?INOEOOO AA?IIOIEIA??
AEAAeAI?? IAAeE*IEO IAOE OE?A?IE
NAI*?E Aaneeue Ieeieaeiae/
OAeE 577.122.5:616.24-36-001
AIEEA IIIIENEAeO AOAEAOeTH OA A?IA?OA?I?? IA NEIOAC AEEICAII?Ae?A OA
AI?III?A, UI ?AAOETHTHOUe CAAEAAEUe EE?OEI A EAAAIAA?E OEAIEI?
03.00.04 – a?io?i?y
Aaoi?aoa?ao aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy
eaiaeeaeaoa iaaee/ieo iaoe
Ee?a – 1999
Aeena?oaoe??th ? ?oeiien.
?iaioa aeeiiaia a Iaoeiai-aeine?aeieoeueeiio oeaio?? Eoaainueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.
Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe Eiia?aaoeaaa ??eia
Ieaenaiae??aia i?ioani?, caa?aeoaa/ea eaoaae?e iaaee/ii? o?i??
Eoaainueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo
Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe Aa?o?aonueeee Ianoi?
Na?a?eiae/ i?ioani?, caa?aeoaa/ eaai?aoi??? aiaeie?eiieia?? ?inoeoooo
aa?iioieia?? AII Oe?a?ie i.Ee?a
aeieoi? a?ieia?/ieo iaoe Inoai/aiei Ethaeieea ?aai?aia, aieiaiee
iaoeiaee ni?a?ia?oiee eaoaae?e a?io?i?? Iaoe?iiaeueiiai oi?aa?neoaoo
?iai? Oa?ana Oaa/aiea, i.Ee?a
I?ia?aeia onoaiiaa: ?inoeooo aiaeie?eiieia?? oa iai?io ?a/iaei
?i.A.I.Eii?na?aiea AII Oe?a?ie, i.Ee?a, eaai?auei??y iae?io?i??
Caoeno a?aeaoany 23 aa?aniy 1999 ?ieo i 14-30 ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.551.01 a ?inoeooo?
aa?iioieia?? AII Oe?a?ie (252114, i.Ee?a, aoe.Aeoai?iaenueea, 67).
C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeoooo
Aaoi?aoa?ao ?ic?neaiee “4”na?iiy 1999 ?.
A/aiee nae?aoa?
niaoe?ae?ciaaii? a/aii? ?aaee ?.?.Iioaiaiei
CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE
Aeooaeuei?noue oaie. Aei oeueiai /ano aoea i?iaaaeaia aaeeea e?euee?noue
aeine?aeaeaiue, i?aaeiaoii yeeo aoei aea/aiiy nenoai, ui aa?ooue o/anoue
a ?aaoeyoe?? ee?oeiii? caaeaae?, a oaeiae oiia, ye? aaaeooue aei ??
?icaeoeo (Virchow R. 1977; Lockshin R.A. 1997). Ee?oeiia nia?oue ia
?icaeyaea?oueny a?eueoa ye eaoano?io?/ia ?oeioaaiiy ee?oeiii?
oe?e?niino? – a ye e?ioeaaa oi/ea oe?eiai ?yaeo eaneaae?a iaoaaie?/ieo
i?ioean?a, ui i?io?eathoue ye ana?aaeei? ee?oeie, oae ? a i?aai?ci? a
oe?eiio. Iaeia c nenoai, yea aa?a o/anoue a ?aaoeyoe?? ee?oeiii?
caaeaae?, ? nenoaia aeeicaii?ae?a (Vane J.R 1971, Aiiaceia I.A. 1987).
Oe?eaa? ee?i?/i? oa aenia?eiaioaeuei? niinoa?aaeaiiy, ye? iia’ycai? c
?i?oe?aoe??th aaiieo iaoai?ci?a aiiioico oa ?icaeoeii ee?oeiii? nia?o? a
??cieo oeaieiao i?ney aieeao iiiieneaeo aoaeaoeth, aeeeeeathoue
iaiao?aei?noue o a?eueo oe?ieiio ?icaeyae? ?ie? oe??? iiaeae? a i?ioean?
ee?oeiii? nia?o? (Piantaqdosi C.A. 1997, Uoeianueeee A.A. oa ?i. 1996).
Iniaeeaee ?ioa?an nueiaiaei? i?eaa?oa? ieoaiiy, i?enay/aia aecia/aiith
?ie? ? i?noey iiiieneaeo aoaeaoeth (NI) oa nenoaie aeeicaii?ae?a a
i?ioean? ?aaoeyoe?? ee?oeiii? caaeaae? a eaaaiaa?e oeaiei?, ui
aena?oeaia iaaeinoaoiuei. Ieoaiiy i?i aieea a?iien?? ? a?ia?oa?i?? oa ?o
noi?nii? ae?? ye /eiiee?a, ui aeeeeeathoue ee?oeiio nia?oue, ia ??aaiue
neioaco aeeicaii?ae?a, noai iae?iaoii?aeueii? nenoaie oa ia ee?oeiio
oe?e?ni?noue, caeeoa?oueny iaei aea/aiei, iacaaaeath/e ia oa, ui oe?e
i?iaeai? oaeiae i?eae?ey?oueny oaaaa (Naa/aieiaa E.A. 1995; Wyllie
A.H.1993; Aaaoenyi A.I. ?c ni?aaao. 1987).
O i?aaenoaaeai?e ?iaio? i?iaaaeaii aea/aiiy a?ineioaco aeeicaii?ae?a a
oiiaao ia?aa??aaiiy, ae?? iiiieneaeo aoaeaoeth, a oaeiae ca oiiae ?o
noi?niiai aieeao, ui aeicaieeei aeyaeoe iaa?aeii? aein? aca?iia?aeiineie
i?ae ??aiyie neioaco i?inoaaeaiaeei?a ??cieo a?oi, oeeee?/ieo
ioeeaioeae?a oa nooiaiai ee?oeiii? caaeaae? a eaaaiaa?e oeaiei? uo??a.
Ie??i oeueiai aeaia aeine?aeaeaiiy aeaei a?aeiia?aeue ia ieoaiiy, yeei
/eiii aiaeie?eiia nenoaia ?aaao? ia oiiae, ui i?ecaiaeyoue aei ?icaeoeo
ee?oeiii? caaeaae?.
Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Iiaeaia ?iaioa
aeeiiaia a iaaeao eiieo?nii? aea?aeathaeaeaoii? oaie IIC Oe?a?ie oa
ieaiiai? aea?aeathaeaeaoii? oaiaoeee Eoaainueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo – “Aieea aeieia?/ii iaaacia/ieo oaeoi??a ia
i?aai?ci a oiiaao i?iieneiaiai ?aa?iio oa ?ic?iaea iaoiae?a ei?aeoe??
iaoaaie?cio e ?ioaineaii? oa?ai??” ? aea?aeaaii? ?a?no?aoe??
01.9.10.033409.
Iaoa ? caaaeaiiy aeine?aeaeaiiy. Iaoith ?iaioe aoei aecia/aiiy ai?noo
i?inoaaeaiaeei?a, oeeee?/ieo ioeeaioeae?a oa ai?iii?a, ui aa?ooue
o/anoue a ?aaoeyoe?? ee?oeiii? caaeaae? a eaaaiaa?e oeaiei?, yea aeieea?
i?ae aieeaii a?ia?oa?i??, iiiieneaeo aoaeaoeth, oa ?o noi?ni?e ae??.
Aeey ?aae?caoe?? iaoe aoei ae??oaii oae? caaaeaiiy:
?ic?iaeaii aenia?eiaioaeueio iiaeaeue, ui aeeeeea? caaeaaeue ee?oei
a?iioiaeueaaiey?iiai aea?aaa in vivo a oiiaao aieeao a?ia?oa?i??,
iiiieneaeo aoaeaoeth oa ?o noi?nii? ae??.
Anoaiiaeaii iniaeeaino? a?ineioaco i?inoaaeaiaeei?a A2 ? F2a ?c
aiaeiaaiieo iiia?aaeiee?a oa oeeee?/ieo ioeeaioeae?a a oeaieiao ie?ie
(ei?? ? iaaeoe?) a oiiaao a?ia?oa?i??, a oaeiae eiioeaio?aoe?th oeeo
niieoe a eaaaiaa?e oeaiei? (a i?aa?e ? e?a?e eaaai?) o oaa?ei i?e
a?ia?oa?i??, a?iien?? oa ?o noi?niiio aieea?.
Aeine?aeaeaii nooi?iue ?oeioaaiiy ai?oae?th a?iioiaeueaaiey?iiai
aea?aaa, oeyoii aecia/aiiy ?iaeaeno aeaaaia?aoe?? a?thaaoiai ai?oae?th
(?AeAA) a aenia?eiaioaeueieo oiiaao ? aeyaeaii noai ee?oeiieo
oeueo?ano?oeoo? a oeaieiao eaaaiue, ie?ie ? ia/?iee uo??a e?i?? Wistar a
oiiaao a?ia?oa?i??, aeey i?aeoaa?aeaeaiiy ?icaeoeo ee?oeiii? caaeaae?.
Aecia/aii noai aioo??ee?oeiieo oa?iaioaoeaieo nenoai aeueaaiey?ieo
iae?ioaa?a eaaaiue uo??a i?e a?ia?oa?i??, a?iien?? ? ?o ni?eueiiio
aieea? ye iaei??? ?c oa?aeoa?enoee ee?oeiii? caaeaae?.
Aecia/aii ai?no aae?aiiei?oeeio?iiiiai ai?iiio (AEOA), iao-aieaoae?io,
ia?aoe?ai?aeiiai ai?iiio (IOA), eaeueoeeoii?io, aeueaeinoa?iio,
aeoeaiino? ?ai?io ieacie (A?I) o ?ioaeoieo oaa?ei oa oaa?ei i?ae aieeaii
a?ia?oa?i??, iiiieneaeo aoaeaoeth oa ?o noi?niiio aieea?.
Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa ?ic?iaeaii
aenia?eiaioaeueio iiaeaeue noeioeueiaaii? ee?oeiii? caaeaae?, eio?a
?icaeaaeany a eaaaiaa?e oeaiei? i?ae aieeaii a?ia?oa?i??, iiiieneaeo
aoaeaoeth oa ?o noi?ni?e ae??. Aia?oa cae?eniaii eiiieaenia
aeine?aeaeaiiy ? i?iaaaeaii ii??aiyeueiee aiae?c ae?? a?ia?oa?i??,
iiiieneaeo aoaeaoeth oa ?o ni?eueiiai aieeao (ye /eiiee?a, ui
aeeeeeathoue ee?oeiio nia?oue) ia ciiaeueio ie?eiao (ei?eiao oa
iaaeoey?io) ? eaaaiaao (i?aaa ? e?aa eaaaiy) eiioeaio?aoe?th
i?inoaii?ae?a (i?inoaaeaiaeeie A2 ? F2a) oa oeeee?/ieo ioeeaioeae?a
(oe-AIO ? oe-AIO). Aia?oa iieacaia ??cieoey i?ae oeaieiieie
eiioeaio?aoe?yie i?inoaaeaiaeei?a oa oeeee?/ieo ioeeaioeae?a o i?aa?e oa
e?a?e eaaai? i?ae aieeaii i?aeaeuaii? oaiia?aoo?e, iiiieneaeo aoaeaoeth
oa ?o aca?iiae??. Aia?oa iieacaii aieea aeine?aeaeoaaieo oaeoi??a ia
aeaye? eaiee aiaeie?eiii? nenoaie, ye? a?aeiia?aeathoue ca aaeaioaoe?th
aei oiia oaiia?aoo?iiai oa a?iiene/iiai no?ano, oa ca’ycie oeeo
i?ioean?a ?c ai?noii ?ii?a Na+ ? Ca2+ a ie?eia?e oeaiei? ? ieaci? e?ia?
a aenia?eiaioaeueieo oaa?ei. Aecia/ai? eiioeaio?aoe?? iao-aieaoae?io,
AEOA, IOA, eaeueoeeoii?io, aeueaeinoa?iio, A?I, ui aeicaieeei
cai?iiiioaaoe noaio aaeaioaoe?eii-eiiiainaoi?ieo iaoai?ci?a, ui
aeieeathoue i?ae /an ?icaeoeo ee?oeiii? caaeaae? a oiiaao ?ic?iaeaii?
iaie aenia?eiaioaeueii? iiaeae?.
I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Aeyaeai? ci?ie ?AeAA,
ii?ooaiiy a?ineioaco i?inoaaeaiaeei?a oa ai?noo oeeee?/ieo ioeeaioeae?a
a eaaaiaa?e ? ie?eia?e oeaieiao, a oiiaao ae?? a?ia?oa?i?? oa iiiieneaeo
aoaeaoeth, iiaeooue neoaeeoe aeiiii?aeieie iieacieeaie aeey aecia/aiiy
nooiaiy ?icaeoeo a ieo ee?oeiii? caaeaae?.
Aeyaeai? ci?ie a aeeoo?aiio oeeee? ee?oei (aeeooy ee?oeie – caaeaaeue
ee?oeie) a oiiaao aieeao a?ia?oa?i??, a?iien?? oa ?o ii?aeiaiiy aeathoue
i?aenoaao i?eionoeoe, ui i?e ?icaeoeo a?ia?i?ie?oa?aoeaieo i?ioean?a, a
iniia? yeeo eaaeeoue i?eai?/aiiy i?ioean?a i?ia?aiiaaii? ee?oeiii?
caaeaae?, iiaeeeaa ? aeioe?eueia canoinoaaiiy oieaeueii? a?ia?oa?i??, ye
/eiieea, ui noeioeth? ee?oeiio caaeaaeue.
?acoeueoaoe aeine?aeaeaiiy aca?iica’yceo neioaco i?inoaii?ae?a,
oeeee?/ieo ioeeaioeae?a oa ai?iii?a c ?aaoeyoe??th aeaeo?ie?oiiai
aaeaino a ii?i? ? a aenia?eiaioaeueieo oiiaao, aeeth/ai? a o/aiao
i?ia?aio eaoaae?e iaaee/ii? o?i?? Eoaainueeiai Aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo c oai: “Aiaeii-nieueiaee iai?i ? eiai ?aaoeyoe?y” ?
“Ai?iiie, ai?iiiiiiae?ai? ?a/iaeie oa ?o iina?aaeieee”.
Iniaenoee aianie caeiaoaa/a. Aianie aaoi?a i?e aeeiiaii? aeena?oaoe?eii?
?iaioe iieyaa? ianaiia?aae o naiino?eiiio aeeiiaii? iaeyaeo e?oa?aoo?e,
o/ano? o aeeiiaii? aenia?eiaioo, noaoenoe/i?e ia?iaoe? io?eiaieo
aiae?c?a oa ?ioa?i?aoaoe?? io?eiaieo aeaieo, a oaeiae o oi?ioethaaii?
aeniiae?a ?iaioe. Noaoo?, ui iioae?eiaai? a ni?aaaoi?noa? a “Oe?aeineii
aeioeie/aneii aeo?iaea” ? a “I?iaeaiao aeieia?/ii? oa iaaee/ii? aaiaoeee
? ee?i?/ii? ?ioiieia??”, i?noyoue iaea?aeai? caeiaoaa/ai ?acoeueoaoe, a
yeeo a?aeia?aaeai? iaoiaeeee aenia?eiaioaeueiiai aeine?aeaeaiiy c
aecia/aiiy ai?noo i?inoaaeaiaeei?a, ii?oieia?/i? aeine?aeaeaiiy.
Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee ?acoeueoao?a
aeena?oaoe?? aeiiia?aeaeeny ia XV c’?cae? Oe?a?inueeiai o?c?ieia?/iiai
oiaa?enoaa (i. Aeiiaoeuee 1998 ?.); ia IV i?aeia?iaeiiio eiia?an?
iieiaeeo a/aieo ? nooaeaio?a – iaaeee?a (Iieueua 1998 ?.); ia
i?aeeaoaae?aeueiiio can?aeaii? i?aoe?aiee?a eaoaae?e iaaee/ii? o?i?? ?
iaoeiai-aeine?aeiiai oeaio?o Eoaainueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo.
Ioae?eaoe??. Ca ?acoeueoaoaie aeaii? ?iaioe iioae?eiaaii 6 iaoeiaeo
noaoae a o?ueio oaoiaeo aeaeaiiyo, c ieo aea? a ?aeeiiio aaoi?noa?, oa 2
aeiiia?ae? – a iaoa??aeao aeaio iaoeiaeo eiioa?aioe?e oa c’?cae?a.
No?oeoo?a oa ianya aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 159
noi??ieao iaoeiiieniiai oaenoo ? neeaaea?oueny c? anooio, iaeyaeo
e?oa?aoo?e, iieno iaoa??ae?a oa iaoiae?a aeine?aeaeaiiy, 3 ?icae?e?a
aeanieo aeine?aeaeaiue, caeeth/iiai iaaiai?aiiy iaea?aeaieo ?acoeueoao?a
oa aeniiae?a. Nienie aeei?enoaii? a?o/eciyii? oa ?iicaiii? e?oa?aoo?e
aeeth/a? 32 a?o/eciyieo oa 323 ca?oa?aeieo aeaea?aea. ?iaioa
?ethno?iaaia 12-ia oaaeeoeyie, 6-ia ae?aa?aiaie, 3-ia ?enoieaie, 4-ia
i?e?ioioia?ao?yie.
INIIAIEE CI?NO ?IAIOE
Ia’?eoe oa iaoiaee aeine?aeaeaiiy. Aeine?aee iinoaaeai? ia 220
uo?ao-naioeyo 3 i?ny/iiai a?eo ianith 200-250 a?. Oaa?eie aoee iiae?eai?
ia 3 aenia?eiaioaeuei? a?oie oa iaeio a?oio eiio?ieth. Aeey i?iaaaeaiiy
aenia?eiaioo aoei canoiniaaii oa?iioieneeieia?/io eaia?o (Iiaea?a A.I.
1988 (AN 1452526)). O ia?o?e aenia?eiaioaeuei?e a?oi? oaa?ei i?aeaeaaaee
ae?? a?ia?oa?i?? (+43 – +45°C) i?ioyaii 1 aiae., a ae?oa?e – ae??
iiiieneaeo aoaeaoeth (NI) a eiioeaio?aoe?? 2000-2500 ia/i3 i?ioyaii 10
oa., a o?ao?e – ni?eueiiio aieeao a?ia?oa?i?? oa NI. O eiaei?e a?oi?
aecia/aeeny ??ai? aiaeiaaiiiai a?ineioaco i?inoaaeaiaeei?a (IA) A2, F2a
oa oeeee?/ieo ioeeaioeae?a a aiiiaaiaoao eaaaiaai? oeaieie (i?aai? oa
e?ai? eaaai? ie?aii) (Oliw 1980). Aoee aecia/ai? eiioeaio?aoe?? AEOA,
iao-aieaoae?io, IOA, eaeueoeeoii?io, aeueaeinoa?iio a ne?iaaooe? oa
aeoeai?noue ?ai?io ieacie (A?I). Aoa ae?aooaaiee ?iaeaen aeaaaia?aoe??
a?thaaoiai ai?oae?th (?AeAA), iinoaaeai? ?aaeoe?? aeey aeyaeaiiy noaio
aeoeaiino? aeueaaiey?ieo iae?ioaa?a (AI) (INO-oano, oaaioeeoa?ia /enei,
oaaioeeoa?iee ?iaeaen, e?euee?noue aeeaeo AI).
E?euee?nia aecia/aiiy an?o iaoaaie?o?a i?iaiaeeeiny iaoiaeii
?aae?i?ioiiiai aiae?co i?ney ?o iiia?aaeiuei? aeno?aeoe?? oa
eiioeaio?aoe??. Aeine?aeaeaiiy aeeiiai? ca aeiiiiiaith noaiaea?oieo
eiia?oe?eieo iaai??a o iiai?e a?aeiia?aeiino? c aeiaeaieie aei ieo
?ino?oeoe?yie. Aoee aeei?enoai? iaai?e oaeeo o??i: AEOA, IOA, A?I o??ie
“CIS Biointernational” (O?aioe?y), aeueaeinoa?iio – o??ie “Sorin
Biomedica” (?oae?y), eaeueoeeoii?io – o??ie “Byk-Sangtec Diagnostica”
(O?aioeey), iao-aieaoae?io – o??ie “Instar Corporation” (NOA), IAF2a –
o??ie “Institute of isotopes” (Oai?ueia), IAA2 – o??ie “Advanced
Magnetics Inc.” (Aaeeeia?eoai?y), oeAIO ? oeAIO – o??ie “Chemapol”
(*aoineiaae?y). I?ae?aooiie ?aae?iaeoeaiino? i?iaiaeeee ia e?/eeueieeao
“Aaoa-1” e “Aaiia-1”. O ia?o?e aenia?eiaioaeuei?e oa eiio?ieueieo a?oiao
o oaa?ei aeiaeaoeiai aecia/aee ??aaiue ?ii?a Na2+ oa Na+ a ei?eiaiio oa
iiceiaiio oa?? ie?ie ? a ieaci? e?ia?. Oaeiae aoei aeeiiaii
aeaeo?iiii-i?e?ineii?/ia aeine?aeaeaiiy oeaieie ie?ie, eaaaiue oa
ia/?iee aeey aecia/aiiy iciae, oa?aeoa?ieo aeey ?icaeoeo ee?oeiii?
caaeaae?. E?euee?nia aecia/aiiy a?eea i?iaiaeeee ca iaoiaeii Lowry
(1951). Aei??thaaiiy aeaeo?ie?o?a a oeaiei? oa ne?iaaooe? e?ia?
i?iaiaeeeenue ca aeiiiiiaith aoiiii-aaeni?aoe?eiiai niaeo?ioioiiao?o
N-115-I1.
Ia?aeiiee oeeo?iaee iaoa??ae aenia?eiaioaeueieo aeine?aeaeaiue aoa
ia?iaeaiee o?aaeeoe?eieie iaoiaeaie aa??aoe?eii? noaoenoeee. Aeey
ioe?iee a??ia?aeiino? io?eiaieo ?acoeueoao?a aoa aeei?enoaiee e?eoa??e
Nouethaeaioa. ?acoeueoaoe ?icoe?ithaaeenue ye noaoenoe/ii aeinoia??i?
i?e p
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