai?ea
%30,0±2,343,92,7*46,0±5,1*49,0±5,1*Noaeiaiaee Aei
e?eoaaiiy17,7±1,420,73,917,2±2,024,172,8?iaeaenI?ney12,8±1,112,3±2,910,2
±1,612,78±1,32(aaee)Aeeiai?ea
%27,9±1,643,9±3,0*45,0±5,1*45,5±3,9*O?eaae?noue Aei
e?eoaaiiy210±29155±28166±27187,5±35,1a?ai?oiuei?I?ney
134±2892±22105±25100,0±21,6neooino? (oa)Aeeiai?ea
%47,3±4,447,1±6,042,8±5,352,8±6,0?iaeaen Aei
e?eoaaiiy10,2±0,811,9±2,1610,1±1,0814,1±1,98iaa?yeaiiyI?ney
7,5±0,677,5±1,566,11±0,96,28±0,84(aaee)Aeeiai?ea
%27,1±2,541,7±5,0*45,8±6,0*54,5±6,0*NoaeiaiaeeAei
e?eoaaiiy6,9±0,58,3±1,327,3±0,78,61±1,02?aooiieI?ney
5,2±0,456,3±1,205,4±0,75,17±0,84(aaee)Aeeiai?ea
%26,0±3,028,4±6,033,3±6,039,8±6,0Oaeaee?noue Aei
e?eoaaiiy55,3±2,672,9±7,3256,8±2,259,0±4,5oiaeueae 40 iI?ney
45,8±1,852,7±3,148,2±2,147,88±3,96(naeoiaee)Aeeiai?ea
%16,9±1,422,1±2,715,4±2,118,1±2,2I?ei?oea: “*” – aeinoia??ia
a?aei?ii?noue uiaei a?oie “?iaeiiaoaoeei”

Iaaaaeai? aeai? cana?ae/othoue i/aaeaeio ee?i?/io aoaeoeai?noue
canoinoaaiiy aaa?oo oa naeaie ?acii c ?iaeiiaoaoeeiii a eiiieaeniiio
e?eoaaii? oai?eo ia ?aaiaoi?aeiee a?o?eo.

Eaai?aoi?i? iieacieee aeyaeeenue iaio /ooeeaeie aei e?eoaaeueiiai aieeao
?iaeiiaoaoeeio. I?ioyaii eiio?ieueiaaiiai oa?i?io canoinoaaiiyi
?iaeiiaoaoeeio ia aaeaeinue ?noioii caaaeueioaaoe aeoeai?noue IIE oa
aeinyaoe ??aiiaaae c iieacieeaie aioeieneaeaioii? nenoaie (AIN). Eeoa
aeiaeaoeiaa i?ecia/aiiy aioeieneaeaio?a caaacia/eei cia/ia cieaeaiiy
ai?noo ia?aeiieo oa aoi?eiieo i?iaeoeo?a IIE, ni?eyei c?inoaiith
a?eueoino? oaeoi??a aioeieneaeaioiiai caoenoo, oi/a iiaii? ii?iae?caoe??
aeine?aeaeaieo ia?aiao??a aeinyaoe ia aaeaeinue. I??a ii?iae?caoe??
aaeaino nenoaie IIE:AIN a iniiaiiio a?aeiia?aeaea aeeiai?oe? ee?i?/ieo
i?iya?a caoai?thaaiiy. O oai?eo, ye? ?acii c ?iaeiiaoaoeeiii io?eioaaee
aaa?o oa naeaio, niinoa??aaee iaeneiaeueia ca?eueoaiiy aeoeaiino? AII,
yea neeaei 46,2±2,85%, ui iaoiiaeaii aeeth/aiiyi aei eiiieaeno e?eoaaiiy
iaio a?oai?i?a oa naeaie.

Iaie i?iaiae?ciaaia /anoioa iia?/ieo aoaeo?a ?iaeiiaoaoeeio i?e eiai
ii?aeiaii? c aioeieneaeaioaie. Aeyaeeinue, ui i?e canoinoaaii?
?iaeiiaoaoeeio iia?/i? aoaeoe cono??/aeenue o 56% oai?eo. C ieo 70%
neeaee iia?/i? aoaeoe c aieo oeoieiai-eeoeiaiai o?aeoo. I?ae aieeaii
oieioa?ieo c naeaiith /anoioa iia?/ieo aoaeo?a ?iaeiiaoaoeeio
nei?ioeeanue c 56 aei 29%, a i?ae aieeaii ii?aeiaiiy c naeaiith oa
?aoeiieii – aei 42%. Iaeneiaeueii nei?i/oaaeanue /anoioa iia?/ii? ae??
?iaeiiaoaoeeio, eiee aei eiiieaeno e?eoaaiiy aeeth/aee aaa?o oa naeaio –
anueiai 22,2%.

Oaeei /eiii, i?iaaaeai? aenia?eiaioaeuei? oa ee?i?/i? aeine?aeaeaiiy
iieacaee, ui oa?iaeioa?ai?y ?iaeiiaoaoeeiii oa?aeoa?eco?oueny
iaaeinoaoiueith aoaeoeai?noth oa oe?eei ?yaeii iia?/ieo aoaeo?a ? oiio
aeiaaa? iioei?caoe?? ye c oi/ee ci?o i?aeaeuaiiy aoaeoeaiino?, oae ? c
iaeyaeo aacia/iino?.

Aeeth/aiiy aei eiiieaeno e?eoaaiiy oai?eo ia ?aaiaoi?aeiee a?o?eo
?aoeiieo oa oieioa?ieo c naeaiith aeicaieeei ?noioii i?aeaeueoe
aoaeoeai?noue oa?ai?? oa ciaioeoe iiae?acithth/ee aieea ?iaeiiaoaoeeio
ia oeoieiai-eeoeiaee o?aeo. Iaeneiaeueiee iioei?coth/ee aoaeo ni?aaeyei
aeiaeaoeiaa i?ecia/aiiy aaa?oo oa naeaie, yea caaacia/eei a?eueo iiaio
ii?iae?caoe?th iieaciee?a IIE oa aioeieneaeaioii? nenoaie,
ii?iae?caoe?th ai?noo naeaio a ieaci? e?ia?, i?aeaeuoaaei oa?aiaaoe/io
aeoeai?noue ? aeeeeeaei iaeiaioo e?euee?noue iia?/ieo aoaeo?a.

A E N I I A E E

1. Anoaiiaeaii, ui oa?iaeioa?ai?y ?iaeiiaoaoeeiii iiaeeaeth? aeeeeeaiee
aae’thaaioiei a?o?eoii aeao?oeeo ?aoeiieo oa oieioa?ieo a ieaci? e?ia?
oa a?aeiiaeaiiai aeooao?iio a ia/?ioe? uo??a.

2. Aenia?eiaioaeueii anoaiiaeaii, ui ooeiaeaeoth/ee aieea ?iaeiiaoaoeeio
ia oeoieiai-eeoeiaee o?aeo noi?iaiaeaeo?oueny cieaeaiiyi ai?noo
caaaeueieo e?i?ae?a oa oinoie?i?ae?a a neecia?e iaieiioe?, iaeiie/aiiyi
oai iaeiiiaiai aeeaeueaeaa?aeo oa i?aeaeuaiiyi aeoeaiino?
aaia-aeooai?eo?ainiaioeaeace.

3. Aenia?eiaioaeueii anoaiiaeaii, ui ii?aeiaiiy aioeieneaeaio?a, ye?
i?iyaeythoue aeanio i?ioecaiaeueio aeoeai?noue, ?acii c ?iaeiiaoaoeeiii
i?ecaiaeeoue aei iaiiaii? noiaoe?? i?ioecaiaeueiiai oa ciaaiethth/iai
aoaeo?a. Aeiaeaoeiaa i?ecia/aiiy aaa?oo onoaa? aeao?oeeo oieioa?ieo oa
?aoeiieo a ieaci? e?ia?.

4. Canoinoaaiiy a aenia?eiaio? aioeieneaeaio?a ?acii c ?iaeiiaoaoeeiii
ciaioo? eiai oeueoea?iaaiiee aoaeo, ii?iae?co? e?i?aeiee niaeo? neeciai?
iaieiiee oeoieo, cieaeo? aeoeai?noue aaia-aeooai?eo?ainiaioeaeace oa
i?aeaeuo? ai?no a?aeiiaeaiiai aeooao?iio a ia/?ioe?.

5. Anoaiiaeaii, ui iiai?acie aaeueio? iaoaaie?/io ?iaeoeaaoe?th
?iaeiiaoaoeeio, i?aeaeuo? eiioeaio?aoe?th iaci?iaii? oi?ie i?aia?aoo a
ieaci? e?ia?, iineeth? eiai i?ioecaiaeueio aeoeai?noue ? ciaioo?
iiae?acithth/ee aieea ia oeoieiai-eeoeiaee o?aeo.

6. Ee?i?/i? niinoa?aaeaiiy iieacaee, ui canoinoaaiiy aioeieneaeaio?a oa
?iaeiiaoaoeeio a eiiieaeni?e oa?ai?? oai?eo ia ?A aeicaiey? i?enei?eoe
ee?i?/iee ?aa?an caoai?thaaiiy ? ciaioeoe /anoioo oa nooi?iue i?iyao
iia?/ieo aoaeo?a ?iaeiiaoaoeeio.

7. ?ic?iaeaii /ooeeaee ? aeinooiiee aeey a?io?i?/ieo eaai?aoi??e
e?eoaaeueieo caeeaae?a eiei?eiao?e/iee iaoiae aecia/aiiy ?iaeiiaoaoeeio
a a?ieia?/ieo ??aeeiao, yeee ?c canoinoaaiiyi oiieioa?iai? o?iiaoia?ao??
aeicaiey? a?aeie?aieoe iaci?iaio oi?io i?aia?aoo a?ae iaoaaie?o?a ?
eiio?iethaaoe ?? ??aaiue a oiae? oa?iaeioa?ai?? ?iaeiiaoaoeeiii.

I ? A E O E * I ? ? A E I I A I Ae A Oe ? ?

1. I?e e?eoaaii? oai?eo ia ?aaiaoi?aeiee a?o?eo ?iaeiiaoaoeeiii c iaoith
i?aeaeuaiiy aoaeoeaiino? i?ioecaiaeueii? oa?ai??, ciaioaiiy /anoioe
iia?/ieo aoaeo?a c aieo oeoieiai-eeoeiaiai o?aeoo aei eiiieaenii?
oa?ai?? ?aeiiaiaeo?oueny aeeth/aoe aaa?o. Iieacaiiyie aeey canoinoaaiiy
ne?ae aaaaeaoe i?aeaeuaiee ??aaiue a ieaci? e?ia? AeEii, AeEao oa
I?-OAE.

2. A ee?i?/i?e i?aeoeoe? ne?ae a?aoiaoaaoe iiaeeea?noue
oa?iaeie?iaoe/ii? oa oa?iaeiaeeiai?/ii? ?ioa?oa?aioe?? i?ae iiai?acieii
oa ianoa?i?aeiei i?ioecaiaeueiei i?aia?aoii ?iaeiiaoaoeeiii, yea
oa?aeoa?eco?oueny oiia?eueiaiiyi ae?i?iaoe?? ?iaeiiaoaoeeio c ieacie
e?ia? ? i?aeaeuaiiyi eiai oa?iaeieia?/ii? ae??.

3. C iaoith i?aeaeuaiiy aoaeoeaiino? i?ioecaiaeueii? oa?ai?? o oai?eo ia
?A oa ciaioaiiy iia?/ieo aoaeo?a ?iaeiiaoaoeeio aei eiiieaeno
e?eoaaeueieo caoiae?a aeioe?eueii aeiaeaoeiai aeeth/aoe naeaio.
Iieacaiiyi aei ?? i?ecia/aiiy neoaeeoue cieaeaiiy ??aiy caaaeueiiai
naeaio a ieaci? e?ia? a?eueo i?ae a 1,3 ?ace, aeoeaiino? naeaicaeaaeii?
aeooao?iiia?ieneaeace a?eueo i?ae ia 30% ? aioeia?aeeniiai ?iaeaeno
a?eueo i?ae o 2 ?ace.

4. Aeey eiio?ieth ca ??aiai ?iaeiiaoaoeeio a ieaci? e?ia? a i?ioean?
oa?iaeioa?ai?? ne?ae aeei?enoiaoaaoe ?ic?iaeaiee niaoeeo?/iee oa
/ooeeaee eiei?eiao?e/iee iaoiae aecia/aiiy.

NIENIE ?IA?O, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe??

1. Noaieneaa/oe I.A., Iaiothe A.A., Inoai/oe A.E., Aiae I.A. Aeeyiea
?aoeiiea, oieioa?iea e oeeiaoeaeeia ia oeueoea?iaaiiue yooaeo i?oioaia,
eiaeiiaoaoeeia e iai?ienaia// Yenia?eiaioaeueiay e eeeie/aneay
oa?iaeieiaey.- 1995, ? 6.- N. 33-35.

2. Noaieneaa/oe I.A., Ai?oeia A.E., Iaiothe A.A., Inoai/oe A.E. Aiae
I.A. Aioeiioeeoeaioeaiue yooaeo o?aiaea a oneiaeyo aai eiiaeie?iaaiey n
ianoa?ieaeiuie i?ioeaiainiaeeoaeueiuie i?aia?aoaie// Yenia?eiaioaeueiay
e eeeie/aneay oa?iaeieiaey.- 1997, ? 1.- N. 22-24.

3. Inoai/oe I.?., Noai?neaa/oe I.A., N??eiaa A.E. Noai
ieneaeaioii-aioeieneaeaioii? nenoaie o oai?eo ia ?aaiaoi?aeiee a?o?eo a
caeaaeiino? a?ae aeoeaiino? caiaeueiiai i?ioeano// A?niee A?iieoeueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.- 1997.- ?1.- N. 48-49.

4. Inoai/oe I.?., Iaaea?aeue C.N., Noai?neaa/oe I.A. Aieea
oeeiaoeaeeio, o?ai?iaeeoinoaoo oa oaiiaa?a?oaeo ia oa?iaeie?iaoeeo oa
oa?iaeieia?/iee aoaeo ?iaeiiaoaoeeio o uo??a// A?niee A?iieoeueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.- 1997.- ?2.- N. 28-29.

5. Iaiothe I.I., Inoai/oe I.?., Noai?neaa/oe I.A., ?noioei A.I. Aieea
iaaeinoaoiino? a?oai?i?a A ? A oa aeiaeaoeiaiai aaaaeaiiy ?aoeiieo,
oieioa?ieo, naeaie oa aeeaoiieo ia oeueoea?iaaiio ae?th i?oioaio,
iai?ienaio oa ?iaeiiaoaoeeio// E?ee.- 1998, ?4.- N. 12-15.

6. Inoai/oe I.?. Aieea ?aoeiieo, oieioa?ieo oa oeeiaoeaeeio ia iia?/i?
aoaeoe ?iaeiiaoaoeeio// Oe?a?inueeee ea?ae?ieia?/iee aeo?iae
(aeiaeaoie).- 1995.- N. 88-89.

7. Noaieneaa/oe I.A., Iaiothe A.A., Aiae I.A., Inoai/oe A.E.,
Neeaea I.ss. Iiaeeoeeaoeey i?ioeaiainiaeeoaeueiiai yooaeoa i?oioaia,
eiaeiiaoaoeeia e iai?ienaia eiaeoeoi?aie e eiaeaeoi?aie iaoaaieecia
enaiiaeioeeia e aeoaieiiuie i?aia?aoaie// Oace aeiiia?aeae ?
Oe?a?inueei? iaoeiai? eiioa?aioe?? ca o/anoth e?a?i NIAe “Aeooaeuei?
i?iaeaie ee?i?/ii? oa?iaeieia??”.- A?iieoey.- 1993.- N. 39-40.

8. Inoai/oe I.?. Aeeiai?ea iieaciee?a ia?aeeniiai ieeneaiiy e?i?ae?a oa
aeooao?iiiai? aioeia?aeenii? nenoaie o oai?eo ia ?aaiaoi?aeiee a?o?eo
i?ae aieeaii e?eoaaiiy ?iaeiiaoaoeeiii oa eiai ii?aeiaiiyi c ?aoeiieii//
Iaoa??aee ?? Iaoe?iiaeueiiai eiia?ano ?aaiaoieia?a Oe?a?ie.- Ee?a.-
1997.- N. 145.

9. Inoai/oe I.?., Noai?neaa/oe I.A., N??eiaa A.E. Aieea aaa?oo oa
naeaio ia aoaeoeai?noue i?ioecaiaeueii? oa?ai?? ?iaeiiaoaoeeiii oai?eo
ia ?aaiaoi?aeiee a?o?eo// Iaoa??aee ?? Oe?a?inueei? iaoeiai?
eiioa?aioe?? c i?aeia?iaeiith o/anoth “Aeooaeuei? i?iaeaie ee?i?/ii?
oa?iaeieia??”.- A?iieoey.- 1998.- N. 193-195.

10. Noaieneaa/oe I.A., Inoai/oe A.E., Iaaeaeaeue C.N. Ii?aaeaeaiea
eiaeiiaoaoeeia a eaea?noaaiiie oi?ia e aeieiae/aneii iaoa?eaea//
Eioi?iaoeeiiiue eenoie. – Aeiieoea, 1998. – 3 n.

Inoai/oe I.?. Aieea aioeieneaeaio?a oa iiai?acieo ia i?ioecaiaeueio
aeoeai?noue, iia?/io ae?th oa oa?iaeie?iaoeeo ?iaeiiaoaoeeio. – ?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe
ii niaoe?aeueiino? 14.03.05 – oa?iaeieia?y.- ?inoeooo oa?iaeieia?? oa
oieneeieia?? AII Oe?a?ie, Ee?a, 1999.

Eeth/ia? neiaa: ?iaeiiaoaoeei, aioeieneaeaioe, iiai?acie,
oa?iaeie?iaoeea, iia?/ia ae?y, ?aaiaoi?aeiee a?o?eo.

Aeena?oaoe?y i?enay/aia iaa?oiooaaiith aeioe?eueiino? aeei?enoaiiy
aioeieneaeaio?a (?aoeiieo, oieioa?ieo, aaa?oo, naeaie) oa iiai?acieo ye
cania?a i?aeaeuaiiy aoaeoeaiino? oa aacia/iino? oa?iaeioa?ai??
ianoa?i?aeiei i?ioecaiaeueiei i?aia?aoii ?iaeiiaoaoeeiii.

Anoaiiaeaii, ui oa?iaeioa?ai?y ?iaeiiaoaoeeiii iiaeeaeth? aeeeeeaia
aae’thaaioiei a?o?eoii cieaeaiiy ai?noo ?aoeiieo oa oieioa?ieo a ieaci?
e?ia?, ni?e/eiy? ooeiaeaeaiiy oeoieiai-eeoeiaiai o?aeoo. Aeeth/aiiy aei
eiiieaeno e?eoaaiiy aioeieneaeaio?a (aaa?oo oa naeaie) e?ea?aeo?
aeao?oeeo a?oai?i?a a i?aai?ci? ? ciaioo? oeueoea?iaaiiee aoaeo
?iaeiiaoaoeeio. Iaeneiaeuei? aano?ii?ioaeoi?i? aeanoeaino? aeyaeaii i?e
ii?aeiaii? aaa?oo c naeaiith.

Iiai?acie oiia?eueith? ae?i?iaoe?th iaci?iaii? oi?ie ?iaeiiaoaoeeio c
ieacie e?ia?, ca?eueoo? aoaeoeai?noue i?ioecaiaeueii? oa?ai?? ? ciaioo?
/anoioo iia?/ieo aoaeo?a c aieo oeoieiai-eeoeiaiai o?aeoo.

O oai?eo ia ?aaiaoi?aeiee a?o?eo anoaiiaeaii cieaeaiiy ??aiy naeaio a
ieaci? e?ia?, iieacaia aeioe?euei?noue aeeth/aiiy aei eiiieaeno
e?eoaaiiy aioeieneaeaio?a aaa?oo oa naeaie. Oea aeicaieeei i?enei?eoe
cai?ioi?e ?icaeoie ee?i?/ieo neiioii?a caoai?thaaiiy ? ciaioeoe /anoioo
oa aaaee?noue iia?/ieo aoaeo?a ?iaeiiaoaoeeio. Cae?eniaii ai?iaaaeaeaiiy
i?eioeei?a ?aoe?iiaeueii? i?ioecaiaeueii? oa?ai?? ?iaeiiaoaoeeiii a
ee?i?/io i?aeoeeo.

Inoai/oe I.E. Aeeyiea aioeieneaeaioia e iiai?aciea ia
i?ioeaiainiaeeoaeueioth aeoeaiinoue, iiai/iia aeaenoaea e
oa?iaeieeiaoeeo eiaeiiaoaoeeia. – ?oeiienue.

Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe
ii niaoeeaeueiinoe 14.03.05 – oa?iaeieiaey.- Einoeooo oa?iaeieiaee e
oieneeieiaee AII Oe?aeiu, Eeaa, 1999.

Eeth/aaua neiaa: eiaeiiaoaoeei, aioeieneaeaiou, iiai?acie,
oa?iaeieeiaoeea, iiai/iia aeaenoaea, ?aaiaoieaeiue a?o?eo.

Aeenna?oaoeey iinayuaia iainiiaaieth oeaeaniia?aciinoe eniieueciaaiey
aioeieneaeaioia (?aoeiiea, oieioa?iea, aaaeoa, naeaiu) e iiai?aciea a
ea/anoaa n?aaenoa iiauoaiey yooaeoeaiinoe e aaciianiinoe oa?iaeioa?aiee
ianoa?ieaeiui i?ioeaiainiaeeoaeueiui i?aia?aoii eiaeiiaoaoeeiii.

A yenia?eiaioa ia iiaeaee aaeuthaaioiiai a?o?eoa e?un onoaiiaeaii, /oi
o?iie/aneia aooieiioiiia ainiaeaiea nii?iaiaeaeaaony oi?ie?iaaieai
aeaoeoeeoa ?aoeiiea e oieioa?iea a i?aaiecia yenia?eiaioaeueiuo
aeeaioiuo. Oa?iaeioa?aiey eiaeiiaoaoeeiii ia?yaeo n
i?ioeaiainiaeeoaeueiui e aioeiioeeoeaioeaiui aeaenoaeai ieacuaaao oeaeue
?yae iiai/iuo yooaeoia. Ca?aaeno?e?iaaii onoaoaeaiea A- e A-aeoaieiiie
iaaeinoaoi/iinoe. I?eiaiaiea eiaeiiaoaoeeia ieacuaaao oaeaea
cia/eoaeueiia iia?aaeaeathuaa aeaenoaea ia aeaeoaei/ii-eeoa/iue o?aeo
yenia?eiaioaeueiuo aeeaioiuo n oi?ie?iaaieai aeenaaeaina eeieaeiiai
ninoaaa neecenoie iaiei/ee, enoiuaieai aioeieneaeaioia e aeoeaaoeeae
aaiia-aeooaieeo?ainiaioeaeacu. A neecenoie iaiei/ea oiaiueoaeinue
niaea?aeaiea eeieaeia, i?e/ai i?aeiouanoaaiii ca n/ao oinoieeieaeia.
Aioeieneaeaiou (aaaeo, naeaia e aeeaoiie) aeaaeatho oia?aiiie
nianoaaiiie i?ioeaiainiaeeoaeueiie aeoeaiinoueth. Eo ni/aoaiea n
eiaeiiaoaoeeiii iiauoaao i?ioeaiainiaeeoaeueiue e iaacaieeaathuee yooaeo
i?aia?aoa. Aeeth/aiea a eiiieaen ea/aiey aioeieneaeaioia
nii?iaiaeaeaaony oaeaea oiaiueoaieai /anoiou e oyaeanoe iiai/iuo
yooaeoia eiaeiiaoaoeeia. A /anoiinoe, aeiiieieoaeueiia iacia/aiea aaaeoa
ono?aiyao aeaoeoeeo oieioa?iea e ?aoeiiea a ieacia e?iae e ieacuaaao
nouanoaaiiia aano?ii?ioaeoeaiia aeaenoaea. Eo/oa anao caueuaei
neecenooth iaiei/eo io iia?aaeaeathuaai aeaenoaey eiaeiiaoaoeeia
aeeth/aiea a eiiieaen ea/aiey aaaeoa aianoa n naeaiie. Eiee/anoai
ycaaiiuo aeaoaeoia neecenoie iiae aeeyieai yoeo aioeieneaeaioia
nie?auaeinue a 2,5 ?aca. Ia aeioeie/aneii o?iaia aano?ii?ioaeoeaiue
yooaeo aioeieneaeaioia oa?aeoa?eciaaeny ii?iaeecaoeae eeieaeiiai ninoaaa
neecenoie iaiei/ee, nieaeaieai aeoeaiinoe a iae IIE e
aaiia-aeooaieeo?ainiaioeaeacu. I?e yoii a ia/aie iiauoaeinue
niaea?aeaiea ainnoaiiaeaiiiai aeooaoeiia.

?ac?aaioai eiei?eiao?e/aneee iaoiae ii?aaeaeaiey eiaeiiaoaoeeia a
aeieiae/aneii iaoa?eaea, eioi?ue ii i?inoioa eniieuecoaiuo ?aaeoeaia e
iai?oaeiaaiey iiaeao auoue aiaae?ai a i?aeoeeo ?aaiou aeioeie/aneeo
eaai?aoi?ee ea/aaiuo o/a?aaeaeaiee. N eniieueciaaieai ?ac?aaioaiiiai
iaoiaea eco/aia oa?iaeieeiaoeea eiaeiiaoaoeeia a oneiaeyo aai ni/aoaiey
n aeieaoi?ii i?ioiiiie “iiiiu” iiai?acieii. Onoaiiaeaii
oa?iaeieeiaoe/aneia acaeiiaeaenoaea iaaeaeo yoeie i?aia?aoaie. Iieacaii,
/oi i?e eo niaianoiii i?eiaiaiee caiaaeeyaony yeeieiaoeey iaeciaiaiiie
oi?iu eiaeiiaoaoeeia ec i?aaiecia e iiauoaaony aa eiioeaio?aoeey a
ieacia e?iae. Ni/aoaiea iiai?aciea n eiaeiiaoaoeeiii o aeeaioiuo n
aaeuthaaioiui a?o?eoii iiauoaei i?ioeaiainiaeeoaeueioth aeoeaiinoue
iineaaeiaai e nouanoaaiii oiaiueoaei /anoioo e au?aaeaiiinoue iiai/iuo
yooaeoia eiaeiiaoaoeeia ni noi?iiu aeaeoaei/ii-eeoa/iiai o?aeoa.

A eeeieea ianeaaeiaaii 104 aieueiuo ?aaiaoieaeiui a?o?eoii n ?acee/iie
noaiaiueth aeoeaiinoe ainiaeeoaeueiiai i?ioeanna. O aieueoeinoaa ec ieo
auyaeaii nouanoaaiiia nieaeaiea iieacaoaeae aeooaoeiiiaie aioeia?aeeniie
nenoaiu a y?eo?ioeeoao e o?iaiy naeaia a ieacia e?iae, ei??aee?othuaa n
aeoeaiinoueth ainiaeeoaeueiiai i?ioeanna. Eco/aii oa?iaeieeiaoe/aneia
acaeiiaeaenoaea iaaeaeo ianoa?ieaeiui i?ioeaiainiaeeoaeueiui i?aia?aoii
eiaeiiaoaoeeiii e aeieaoi?ii i?ioiiiie “iiiiu” iiai?acieii i?e eo
niaianoiii iacia/aiee. Onoaiiaeaia niiniaiinoue iiai?aciea caiaaeeyoue
yeeieiaoeeth eiaeiiaoaoeeia ec i?aaiecia aieueiuo ?aaiaoieaeiui
a?o?eoii. Iieacaii, /oi iiaeeoeoee?othuee oa?iaeieeiaoeeo eiaeiiaoaoeeia
yooaeo iiai?aciea naycai n aai niiniaiinoueth caiaaeeyoue
iaoaaiee/aneoth eiaeoeaaoeeth i?aia?aoa. A ?aaioa yenia?eiaioaeueii
iainiiaaia oeaeaniia?aciinoue aeeth/aiey a eiiieaen ea/aiey aieueiuo
?aaiaoieaeiui a?o?eoii aioeieneaeaioia ?aoeiiea, oieioa?iea, aaaeoa e
naeaiu. ?ac?aaioaiu iieacaiey e eo i?eiaiaieth. I?iaeaiiino?e?iaaia
yooaeoeaiinoue e aaciianiinoue eiiaeie?iaaiiie oa?aiey eiaeiiaoaoeeiii e
aioeieneaeaioaie. Aeeth/aiea a eiiieaen ea/aiey aaaeoa e naeaiu
iicaieeei onei?eoue ia?aoiia ?acaeoea eeeie/aneeo neiioiiia caaieaaaiey
e oiaiueoeoue /anoioo e au?aaeaiiinoue iiai/iuo yooaeoia eiaeiiaoaoeeia,
iniaaiii, ni noi?iiu aeaeoaei/ii-eeoa/iiai o?aeoa. I?iaaaeaiiia
enneaaeiaaiea iicaieeei iiauneoue yooaeoeaiinoue e aaciianiinoue
oa?iaeioa?aiee eiaeiiaoaoeeiii iooai aai niaianoiiai eniieueciaaiey n
aioeieneaeaioaie.

Ostapchuk O.I. Effect of Antioxidants and Omeprazol on antiinflammatory
activity, side effects and pharmacokinetics of Indomethacin.-
Manuscript.

Thesis for a kandidat’s degree by speciality 14.03.05 – Pharmacology.-
The Institute of Pharmacology and Toxicology Academy of Medical Science
of Ukraine, Kyiv, 1999.

Key words: indomethacin, antioxidantes, omeprazol, pharmacokinetics,
side effect, rheumatoid arthritis.

The dissertation is devoted to the basis of the expediency of using of
the antioxidantes (retinol, tocopherol, aevit, selena) and omeprazol as
agent of the increase of the efficiency and the safety of
pharmacotherapy by nonsteroidal antiinflammatory drug indomethacin.

It is established that pharmacotherapy by indomethacin aggravates the
caused by adjuvant arthritis decrease of retinol and tocopherol levels
in blood plasma, leads to the damage of gastro-intestinal tract. The
inclusion of antioxidants (aevit and selena) in a complex of treatment
liquidates deficiency of vitamins and decreases ulcerogenal effect of
indomethacin. Maximum gastroprotective propertys of the combynation of
aevit and selena is revealed. Omeprazol slows down the elimination of
the unchanged form of indomethacin from blood plasma, increases the
efficiency of antiinflammatory therapy and decreases the frequency of
side effects on the gastro-intestinal tract.

The decrease of selenium level in plasma of rheumatoid arthritis
patients is established. The expediency of the inclusion of
antioxidants aevit and selena in a complex of the treatment is shown.
The introduction of principles of rational antiinflammatory therapy by
indomethacin in clinical practice is carried out.

I?aeienaii aei ae?oeo 8.04.99 ?.

Cai. 125/4. Oi?iao A5. Ae?oe ionaoiee,

Oi. ae?oe. a?e. – 2. Oe?aae 100 aec.

Oeiia?ao?y A?iieoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo

A?iieoey, aoe. Ie?iaiaa, 56

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