IAOe?IIAEUeIA AEAAeAI?ss IAOE OE?A?IE?INOEOOO A?IO?I?? ?i. I. A.
IAEEAAe?IA
OAOIAIIEAIA AANEE?AIA
OAeE 577. 115.3+577.161.3+577.352.333
INIAEEAINO? O?C?IEIA?*II? OA IAIA?AIIO?IIII? Ae?? A?IEIA?*II AEOEAIIAI
EIIIEAENO OINOIE?I?Ae?A C A?Ae?IA?IIO?A
03.00. 04 – A?io?i?y
Aaoi?aoa?aoaeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa
a?ieia?/ieo iaoe
Ee?a – 1999
Aeena?oaoe??th ? ?oeiien.
?iaioa aeeiiaia a ?inoeooo? a?io?i?? ?i. I.A. Iaeeaae?ia IAI Oe?a?ie.
Iaoeiaee ea??aiee – aeieoi? a?ieia?/ieo iaoe, /eai-ei?. IAI Oe?a?ie
Aeii/aiei Aai?a?e A?eoi?iae/,
?inoeooo a?io?i?? ?i. I.A. Iaeeaae?ia IAI Oe?a?ie,
caa?aeoaa/ a?aeae?eo a?io?i?? eioa?iaio?a.
Io?oe?ei? iiiiaioe: aeieoi? a?ieia?/ieo iaoe, no.iaoe.ni?a?.
Iaeeoaaa Ia?aa?eoa Einoyioei?aia,
?inoeooo o?c?ieia?? ?i. I.I. Aiaiiieueoey IAI Oe?a?ie,caa?aeoaa/
a?aeae?eo iae?io?i??;
eaiaeeaeao a?ieia?/ieo iaoe
Ee?iaoaanueeee A?oae?e Ia?’yiiae/,
?inoeooo a?io?i?? ?i. I.A. Iaeeaae?ia IAI Oe?a?ie,
no. iaoe. ni?a?. a?aeae?eo a?io?i?? e?i?ae?a.
I?ia?aeia onoaiiaa – Ee?anueeee oi?aa?neoao ?i. Oa?ana Oaa/aiea,
eaoaae?a a?io?i??.
Caoeno a?aeaoaeaoueny “22” ethoiai 1999 ?. i 14 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.240.01 a ?inoeooo? a?io?i?? ?i.
I.A.Iaeeaae?ia IAI Oe?a?ie (252601, Ee?a-30, aoe. Eaiioiae/a, 9).
C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeoooo
a?io?i???i. I.A.Iaeeaae?ia IAI Oe?a?ie (252601, Ee?a-30, aoe.
Eaiioiae/a, 9).
Aaoi?aoa?ao ?ic?neaiee “21” n?/iy 1999 ?.
A/aiee nae?aoa?
niaoe?ae?ciaaii? a/aii? ?aaee
eaiaeeaeao a?ieia?/ieo iaoe
E??NAIEI I.A.
15
CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE
Aeooaeuei?noue oaie. Ca inoaii? ?iee oaaaa aeine?aeiee?a caa?iaia aei
ieoaiiy canoinoaaiiy oinoie?i?ae?a oa iie?iaiane/aieo aee?ieo eeneio, ye
e?eoaaeueieo i?aia?ao?a oe?ieiai niaeo?o a?ieia?/ii? ae??, ui
aeyaeythoue aoaeo i?e ??cieo ?ioieneeaoe?yo o ia/?ioe?, aiaeie?eiieo
?iceaaeao oa na?oeaai-noaeeiieo caoai?thaaiiyo [Patel J.M., 1993].
Inoaii?i /anii c?iaeaii aaeeeee e?ie o ?icoeo?oaaii? cia/aiiy e?i?aeieo
eiiiiiaio?a iaia?ai, ye? aeeiiothoue ia eeoa no?oeoo?io ?ieue, aea e
aa?ooue o/anoue o eeth/iaeo i?ioeanao ia?aaea/? ?aaoeyoi?ieo neaiae?a,
?aaoeyoe?? aeoeaiino? iaia?aiica’ycaieo oa?iaio?a. Aaeaioiaaiiee
oa?aeoa? i?e aeno?aiaeueieo neooaoe?yo oa iaoieia?/ieo noaiao ia? ci?ia
??aiy oinoie?i?ae?a, ui iia’ycai? ?c ci?iaie i?ioeano ?o neioaco oa
iai?io ?a/iaei. Oinoie?i?aee, ye iiaa?oiaai-aeoeai? ?a/iaeie,
a?ae?a?athoue aaaeeeao ?ieue o caaacia/aii? ?ani??aoi?ii? ooieoe?? oa
caoeno? eaaaiue a?ae eiioaeoo c ??cieie i?e?i/anoeaie oa c
i?e?ii?aai?ciaie [Aa?aieiae/ A.I., 1983]. A?ieia?/i? iaia?aie oeaiei c
??ciith ooieoe??th iathoue o nai?io neeaae? oinoie?i?aee c iaaieie
aa??aioaie aee?iieeneioieo caeeoe?a. A?ae aee?iieeneioiiai neeaaeo
oinoie?i?ae?a caeaaeeoue ?o iaoaaie?/ia aeoeai?noue, a oaeiae
u?euei?noue aai ??aeeii?noue iaia?ai [I?aaaeeia E.I., 1975]. Ia a?aei?io
a?ae nnaaoe?a e?i?aee ii?nueeeo i?aai?ci?a aaaao? iie??iiaeie aee?ieie
eeneioaie, iniaeeai iiaaa – iaiane/aieie aeeicaiaioa?iiaith oa
aeieicaaaena?iiaith eeneioaie [Metzman M.S., 1978]. Ieoaiiy i?i
a?ieia?/i? aeanoeaino?, niaoeeo?/io o?c?ieia?/io aeoeai?noue
oinoie?i?ae?a c ii?nueeeo i?aai?ci?a oa iaoai?ci iai?io a iaia?aiao
ee?oei ia aeinoaoiuei c’yniaaii. ??ciiiai?oiee aee?iieeneioiee neeaae
oinoie?i?ae?a iaoiiaeth? ?nioaaiiy ??cieo ioe?a oinoie?i?ae?a iaeiiai
aeaeo, ui ni?e/eiy? aeeiiaiiy ieie ??cieo ooieoe?e -– a?ae no?oeoo?ieo
oa aioeieneaeaioieo aei ooieoe?e ?aaoeyoe?? aeoeaiino? oa?iaio?a,
o?ainii?oo, ia?aaea/? neaiae?a, – an?o i?ioean?a, ye? ia?aa?aathoue ia
??ai? iaia?ai. Oiio aea/aiiy a?ieia?/ieo aeanoeainoae, niaoeeo?/ii?
o?c?ieia?/ii? ae?? oinoie?i?ae?a c ii?nueeeo i?aai?ci?a oa ?o
?aaoeyoi?ii? ?ie? a iaia?aiao oeaiei i?aai?cio aecia/a? aeooaeuei?noue
?iaioe o oeueiio iai?yieo.
Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. I?iaaaeai?
aeine?aeaeaiiy ? i?aai?/iith neeaaeiaith /anoeiith iaoeiaiai iai?yieo
?iaioe eaai?aoi??? oaoiieia?? a?ii?aia?ao?a a?aeae?eo eioa?iaio?a
?inoeoooo a?io?i?? ?i.I.A. Iaeeaae?ia IAI Oe?a?ie. Ie?ai? ?icae?ee
?iaioe aeeiioaaeenue ca?aeii c ieaiaie iaoeiai-aeine?aeieo ?ia?o ii
oaiao: “?ic?iaea oaoiieia?? iaea?aeaiiy ?c ii?nueeeo i?aai?ci?a
o?c?ieia?/ii aeoeaieo niieoe niaoeeo?/ii? ae?? aeey iio?aa iaaeeoeeie”
(IAe? ? aea?aeaaiiai ?a?no?o EA 01007145 ?.), “Aea/aiiy aca?iica’yceo
i?e?iaeieo aioeieneaeaio?a oa oinoie?i?ae?a a ?aaoeyoe??
no?oeoo?ii-ooieoe?iiaeueiiai noaio iaia?ai ee?oei c ??ciith ooieoe??th”
oa iaoeiai-aeine?aeieo ?ia?o, ye? iaea?aeaee i?ei?eoaoia o?iainoaaiiy ca
i?aenoieaie ?anioae?eainueeeo eiieo?n?a: “?ic?iaea iiaiai caniao ia
iniia? oinoie?i?ae?a c ii?nueeeo i?aai?ci?a, ui ia?
iaia?aiinoaa?e?coth/?, aioeieneaeaioi? ? no?oaeoaioi? aeanoeaino?,
aieeaath/iai ia iai?ii? oa ?aia?aoeaiee i?ioeane”, “?aaoeyoi?iee
iaoai?ci iai?io oinoie?i?ae?a o iaia?aiao ee?oei ia/?iee ? eaaaiue oa
?ieue i?e?iaeieo aioeieneaeaio?a a ?aaoeyoe?? no?oeoo?ii? ?
ooieoe?iiaeueii? i?aai?caoe?? iaia?ai”, “Ooieoe?iiaeuei? ci?ie
?ai?iaeoeoeaieo oa aeeoaeueieo i?aai?a oaa?ei i?ae aieeaii iaeeo aeic
?aae?aoe?? oa ?ic?iaea iiaeo aoaeoeaieo cania?a a?aeiiaeaiiy ci?iaieo
ooieoe?e ca aeiiiiiaith niaoeeo?/ieo a?i?aae?ii?ioaeoi??a c iiethne?a”.
Iaoa ? caaea/? aeine?aeaeaiiy. Iaoith ?iaioe aoei aea/aiiy o?i?/iiai
neeaaeo, niaoeeo?/ii? o?c?ieia?/ii? aeoeaiino?, a?ieia?/ieo aeanoeainoae
eiiieaeno “ii?nueeeo” oinoie?i?ae?a, ui aoee aeae?eai? c iiethne?a, oa
aea/aiiy ?o iai?io o iaia?aiao ee?oei aeey noai?aiiy i?e?iaeiiai
aoaeoeaiiai i?io?eaeoe/iiai oa e?eoaaeueiiai caniao e?i?aeii? i?e?iaee c
a?ae?ia?iio?a.
A?iia?aeii aei iniiaii? iaoe a ?iaio? ae??ooaaeenue ianooii? caaaeaiiy:
1. Aea/eoe o?i?/iee neeaae i?e?iaeiiai eiiieaeno oinoie?i?ae?a,
io?eiaiiai c aiiaae aieiaiiiaeo iiethne?a, oa aecia/eoe e?euee?niee oa
ye?niee ai?no oinoie?i?ae?a, aee?ieo eeneio ? ai?iieeneio.
2. Aeine?aeeoe a?ieia?/i? aeanoeaino? oa niaoeeo?/io o?c?ieia?/io ae?th
a?ii?aia?aoo, noai?aiiai ia iniia? eiiieaeno “ii?nueeeo“ oinoie?i?ae?a.
3. Aea/eoe aioeieneaeaioi? aeanoeaino? eiiieaeno oinoie?i?ae?a in vitro
oa in vivo oa eiai aieea ia nenoaio aioeieneaeaioiiai caoenoo i?aai?cio.
4. Aeine?aeeoe ?ieue “ii?nueeeo” oinoie?i?ae?a o iiaeoeyoe??
no?oeoo?ii-ooieoe?iiaeueiiai noaio iaia?ai ee?oei oaa?ei.
Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa aoei aea/aii /?i?/iee
neeaae eiiieaeno oinoie?i?ae?a c aiiaae aieiaiiiaeo iiethne?a ?
iieacaii, ui ?o aieiaia a?aei?ii?noue a?ae oinoie?i?ae?a nnaaoe?a
iieyaa? a iniaeeainoyo aee?iieeneioiiai neeaaeo. Ia iniia? “ii?nueeeo”
oinoie?i?ae?a aia?oa noai?aii oa ioa?aeoa?eciaaii iiaee aoaeoeaiee,
i?e?iaeiee, e?eoaaeueii-i?io?eaeoe/iee can?a – a?ii?aia?ao “Eaeueiio?e”,
anoaiiaeaii eiai no?oaeoaioio, aioeieneaeaioio oa iaia?aiinoaa?e?coth/o
ae?th. Aeyaeaii, ui iaia?aiio?iiia ae?y oinoie?i?ae?a c a?ae?ia?iio?a
iia’ycaia c ?aaoeyoe??th no?oeoo?ii-ooieoe?iiaeueiiai noaio iaia?ai ? ui
aeaiee oinoie?i?aeiee eiiieaen ia? oe?ieee niaeo? o?c?ieia?/ii? oa
oa?iaeieia?/ii? aeoeaiino?.
I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoao?a. Aacoth/enue ia iaaaaeaieo
aenia?eiaioaeueieo aeaieo, aeyaeaii, ui aeine?aeaeoaaiee i?aia?ao
“Eaeueiio?e” ? aoaeoeaiei o e?eoaaii? ?yaeo aenia?eiaioaeueieo
iaoieia?e: a?i caiia?aa? ?icaeoeo iaa?yeo eaaaiue, ei?eao?
iaaeinoaoi?noue no?oaeoaioo oa iie?ioo? noai
ia/?iee i?e oiene/iiio aaiaoeo?. Iieacaii eiai aioeieneaeaioi?
aeanoeaino?, caeaoi?noue aieeaaoe ia aeoeai?noue aioeieneaeaioieo
oa?iaio?a o oeaieiao c ??ciith ooieoe??th, ii?iae?coaaoe oinoie?i?aeiee
neeaae i?e?iniiaeueieo iaia?ai, ci?ithaaoe neeaae aee?ieo eeneio
iaia?aiieo oinoie?i?ae?a. Cai?iiiiiaaii canoinoaaiiy i?aia?aoo c
“ii?nueeeo” oinoie?i?ae?a aeey e?eoaaiiy oa i?io?eaeoeee oai?ia, ye?
noi?iaiaeaeothoueny ieenethaaeueiei no?anii.
Iaea?aeaii “Iaoiaeeeo aea?aeaaieo aei?iaoaaiue” oa “Ianoaiiao” aeey
canoinoaaiiy i?aia?aoo o aaoa?eia??? i?ae iacaith “Ii?ao?e”.
Aeey ?ic?iaee iaaee/iiai caniao “Eaeueiio?e” neeaaeaii aeieoiaioe
aeiee?i?/ieo aei?iaoaaiue aeey i?aaenoaaeaiiy o oa?iaeieia?/iee eii?oao
IIC Oe?a?ie.
Iniaenoee aianie caeiaoaa/ee iieyaa? o aeeiiaii? aenia?eiaioaeueii?
/anoeie ?iaioe, i?aeai?? oa ia?iaoe? e?oa?aoo?ieo aeaieo. Aiae?c oa
iaaiai?aiiy i?iaaaeaii ni?eueii c iaoeiaei ea??aieeii.
Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee aeena?oaoe??
aeiiia?aeaeenue ? iaaiai?thaaeenue ia can?aeaiiyo a?aeae?eo a?io?i??
eioa?iaio?a, iaoeiaeo nai?ia?ao ?inoeoooo a?io?i?? ?i I.A. Iaeeaae?ia
IAI Oe?a?ie, V I?aeia?iaei?e eiioa?aioe?? “Aeiaioeieneaeaio”.
Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?eii? ?iaioe iioae?eiaaii 3 noaoo?
oa 1 oace aeiiia?ae?.
No?oeoo?a oa ianya ?iaioe. Aeena?oaoe?y neeaaea?oueny ?c anooio, iaeyaeo
e?oa?aoo?e, iieno iaoa??ae?a oa iaoiae?a aeine?aeaeaiue, ?acoeueoao?a oa
?o iaaiai?aiiy, aeniiae?a ? nieneo e?oa?aoo?e c 292 iaeiaioaaiue. ?iaioa
aeeeaaeaia ia 120 noi??ieao iniiaiiai oaenoo, ?ethno?iaaia 5 ?enoieaie ?
17 oaaeeoeyie.
IAOA??AEE OA IAOIAeE AeINE?AeAEAIUe.
Oinoie?i?aeiee eiiieaen ?c aieiaiiiaeo iiethne?a io?eioaaee ca iaoiaeii
Aeaoeaiei C.I. oa ?i. (Aao. Na?ae 1175486 NNN? A 61E 37/22).
Aenia?eiaioe i?iaiaeeeeny ia uo?ao-naioeyo e?i?? A?noa? aaaith 120-150
a, ye? ia?aaoaaee ia noaiaea?oiiio ?aoe?ii? aiae?ae? oa ia
A-aa?oai?iici?e ae??o?. Ia’?eoii aeine?aeaeaiue neoaeeea ia/?iea oa
eaaai?.
Aenia?eiaioaeueiee A-a?iia?oai?iic o uo??a iiaeaethaaee, oo?eioth/e ?o c
/ioe?eoeaeiaaiai a?eo ia iai?aooo/i?e ae??o? aac a?oai?io A i?ioyaii 4
i?nyoe?a ca iaoiaeii A.A. Nie?e/aaa oa ?i. (1979). Aeey ei?aeoe??
A-a?iia?oai?iiciiai noaio uo??a iaei?e a?oi? aaiaeeee ia?i?aeueii ii 2
ia a?oai?io A o aeaeyae? ie?eiiai ?ic/eio ia 100 a iane o?ea oaa?eie ia
aeiao i?ioyaii aeaio oeaei?a, ?io?e a?oi? – i?ioyaii oaeiai ae /ano
aioo??oiueii/a?aaeiii aaiaeeee “Eaeueiio?e” ii 50 ia ia 100 a iane o?ea
ia aeiao o aeaeyae? aioeuen?? o o?c?ieia?/iiio ?ic/ei?, i?iaeiaaeoth/e
oo?eioaaoe uo??a ia A-aa?oai?iici?e ae??o?.
?ioieneeaoe?th CCl 4 o uo??a iiaeaethaaee:
1) aeey aeine?aeo c o?ii?/iei NNl4-?iaeoeiaaiei aaiaoeoii – oeyoii
aioo??oiueii’ycaaiai aaaaeaiiy 50% ie?eiiai ?ic/eio NNl4 c ?ic?aooieo
0,4 ie/100 a iane oaa?eie (EAe50) i?ioyaii 4 ae?a. Ei?eaoth/ee aieea
“Eaeueiio?eo” aea/aee i?e eiai aioo??oiueii/a?aaeiiiio aaaaeaii? 10
ia/100 a iane o?ea oaa?eie ii/eiath/e c 4 aei 12 aeiae;
2) aeey aeine?aeo c aino?ei NNl4-?iaeoeiaaiei aaiaoeoii – oeyoii
iaeii?aciaiai aioo??oiueii/a?aaeiiiai aaaaeaiiy 50% ie?eiiai ?ic/eio
NNl4 c ?ic?aooieo 0,2 ie/100 a iane oaa?eie (EAe25), ?io?e a?oi?
iaeii/anii c NNl4 aaiaeeee o oaeee aea niin?a ii 50 ia 50% ie?eiiai
?ic/eio “Eaeueiio?eo” ia 100 a iane o?ea. Eiio?ieuei?e a?oi? oaa?ei
aaiaeeee oaeee aea ia’?i ie??.
E?i?aei? aeno?aeoe io?eioaaee ca iaoiaeii L.Folch et al. (1957).
Oieanoa?ei aecia/aee ca iaoiaeii E.E.?icaioeaaeaa (1962), ai?no
oinoie?i?ae?a o e?i?aeieo aeno?aeoao ca iaoiaeii P.S.Chen (1956), ai?no
?iaeea?aeoaeueieo oinoie?i?ae?a aecia/aee ca e?euee?noth iai?aai?/iiai
oinoi?o ca aeiiiiiaith iie?aaeaoiiai ?aaaaioo ca iaoiaeii V.E. Vaskovsky
(1975), ai?no aoaeaaiae?a ca iaoiaeii R.J.Dimler (1952), ai?no
caaaeueiiai acioo ca iaoiaeii Ae.E.Oa?aeiaia (1957).
O?iiaoia?ao?/ia ?icae?eaiiy ?iaeea?aeoaeueieo oinoie?i?ae?a i?iaiaeeee
ca iaoiaeii aeaiaei??ii? oiieioa?iai? o?iiaoia?ao?? ia ieao?aeao c
nee?eaaaeai ENE-2 oa ieao?aeao Sorbfil (N?N?). I?e ?icaiioe? o ia?oiio
iai?yieo aeei?enoiaoaaee nenoaio oei?ioi?i:iaoaiie:aaicie:28% ai?ae
(65:30:10:6-8), a a ae?oaiio –
oei?ioi?i:iaoaiie:aaicie:aoeaoii:eueiaeiaa ioeoiaa eeneioa
(70:30:10:5:4:1) (V.I. Svetashev; V.E. Vaskovsky, 1972).
?aeaioeo?eaoe?th oinoie?i?ae?a i?iaiaeeee ca aeiiiiiaith niaoeeo?/ieo
?aaeoe?e ia ?o ooieoe?iiaeuei? a?oie (I. Eaeon, 1975; V.E. Vaskovsky,
N.A. Latyshev, 1975; C.M. van Gert et al., 1973).
Ai?no aee?ieo eeneio aecia/aee o?iiaoia?ao?/iei iaoiaeii ca aeiiiiiaith
aaci-??aeeiiiai o?iiaoia?aoa “Carlo Erba” (Italy) c iiia?aaei?i
iaoeethaaiiyi c?ace?a (J.P. Carreau, J.P.Dubaco, 1978). Aeey
e?euee?niiai aiae?co iaoeeiaeo ao???a aee?ieo eeneio aeei?enoiaoaaee
iaaeai? eieiiee ?ici??ii 3,5i o 3 ii. sse iin?e canoiniaoaaee Chromatron
NAW-DMSC ?c 7,5% iaianaiith oacith Silar-5 N? (Serva, Aa?iai?y).
A?aenioeiaee ai?no aee?ieo eeneio a aeno?aeo? ?ic?aoiaoaaee ca ieiuath
i?e?a.
Iiaa?oiaaee iaoya aecia/aee ca iaoiaeii aoyaiooi? neee ieanoeiee ca
aeiiiiiaith aa?oeeaeueieo oa?ac?a A?eueaaeueia ca iaoiaeii A.A Ae?eoi
(1981).
No?oaeoaioe eaaaiue e?ie?a oa uo??a iaea?aeoaaee ca iaoiaeii R.H. Notter
et al. (1983). I?e?iniie oeaiei uo??a aeae?eyee ca iaoiaeii J.B.
Shenkman et al. (1974). Ai?no caaaeueiiai a?eeo aecia/aee ca iaoiaeii
O.H. Lowry, et al. (1951). Noia?ieneaeaeeniooacio o?aeoe?th io?eioaaee
ia iniia? iaoiae?a J.M. Cord, I. Fridovich et al. (1969), B.B. Keele et
al. (1971) o iiaeeo?eaoe?? aeey i?e?inii.
Aecia/aiiy aeoeaiino? noia?ieneaeaeeniooace (NIAe) i?e?inii i?iaiaeeee
ca iaoiaeii Marklund S. at al. (1974). Aeoeai?noue eaoaeace aecia/aee ca
iaoiaeii I.A. Ei?iethe oa ?io. (1988). ?ioaineai?noue ia?aeeniiai
ieeneaiiy e?i?ae?a (IIE) aea/aee ii iaeiie/aiith iaeiiiaiai
ae?aeueaeaa?aeo (IAeA) ca iaoiaeaie TH.A. Aeaaeeie?iaa oa ?io. (1972),
?.Ae. Noaeueiie (1977), oa ii ooai?aiith ae??iiaeo eii’thaao?a (AeE) ca
iaoiaeii TH.A. Aeaaeeie?iaa oa ?io. (1972) oa E.?. Aeyoaaie oa ?io.
(1991).
?acoeueoaoe aeine?ae?a ia?iaeai? noaoenoe/ii c aeei?enoaiiyi t-e?eoa??y
No’thaeaioa ii E.A.Ieaeio (1960). A??ia?aeieie aaaaeaee ?acoeueoaoe i?e
p0,05.
?ACOEUeOAOE AeINE?AeAEAIUe OA ?O IAAIAI?AIIss.
1. Aea/aiiy o?i?/iiai neeaaeo oinoie?i?aeiiai eiiieaeno c aiiaae
iiethne?a
Oaaeeoey 1.1.
O?i?/iee neeaae oinoie?i?aeiiai eiiieaeno, aeae?eaiiai c aiiaae
aieiaiiiaeo iiethne?a.
?a/iaeie% a?ae caaaeueii? e?eueeino?Oinoie?i?aee75,0 – 85,0Caaaeueiee
oieanoa?ei2,0 – 5,0A?euei? aee?i? eeneioe0,1 – 2,8Aoaeaaiaee0,1 –
0,3Iaioeaee0,1 – 0,5A?eie-?iaeea?aeoaeuei? oinoie?i?aee
:Oinoaoeaeeeoie?i72,0 – 87,0Oinoaoeaeeeaoaiieai?i7,0 –
12,0No?iaii??e?i7,0 – 9,0Aeeoinoaoeaeeeae?oea?ei0,4 –
0,8Oinoaoeaeee?iiceoie1,5 – 2,2Oinoaoeaeeena?ei0,6 – 1,2I?ei?oea. O
oaaeeoe? iaaaaeaii ocaaaeueiai? aeai? o?i?/iiai neeaaeo oinoie?i?aeieo
eiiieaen?a c a?ae?ia?iio?a, ui aoee io?eiai? c ??cii? ne?iaeie.
?acoeueoaoe aeine?aeaeaiue o?i?/iiai neeaaeo oinoie?i?aeiiai eiiieaeno,
io?eiaiiai ?c aiiaae aieiaiiiaeo iiethne?a, na?ae/aoue, ui aei eiai
neeaaeo aoiaeeoue aei 80% oinoie?i?ae?a, iacia/ia e?euee?noue
oieanoa?eio, a?eueieo aee?ieo eeneio, aoaeaaiae?a, ai?iieeneio,
iaioeae?a oa ne?aeia? caeeoee a?oai?io A (oaae.1.1).
Na?aae oinoie?i?ae?a 70% noaiiaeoue oinoaoeaeeeoie?i oa o cia/ii iaio?e
e?eueeino? oinoaoeaeeeaoaiieai?i, no?iaii??e?i, oinoaoeaeee?iiceoie,
oinoaoeaeeena?ei, oinoaoeaeeeaeeae?oea?ei.
I?e ii??aiyeueiiio aeine?aeaeaii? oinoie?i?aeiiai eiiieaeno, io?eiaiiai
c a?ae?ia?iio?a, oinoie?i?ae?a eo?y/eo y?oeue oa ??cieo oeaiei nnaaoe?a,
aeyaeaii, ui “ii?nuee?” oinoie?i?aee e??i iniiaieo aee?ieo eeneio, ye?
oa?aeoa?i? aeey an?o oaa?ei, oiaoi iaeuei?oeiiai? (N 16:0), noaa?eiiai?
(N 18:0), iea?iiai? (N 18:1), i?noyoue oae? aeeoo?ai iaiao?aei? eeneioe,
ye e?iieaiiaa (N 18:3) oa cia/io e?euee?noue a?ieia?/ii aeoeaieo aee?ieo
eeneio- a?ao?aeiiiao (N 20:4), aeeicaiaioa?iiao (N 20:5),
aeieicaaaena?iiao (N 22:6), ye? o neeaae? oinoie?i?ae?a ?ioiai
iioiaeaeaiiy i?noyoueny o ne?aeiaeo e?eueeinoyo, aai cian?i a?aenooi?
(oaae.1.2).
Oaaeeoey 1.2
A?aenioeiaa ni?aa?aeiioaiiy iaoeeiaeo ao???a aee?ieo eeneio o neeaae?
oinoie?i?ae?a ?c ??cieo aeaea?ae.
AEe?i? eeneioeAiiaaee eaeueia?asseoey eo?y/?Na?oea
oaa?eiIa/?ieaoaa?eiIicie oaa?eiN 16 : 048,433,922,713,429,8N 16 :
10,71,0–1,1N 18 : 06,510,55,722,314,1N 18 : 19,831,114,511,330,3N 18 :
20,517,739,814,59,2N 18 : 310,6—-N 20 : 0—–N 20 : 1—–N 20 :
2—–N 20 : 3–3,56,3-N 20 : 41,53,17,615,76,1N 20 : 54,5—-N 22 :
00,9—-N 22 : 53,0—-N 22 : 612,3–4,02,6I?eei?oea. Aeai? neeaaeo AEE
c eo?y/eo y?oeue, oeaiei na?oey, ia/?iee oa iiceo oaa?ei acyo? c
e?oa?aoo?e (E.Ae.Aa?aaeuenii; “Avanti” Polar Lipids,1995).
2. No?oaeoaioii-iiae?ai? aeanoeaino? oinoie?i?aeiiai eiiieaeno ?c aiiaae
eaeueia??a
Aeyaeaii iiae?ai?noue o?i?/iiai neeaaeo oinoie?i?aeiiai eiiieaeno ?c
aiiaae iiethne?a ? no?oaeoaio?a eaaaiue nnaaoe?a, o yeiio oinoie?i?aee
oaeiae neeaaeathoue aei 80% ii?yae c iacia/iith e?euee?noth oieanoa?eio,
a?eueieo aee?ieo eeneio, aoaeaaiae?a, iaioeae?a. Na?aae oinoie?i?ae?a o
iaio aeiaaeeao ia?aaaaea? oinoaoeaeeeoie?i (oaae.2.1).
I?e aea/aii? a?ieia?/ieo aeanoeainoae “ii?nueeeo” oinoie?i?ae?a
aeyaeaii, ui eiiieaen, aeae?eaiee c aiiaae aieiaiiiaeo iiethne?a,
i?iyaey? iiaa?oiaao aeoeai?noue, ye ? no?oaeoaio eaaaiue oaa?ei.
I?i?iaeueiee iiaa?oiaaee iaoya i?aia?aoo oa no?oaeoaioa uo?a noaiiaea
11,70,8 oa 10,30,6 a?aeiia?aeii, a iaeneiaeueiee – 46,50,8 oa 42,30,2.
Oaaeeoey 2.1.
O?i?/iee neeaae oinoie?i?aeiiai eiiieaeno ?c aiiaae aieiaiiiaeo
iiethne?a ? no?oaeoaio?a c eaaaiue nnaaoe?a (% a?ae caaaeueii?
e?eueeino?).
?a/iaeiaAiiaaee eaeueia?a (“Eaeueiio?e”)No?oaeoaioe eaaaiue
nnaaoe?aCaaaeueiee oieanoa?ei2,0-5,00-8,0A?euei? aee?i?
eeneioe0,1-2,81,0-27,7Aoaeaaiaee0,1-0,30,1-2,0Iaioeaee0,1-0,51,0-3,0Oino
ie?i?aee
:75,0-85,068,6-90,7Oinoaoeaeeeoie?i72,0-87,058,4-85,0Oinoaoeaeeeaoaiieai
?i7,0-12,03,5-2,6No?iaii??e?i7,0-9,03,2-12,1Aeeoinoiae?oea?eae0,4-0,80,1
-12,0Oinoaoeaeee?iic?oie1,5-2,21,2-6,6Oinoaoeaeeena?ei0,6-1,21,0-6,4I?ei
?oea.O oaaeeoe? iaaaaeaii ocaaaeueiai? aeai? o?i?/iiai neeaaeo
no?oaeoaio?a eaaaiue ??cieo oaa?ei.
I?e ?iaaeyoe?eiiio canoinoaaii? i?aia?aoo “Eaeueiio?e” ia iniia?
“ii?nueeeo” oinoie?i?ae?a c iiethne?a i?e ?ioieneeaoe?? oaa?ei ai?aeii,
aaiceiii, iai?ioaiii aeyaeaii iiceoeaiee aieea ia caaaeueiee noai oaa?ei
oa ia ?o aeaeeaaiiy, a oaeiae, cie?aia, ia ii?iae?caoe?th ii?ooaieo
ooieoe?e eaaaiue, – cieaeaiiy ?ioaineaiino? i?ioeano i?iiooai?aiiy,
ii?iae?caoe?th ee?oeiii? ?aaeoe?? no?oaeoaioo eaaaiue, iieaaoaiiy oiaeo
oiene/iiai i?ioeano, ye iieacaii o oaae.2.2., ui na?ae/eoue i?i
no?oaeoaioiiiiae?ai? aeanoeaino? i?aia?aoo.
Oaaeeoey 2.2.
Noai iiaa?oiaai-aeoeaieo aeanoeainoae eaaaiue aeine?aeaeoaaieo oaa?ei.
?ioieneea-oe?yEiio?ieueNa?aaeiy eaoaeueia eiioeaio?aoe?y
?a/iaeieNa?aaeiy eaoaeueia eiioeaio?aoe?y + “Eaeueiio?e”Iia. iaoya *10-3
i/iIae?ioa-ae o 10-3 ieIia. iaoya *10-3 i/iIae?ioaae o 10-3 ieIia.
iaoya*10-3 i/iIae?ioaae o 10-3
ieIi?ia15,20±0,640,1±0,3Iai?ioai–7,8±1,754,9±0,714,7±0,542,2±2,7Ai?ae–
6,4±0,951,3±1,613,8±0,642,0±0,9Aaicei–8,20±1,0249,9±0,515,8±0,347,6±0,8
3. Aioeieneaeaioi? aeanoeaino? “ii?nueeeo” oinoie?i?ae?a
I?e aeine?aeaeaii? aioeieneaeaioieo aeanoeainoae i?aia?aoo “Eaeueiio?e”
o ii??aiyii? ?c caaaeueiia?aeiiei aioeieneaeaioii a?oai?iii A o
aeine?aeao in vitro aeyaeaia aeicicaeaaeia caeaoi?noue i?aia?aoo
aaeueioaaoe IIE (oaae.3.1).
Oaaeeoey 3.1
Iaeiie/aiiy IAeA o aiiiaaiao? ia/?iee uo??a a i?ioean? niiioaiiiai IIE
i?e aeiaeaaaii? ie?aii a?oai?io A oa i?aia?aoo “Eaeueiio?e” a aeine?aeao
in vitro (n=7, M±m).
Aeica i?aia?ao?a o i?ia? (iea/ca 60 oa.)Ai?no IAeA (iiieue/ia
a?eea)Aaeueioaaiiy IIE i?aia?aoaie (%).A?oai?i A“Eaeueiio?e”A?oai?i
A“Eaeueiio?e”Eiio?ieue0,47±0,15030,45±0,010,47±0,021050,45±0,010,47±0,01
10200,42±0,050,44±0,1272300,40±0,060,44±0,14103400,37±0,030,43±0,4020450
0,27±0,010,44±0,094041000,24±0,010,38±0,0150202000,14±0,020,33±0,0270305
000,04±0,01*0,21±0,06924510000,04±0,02*0,16±0,03*9265I?ei?oea. * –
a?aei?iiino?, a??ia?aei? o ii??aiyii? c eiio?ieai (?
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