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EAA?IAO I?I?NO??A OE?A?IE

IAOe?IIAEUeIEE AA?A?IEE OI?AA?NEOAO

OAeE 619:616.9.578.828.

11:577.1:636.2

EIAAEAIEI

Ea?ena Aieiaeeie??aia

IA?AEENIA IEENEAIIss E?I?Ae?A OA OOIEOe?IIAEUeIEE NOAI A?EO?IOeEO?A
AAEEEI? ?IAAOI? OOAeIAE I?E EAEEIC?

03.00.04 – a?io?i?y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa a?ieia?/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a ?inoeooo? aenia?eiaioaeueii? ? ee?i?/ii? aaoa?eia?ii?
iaaeeoeeie OAAI oa a?aeae?eao a?io?i?? ? a?io?ceee ?inoeoooo i?iaeai
e??ia?ieia?? ? e??iiaaeeoeeie IAI Oe?a?ie

Iaoeiaee ea??aiee – aeieoi? iaaee/ieo iaoe, i?ioani?, /eai-ei?aniiiaeaio
IAI Oe?a?ie A?eion Aiieii Iaeneiiae/, ?inoeooo i?iaeai e??ia?ieia?? ?
e??iiaaeeoeeie IAI Oe?a?ie, aieiaiee iaoeiaee ni?a?ia?oiee

Io?oe?ei? iiiiaioe – aeieoi? a?ieia?/ieo iaoe, Eaca??a Ieaen?e Iaaeiae/,
?inoeooo aaoa?eia?i? iaaeeoeeie OAAI, caa?aeoaa/ eaai?aoi??? a?io?i??

– aeieoi? iaaee/ieo iaoe, i?ioani? Oeyoiaaiei Aieiaeeie? Ieaen?eiae/,
?inoeooo aenia?eiaioaeueii? iaoieia??,iieieia?? ? ?aae?ia?ieia?? ?i.
?.A.Eaaaoeueeiai IAI Oe?a?ie, caa?aeoaa/ a?aeae?eo aiceiieia??

I?ia?aeia onoaiiaa – Oa?e?anueeee aea?aeaaiee oi?aa?neoao, eaoaae?a
a?io?i??

Caoeno aeena?oaoe?? a?aeaoaeaoueny “_12__” aa?aciy 1999 ?. i 14.00
aiaeei? ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.004.08 o
Iaoe?iiaeueiiio aa?a?iiio oi?aa?neoao? ca aae?anith: 252041, Ee?a-41,
aoe. Aa?i?a Iai?iie, 15, iaa/aeueiee ei?ion 3, aoae. 65.

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Iaoe?iiaeueiiai
aa?a?iiai oi?aa?neoaoo ca aae?anith: 252041, Ee?a-41, aoe. Aa?i?a
Iai?iie, 11, iaa/aeueiee ei?ion 10.

Aaoi?aoa?ao ?ic?neaiee 6 ethoiai 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee _________ Oea?e?oianueeee I.?.

Caaaeueia oa?aeoa?enoeea ?iaioe

Aeooaeuei?noue oaie. Oe?iea ?iciianthaeaeaiiy eaeeico (I.I. Aeaen??a,
?.A. Ai?iioeia 1988; A.I. Oeoeia ? ni?aaao., 1988; I.A. N?iiiyi 1995;
I.I. Aeinoi?anueeee, 1997; S.G. Hopkins, R.F. Digiacomo, 1996),
iiae?ai?noue eiai iaoiaaiaco o ethaeeie ? oaa?ei, a oaeiae iayai?noue
caaaeueieo aeaoa?i?iaio a??on?a aeaii? ?ioaeoe?? o aaeeei? ?iaaoi?
ooaeiae oa O-ee?oeiiiai eaeeico ethaeeie noaaeyoue aeine?aeaeaiiy
eaeeico aaeeei? ?iaaoi? ooaeiae a ?yae aaaeeeaeo caaaeueiia?ieia?/ieo oa
ia?iaeiiainiiaea?nueeeo caaaeaiue (C.A. Aooaiei ? ni?aaao., 1984, 1989;
I.N. Iaiaeea?a, 1995; A.?. Oeeiaae, 1998).

Ia oii? iioae?eiaaieo iaoeiaeo i?aoeue, i?enay/aieo aea/aiith
ao?iiaoiaaiaco eaeeic?a (Ae.O. Aeociai 1978; A.I. Oeyoiaaiei ? ni?aaao.,
1993, ?.A. Ai?e?i ? ni?aaao., 1998; T.M. Cherney, R.P. Schuliz, 1996),
aeanoeainoae a?eeo ee?oei e?ia? (A.A. A?iiooaei, 1979; I.?. Aoethe?i ?
ni?aaao., 1989; I.A. Eoci?oeiaa ? ni?aaao., 1992; M.van Lindern at all.,
1992), ? aeoaea iacia/ia e?euee?noue ?ia?o, aaoi?e yeeo aea/aee
iaoaaie?/i? oa no?oeoo?ii-ooieoe?iiaeuei? c?ooaiiy a?eo?ioeeo?a i?e
cacia/ai?e iaoieia?? o ethaeeie oa n?eueneiainiiaea?nueeeo oaa?ei.
Anoaiiaeaii, ui i?e eaeeic? ci?ith?oueny oi?ia ee?oei (A.A. ?aeia ?
ni?aaao.,1990), ?ioaineai?noue iaoaaie?/ieo i?ioean?a a ieo (I.I.
A?eai?’?aa, 1979) oa neeaae oinoie?i?ae?a iaia?ai a?eo?ioeeo?a
(A.I. Aaiaeo, 1975); ii?ooo?oueny ?o eeneioii-iniioe/ia ?acenoaioiinoue
(A.I. Eaaee?iaa, 1969; E.A.?iaiaeeia, A.A.Ethey?aa,1987; I.A.
Ceaoiiaa,1994). Iaeiae oe? aeai? ia aeicaieythoue anoaiiaeoe caaaeuei?
caeiiii??iino? oa oa?aeoa? a?io?i?/ieo ci?i a a?eo?ioeeoao, ye?
i?ecaiaeyoue aei cieaeaiiy ia?oe?aeueiiai oeneo eenith a oeaieiao oai?eo
ia eaeeic oaa?ei (I.A.Iao?aeia, 1989) oa ?icaeoeo aiai?? ia
oa?i?iaeuei?e noaae?? oai?iae (A.I. Oeoeia ? ni?aaao.,1986).

Aacoth/enue ia e?oa?aoo?ieo aeaieo i?i a?aaeaiiy a??onii eaeeico
noaieiaeo iie?iioaioieo ee?oei e?noeiaiai iiceo (C.A. Aooaiei, 1985;
I.I. Ae?iia, 1990; ?.I. Aaee, Ae. Aoooo??i?, 1991), iiaeia i?iaiicoaaoe
a??on?iaeoeiaai? ci?ie a?io?i?/ieo i?ioean?a a a?eo?ioeeoao, ye?
i?ecaiaeyoue aei ii?ooaiiy ooieoe?iiaeueiiai noaio oeeo ee?oei, ? oei
naiei ni?e/eiythoue ?icaeoie aoi?eiieo iaoio?i?/ieo ci?i o oai?iio ia
eaeeic i?aai?ci?.

Aeoiaey/e c aeuaneacaiiiai, i?iaaaeai? iaie aeine?aeaeaiiy aoee
cina?aaeaeai? ia aea/aii? iniaeeainoae iiaeeo?eaoe?? a?io?i?/ieo
i?ioean?a a iaia?aiao oa oeeoiieaciaoe/ieo ooieoe?iiaeueieo nenoaiao
a?eo?ioeeo?a aaeeei? ?iaaoi? ooaeiae a aeeiai?oe? eaeeiciiai i?ioeano.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. ?iaioa
aeeiioaaeanue o a?aeiia?aeiino? aei iaoeiai? oaiaoeee “Noai?aiiy
?ioaa?iaaii? nenoaie caoenoo aaeeei? ?iaaoi? ooaeiae a?ae eaeeico”
(iiia? aea?aeaaii? ?a?no?aoe?? 0197V000756).

Iaoa ? caaea/? aeine?aeaeaiue. Iaoa ?iaioe iieyaa? o aeyaeaii?
iniaeeainoae i?ioean?a ia?aeeniiai ieeneaiiy e?i?ae?a iaia?ai oa
ooieoe?iiaeueiiai noaio a?eo?ioeeo?a aaeeei? ?iaaoi? ooaeiae ia ??cieo
noaae?yo ?icaeoeo niiioaiiiai eaeeico.

O ca’yceo c oeei aoee iinoaaeai? oae? caaea/?:

1) aeine?aeeoe ??aaiue ia?aeeniiai ieeneaiiy e?i?ae?a (IIE), a oaeiae
aeoeai?noue aeooao?iicaeaaeieo oa?iaio?a – aeooao?iiia?ieneaeace (GSH-?;
EO. 1.11.1.9) ? aeooao?ii?aaeoeoace (GSH-R; EO.1.6.4.2);

2) anoaiiaeoe oa?aeoa? iiaeeo?eaoe?? a?ee?a i?eiaia?aiiiai ea?eano
a?eo?ioeeo?a;

3) aea/eoe noai i?iieeeeaino? iaia?ai a?eo?ioeeo?a aeey ?ii?a eaeueoe?th
a aeeiai?oe? eaeeiciiai i?ioeano;

4) aeine?aeeoe aieea eaeeicii? ?ioaeoe?? ia e?euee?ni? oa ye?ni?
oa?aeoa?enoeee aaiiaeia?io;

5) c’ynoaaoe oaeaee?noue ?iciaaeo oinoi?i?aai?/ieo niieoe (AOP, ADP) a
a?eo?ioeeoao ca aeiiiiiaith iaoiaeo yaea?iiai iaai?oiiai ?aciiaino
(ssI?).

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aeai?, ye? aena?oeththoue
oa?aeoa? ci?i ?yaeo no?oeoo?ii-ooieoe?iiaeueieo nenoai a?eo?ioeeo?a
aaeeeie ?iaaoi? ooaeiae i?e eaeeic?, io?eiai? aia?oa. Anoaiiaeaii, ui
a?eo?ioeeoe caeo/athoueny aei iaoieia?/iai i?ioeano aaea ia i?eoiaai?e
noaae?? eaeeico, i?i ui na?ae/eoue ii?ooaiiy ??aiiaaae o ni?aa?aeiioaii?
oi?i aaiiaeia?io: i?aeaeuo?oueny ai?no iaoaaiiaeia?io (Hi) oa
cieaeo?oueny ieneaaiiaeia?io (HbO). C?inoa? oaeiae aeoeai?noue GSH-P, ui
? iaei??th c i?e/ei cieaeaiiy ?ioaineaiino? i?ioean?a IIE ia ianooii?e,
noaeaeeai?/i?e noaae?? eaeeico. Ii?yae c oeei a?aeaoaa?oueny cieaeaiiy
aeoeaiinoi GSH-R, ?ioaineaiino? i?iieeiaiiy Na2+ a a?eo?ioeeoe oa
iineeaiiy anioe?aoeaieo ca’yce?a niaeo?eio c ye??ieie a?eeaie iaia?ai
a?eo?ioeeo?a. Eaeeai?/ia noaae?y oa?aeoa?eco?oueny iiaeeaeaiiyi
iaoieia?/ieo c?ooaiue o /a?aiieo ee?oeiao e?ia?. Anoaiiaeai? a?io?i?/i?
ci?ie no?oeoo?iiai oa ooieoe?iiaeueiiai noaio nenoai ee?oeie o?nii
iia’ycai? c? ci?iith iaoaaie?cio oinoi?i?aai?/ieo niieoe oa c
iiieaeaiith caeaoi?noth a?eo?ioeeo?a i?aeo?eioaaoe iioeiaeueiee ??aaiue
?I aac aeinooio aetheice c ?icaeoeii eaeeico.

I?aeoe/ia cia/aiy iaea?aeaieo ?acoeueoao?a. Io?eiai? aeai? aeicaieeee
anoaiiaeoe iaoai?cie ci?i no?oeoo?ii-iaoaaie?/ieo i?ioean?a ye a
a?eo?ioeeoao, oae ? oe?eiio i?aai?ci? i?e e?ioii?ie?oa?aoeaieo
caoai?thaaiiyo, ui ia?aa?aathoue c ?icaeoeii ?ioiiaeao?oeeoiiai noaio.
?acoeueoaoe ?iaioe a?aoiaai? i?e ?ic?iaoe? iaoeiai? oaiaoeee ?inoeoooo
aenia?eiaioaeueii? ? ee?i?/ii? aaoa?eia?ii? iaaeeoeeie, a eaai?aoi??yo
a?io?i?? oa aea/aiiy oai?ia iieiaeiyea yeiai cai?iaaaeaeaii ?yae
aeei?enoaieo o ?iaio? iaoiaee/ieo i?aeoiae?a, a oaeiae a o/aiaiio
i?ioean? eaoaae?e oa?ai?? A?eioea?e?anueeiai aea?aeaaiiai aa?a?iiai
oi?aa?neoaoo.

Iniaenoee aianie caeiaoaa/a o ?ic?iaeo iaoeiaeo ?acoeueoao?a.
Caeiaoaa/ai aeanii?o/ii i?iaaaeaii ee?i?/i?, na?ieia?/i? oa a?io?i?/i?
aeine?aeaeaiiy, a oaeiae cae?eniaii aiae?oe/io oa iaoaiaoe/io ia?iaeo
iaea?aeaieo ?acoeueoao?a. Ca aaciina?aaeiuei? o/ano? caeiaoaa/a
?ic?iaeyeanue iaoiaeeea aeine?aeaeaiue. I?e aeeiiaii? aeayeeo aeae?a
?ia?o eiinoeueoaoeaio ? oaoi?/io aeiiiiiao iaaeaaaee ni?a?ia?oieee
a?aeiia?aeieo i?ae?icae?e?a iaoeiaeo onoaiia, o yeeo aeeiioaaeanue
?iaioa. Aeine?aeaeaiiy iaoiaeii yaea?iiai iaai?oiiai ?aciiaino
i?iaiaeeeenue ni?eueii ?c caa?aeoaa/ai eaai?aoi??? yaea?ii-iaai?oiiai
?aciiaino ?inoeoooo i?iaeai e??ia?ieia?? oa e??iiaaeeoeeie, aeieoi?ii
a?ieia?/ieo iaoe A.Ae. C?i/aieii.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. ?acoeueoaoe aeena?oaoe?? aoee
i?aaenoaaeai? ia I?aeia?iaeieo iaoeiai-i?aeoe/ieo eiioa?aioe?yo
(I?inuee, 1996; Aieiaeeie?, 1996 ; Oa?e?a, 1997), ?anioae?eainueeeo
iaoeiaeo oa iaoeiai-i?aeoe/ieo eiioa?aioe?yo (Euea?a, 1995, 1997; A?ea
Oea?eaa, 1995; Oa?e?a, 1995, 1997; ??aia, 1998) oa can?aeaiiyo A/aii?
?aaee ?inoeoooo aenia?eiaioaeueii? ? ee?i?/ii? aaoa?eia?ii? iaaeeoeeiee
OAAI (Oa?e?a,1994 1995).

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 12 iaoeiaeo
i?aoeue, a yeeo aena?oeaii iniiaiee ci?no iaoeiaeo aeine?aeaeaiue.

No?oeoo?a oa ianya aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 139
noi??ieao iaoeiiieniiai oaenoo, i?noeoue 9 oaae., 19 ?enoie?a ?
neeaaea?oueny c anooio, iaeyaeo e?oa?aoo?e, iaoa??ae?a aeanieo
aeine?aeaeaeaiue, aeniiae?a oa nieneo aeei?enoaii? e?oa?aoo?e c 269
aeaea?ae, c yeeo 80 – ?iicaii?.

CAAAEUeIA IAOIAeEEA OA INIIAI? IAOIAeE AeINE?AeAEAIUe

?iaioa aeeiiaia o 1993-1995 ?.?. a ?inoeooo? aenia?eiaioaeueii? ?
ee?i?/ii? aaoa?eia?ii? iaaeeoeeie OAAI, a?aeae?eao a?io?i?? ? a?io?ceee
?inoeoooo i?iaeai e??ia?ieia?? oa e??iiaaeeoeeie IAI Oe?a?ie.

Ia’?eoii aeine?aeaeaiiy aoee a?eo?ioeeoe oa ieacia (i?e aecia/aii?
?ioaineaiino? IIE), aeae?eai? c e?ia? 130 ei??a 3-5 ??/iiai a?eo a
ceiiaee ia??iae. Ca ?acoeueoaoaie aaiaoieia?/ieo oa na?ieia?/ieo
aeine?aeaeaiue oe? oaa?eie aoee ?iciiae?eai? ia 5 a?oi: ia?oa a?oia
-oaa?eie, a?euei? a?ae a??ono eaeeico aaeeei? ?iaaoi? ooaeiae (BLV),
eiio?ieue; ae?oaa – c i?eoiaaiei ia?aa?aii ?ioaeoe??; o?aoy – c
noaeaeeai?/ieie iciaeaie caoai?thaaiiy; /aoaa?oa – c eaeeai?/iei i?iyaii
caoai?thaaiiy; i’yoa – ia ee?i?/i?e noaae?? ?icaeoeo eaeeico.

Ee?i?/iee noai oa aaiaoieia?/i? iieacieee oaa?ei aecia/aee ca
aeiiiiiaith caaaeueiii?eeiyoeo iaoiaeee, a iai?oaeai?noue niaoeeo?/iiai
?ioi?oaoo – ca ?aaeoe??th ?ioiiaeeooc??.

Niaeo?ioioiiao?e/iei iaoiaeii aecia/aee e?euee?noue a?eo?ioeeo?a (A.O.
Caaieioeueeee, A.?. Iieyeia, 1965) oa ai?no a ieo caaaeueiiai
aaiiaeia?io (A.A. Aea?a?oe, A.I. Ai?iaeia, 1959).

Aeey a?io?i?/ieo aeine?aeaeaiue aeei?enoiaoaaee e?ia, yeo noaa?e?coaaee
aetheici-oeeo?aoiith noi?ooth a ni?aa?aeiioaii? 4:1.

A?eee iaia?ai a?eo?ioeeo?a aeine?aeaeoaaee iaoiaeii aeaeo?ioi?aco a IAAA
(U.K.Laemmli, 1970), c iiia?aaei?i iaea?aeaiiyi “a?eeo o?iae” oeyoii
a?iioii?/iiai e?ceno oa ?o ia?iaeith 1%-iei ?ic/eiii SDS-Na.

Ioe?ithth/e ?ioaineai?noue i?ioean?a IIE, a?aoiaoaaee oa?aeoa?
niiioaiii? oa ?iaeoeiaaii? ?iiaie Fe2±oai?ethi?i?noeaioe?? (OE) 5%-ii?
noniaic?? a?eo?ioeeo?a a ?ic/ei? Dulbecco (Serva). Aei??thaaiiy
i?iaiaeeee ia a?ioai?ethiaiiiao?? AOE-06 i?ioyaii 3 oa. ??aaiue
ae??iiaeo eiiuethaao?a (AeE) a aaioaiiaeo aeno?aeoao a?eo?ioeeo?a oa
ieacie e?ia? aei??thaaee ca aeiiiiiaith niaeo?ioioiiao?a NO-16 i?e ?=232
ii (A.A. Aaa?eeia, I.?. I?oei?oaeia, 1983). E?euee?noue iaeiiiaiai
aeeaeueaeaa?aeo (IAeA) a a?eo?ioeeoao oa ieaci? e?ia? aecia/aee ca
aeiiiiiaith ?aaeoe?? c o?iaa?a?oo?iaith eeneioith (L.A. Buege, S.D.
Aust, 1975).

Aeoeai?noue GSH-P (EO 1.11.1.9). ioe?ithaaee ca oaeaee?noth ieeneaiiy
aeooao?iio a i?enooiino? a?ae?iia?aeeno o?aoe/iiai aooeeo,
aeei?enoiaoth/e niaeo?ioioiiao??th ia NO-16 (A.I. Ii?i, 1986), a GSH-R
(EO.1.6.4.2) – ca oaeaee?noth ieeneaiiy NAD?H (ss.I. Aa?an?iia, E.O.
Iai/aiei, 1975) ca aeiiiiiaith aeaii?iiaiaaiai niaeo?ioioiiao?a
“Spekord” UV-VIS.

Oaeaee?noue aoiaeo 45Na2+ a a?eo?ioeeoe ?ic?aoiaoaaee ca aeiiiiiaith
?aae?ia?ao?/iiai iaoiaeo (I.?. Iieoae?i, A.A. Iao?oiyea, 1988).

Ai?no oi?i aaiiaeia?io a a?eo?ioeeoao aecia/aee oeyoii aeeoa?aioe?eii?
niaeo?ioioiiao??? ca A. Zwart et al., (1973), aeei?enoiaoth/e
niaeo?ioioiiao? PUE UNICAM SP-800.

Aeey ia?oei?aiiai eiio?ieth ca oaeaee?noth ooee?caoe?? iae?ia?a?/ieo
niieoe (AO?, ADP) aeei?enoiaoaaee iaoiae 31?-ssI?. ??aaiue ?I a
a?eo?ioeeoao aecia/aee ca iaoiaeeeith R.B. Moon, J.M. Richards, (1973).
Niaeo?e 31?-ssI? io?eioaaee ca aeiiiiiaith niaeo?ioioiiao?a Bruker
CXP-200 c ?iai/ith /anoioith 80, 99 Aoe. Aeei?enoiaoaaee 60-a?aae?aioi?
?iioeuene, ye? iiaoi?thaaeenue eiaei? 3 nae. A?eo?ioeeoe io?eioaaee a?ae
caei?iaeo ei??a oa oaa?ei ia i?eoiaai?e ? eaeeai?/i?e noaae?yo ?icaeoeo
eaeeico. O eiaei?e a?oi? aoei aeine?aeaeaii ia iaioa 5 oaa?ei.

Noaoenoe/io ia?iaeo aenia?eiaioaeueieo aeaieo i?iaiaeeee ia
ia?niiaeuei?e AAI c aeei?enoaiiyi e?eoa???a O?oa?a-Nouethaeaioa.

INIAEEAINO? EE?I?EI – AAIAOIEIA?*IIAI OA ?IOIIEIA?*IIAI NOAOONO
OAA?EI IA ??CIEO NOAAe?ssO EAEEICIIAI I?IOeANO

Na?ieia?/i? aeine?aeaeaiiy iieacaee, ui ?icaeoie eaeeiciiai i?ioeano
noi?iaiaeaeo?oueny i?aeaeuaiiyi oeo?o aioeo?e aei a??ono eaeeico aaeeei?
?iaaoi? ooaeiae a ne?iaaooe? e?ia? c 1:1-1:2 ia i?eoiaai?e noaae??
?ioaeoe?? aei 1:128 i?e ee?i?/ieo iciaeao caoai?thaaiiy. E?euee?noue
eaeeioeeo?a a e?ia? c?inoaea aei 17,7+1,35 oen/iee ? aei 25,2+5,06
oen/iee. ia eaeeai?/i?e oa ee?i?/i?e noaae?yo a?aeiia?aeii, 92-98% yeeo
noaiiaeee e?ioioeeoe. I?e aecia/aii? e?eueeino? a?eo?ioeeo?a oa ai?noo a
ieo caaaeueiiai aaiiaeia?io ia noaae?yo, ui aea/aeeny, a iieacieeao
caei?iaeo oa oai?eo ia eaeeic ei??a nooo?aeo a?aei?iiinoae ia aeyaeaii.

Iaeiae i?e aeine?aeaeaii? a?io?i?/ieo i?ioean?a a a?eo?ioeeoao aoei
aeiaaaeaii, ui c ?icaeoeii eaeeico aaeeei? ?iaaoi? ooaeiae
a?aeaoaathoueny ci?ie iaoaaie?/iiai oa no?oeoo?iiai noaio iaia?aie ?
oeeoiieaciaoe/ieo nenoai oeeo ee?oei, aeeaeia i?iyao yeeo caeaaeeoue
a?ae noaae?? ?ioaeoe?eiiai i?ioeano.

?IOAINEAI?NOUe I?IOeAN?A IIE A AeEIAI?Oe? BLV – ?IOAEOe??

A a?eo?ioeeoao oa ieaci? e?ia? caei?iaeo ei??a ia anoaiiaeaii
aeinoia??ieo a?aei?iiinoae i?ae ??aiai niiioaiii? oa ? ?iaeoeiaaii?
oai?ethi?ianoeaioe??(OE). Eaeeiciee i?ioeann nooo?ai ci?ith?
?ioaineai?noue ia?aeenieo i?ioean?a a i?aai?ci? oaa?ei (?en. 1). Ia
i?eoiaai?e oa noaeaeeai?/i?e noaae?yo i?iyao ?ioaeoe?? ??aaiue
niiioaiii? OE a?eo?ioeeo?a i?aeaeuo?oueny ia 22 ? 27%, a?aeiia?aeii, a o
oaa?ei c eaeeai?/iei ia?aa?aii iaiieanoe/iiai i?ioeano IIE
i?eai?/o?oueny ia 41% o ii??aiyii? c eiio?ieueieie iieacieeaie.

?ioaineai?noue ?iaeoeiaaii? Fa2± OE a a?ieia?/ieo ia’?eoao ci?ithaaeanue
ii-?ioiio. A ieaci? oeae iieaciee i?aeaeuoaaany a 1, 4 ?ace aaea ia
i?eoiaai?e noaae?? ?ioaeoe?? ? caeeoaany i?aeoe/ii iaci?iiei ia
ianooiieo noaae?yo. A a?eo?ioeeoao iiae?ai? ci?ie ianoaaaee eeoa ia
noaae?? aaiaoieia?/iiai i?iyao eaeeico (3-oy ? 4-oa a?oie), ui aeaco? ia
caa?aaeaiiy aioeieneaeaioieo nenoai a oeeo ee?oeiao ia noaae??
i?eoiaaiiai ia?aa?ao ?ioaeoe??.

?en. 1. Caeaaei?noue ?ioaineaiino? niiioaiii? (A) oa ?iaeoeiaaii? (A)
oai?ethi?ianoeaioe?? a?eo?ioeeo?a a?ae e?eueeino? eaeeioeeo?a (e?eaa) o
e?ia? oaa?ei: 1 – caei?ia? oaa?eie (eiio?ieue); 2 -c i?eoiaaiei
ia?aa?aii ?ioaeoe??; 3 – ia noaeaeeai?/i?e ? 4 – ia eaeeai?/i?e noaae?yo
caoai?thaaiiy.

Iieacieee OE oa?aeoa?ecothoue caaaeueiee ??aaiue i?ioean?a
ia?aieeneaiiy, aea ia ?ice?eaathoue ?o aeeiai?ee. O ca’yceo c oeei ie
aecia/aee eiioeaio?aoe?th ae??iiaeo eiiuethaao?a (AeE) ? iaeiiiaiai
aeeaeueaeaa?aeo (IAeA) a e?ia? aaeeei? ?iaaoi? ooaeiae ia ??cieo
noaae?yo eaeeiciiai i?ioeano.

I?e aecia/aii? ??aiy AeE aoei anoaiiaeaii, ui ?o eiioeaio?aoe?y c
ia?aa?aii ?ioaeoe?? ci?ith?oueny. C aeaieo ?en. 2 aeieeaa?, ui ? a
a?eo?ioeeoao, ? a ieaci? e?ia? i?eoiaaii ?io?eiaaieo ei??a (2-aa a?oia)
niinoa??aa?oueny oaiaeaioe?y aei cieaeaiiy ??aiy AeE; ??cieoey i?ae
iieacieeaie eiio?ieueii? oa 3-? a?oi oaa?ei noa? noaoenoe/ii
aeinoia??iith, a a a?eo?ioeeoao ei??a 4-? a?oie ai?no AeE ciaioo?oueny
ia 25% ii??aiyii c eiio?ieai (??0, 05). A ieaci? e?ia? aeyaeaii iacia/i?
eieeaaiiy ??aiy AeE, ui caeaaeaee a?ae noaae?? eaeeiciaaiaco, iaeiae
iaeieae/eeee ?o ??aaiue anoaiiaeaii o oaa?ei 4-? a?oie.

a?eo?ioeeoe ieacia e?ia?

?en. 2. ??aaiue ae??iiaeo eii’thaao?a o e?ia? ei??a, ?io?eiaaieo BLV.1 –
caei?ia? oaa?eie (eiio?ieue), 2 – c i?eoiaaiei ia?aa?aii ?ioaeoe??, 3 –
ia noaeaeeai?/i?e ? 4 – ia eaeeai?/i?e noaae?yo caoai?thaaiiy.

Aiaeia?/ia oaiaeaioe?y niinoa??aaeanue uiaei e?eueeino? IAeA a
a?eo?ioeeoao (?en.3).C ?icaeoeii caoai?thaaiiy eiai ai?no iinooiiai
cieaeoaaany; ia eaeeai?/i?e noaae?? oea cieaeaiiy aeinyaaei iaeaea
35%(??0, 05) a?ae eiio?ieueieo iieaciee?a.

?en.3. Ai?no iaeiiiaiai aeeaeueaeaa?aeo a a?eo?ioeeoao (A) oa ieaci?
e?ia? (A) ei??a, ?io?eiaaieo BLV. 1-caei?ia? oaa?eie (eiio?ieue); 2-c
i?eoiaaiei ia?aa?aii ?ioaeoe??; 3 – ia noaeaeeai?/i?e ? 4 – ia
eaeeai?/i?e noaae?yo caoai?thaaiiy.

Anoaiiaeaia cieaeaiiy eiioeaio?aoe?? a?eueieo ?aaeeeae?a, AeE oa IAeA a
iaia?aiao a?eo?ioeeo?a ? a ieaci? e?ia? na?ae/eoeoue, ui c ?icaeoeii
eaeeico a?aeaoaa?oueny i?eai?/aiiy i?ioean?a IIE a e?ia? aaeeei? ?iaaoi?
ooaeiae.

Oea yaeua, i/aaeaeii, iia’ycaia c iiaeeo?eaoe??th e?i?aeiiai neeaaeo
iaia?ai ee?oei i?e iaiieanoe/iiio ?ino? (A.I. Aaiaeo, 1975) oa aeyaeaiei
iaie i?aeaeuaiiyi aeoeaiino? GSH-P ia i?eoiaai?e noaae?? ?ioaeoe??.

AEOEAI?NOUe AEOOAO?IICAEAAEIEO OA?IAIO?A AIOEIENEAeAIOII? NENOAIE
A?EO?IOeEO?A

Aeoiaey/e c aaaeeeai? ?ie? aeooao?iicaeaaeieo oa?iaio?a o iaoaaie?ci?
a?eo?ioeeo?a oa i?aeo?eiaii? aiiainoaco ?o aioo??oiueiai na?aaeiaeua ie
aea/aee aeoeai?noue GSH-P oa GSH-R a a?eo?ioeeoao aaeeei? ?iaaoi?
ooaeiae a aeeiai?oe? eaeeiciiai i?ioeano. sse aeaeii c aeaieo oaae. 1,
aeoeai?noue GSH-P ??cei (ia 53%) i?aeaeuo?oueny o oaa?ei 2-? a?oie ? ia
ianooiieo noaae?yo caoai?thaaiiy ia?aaeuo? eiio?ieuei? aaee/eie ia
41-38%. I?e oeueiio ?icaeoie aaiaoieia?/ieo iciae eaeeico, yeui
ii??aithaaoe c i?eoiaaiith noaae??th ?ioaeoe??, noi?iaiaeaeo?oueny
oaiaeaioe??th aei cieaeaiiy oeueiai iieacieea.

Aeoeai?noue oa?iaioo GSH-R a a?eo?ioeeoao ei??a c ?icaeoeii eaeeiciiai
i?ioeano cieaeo?oueny. O oai?eo oaa?ei 3-? a?oie oea cieaeaiiy noa?
noaoenoe/ii aeinoia??iei ? nyaa? 31%, a ia eaeeai?/i?e noaae?? – 53%
ii??aiyii c eiio?ieai.

Ii?ooaiiy aeoeaiino? aeuacacia/aieo oa?iaio?a i?ecaiaeeoue aei ci?ie
eiioeaio?aoe?e o?aeoe?e aeooao?iio a?eo?ioeeoao. A ee?oeiao caei?iaeo
oaa?ei ??aaiue a?aeiiaeaiiai aeooao?iio (GSH) noaiiaeoue 30, 8+1, 48
ia%; ?icaeoie aaiaoieia?/ieo iciae eaeeico noi?iaiaeaeo?oueny iacia/iei
ciaioaiiyi eiai ai?noo, a ee?i?/ia noaae?y oa?aeoa?eco?oueny
aeinoia??iei cieaeaiiyi oeueiai iieacieea ia 27% ii??aiyii c eiio?ieai.
Ai?no ieeneaiiai aeooao?iio (GS-SG) i?aeaeuo?oueny a 1,5 ?aca o ei??a
2-? a?oie, a o oaa?ei 3-? ? 4-? – a 2,5 ? 3,6 ?aca, a?aeiia?aeii,
ii??aiyii c eiioi?ieueiei iieacieeii 2,7±0,25 ia%. A?eo?ioeeoe ei??a 5-?
a?oie i?noyoue a 5,6 ?aca a?eueoa iaaeoeaii? oi?ie aeooao?iio, i?ae
eiio?ieueii? (??0,001).

Oaaeeoey 1

Aeoeai?noue GSH-P ? GSH-R a?eo?ioeeo?a ei??a, oai?eo ia eaeeic (I±m)

A?oia

Noaae?y i?ioeano

nGSH-P,

ieiieueGSH/

a Hb oaGSH-R,

ieiieue NADPH/

1 a Hb oa1caei?ia?
oaa?eie20168,5±14,04,5±0,52i?eoiaaia20258,5±20,3*3,8±0,63noaeaeeai?/ia14
237,2±20,8*3,1±0,3*4eaeeai?/ia20233,2±19,9*2,1±0,8*

I?ei?oea: * – a?aei?iiino? aeinoia??i? (??0, 05) ii a?aeiioaiith aei
eiio?ieth.

A?aoiaoth/e cia/aiiy aeooao?iio oa ?acoeueoaoe aeanieo aeine?aeaeaiue,
iiaeia c?iaeoe aeniiaie, ui iaei??th c i?e/ei cieaeaiiy ?ioaineaiino?
i?ioean?a IIE a a?eo?ioeeoao aaeeei? ?iaaoi? ooaeiae ca eaeeico ?
aeoeaaoe?y GSH-P, oiae? ye ciaioaiiy aeoeaiino? GSH-R i?ecaiaeeoue aei
cieaeaiiy aoaeoeaiino? iiiiaiaiiy ioeo GSI.

Io?eiai? ?acoeueoaoe ni?aiaaeathoue c aeaieie e?oa?aoo?e i?i
eiiiainaoi?io aeoeaaoe?th aioeieenethaaeueieo nenoai a i?aai?ci?
ethaeeie ia ii/aoeiaeo noaae?yo iaiieanoe/iiai ?inoo (TH.I. Eiceia,
1979; E.ss. Na?e?c, 1984; A.O. A?eeinueeee, O.A. Oaoe?/, 1992).

NO?OEOO?II – OOIEOe?IIAEUeI? OA?AEOA?ENOEEE IAIA?AI A?EO?IOeEO?A I?E
EAEEIC?

Aiaeiaaii? ia?aeene e?i?ae?a ? o?c?ieia?/ieie iiaeeo?eaoi?aie
a?ae?ioiaieo aeanoeainoae iaia?ai, ? /anoeiai – ooieoe?? o?ainii?oieo
a?ee?a (TH.I. Eiceia, 1979; TH.A. Aeaae?i??ia ? ni?aaao., 1989). Oiio
iaie aoee aeine?aeaeai? no?oeoo?ii-ooieoe?iiaeuei? oa?aeoa?enoeee
iaia?ai ca oaeaee?noth i?iieeiaiiy ?ii?a Na2+ aei a?eo?ioeeo?a oa
ai?noii iaia?aiieo a?ee?a.

Anoaiiaeaii, ui o caei?iaeo oaa?ei aeoeai?noue i?iieeiaiiy 45Na2+ a
a?eo?ioeeoe aeineoue aeniea ? neeaaea? 1,8 ieiieue/ie ee?oei ca oaeeeio.
Aaea ia i?eoiaai?e noaae?? eaeeico a?aei?/aii cieaeaiiy oaeaeeino?
i?iieeiaiiy Na2+ a a?eo?ioeeoe ia 23% ii??aiyii c eiio?ieai. ?icaeoie
?ioaeoe?? oa?aeoa?eco?oueny iiaeaeueoei aaeueioaaiiyi oaeaeeino?
i?iieeiaiy oeueiai ?iia: ia noaeaeeai?/i?e noaae?? eiai ?ioaineai?noue
cieaeo?oueny a?eueo, i?ae ia 50%, a o oai?eo c eaeeai?/ieie iciaeaie
caoai?thaaiiy – ia 58% (??0,001).

Oae? ci?ie iiaeooue coiiaethaaoenue ii?ooaiiyi eaiaeueiiai o?ainii?oo
Na2+ a ?acoeueoao? ci?i aeanoeainoae iiaa?oi? iaia?aie ee?oei,
iiaeeo?eaoe?? ?o e?i?aeiiai neeaaeo aai ii?ooaiiyi ooieoe?? Na2+-AOOace
(H.J. Schatzman, 1982; B.Sarcadi, 1980).

Ci?ia ?ioaineaiino? i?iieeieiiy Na2+ a ee?oeie, ye i?aaeei, aeeeeea?
ii?ooaiiy aaeaino ?yaeo no?oeoo?ii-ooieoe?iiaeueieo nenoai ee?oei oa
?aaoeyoi?ieo a?ee?a, ooieoe?y yeeo ?aaoeth?oueny ?ii?ciaaiith oi?iith
Na2± (A.I. A?eion, 1983).

Iaie anoaiiaeaii, ui a “a?eeo o?iyo” a?eo?ioeeo?a oaa?ei 3-? a?oie,
ii??aiyii c eiio?ieai, i?ney aeno?aeoe?? noia?ieo a?ee?a caeeoa?oueny ia
20% a?eueoa niaeo?eio, a ia eaeeai?/i?e noaae?? oea ca?eueoaiiy
noaiiaeoue 35% ? noa? noaoenoe/ii a??ia?aeiei. I?aeaeuo?oueny oaeiae
ai?no aeoeio (oaae. 2). A oie aea /an e?euee?nia ni?aa?aeiioaiiy ai?noo
?ioeo a?ee?a oeeoineaeaoo nooo?ai ia ci?ithaaeinue.

I?aeaeuaiiy ai?noo niaeo?eio, yeee caeeoa?oueny a “a?eeo o?iyo”, iiaea
aooe iia’ycaia c ooai?aiiyi i?oei?oeo ca’yce?a niaeo?eio c ye??ieie
a?eeaie iaia?aie.

Oaaeeoey 2

Neeaae iaia?aiieo a?ee?a (%) a “a?eeo o?iyo” a?eo?ioeeo?a ei??a, oai?eo
ia eaeeic (M±m)

A?oie oa noaae??

i?ioeanonO?aeoe?y a?ee?a. Iie.iana, eAeniaeo?ei

220-240a?eie iieine 3 95aeoei

431-caei?ia?
oaa?eie107,7±0,311,4±0,33,1±0,72-i?eoiaaia107,5±0,612,1±0,44,0±0,53-noae
aeeai?/ia79,3±0,7*10,8±0,23,7±0,34-eaeeai?/ia810,4±0,7*11,1±0,53,7±0,3

I?ei?oea: * – a?aei?iiino? aeinoia??i? (??0, 05) ii a?aeiioaiith aei
eiio?ieth.

Aeacai? ci?ie na?ae/aoue i?i iiaeeo?eaoe?th ii?iaeueii? eiino?oeoe??
oeeoineaeaoo, ui i?ecaiaeeoue aei oi?ioaaiiy aei?noe?oi?, ?ea?aeii?
a?eeiai? no?oeoo?e, ? oaeei /eiii ci?ithaaoe ye i?iieei?noue
ieaciaoe/ii? iaia?aie aeey ?ii?a ? iaoaaie?o?a, oae ? ?aieia?/i?
aeanoeaino? ee?oei e?ia?. Oea iniaeeai aaaeeeai aeey a?eo?ioeeo?a,
aieiaiith ooieoe??th yeeo ? iinoa/aiiy eenith a oeaieie i?aai?cio.

NI?AA?AeIIOAIIss ??CIEO OI?I AAIIAEIA?IO A A?EO?IOeEOAO

?acoeueoaoe aeine?aeaeaiue aeicaieythoue noaa?aeaeoaaoe, ui iniaeeai
?aii? ? aeeaie? ci?ie i?e eaeeic? aaeeei? ?iaaoi? ooaeiae
a?aeaoaathoueny naia a nenoai? aaiiaeia?io (oaae.3). A a?eo?ioeeoao
oaa?ei c i?eoiaaiei ia?aa?aii eaeeico anoaiiaeaia ci?ia ii?iaeueiiai
ni?aa?aeiioaiiy ai?noo ??cieo oi?i aaiiaeia?io: ia 64% i?aeaeuo?oueny
e?euee?noue iaoaaiiaieia?io (Hi) ? ia 17% ciaioo?oueny e?euee?noue
ieneaaiiaeia?io (IbO). C ?icaeoeii noaeaeeai?/ii? oa eaeeai?/ii? noaae?e
caoai?thaaiiy iaoieia?/iee i?ioean iiaeeaeth?oueny. Oae, a?eo?ioeeoe
ei??a 3-? oa 4-? a?oi i?noyoue 83 ? 66% HbO i?ioe iieaciee?a
eiio?ieueii? a?oie, ai?no I? i?aeaeuo?oueny ia 63 ? 120%, a e?euee?noue
aeaieneaaiiaeia?io (Hb) noaoenoe/ii aeinoia??ii ca?eueoo?oueny ia 42 ?
64% a?aeiia?aeii. Ii?ooaiiy oa?aeoa?iiai aeey caei?iaeo oaa?ei ai?noo
??cieo oi?i aaiiaeia?io i?ecaiaeyoue aei ci?ie ?o ni?aa?aeiioaiiy a
a?eo?ioeeoao ?io?eiaaii? a??onii eaeeico aaeeei? ?iaaoi? ooaeiae. A
a?eo?ioeeoao ei??a c aaiaoieia?/ieie iciaeaie caoai?thaaiiy iieiaeio
caaaeueii? e?eueeino? aaiiaeia?io neeaaeathoue o? eiai oi?ie, ye? ia
caeaoi? ia?aiineoe eenaiue.

Oaaeeoey 3

Ai?no oi?i aaiiaeia?io a a?eo?ioeeoao caei?iaeo oa ?io?eiaaieo BLV ei??a
(M±m)

A?oieNoaae?y i?ioeanonOi?ie aaiiaeia?io % HbOHbHi1caei?ia?
oaa?eie4574,3±1,611,0±0,914,6±1,12i?eoiaaia4062,0±1,3*14,6±0,923,6±0,7*3
noaeaeeai?/ia1460,5±2,0*15,7±0,8*23,8±1,9*4eaeeai?/ia2149,6±2,2*18,0±2,4
*32,3±1,6*I?ei?oea: * – a?aei?iiino? aeinoia??i? (??0, 05) ii
a?aeiioaiith aei eiio?ieth.

Io?eiai? ?acoeueoaoe aeathoue i?aenoaao noaa?aeaeoaaoe, ui aaea ia
noaae?? ?io?eoaaiiy a??onii eaeeico a a?eo?ioeeoao ei??a a?aeaoaa?oueny
iineeaia ieeneaiiy Fe2+ aaio aei Fe3+, yeee ia iiaea i?e?aeioaaoe
eenaiue oa ia?aiineoe eiai aei oeaiei. Niinoa??aa?oueny oaeiae cieaeaiiy
??aiy ieneaaiaoe?? Ib. An? oe? oaeoi?e iiaeooue neoaeeoe i?e/eiith
ciaioaiiy ieneaaiaoe?? i?aai?cio oa ?icaeoeo a?iien?? o oai?eo ia eaeeic
oaa?ei (I.I. Iao?aeia, 1989).

Aeyaeai? iaie ci?ie noaio aai?iiaiai cae?ca iiaeooue aooe iaoiiaeai?
aieeaii ??ciiiai?oieo ieeniee?a, ooai?aiiyi iieaeoe aaiiaieia?io c
aeia?iiaith /anoeiith, yea ni?ey? ieeneaiith aaia oa ci?iith ??aiy ?I a
a?eo?ioeeo?. Oea niiioeaei ian aea/eoe aeeiai?eo ?iciaaeo
oinoi?i?aai?/ieo niieoe a a?eo?ioeeoao iaoiaeii yaea?iiai iaai?oiiai
?aciiaino ia yae?ao oinoi?o (31?-ssI?), yeee aea? iiaeeea?noue aecia/aoe
aaee/eio ?I oa ioe?ithaaoe ?ioaineai?noue ae?eie?oe/ieo i?ioean?a a
ee?oei?.

OAEAeE?NOUe ?ICIAAeO OINOI?I?AAI?*IEO CIIEOE A A?EO?IOeEOAO OAA?EI IA
??CIEO NOAAe?ssO EAEEICO

I?e i?iaaaeaii? aenia?eiaio?a ca aeiiiiiaith iaoiaeo 31?-ssI? aoei
aeei?enoaii aieiaio ia?aaaao oeueiai iaoiaeo – iiaeeea?noue
ia?iaaceaiiai eiio?ieth ca aeeiai?eith ia?aa?ao a?io?i?/ieo i?ioean?a ia
iaeieo ? oeo aea ee?oeiao i?ioyaii o?eaaeiai /ano.

Ia ?en. 4 i?aaenoaaeai? oeiia? na??? niaeo??a 31?-ssI? a?eo?ioeeo?a
caei?iai? ei?iae oa ia noaae?? i?iyao eaeeai?/ieo iciae caoai?thaaiiy.C
aiae?co io?eiaieo niaeo??a aeieeaa?, ui a oiae? ?ieoaaoe?? a?eo?ioeeo?a
aac aeinooio aetheice a ieo a?aeaoaa?oueny ?iciaae AO?, ui i?ecaiaeeoue
aei ciaioaiiy iieacieea ni?aa?aeiioaiiy eiioeaio?aoe?? AO?/ADP, i?e/iio
oaeaee?noue oeueiai ciaioaiiy i?e iaoieia?? aeua, i?ae o ii?i?.

?en.4. Niaeo?e 31?-ssI? a?eo?ioeeo?a caei?iai? (A) ei?iae oa c
eaeeai?/iei ia?aa?aii eaeeico (A): a – ia ii/aoeo ?ieoaaoe??, a – /a?ac
6 aiaeei. Neaiaee: 1 -aoaeii; 2 – oinoaoe oeoe??a; 3 – iai?aai?/iee
oinoi? (??); 4, 5, 6- o?e neaiaee aoii?a oinoi?o AO? a?aeiia?aeii a ?-,
?-, ? ?- iieiaeaiiyo.

Oea na?ae/eoue i?i ?ioaineo?eaoe?th i?ioean?a ae?eie?co a aeeiai?oe?
eaeeiciiai i?ioeano, ui ca?aa?oueny c aeaieie A.A. Oa?aia (1975), yeee
aeyaea i?aeaeuaiiy ?ioaineaiino? ?iciaaeo aetheice a ee?oeiao e?noeiaiai
iiceo ei??a, oai?eo ia eaeeic. A a?eo?ioeeoao ethaeeie i?e ??cieo
iaoieia?/ieo i?ioeanao a?aeaoaa?oueny i?enei?aiee ?iciaae 2, 3-AeOA,
oiae? ye eiioeaio?aoe?y AO? ci?ith?oueny iaioith i??ith (H.G. Gadian,
1982). A ca’yceo c oeei iaiao?aeii a?aecia/eoe, ui ci?ia oaiio
aia?aaoe/iiai iaoaaie?cio a?eo?ioeeo?a i?e iaoieia?yo yaey? niaith
oi?aa?naeueio aeanoea?noue oeeo ee?oei aeey ??cieo aeaeiaeo oi?i.

Ca aeiiiiiaith e?eaeo oeo?oaaiiy ?? (R.B. Moon, J.M. Richards, 1973)
aecia/aee caeaaei?noue ci?ie ?I a a?eo?ioeeoao ?io?eiaaieo a??onii
eaeeico oa caei?iaeo oaa?ei a?ae /ano ?ieoaaoe?? a na?aaeiaeu? aac
aetheice (?en.5).

Anoaiiaeaii, ui a a?eo?ioeeoao caei?iaeo oaa?ei niinoa??aathoueny 2
noaae?? ci?ie aioo??oiueiee?oeiii? eiioeaio?aoe?? I+: ia ia?o?e aaee/eia
?I ia ci?ith?oueny i?ioyaii ia?oeo 400 oa. ?ieoaaoe?? (eaa-ia??iae), ia
ae?oa?e oeae iieaciee ii/eia? cieaeoaaoenue, ui iia’ycaii c ?iciaaeii
eaeoaoo (E.Raftos et al., 1986).A a?eo?ioeeoao ei??a c i?eoiaaiei
ia?aa?aii eaeeico niinoa??aa?oueny cieaeaiiy aaee/ee ?I aaea ia
ii/aoeia?e noaae?? ?ieoaaoe??, a /a?ac 300 oa. eiai oaii
i?enei?th?oueny. O oaa?ei ia eaeeai?/i?e noaae?? caoai?thaaiiy
eaa-ia??iae a?aenooi?e ? niaae ??aiy ?I ia? e?i?eiee oa?aeoa?.

C io?eiaieo ?acoeueoao?a aeieeaa?, ui ?icaeoie eaeeico o aaeeei? ?iaaoi?
ooaeiae noi?iaiaeaeo?oueny i?enei?aiii ia?aa?aii i?ioean?a
ae?eie?oe/iiai oeeeeo, a oaeaee?noue cieaeaiiy ?I a ?cieueiaaieo
a?eo?ioeeoao i?aeaeuaia ii??aiyii c ii?iith.

?en.5 Caeaaei?noue aaee/eie ?I a?eo?ioeeo?a a?ae /ano eieoaaoe??. 1-
caei?ia? oaa?eie; 2- c i?eoiaaiei ia?aa?aii ?ioaeoe??; 3- eaeeai?/ieie
iciaeaie caoai?thaaiy.

AENIIAEE

1. A?io?i?/i? ci?ie, ye? noi?iaiaeaeothoue ?icaeoie eaeeico o aaeeei?
?iaaoi? ooaeiae a iaia?aiao oa oeeoiieaciaoe/ieo nenoaiao a?eo?ioeeo?a,
aei oeueiai /ano aoee aea/ai? iaaeinoaoiuei, ui ia aeicaieyei aecia/eoe
?ieue oeeo ee?oei o iaoiaaiac? e?ioii?ie?oa?aoeaieo caoai?thaaiue,
?icoe?eoe iaoiaee ae?aaiinoeee oa e?eoaaiiy eaeeico c o?aooaaiiyi
noaae?? caoai?thaaiiy.

2. A iaia?aiao a?eo?ioeeo?a ?io?eiaaieo a??onii eaeeico oaa?ei
a?aeaoaa?oueny i?eai?/aiiy ia?aeeniiai ieeneaiiy e?i?ae?a, yea
i?iyaey?oueny a aeinoia??iiio cieaeaii? niiioaiii? oai?ethi?ianoeaioe??,
a oaeiae ??aiy ae??iiaeo eii’thaao?a oa iaeiiiaiai aeeaeueaeaa?aeo ia
aaiaoieia?/i?e noaae?? caoai?thaaiiy.

3. I?aeaeuaiiy a 1,5 ?aca aeoeaiino? aeooao?iiia?ieneaeace ia i?eoiaai?e
noaae?? ?icaeoeo eaeeico ? iaei??th c i?e/ei aaeueioaaiiy i?ioean?a IIE
a a?eo?ioeeoao (??0,05).

4. Anoaiiaeaii ciaioaiiy a?aeiiaiiai iioaioe?aeo ee?oei, yea
oa?aeoa?eco?oueny cieaeaiii aeoeaiino? aeooao?ii?aaeoeoace c 4,5±0,5
ieIieue NADPH/1a Hb oa o caei?iaeo oaa?ei aei 3,1±

+0,3 ? 2,1+0,6 ia noaeaeeai?/i?e oa eaeeai?/i?e noaae?yo eaeeico
a?aeiia?aeii, a oaeiae i?aeaeuaiiyi a 5,6 ?ace ??aiy ieeneaiiai
aeooao?iio c ?icaeoeii eaeeiciiai i?ioeano (ee?i?/ia noaae?y) (??0,001).

5. I?aeaeuaiiy ia 35% ai?noo niaeo?ei-aeoeiiaiai eiiieaeno a “a?eeo
o?iyo” a?eo?ioeeo?a i?e eaeeic? na?ae/eoue i?i iineeaiiy eieaeueieo
ca’yce?a niaeo?eio c ye??ieie a?eeaie ieaciaoe/ii? iaia?aie (??0,05).

6. Aeyaeaia aaeueioaaiiy oaeaeeino? i?iieeiaiiy Na2+ a a?eo?ioeeoe ia
i?eoiaai?e noaae?? a 1,4 ? ia aaiaoieia?/i?e o 2 ?ace, ii??aiyii c?
caei?iaeie oaa?eiaie, aeaco? ia ii?ooaiiy i?ioean?a o?ainiaia?aiiiai
ia?aiino a a?eo?ioeeoao oaa?ei, ?io?eiaaieo a??onii eaeeico (??0,01).

7. C ?icaeoeii eaeeiciiai i?ioeano a a?eo?ioeeoao ci?ith?oueny
ni?aa?aeiioaiiy ??cieo oi?i aaiiaeia?io a a?e i?aeaeuaiiy aeaiene- oa
iaoaaiiaeia?io, ia caeaoieo o?ainii?ooaaoe eenaiue, ui i?ecaiaeeoue aei
cieaeaiiy ieneaaiaoe?? oeaiei oa ?icaeoeo a?iien?? a i?aai?ci? oai?i?
oaa?eie.

8. I?enei?aiee ?iciaae ATP, ciaioaiiy aaee/eie ni?aa?aeiioaiiy ATP/ ADP,
i?enei?aia cieaeaiiy aaee/eie ?I a a?eo?ioeeoao ei??a, oai?eo ia eaeeic,
anoaiiaeai? iaoiaeii 31?-ssI?, aeacothoue ia ?ioaineo?eaoe?th
ae?eie?oe/ieo i?ioean?a a oeeo ee?oeiao.

9. Iieacaii, ui aecia/aiiy ??aiy ia?aeeniiai ieeneaiiy e?i?ae?a a
a?eo?ioeeoao oa ieaci? e?ia? iiaea neoaoaaoe ianiaoeeo?/iei
aeeoa?aioe?eii-ae?aaiinoe/iei ? i?iaiinoe/ii oanoii i?e aeine?aeaeaii?
eaeeico a iaoeiai-aeine?aei?e ?iaio? oa eaai?aoi?i?e i?aeoeoe?.

NIENIE ?IA?O, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe??

1. ?ycaioeaa A.A., Eiaaeaiei E.A., Aaeion A.I.
No?oeoo?ii-ooieoeeiiaeueiua eciaiaiey iaia?ai y?eo?ioeeoia i?e
eeioieaeeica o ei?ia//Oe?. aeioei. aeo?i.-1996. – T.68. – N 1. – N.
92-95.

Aeena?oaioii i?iaaaeaii a?aea?? ? i?aeaioiaeo iaoa??aeo, na?ieia?/i?,
aaiaoieia?/i? oa niaeo?ioioiiao?e/i? aeine?aeaeaiiy, a oaeiae
noaoenoe/io ia?iaeo io?eiaieo ?acoeueoao?a.

2. Eciaiaiea niioiioaiey oi?i aaiiaeiaeia a y?eo?ioeeoao ei?ia, aieueiuo
eaeeicii / E.A. Eiaaeaiei, A.Ae. ?icaiiaa, A.Ae. Cei/aiei, A.I. Aaeion
// Aeii.Iaoe. aeaae. iaoe Oe?a?ie.- 1995.- N9.- N.101 103.

Aeena?oaioii a?ae?a?ai? i?iae e?ia?, i?aeaioiaeai? a?eo?ioeeoe oa
aecia/aii ai?no ??cieo oi?i aaiiaeia?io, i?iaaaeaia noaoenoe/ia ia?iaea
?acoeueoao?a.

3. Iienaaaa I.O., EiaaeaieiE.A., Eiaaeaiei A.I. Aeioeie/aneea eciaiaiey
y?eo?ioeeoia e ninoiyiea niaoeeoe/aneiai eiioieoaoa i?e eeioieaeeica E?N
// Eaeeicu e?oiiiai ?iaaoiai neioa: Iaaeaaae. na.iao/. o?./AEYA.-I.,
1985. – N.55-60.

Aeena?oaio i?eeiaea o/anoue o a?aeai?? iaoa??aeo, i?iaaaeaii?
aaiaoieia?/ieo ? na?ieia?/ieo aeine?aeaeaiue oa aecia/eea ai?no oi?i
aeooao?iio a a?eo?ioeeoao; cae?enieea noaoenoe/io ia?iaeo ?acoeueoao?a.

4. Eiaaeaiei E.A., Ianea I.I., Aiiaea?aiei Ae.I. Aeayei iieacieee i?iyao
ieenethaaeueii-aiaeiiaieo ?aaeoeie o ei?ia caeaaeii aiae noaaei?
eaeeiciiai i?ioeano//Aao. iaaeeoeeia: Iiaeaiae. oaiaoe/. iaoe. ca.- E.,
1995. – Aei.70. – N.13-16.

Aeena?oaio i?eeiaea o/anoue o a?aeai?? iaoa??aeo, i?iaaaeaii?
aaiaoieia?/ieo ? na?ieia?/ieo aeine?aeaeaiue oa aeine?aeeea a?io?i?/i?
iieacieee a?eo?ioeeo?a.

5. Eiaaeaiei E.A. Ianiaoeeo?/i? oanoe o aecia/aii? noaae?eiino? eaeeico
aaeeei? ?iaaoi?? ooaeiae // No/ani? i?iaeaie a?ieia??, aaoa?eia?ii?
iaaeeoeeie, cii?iaeaia??? oa oaoiieia?? i?iaeoeo?a oaa?eiieoeoaa:. Ca.
no./ I?aeia?iae. iaoe.- i?aeo. eiio.- Euea?a, 1997.- N. 184-186.

6. Eiaaeaiei E.A., ?ycaioeaa A.A. Aeoeaiinoue aeooaoiiicaeaaeieo
oa?iaioia a a?eo?ioeeoao caei?iaeo oa oai?eo eaeeicii ei?ia// Oac./
Anaoe?. eiio. c oiciieiai? oa aiioiii? oaa?ei.- Eueaia, 1994.- N.74.

7. ?ycaioeaa A.A., Caieyineeo I.A., Eiaaeaiei E.A. Ninoiyiea o?ainii?oa
Ca2+ e iaia?aiiuo aaeeia y?eo?ioeeoia aeeaioieo i?e eaeeica// Oac./1-e
nueacae Aaei?on. i-aa oioiaeieiaia e aeioeceeia. Ieine, 1994. – N.150.

8. Aonie A.A., Eiaaeaiei E.A., Iyaeeo I.A. Eciaiaiea ooieoeeiiaeue-
ii-no?oeoo?iuo iieacaoaeae y?eo?ioeeoia i?e eeioieaeeica e?oiiiai
?iaaoiai neioa//Ae?on. aieacie n.-o. aeeaioieo: Oac. aeiee./ Ana?in.
iao/.-i?aeo. eiio., 17-21 ai?. 1995 a.-Aeaaeeie?, 1995. – N.212.

9. Eiaaeaiei E.A. Oiceei-aiioiii/ia aeineiaeaeaiiy a?eo?ioeeoia
nieuenueeiainiiaea?nueeeo oaa?ei // Iaiioaeoe. iaoieiaiy oaa?ei:
Iaoa?iaee / Iaoe.-i?aeo. eiio., i. Aiea Oea?eaa, 7-8 /a?a. 1995 ?.Aiea
Oea?eaa, 1995. – *.1. – N.51-52.

10. Eiaaeaiei E.A. Iniiae a?io?i?? iooeeiiiai ?inoo // Iaoe. aeinyaiaiy
a aaeoc? aaoa?eia?ii? iaaeeoeeie.:Iaoa??aee./ I?aeia?.iaoe.-i?aeo. eiio.
-Oa?e?a, 1997.- N. 29-31.

11. Eiaaeaiei E.A. I?ioeannu ia?aeeniiai ieeneaiey eeieaeia a
??eo?ioeeoao e?oiiiai ?iaaoiai neioa a ii?ia e i?e eaeeica // ?icaeoie
aaoa?eia?ii? iaoee a Oe?a?i?: caeiaooee oa i?iaeaie.: Ca. iaoa??ae?a.
/I?aeia?.iaoe.-i?aeo. eiio.- Oa?e?a, 1997. -N. 113-115.

12. Eiaaeaiei E.A. Ooieoeeiiaeueiia ninoiyiea aaiiaeiaeia a aeeiaieea
eaeeiciiai i?ioeanna o e?oiiiai ?iaaoiai neioa // ?icaeoie aaoa?eia?ii?
iaoee a Oe?a?i?: caeiaooee oa
i?iaeaie.:Ca.iaoa??ae?a./I?aeia?.iaoe.-i?aeo. eiio.- Oa?e?a, 1997. -N.
113-115.

Eiaaeaiei E.A. Ia?aeenia ieeneaiiy e?i?ae?a ? ooieoe?iiaeueiee noai
a?eo?ioeeo?a aaeeei? ?iaaoi? ooaeiae i?e eaeeic?. – ?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa a?ieia?/ieo iaoe
ca niaoe?aeuei?noth 03.00.04 – a?io?i?y. Iaoe?iiaeueiee aa?a?iee
oi?aa?neoao, Ee?a, 1999.

A aeena?oaoe?? aeeeaaeai? oa ocaaaeueiai? ?acoeueoaoe aeine?aeaeaiue
?yaeo i?ioean?a, ca’ycaieo c iaia?aiith, oa ooieoe?iiaeueieo
aeanoeainoae a?eo?ioeeo?a a aeeiai?oe? eaeeico aaeeei? ?iaaoi? ooaeae.
Anoaiiaeaii ci?ie a ?ioaineaiino? i?ioean?a IIE, aeoeaiino? oa?iaio?a
aioeieneaeaioii? nenoaie oa iciaee cieaeaiiy ?? a?aeiiaiiai
iioaioe?aeo. Nooi?iue c?ooaiiy no?oeoo?iiai oa ooieoe?iiaeueiiai noaio
iaia?ai a?eo?ioeeo?a caeaaeeoue a?ae noaae?? eaeeico. ?icaeoie
?ioaeoe?eiiai i?ioeano noi?iaiaeaeo?oueny iaeiie/aiiyi oi?i aaiiaeia?io,
ye? ia caeaoi? ia?aiineoe eenaiue, iineeaiiyi ?ioaineaiino? i?ioean?a
?iciaaeo iae?ia?a?/ieo niieoe a a?eo?ioeeoao oa cieaeaiiyi caeaoiino?
ee?oei i?aeo?eioaaoe ??aaiue ?I a oiiaao aac aeinooio aetheice.

Eeth/ia? neiaa: eaeeic, a?eo?ioeeoe, iaia?aia, ia?aeenia ieeneaiiy
e?i?ae?a, oa?iaioe, aaiiaeia?i.

Eiaaeaiei E.A. Iapaeeniia ieeneaiea eeieaeia e ooieoeeiiaeueiia
ninoiyiea ypeopioeeoia epoiiiai piaaoiai neioa ipe eaeeica. – ?oeiienue.

Aeennapoaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa aeieiae/aneeo iaoe
ii niaoeeaeueiinoe 03.00.04. – aeioeiey. Haoeeiiaeueiue aapapiue
oieaapneoao, Eeaa, 1999.

A aeenapoaoeee eceiaeaiu e iaiauaiu pacoeueoaou enneaaeiaaiee pyaea
aeioeie/aneeo ipioeannia, naycaiiuo n iaiapaiie, e ooieoeeiiaeueiuo
naienoa ypeopioeeoia a aeeiaieea ?aceoey eaeeica epoiiiai piaaoiai
neioa.

Enneaaeiaaiey i?iaaaeaiiu ia 130 eaeoepothueo ei?iaao 3-5-eaoiaai
aicpanoa. Ii ?acoeueoaoai na?ieiae/aneeo (?EAe), aaiaoieiae/aneeo e
eeeie/aneeo enneaaeiaaiee noi?ie?iaaii 5 a?oii aeeaioiuo. A ia?oth
a?oiio aioee ei?iau, naiaiaeiua io aepona eaeeica (eiio?ieue), ai
aoi?oth – ni ne?uoui oa/aieai eioaeoeee (?EAe+), a o?aoueth – n
noaeaeeaie/aneei i?iyaeaieai eioaeoeee (?EAe+, eaeeioeeoia 15,5±1,4
oun/iee; eeioioeeoia 79,3±1,2%;), /aoa?ooth -n eaeeaie/aneei oa/aieai
caaieaaiey (?EAe+ eaeeioeeoia 56,7±3,5 oun/iee; eeioioeeoia 84,0±3,8%).
O aeeaioiuo iyoie a?oiiu ?acaeaaeanue eeeie/aneay noaaey caaieaaaiey
(?EAe+, eaeeioeeoia 25,0±2,9 oun/iee, oaaee/aiea paaeiiapiuo
eeioioceia).

Enneaaeiaaieyie aeioeie/aneeo ipioeannia a ypeopioeeoao auei aeieacaii,
/oi ?acaeoea eaeeica e?oiiiai ?iaaoiai neioa nii?iaiaeaeaaony eciaiaieai
iaoaaiee/aneiai e no?oeoo?iiai ninoiyiey iaia?aiu e oeeoiieaciaoe/aneeo
nenoai yoeo eeaoie, aeoaeia i?iyaeaiey eioi?iai caaeneo io noaaeee
eioaeoeeiiiiai i?ioeanna.

A iaia?aiao y?eo?ioeeoia aieueiuo aeeaioiuo i?ienoiaeeo oaiaoaiea
ia?aeeniiai ieeneaiey eeieaeia, /oi i?iyaeyinue a noaoenoe/anee
aeinoiaa?iii nieaeaiee eioaineaiinoe niiioaiiie oaieethieianoeaioeee ia
41%, o?iaiy aeeaiiauo eiiueaaoia ia 25% e iaeiiiaiai aeeaeueaeaaeaea ia
35% o aeeaioiuo ia eaeeaie/aneie noaaeee caaieaaaiey ii npaaiaieth n
iieacaoaeyie eiiopieueiie apoiiu.

Iaeiie ec ipe/ei nieaeaiey eioaineaiinoe ipioeannia iapaieeneaiey a
y?eo?ioeeoao aieueiuo aeeaioiuo neoaeeo aeoeaaoeey
aeooaoeiiiapieneaeacu. O aeeaioiuo aoi?ie a?oiiu aa aeoeaiinoue
iiauoaeanue ia 51% (p?0,05) e ia iineaaeothueo noaaeeyo caaieaaaiey yoio
iieacaoaeue aue auoa ia 41-38% ii n?aaiaieth n eiio?ieueiui opiaiai
168,5±14,0 ieiieue GSH/1 a Hb iei. Hapyaeo n yoei, a ypeopioeeoao eipia
2-e apoiiu iaaethaeaeanue oaiaeaioeey e nieaeaieth aeoeaiinoe
aeooaoeiipaaeoeoacu, a o aieueiuo aeeaioiuo 4-e a?oiiu aa aeoeaiinoue
nieaeaeanue a 2 ?aca e ninoaaeyea 2,1±0,8 ieiieue NADP/1 a Hb iei.

Aneaaenoaea eciaiaiey aeoeaiinoe aeooaoeiicaaeneiuo oapiaioia ipe
eaeeica a ypeopioeoao ipienoiaeeo iapooaiea niioiioaiey oipi aeooaoeiia.
A eeaoeao caeipiauo eipia opiaaiue ainnoaiiaeaiiiai aeooaoeiia (GSH)
ninoaaeyao 30,8±1,48 ia%, a ieeneaiiiai (GS-SG) 2,7±0,25 ia%. ?acaeoea
aaiaoieiae/aneeo ipeciaeia eaeeica nii?iaiaeaeaaony iacia/eoaeueiui
nieaeaieai eiee/anoaa GSH e noaoenoe/anee aeinoiaapiui oaaee/aieai
eiee/anoaa GS-SG a 2,5-3,6 paca. Ha eeeie/aneie noaaeeee iaeiieaiea
GS-SG ipaauoaei eiiopieueiua iieacaoaee a 5,6 paca (??0,001).

N eciaiaieai eioaineaiinoe ipioeannia iapaeeniiai ieeneaiey eeieaeia
naycaii onoaiiaeaiiia nieaeaiea neipinoe ipiieeiiaaiey eiiia Na2+ a
ypeopioeeou, oaiaeaioeey e eioipiio ipiyaeeanue o nepuoi eioeoeepiaaiiuo
aeeaioiuo. Ha noaeaeeaie/aneie noaaeee eioaineaiinoue aoiaea Na2+
oiaiueoaeanue ia 50%, a ia eaeeaie/aneie – ia 58% ii npaaiaiieth n
iieacaoaeai eiiopieueiuo aeeaioiuo 1,8±0,2 ieiieue/ie eeaoie ca ieiooo.

I?iaaaeaiiua iaie enneaaeiaaiey iieacaee, /oi a iaia?aiiuo oaiyo
y?eo?ioeeoia o aeeaioiuo 3-e a?oiiu, ii n?aaiaieth n eiio?ieai,
niaea?aeeony ia 20% aieueoa niaeo?eia, a ia neaaeothuae noaaeee
eaeeiciaaiaca yoa ?acieoea noaiiaeony noaoenoe/anee aeinoiaa?iie e
ninoaaeyao 35%. Iiauoaaony oaeaea niaeapaeaiea aeoeia.

N iiiiuueth iaoiaea aeeooa?aioeeaeueiie niaeo?ioioiiao?ee onoaiiaeaii,
/oi y?eo?ioeeou caei?iauo aeeaioiuo niaea?aeao 74,3±1,6%
ieneaaiiaeiaeia, 11,0±0,9% aeaieneaaiiaieiaeia e 14,6±1,1%
iaoaaiiaeiaeia io iauaai aai eiee/anoaa. ?acaeoea noaaeee ne?uoiai
i?iyaeaiey eioaeoeee nii?iaiaeaeaaony oaaee/aieai eiee/anoaa
iaoaaiiaeiaeia ia 64% e oiaiueoaieai niaea?aeaiey ieneoi?iu aaiiaeiaeia
ia 17%. A y?eo?ioeeeoao ei?ia ia eaeeaie/aneie noaaeee caaieaaaiey 50%
iauaai eiee/anoaa aaiiaeiaeia ninoaaeytho iaia?aiinyuea eenei?iae oi?iu.

Eniieueciaaiea iaoiaea yaea?iiai iaaieoiiai ?aciiaina ia yae?ao oinoi?a
31 iicaieeei onoaiiaeoue iiauoaiea nei?noe ?aniaaea AO? a y?eo?ioeeoao
aieueiuo eaeeicii ei?ia e onei?aiiia nieaeaiea aaee/eiu ?I a eeaoeao a
oneiaeyo aac aeinooia aetheicu.

Eeth/aaua neiaa: eaeeic, y?eo?ioeeou, iaia?aia, ia?aeeniia ieeneaiea
eeieaeia, oa?iaiou, aaiiaieiaei.

Kovalenko L.V. Lipid peroxidation and functsonal properties of cows
erytrocytes with leucousis.- The manuscript. The disertation

Manuscript for the competition of the Candidate of the Biological
Scienses scienses degre in the03.00.04-biochemistry. National
Agricaltural Unsversiti, Kyiv 1999.

The results of investigations series membrane bond proceses and
functsonal properties of erytrocytes in development of leucousis whas
state and summarise in the disertation. The chenges of intensiti lipid
peroxidation, activiti of anti-peroxidation ensimes was determined. The
degree of breaches membrane structure and function depended on stage of
leukousis. Development of this diseas accompanied of accumulation
unactive hemoglobin forms intensification glicolisis and lovering
abiliti for maintain of cell gomeostasis.

Key words: leukousis, eritrocytes, membrana, lipid peroxidation, ensims,
haemoglobin.

I?aeienaii aei ae?oeo 28 n?/iy 1999 ?. Oi?iao 60o84 1/16. Iai?? io?niee.
Oiia. ae?oe. a?e. 2. Oe?aae 100 i?ei. Caiiaeaiiy ? 0299

Iaae?oeiaaii a AOCO “NAII?O-Oa?e?a”

aoe. I??iiineoeueea, 86,

oae./oaen (0572) 142-260, 142-261, 142-620.

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