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Фармакогностичне вивчення Lotus corniculatus: Автореф. дис… канд. фармац. наук / В.В. Король, Укр. фармац. акад. — Х., 1999. — 18 с. — рус.

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OE?A?INUeEA OA?IAOeAAOE*IA AEAAeAI?ss

EI?IEUe A?eoi??y A?eoi??aia

OAeE 577.15/17:577.115:615.276:616-001.4

OA?IAEIAIINOE*IA AEA*AIIss LOTUS

CORNICULATUS

15.00.02 – oa?iaoeaaoe/ia o?i?y ? oa?iaeiaiic?y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa oa?iaoeaaoe/ieo iaoe

Oa?e?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia ia eaoaae?? oa?iaeiaiic?? Oe?a?inueei? oa?iaoeaaoe/ii?
aeaaeai??, I?i?noa?noai ioi?iie caei?ia`y Oe?a?ie.

Iaoeiaee ea??aiee:aeieoi? oa?iaoeaaoe/ieo iaoe, i?ioani?

EIAAEUeIA Aieiaeeie? Ieeieaeiae/

Oe?a?inueea oa?iaoeaaoe/ia aeaaeai?y, caa?aeoaa/

eaoaae?e oa?iaeiaiic??Io?oe?ei? iiiiaioe:aeieoi? oa?iaoeaaoe/ieo iaoe,
i?ioani?

NA?A?I Aiaoie?e Aaa?eeiae/

Oe?a?inueea oa?iaoeaaoe/ia aeaaeai?y, caa?aeoaa/

eaoaae?e iaaee/ii? aioai?ee

eaiaeeaeao oa?iaoeaaoe/ieo iaoe, aeioeaio

OAAeI??I Aaiaae?e Oaaei?iae/

Oe?a?inueeee ?inoeooo oaeineiiaeaiiy e?ea??a,

aeioeaio eaoaae?e iie?ee?i?/ii? iaae?ao??? ? o?oioa?ai??I?ia?aeia
onoaiiaa:Eaai?aoi??y iiooeo ?ineeiieo i?aia?ao?a ? a?ioaoiieia?e
Aea?aeaaiiai iaoeiaiai oeaio?o e?ea?nueeeo cania?a (i. Oa?e?a)

Aea?aeaaiee eii?oao iaaeeei-a?ieia?/ii? i?iieneiaino? IAI Oe?a?ie

Caoeno a?aeaoaeaoueny “2” eeiiy 1999 ?ieo i 14 aiae. ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 64.605.01 i?e Oe?a?inuee?e
oa?iaoeaaoe/i?e aeaaeai?? ca aae?anith: 310002, i. Oa?e?a, aoe.
Iooe?inueea, 53.

C aeena?oaoe??th iiaeia iciaeiieoeny a a?ae?ioaoe? Oe?a?inueei?
oa?iaoeaaoe/ii? aeaaeai?? (310168, i. Oa?e?a, aoe. Aethoa?a, 4).

Aaoi?aoa?ao ?ic?neaiee “1” /a?aiy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee
A?EOeAIEI ?.N.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Iiooe oa noai?aiiy e?ea?nueeeo i?aia?ao?a
?ineeiiiai iioiaeaeaiiy – iaeia c iaeaaaeeea?oeo caaea/ oa?iaoeaaoe/ii?
iaoee. Oe?eani?yiiaaiee iiooe a?ieia?/ii aeoeaieo noanoaioe?e, aea/aiiy
?o o?ceei-o?i?/ieo oa oa?iaeieia?/ieo oa?aeoa?enoee ? aieiaiei iai?yieii
ae??oaiiy oe??? i?iaeaie.

Oa?iaeieia?/iee aoaeo aaaaoueio o?oio?i?/ieo i?aia?ao?a coiiaeaiee ia
iaei??th ?a/iaeiith, a eiiieaenii ??cieo i?e?iaeieo niieoe.

A ?o ?yaeo ieeueii? oaaae caneoaiaothoue oaiieuei? niieoee oa
e?iio?euei? ?a/iaeie, ye? coiiaeththoue ??ciiiai?oiee niaeo? ae??
e?ea?nueeeo cania?a.

Iaiao?aei?noue eiiieaeniiai aeei?enoaiiy ?ineei oa iayai?noue
aeinoaoiuei? ne?iaeiii? aace iiynith? caoe?eaaeaii?noue aei aea/aiiy
ia?iaeiiainiiaea?nueeeo eoeueoo?. O ca`yceo c oeei, ye ia`?eo
aeine?aeaeaiiy iaie aoea ia?aia ?ineeia eyaeaaiaoeue ?iaaoee (Lotus
corniculatus L.) ?iaeeie aiaiaeo (Fabaceae).

C e?oa?aoo?ieo aeaieo a?aeiii, ui ?ineeie ?iaeo Lotus aaaao? iio?aeieie
oeaaiii?ae?a, ye? iathoue oe?ieee niaeo? oa?iaeieia?/ii? aeoeaiino?. A
ia?iaei?e iaaeeoeei? eyaeaaiaoeue ?iaaoee aeei?enoiao?oueny ye
?aiicaaithaaeueiee, aieaoaioaaeueiee, caaaeueiici?oeithth/ee oa
caniie?eeeaee can?a. Iaaeinoaoi? o?i?/ia oa oa?iaeieia?/ia aea/aiiy eiai
noaee i?aenoaaith aeey iaoiai aeine?aeaeaiiy.

Ca`ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?y
aeeiiaia ca?aeii c ieaiii iaoeiai-aeine?aeieo ?ia?o Oe?a?inueei?
oa?iaoeaaoe/ii? aeaaeai?? c i?iaeaie IIC Oe?a?ie (? aea?aeaaii?
?a?no?aoe?? 0198O007008).

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoa aeaii? ?iaioe – aea/aiiy a?ieia?/ii
aeoeaieo ?a/iaei (AA?) iaaecaiii? /anoeie eyaeaaioey ?iaaoiai oa
noai?aiiy ia ?o i?aenoaa? iiaeo e?ea?nueeeo cania?a.

Aeey aeinyaiaiiy oe??? iaoe aoee iinoaaeai? ianooii? caaea/?:

· i?iaanoe iiia?aaeia o?oio?i?/ia aea/aiiy o?aae Lotus corniculatus;

· aeae?eeoe a ?iaeea?aeoaeueiiio noai? ?a/iaeie ? anoaiiaeoe ?o
no?oeoo?o;

· ?ic?iaeoe oaoiieia?th iaea?aeaiiy oa?iaeieia?/ieo cania?a c o?aae
eyaeaaioey ?iaaoiai ? aecia/eoe ?o aeoeai?noue;

· i?iaanoe e?euee?nia aecia/aiiy ??cieo a?oi AA? a o?aa? Lotus
corniculatus oa iaea?aeaieo oa?iaeieia?/ieo caniaao;

· anoaiiaeoe iniiai? aiaoiii-ae?aaiinoe/i? iciaee ?ineeiii? ne?iaeie –
o?aae Lotus corniculatus;

· ?ic?iaeoe aiae?oe/io ii?iaoeaio aeieoiaioaoe?th (AIAe) ia ne?iaeio oa
oa?iaeieia?/i? caniae.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa i?iaaaeaii eiiieaenia
o?oio?i?/ia aea/aiiy AA? o?aae Lotus corniculatus. Aeyaeaia iayai?noue a
ieo ai?iieeneio, aoaeaaiae?a, oinoie?i?ae?a, noa?i?ae?a, oaiieueieo
niieoe (ieneei?e/ieo eeneio, ieneeoia?ei?a, oeaaiii?ae?a, aeoaeeueieo
?a/iaei), e?iio?eueieo ?a/iaei (oei?io?e?a, ea?ioeii?ae?a, oieioa?ie?a,
aee?ieo eeneio). C o?aae Lotus corniculatus a ?iaeea?aeoaeueiiio noai?
aeae?eaii ? aeine?aeaeaii 24 ?a/iaeie: 5 ieneei?e/ieo eeneio, 4
ieneeoia?ei?a, 13 oeaaiii?ae?a, 1 oinoie?i?ae ? 1 noa?i?ae, 15 c oeeo
?a/iaei aia?oa aeae?eai? c o?aae eyaeaaioey ?iaaoiai. E??i oiai, ii??i
aia?oa aeyaeaii a ?iaeei? aiaiaeo, a ii??i-3-aaeaeoiceae ? iiaith
i?e?iaeiith niieoeith.

?ic?iaeaia eiiieaenia oaoiieia?y iaea?aeaiiy oa?iaeieia?/ieo cania?a c
o?aae Lotus corniculatus, yea neeaaea?oueny c iine?aeiaiiai iaea?aeaiiy
nooiai aeno?aeoo (oiiaia iacaa “Eiei?ei”) oa e?iio?eueiiai aeno?aeoo
(oiiaia iacaa “Eioon”). Aea/aia oa?iaeieia?/ia aeoeai?noue oeeo cania?a,
c yeeo “Eiei?ei” ia? ae?aaeaio i?ioecaiaeueio oa ae?o?aoe/io ae?th, a
“Eioon” – ?aiicaaithaaeueio ae?th. A?aei?aaeaia cayaa ia “Io?eiaiiy
e?iio?eueiiai aeno?aeoo c o?aae eyaeaaioey ?iaaoiai ?aiicaaithaaeueii?
ae??” ia iaea?aeaiiy iaoaioo Oe?a?ie.

Aiaoa aecia/aii e?euee?niee ai?no ieneei?e/ieo eeneio, oeaaiii?ae?a,
aeoaeeueieo ?a/iaei, oei?io?e?a, ea?ioeii?ae?a, aee?ieo eeneio o o?aa?
Lotus corniculatus oa oa?iaeieia?/ieo caniaao. Anoaiiaeai? iniiai?
aiaoiii-ae?aaiinoe/i? iciaee Lotus corniculatus.

I?aeoe/ia cia/ei?noue ?iaioe. ?ic?iaeaia oaoiieia?y iaea?aeaiiy iiaeo
oa?iaeieia?/ieo cania?a c o?aae eyaeaaioey ?iaaoiai c iaoith noai?aiiy
iiaeo e?ea?nueeeo i?aia?ao?a i?ioecaiaeueii?, ae?o?aoe/ii? oa
?aiicaaithaaeueii? ae?? (“Eioon”), yea ii?iaiaaia ia Aeine?aeiiio
caaiae? Aea?aeaaiiai Iaoeiaiai Oeaio?o E?ea?nueeeo Cania?a. ?ic?iaeai?
i?iaeoe oei/aniaeo oa?iaeiiaeieo noaoae (OON) ia “O?aao eyaeaaioey
?iaaoiai”, “Nooee aeno?aeo “Eiei?ei” oa “E?iio?eueiee aeno?aeo “Eioon”.
?acoeueoaoe aeine?aeaeaiue ai?iaaaeaeai? a o/aiaee i?ioean Oe?OA oa
Caii??cueeiai iaaee/iiai oi?aa?neoaoo.

Iniaenoee aianie caeiaoaa/a:

· i?iaaaeaiee aiae?c e?oa?aoo?ieo aeaieo ii ?iciianthaeaeaith,
o?i?/iiio neeaaeo oa aeei?enoaiith ?ineei ?iaeo eyaeaaioeue;

· aeae?eai? ? aecia/ai? iniiai? a?oie a?ieia?/ii aeoeaieo ?a/iaei,
?aeaioeo?eiaai? ?a/iaeie ? anoaiiaeaia ?o aoaeiaa;

· iaa?oioiaaia ? ?ic?iaeaia oaoiieia?y iaea?aeaiiy c o?aae eyaeaaioey
?iaaoiai nooiai aeno?aeoo “Eiei?ei” oa e?iio?eueiiai – “Eioon”;

· aea/aia aiaoii?/ia aoaeiaa iaaecaiieo i?aai?a eyaeaaioey ?iaaoiai;

· ?ic?iaeai? i?iaeoe OON ia o?aao eyaeaaioey ?iaaoiai, nooee aeno?aeo
“Eiei?ei” oa e?iio?eueiee aeno?aeo “Eioon”.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy ?iaioe
aeeeaaeai? ? iaaiai?ai? ia 49-e i?aeaoc?anuee?e iaoeiai-i?aeoe/i?e
eiioa?aioe?? i?ioani?nueei-aeeeaaeaoeueeiai neeaaeo (Ia?i, 1993); ia
iaoeiai-i?aeoe/i?e eiioa?aioe??, i?enay/ai?e 75-??//th Oe?OA
“Aeinyaiaiiy no/anii? oa?iaoe?? – a iaaee/io i?aeoeeo” (Oa?e?a, 1996).

Ioae?eaoe??. Ca oaiith aeena?oaoe?? iioae?eiaaii 7 iaoeiaeo i?aoeue, a
oiio /ene? 4 noaoo? oa 3 oace aeiiia?aeae.

No?oeoo?a aeena?oaoe??. Aeena?oaoe?eia ?iaioa neeaaea?oueny c anooio,
oanoe ?icae?e?a, nieneo e?oa?aoo?ieo aeaea?ae. Caaaeueiee ia`?i
aeena?oaoe?? neeaaea? 132 noi??iie. ?iaioa ?ethno?iaaia 14 noaiaie, 15
iaethieaie ? 20 oaaeeoeyie. Ia?ae?e aeei?enoaieo e?oa?aoo?ieo aeaea?ae
i?noeoue 127 iaeiaioaaiue.

INIIAIEE CI?NO ?IAIOE

1. O?oio?i?/ia aea/aiiy ? aeae?eaiiy a?ieia?/ii aeoeaieo ?a/iaei

c o?aae eyaeaaioey ?iaaoiai

Iiia?aaei?ie o?oio?i?/ieie aeine?aeaeaiiyie anoaiiaeaii iayai?noue o
iaaecaii?e /anoei? eyaeaaioey ?iaaoiai ??ciiiai?oieo a?oi a?ieia?/ii
aeoeaieo ?a/iaei: oeaaiii?ae?a, ieneei?e/ieo eeneio, eoia?ei?a,
aeoaeeueieo ?a/iaei, ai?iieeneio, oinoie?i?ae?a, noa?i?ae?a,
e?iio?eueieo ?a/iaei.

C aeei?enoaiiyi iaoiae?a ??aeeiii? aeno?aeoe??, eieiieiai? o?iiaoia?ao??
ia iie?ai?ae? oa nee?eaaae?, i?aia?aoeaii? o?iiaoia?ao?? ia iaia?? oa o
oiieiio oa?? ni?aaioo c iaaecaiii? /anoeie eyaeaaioey ?iaaoiai aeae?eaii
a ?iaeea?aeoaeueiiio noai? 24 ?a/iaeie: 5 ieneei?e/ieo eeneio, 4
ieneeoia?eia, 13 oeaaiii?ae?a, 1 ?a/iaeio oinoie?i?aeii? oa 1
noa?i?aeii? i?e?iaee.

Aecia/aii e?euee?niee ai?no oeaaiii?ae?a a o?aa? eyaeaaioey, yeee
neeaaea? 1,75 %, ieneei?e/ieo eeneio – 1,35 %, anei?a?iiai? eeneioe –
0,083 %, aeoaeeueieo ?a/iaei – 0,49 %.

Aeaye? o?ceei-o?i?/i? aeanoeaino? aeae?eaieo ?a/iaei iaaaaeai? o
oaaeeoe? 1.

2. O?i?/ia aea/aiiy aeae?eaieo ?a/iaei

No?oeoo?o aeae?eaieo ?a/iaei anoaiiaeaii ia i?aenoaa? o?ce/ieo,
o?i?/ieo, o?ceei-o?i?/ieo oa a?io?i?/ieo iaoiae?a aiae?co.

Ieneei?e/i? eeneioe. ?a/iaeie 2.21 – 2.25 ca oeoi?anoeaioe??th ieyi ia
o?iiaoia?aiao o o?eueo?iaaiiio OO-na?oe? oa ye?nieie ?aaeoe?yie
a?aeianai? aei ieneei?e/ieo eeneio, ui i?aeoaa?aeaeo?oueny aeaieie
OO-niaeo??a.

A i?iaeoeoao eoaeii? aeano?oeoe?? ?a/iaeie 2.21 (n-eoia?iaa eeneioa)
ciaeaeaii n-ieneaaicieio eeneioo, ?a/iaeie 2.23 (oa?oeiaa eeneioa) –
aai?e?iiao eeneioo. Eoaeiee a?ae?ie?c ?a/iaei 2.22 (eioaeia eeneioa),
2.24 (oei?iaaiiaa eeneioa) oa 2.25 (iaioei?iaaiiaa eeneioa) i?eaiaeeoue
aei ooai?aiiy 3,4-ae?ieneaaicieii? (i?ioieaoaoiai?) eeneioe, a 2.24 oa
2.25 – aei ooai?aiiy aea?iieaeoey?ieo e?eueeinoae eioaeii? oa D-o?iii?
eeneio. I?noea i?e?aeiaiiy eioaeii? eeneioe aei D-o?iii? anoaiiaeaii ca
?acoeueoaoaie eaeoii?caoe?? oeeo niieoe. Ooai?aiiy eaeoiio o?i?aeo
niinoa??aa?oueny o?eueee aeey ?a/iaeie 2.25, ui aeaco? ia iayai?noue
a?ae?ienea?oie o N-5 iieiaeaii? D-o?iii? eeneioe.

Oaaeeoey 1.

Aeaye? o?ceei-o?i?/i? aeanoeaino? ?a/iaei aeae?eaieo c eyaeaaioeth
?iaaoiai

?

?a/iaeia, ?? oeo? oa

Caaaeueia

Ooiie, 0N

[]20D,Cia/aiiy Rf o nenoaiao ?ic/eiiee?ai/ino?oeoo?ia
oa?aeoa?enoeeaoi?ioeaa?aaeAAAA123456789Ieneei?e/i? eeneioe1.n-Eoia?iaa
eeneioa (2.21) (4-ieneei?e/-ia eeneioa)N9I6I3 .
I2I212-214-0,900,600,46-2.Eioaeia eeneioa (2.22) (3,4-ae?ieneei-?e/ia
eeneioa)N9I8I4194-196-0,800,500,30-3.Oa?oeiaa eeneioa (2.23)
(3-iene-4-iaoie-neei?e/ia
eeneioa)N10I10I4168-170-0,880,550,44-4.Oei?iaaiiaa eeneioa (2.24)
(5-I-eioa?e-D-o?iia
eeneioa)N16I18I9202-204-32,10,620,700,65-5.Iaioei?iaaiiaa eeneioa (2.25)
(3-I-ei-oa?e-D-o?iia
eeneioa)N16I18I9aii?oi.+2,60,540,750,70-I?iaeiaaeaiiy oaaeeoe?
1.123456789Ieneeoia?eie6.Oiaae?oa?ii (2.05)
(7-ieneeoia?ei)N9I6I3228-230-0,900,64-0,247.Aneoeaoei (2.06)
(6,7-ae?ieneeoia?ei)N9I6I4268-272-0,800,51-0,088.Neiiieaoei (2.04)
(6-iaoiene-7-ieneeo-ia?ei)N10I8I4202-204-0,850,50-0,619.?cineiiieaoei
(2.03)
(6-iene-7-iaoiene-eoia?ei)N10I8I4185-187-0,830,60-0,64Oeaaiii?aee10.Eaii
oa?ie (2.09)
(3,5,7,4`-oao?aieneoea-aii)N15I10I6274-276-0,790,10–11.Ano?aaae?i
(2.12)
(eaiioa?ie-3-I–D-aetheii??aiiceae)N21I20I11173-176-56,00,710,37–12.Iii
oe?i (2.11)
(eaiioa?ie-7-I–D-aeth-eii??aiiceae)N21I20I11270-272-460,60-0,47-13.Eaii
oa?ie-3-I–D-aetheii??aiicee-7-I–D-aetheii??aiiceae
(2.19)N27I30I16198-200-69,00,580,35–14.O?eoie?i (2.13)
(eaiioa?ie-3-I–D-aa-eaeoii??aiiceae)N21I20I11215-217-48,00,610,3315.Eaa
?oeaoei (2.10)
(3,5,7,3`,4`-iaioaiene-oeaaii)N15I10I7310-312-0,670,07–16.?cieaa?oeeo?e
i (2.14)
(eaa?oeaoei-3-I–D-aetheii??aiiceae)N21I20I12229-231-12,50,520,36–17.Ea
a?oeeo?ei (2.15) (eaa?oeaoei
3-I–D-?aiiii??aiiceae)N21I20I11182-185-0,62-0,39-18.Ii??i (2.17)
(3,5,7,2`,4`-iaioaiene-oeaaii)N15I10I7303-305-0,760,270,68-I?iaeiaaeaiiy
oaaeeoe? 1.12345678919.Ii??i-3-I–D-aaeaeoii??aiiceae
(2.18)N21I22I12215-223-0,720,39–20.A?ia?iceae (2.16) (eaa?oeaoei
3-I–D-aa-eaeoii??aiiceae)N21I20I12235-237-58,90,570,28-21.3-Iaoeeeaa?oe
aoei (2.08)
(5,7,3`,4`-oao?a-iene-3`-iaoieneoeaaii)N16I12I7258-260-0,860,16–22.?ci?
aiiaoei (2.07)
(3,5,7,4`-oao?aiene-3`-iaoieneoeaaii)N16I12I7316-318-0,830,11–Oinoie?i?
aee23.Eaoeeoei (2.01)-aineiii-ae?aia-Nenoaia oei?ioi?i-iaoaiie-aiaea
(65:25:4), Rf = 0,2824.-Neoinoa?ei (2.02)N29I50I134-136+37,5Nenoaia
aaicie-aoeeaoeaoao-aoeaoii (100:8:0,5), Rf = 0,34I?ei?oea:A –
i-aooaiie-ioeoiaa eeneioa-aiaea (4:1:2);

A – 15 % ioeoiaa eeneioa;

A – 3 % ioeoiaa eeneioa;

A – oei?ioi?i-25 % oi?iai?ae.Ia i?aenoaa? i?iaaaeaieo aeine?aeaeaiue ?
?acoeueoao?a ii??aiyiiy c a??ia?aeieie c?aceaie ?a/iaeie 2.21 – 2.25
a?aeiia?aeii ?aeaioeo?eiaai? c 4-ieneei?e/iith (n-eoia?iaith),
3,4-ae?ieneei?e/iith (eioaeiith), 3-iene-4-iaoieneei?e/iith
(oa?oeiaith), 5-I-eioa?e-D-o?iiith (oei?iaaiiaith), 3-I-eioa?e-D-o?iiith
(iaioei?iaaiiaith) eeneioaie, ye? aia?oa ciaeaeai? a o?aa? Lotus
corniculatus.

Eoia?eie. Caeaoi?noue ?icuaiethaaoeny i?ae ae??th eiaeenoiaiaeiaai?
eeneioe o na?aaeiaeu? ??aeeiai oaiieo oa ioeoiaiai aia?ae?eaeo aei
eoia?eio aeicaieeei a?aeianoe ?a/iaeie 2.03 – 2.06 aei iio?aeieo
eoia?eio.

A ?*-niaeo?ao aeine?aeaeoaaieo ?a/iaei ? nioae iiaeeiaiiy
a?ae?ieneeueieo a?oi a iaeano? 3350-3260 ni-1, a oaeiae iaoienea?oi – a
iaeano? 2930-2843 ni-1 aeey ?a/iaei 2.03 oa 2.04. Aeoiaey/e c
o?ceei-o?i?/ieo aeanoeainoae, aeaieo iieaeoey?ii? iane, aeaiaioiiai
neeaaeo, OO- oa ?*-niaeo??a, a oaeiae aeanoeainoae i?iaeoeo?a
aoeaoeethaaiiy, iaoeethaaiiy oa aeaciaoeethaaiiy ?a/iaeia 2.03
?aeaioeo?eiaaia c 6-iene-7-iaoieneeoia?eiii (?cineiiieaoe-iii), ?a/iaeia
2.04 – c 6-iaoiene-7-ieneeoia?eiii (neiiieaoeiii), ?a/iaeia 2.05 – c
7-ieneeoia?eiii (oiaae?oa?iiii), ?a/iaeia 2.06 – c 6,7-ae?ieneeoia?eiii
(aneoeaoeiii).

Oeaaiii?aee. Oeaaiii?aeia i?e?iaea ?a/iaei 2.07 – 2.19
i?aeoaa?aeaeo?oueny ?acoeueoaoaie ye?nieo ?aaeoe?e oa aeaieie
niaeo?aeueiiai aiae?co. A ?*-niaeo?ao oeeo niieoe i?enooi? nioae
iiaeeiaiiy, oa?aeoa?i? aeey oeaaiii?ae?a: a iaeano? 3500-3100 ni-1
(oaiieuei? a?ae?ieneee), 1670-1650 ni-1 (ea?aii?eueia a?oia -i??iio) ?
1640-1450 ni-1 (aaeaioi? eieeaaiiy a?iiaoe/ieo e?eaoeue).

?acoeueoaoe ye?nieo ?aaeoe?e oa OO-niaeo?ineii?? na?ae/aoue i?i
iaeaaei?noue aeine?aeaeoaaieo ?a/iaei aei iio?aeieo oeaaiiieo.

Ca ?ooii?noth ia o?iiaoia?aiao a ??cieo nenoaiao ?ic/eiiee?a, a oaeiae
ca ?acoeueoaoaie oe?ai?aeeiiai? ?aaeoe?? ca A??aioii ?a/iaeie 2.07-2.10,
2.17 a?aeianai? aei aae?eii?a, a ?a/iaeie 2.11-2.16, 2.18 ? 2.19 – aei
ae?eiceae?a.

Noaia o?i?/ieo ia?aoai?aiue oeaaiiie?a ia i?eeeaae? ?a/iaeie 2.18
i?aaenoaaeaia ia ?enoieo 1.

?a/iaeia 2.18 yaey? niaith e?enoaee aeiaoiai eieuei?o. Iaaaoeaia
oe?ai?aeeiiaa ?aaeoe?y ii A??aioo aeaco?, ui ?a/iaeia 2.18 ?
oeaaiii?aeiei ae?eiceaeii. Oaiia caaa?aeaiiy ia o?iiaoia?ai? a OO-na?oe?
aeicaiey? i?eionoeoe, ui oey niieoea ? oeaaii aai oeaaiiie c cai?uaiith
ienea?oiith o N-3.

A?aeiinia eaae?noue eeneioiiai a?ae?ie?co ?a/iaeie 2.18 aeicaiey?
i?eionoeoe, ui aoaeaaiaeiee eiiiiiaio ciaoiaeeoueny o N-3 oeaaiii?aeiiai
yae?a. A a?ae?ie?cao? ciaeaeai? D-aaeaeoica ? aae?eii, yeee ii
o?ceei-o?i?/iei aeanoeainoyi ?aeaioe/iee ?a/iaei? 2.17 (ii??io). I?e
e?euee?niiio a?ae?ie?c? io?eiaee aea?iieaeoey?i? e?eueeino? aae?eiio oa
oeoe?iaiai eiiiiiaioo, ui aeaco? ia iiiiceaeio i?e?iaeo aeae?eaii?
niieoee.

I?noea i?e?aeiaiiy aoaeaaiaeiiai eiiiiiaioo anoaiiaethaaee ii??aiyiiyi
OO-niaeo??a ae?eiceaeo oa aae?eiio. A?aenooi?noue aaoio?iiiiai cnoao
iaeneioia ?-i? nioae o i?enooiino? i?o?aoo oe??eii?ea oa eeiiiii?
eeneioe a ae?eiceae? oa iayai?noue eiai a aiaeia?/ieo oiiaao a aae?eii?
aeaco? ia ca`ycie D-aaeaeoice c aae?eiiii /a?ac ienea?oio o N-3.

A?aeuaieaiiy aaeaeoice a?ae ?a/iaeie 2.18 i?e oa?iaioaoeaiiio a?ae?ie?c?
aioeueneiii aeaco? ia iayai?noue -ae?eiceaeiiai ca`yceo, ui
i?aeoaa?aeaeo?oueny ? aeaieie ?*-niaeo?a, a yeiio ii?yae c? nioaaie i?e
3500-3200 ni-1 (a?ae?ienea?oie aoaeaaiaeieo cai?niee?a), 3200-2800 ni-1
(oaiieuei? a?ae?ienea?o- Ia i?aenoaa? i?iaaaeaieo aeine?aeaeaiue ?
?acoeueoao?a ii??aiyiiy c a??ia?aeieie c?aceaie ?a/iaeie 2.21 – 2.25
a?aeiia?aeii ?aeaioeo?eiaai? c 4-ieneei?e/iith (n-eoia?iaith),
3,4-ae?ieneei?e/iith (eioaeiith), 3-iene-4-iaoieneei?e/iith
(oa?oeiaith), 5-I-eioa?e-D-o?iiith (oei?iaaiiaith), 3-I-eioa?e-D-o?iiith
(iaioei?iaaiiaith) eeneioaie, ye? aia?oa ciaeaeai? a o?aa? Lotus
corniculatus.

Eoia?eie. Caeaoi?noue ?icuaiethaaoeny i?ae ae??th eiaeenoiaiaeiaai?
eeneioe o na?aaeiaeu? ??aeeiai oaiieo oa ioeoiaiai aia?ae?eaeo aei
eoia?eio aeicaieeei a?aeianoe ?a/iaeie 2.03 – 2.06 aei iio?aeieo
eoia?eio.

A ?*-niaeo?ao aeine?aeaeoaaieo ?a/iaei ? nioae iiaeeiaiiy
a?ae?ieneeueieo a?oi a iaeano? 3350-3260 ni-1, a oaeiae iaoienea?oi – a
iaeano? 2930-2843 ni-1 aeey ?a/iaei 2.03 oa 2.04. Aeoiaey/e c
o?ceei-o?i?/ieo aeanoeainoae, aeaieo iieaeoey?ii? iane, aeaiaioiiai
neeaaeo, OO- oa ?*-niaeo??a, a oaeiae aeanoeainoae i?iaeoeo?a
aoeaoeethaaiiy, iaoeethaaiiy oa aeaciaoeethaaiiy ?a/iaeia 2.03
?aeaioeo?eiaaia c 6-iene-7-iaoieneeoia?eiii (?cineiiieaoe-iii), ?a/iaeia
2.04 – c 6-iaoiene-7-ieneeoia?eiii (neiiieaoeiii), ?a/iaeia 2.05 – c
7-ieneeoia?eiii (oiaae?oa?iiii), ?a/iaeia 2.06 – c 6,7-ae?ieneeoia?eiii
(aneoeaoeiii).

Oeaaiii?aee. Oeaaiii?aeia i?e?iaea ?a/iaei 2.07 – 2.19
i?aeoaa?aeaeo?oueny ?acoeueoaoaie ye?nieo ?aaeoe?e oa aeaieie
niaeo?aeueiiai aiae?co. A ?*-niaeo?ao oeeo niieoe i?enooi? nioae
iiaeeiaiiy, oa?aeoa?i? aeey oeaaiii?ae?a: a iaeano? 3500-3100 ni-1
(oaiieuei? a?ae?ieneee), 1670-1650 ni-1 (ea?aii?eueia a?oia -i??iio) ?
1640-1450 ni-1 (aaeaioi? eieeaaiiy a?iiaoe/ieo e?eaoeue).

?acoeueoaoe ye?nieo ?aaeoe?e oa OO-niaeo?ineii?? na?ae/aoue i?i
iaeaaei?noue aeine?aeaeoaaieo ?a/iaei aei iio?aeieo oeaaiiieo.

Ca ?ooii?noth ia o?iiaoia?aiao a ??cieo nenoaiao ?ic/eiiee?a, a oaeiae
ca ?acoeueoaoaie oe?ai?aeeiiai? ?aaeoe?? ca A??aioii ?a/iaeie 2.07-2.10,
2.17 a?aeianai? aei aae?eii?a, a ?a/iaeie 2.11-2.16, 2.18 ? 2.19 – aei
ae?eiceae?a.

Noaia o?i?/ieo ia?aoai?aiue oeaaiiie?a ia i?eeeaae? ?a/iaeie 2.18
i?aaenoaaeaia ia ?enoieo 1.

ie), 1660 ni-1 ( = 0, -i??iia), 1610, 1570, 1520 ni-1 (a?iiaoe/ia
i?e?iaea ?a/iaeie), 830-800 ni-1 (1-4 cai?uaiiy e?eueoey A),
a?aei?/athoueny o?e ?ioaineai? nioae iiaeeiaiiy i?e 1090, 1025 ? 1000
ni-1, ye? aeacothoue ia i??aiicio D-aaeaeoico, a nioaa i?e 890 ni-1
oa?aeoa?eco? iayai?noue -ae?eiceaeiiai ca`yceo.

Aeey i?aeoaa?aeaeaiiy aoaeiae ?a/iaeie 2.18 aoa ciyoee II?-niaeo?
(AeINI-Ae6). A e?eueoe? A ae?eiceaea aeyaeythoueny neaiaee i?ioii?a: I-6
(aeoaeao c J = 2,5 Aoe, 6,21 i./.), I-8 (aeoaeao c J = 2,5 Aoe, 6,42
i./.) ? i?ioii a?ae?ienea?oie o N-5 o aeaeyae? neiaeaoo i?e 12,66 i./.
O a?/iiio oai?eueiiio e?eueoe? ?aciiothoue i?ioiie I-3` (aeoaeao c J = 9
Aoe, 7,53 i./.), I-5` (aeoaeao c J = 9 Aoe, 7,67 i./.) ? I-6` (aeoaeao
c J = 9 Aoe, 6,83 i./.). Oea na?ae/eoue, ui cai?nieee a ?a/iaei? 2.18
?icoaoiaai? o N-3, N-5, N-7, N-2` ? N-4`.

A iaaeao 3,38-3,8 i./. aeyaey?oueny a?oia neaiae?a, oa?aeoa?ia aeey
i?ioii?a aoaeaaiaeiiai caeeoeo ?ioaa?aeuei? ?ic?aooiee aeacothoue ia
iayai?noue oanoe i?ioii?a, ui i?aeoaa?aeaeo? iiiiceaeio i?e?iaeo
?a/iaeie 2.18.

Aiiia?iee i?ioii o N-1 aaeaeoice aea? aeoaeao i?e 5,38 i./. c J = 7 Aoe,
ui na?ae/eoue i?i i??aiicio oi?io ? N-3 cai?uaiiy oa iayai?noue
-ae?eiceaeiiai ca`yceo i?ae aae?eiiii oa naoa?ii.

Aeai? II?-niaeo?a iiai?noth ni?aiaaeathoue c ?acoeueoaoaie
o?ceei-o?i?/ieo aeine?aeaeaiue ? aeicaieythoue ioa?aeoa?ecoaaoe ?a/iaeio
2.18 ye 3–I–D-aaeaeoii??aiiceae 5,7,2`,4`-oao?aa?ae?ieneoeaaii
(ii??i-3-aaeaeoiceae), yeee ? iiaith ?a/iaeiith.

3. Io?eiaiiy oa aeine?aeaeaiiy e?iio?eueii? o?aeoe?? c o?aae eyaeaaioey

?iaaoiai.

Aeey io?eiaiiy e?iio?eueii? o?aeoe?? aoee aenia?eiaioaeueii i?ae?a?ai?
oiiae aeno?aaoaaiiy o?aae eyaeaaioey ?iaaoiai. Iaie aoei i?iaaaeaii
io?eiaiiy e?iio?eueii? o?aeoe?? aeaiia iaoiaeaie.

A ia?oiio iaoiae? iiae??aiaio o?aao eyaeaaioey ae/a?iii aeno?aaoaaee
oei?ioi?iii a aia?ao? Nieneaoo. Oei?ioi?iiee aeno?aeo oia?thaaee ia
?ioaoe?iiiiio oia?thaa/? aei aeaeaeaiiy aeno?aaaioo oa i?ney
acaaaeoaaiiy caeeoea aecia/aee a?aenioeiaee ai?no e?i?ae?a, yeee neeaa
6,68 %.

A ae?oaiio iaoiae? aeine?aeaeoaaio ne?iaeio aeno?aaoaaee 70 % aoaiieii.
Iaoea?aoe?th i?iaiaeeee i`yoee?aoii. Nie?oi-aiaeiee aeno?aeo oia?thaaee
aei aiaeiiai caeeoeo ? ia?iaeyee oei?ioi?iii. Oei?ioi?iio o?aeoe?th
oia?thaaee ia ?ioaoe?eiiio oia?thaa/? aei aeaeaeaiiy oei?ioi?io.
E?euee?niee ai?no e?iio?eueii? o?aeoe??, yea aoea io?eiaia ae?oaei
iaoiaeii, neeaaea? 7,23 %. Aecia/aii ?? i?aaiieaioe/i? oa o?ceei-o?i?/i?
aeanoeaino?. Iaea?aeaia e?iio?eueia noanoaioe?y yaey? niaith aonoo
iaeii??aeio iano aac caeaeo aeeth/aiue oaiii-caeaiiai eieuei?o, ia?
neaaeee i?e?iiee caiao, oa?aeoa?iee aeey eyaeaaioey. E?iio?eueiee
aeno?aeo i?aeoe/ii ia ?ic/eiy?oueny o aiae?, 95 % nie?o?, aoeaoii?,
eaaei ?ic/eiy?oueny o aaenai?, oei?ioi?i?, ?ic/eiiee o i?ia?aeueieo oa
?ineeiieo ie?yo.

Aea/aii ye?niee ai?no AA? e?iio?eueii? o?aeoe??, yea i?noeoue oei?io?ee,
oieioa?iee, ea?ioeii?aee, aee?i? eeneioe.

E?euee?niee ai?no oei?io?e?a i?iaiaeeee oioiaeaeo?ieiei?eiao?e/iei
iaoiaeii, ?o ai?no neeaa 1,22 %. E?euee?nia aecia/aiiy ea?ioeii?ae?a
i?iaiaeeee niaeo?ioioiiao?e/iei iaoiaeii, ?o ciaeaeaii 28,4 ia%.
Aaci??aeeiiith o?iiaoia?ao??th aeyaeaii 12 aee?ieo eeneio, c yeeo 8
iane/aieo oa 4 iaiane/aieo eeneio. Ia?aaaaeathoue iaiane/ai? e?iieaiiaa
(35,18 %), e?iieaaa (16,27 %), iea?iiaa (3,56 %) oa iane/ai?
iaeuei?oeiiaa (30,91 %) oa noaa?eiiaa (3,80 %) eeneioe.

Oaaeeoey 2

AEe?iieeneioiee neeaae e?iio?eueii? o?aeoe??

eyaeaaioey ?iaaoiai

? i/iAEe?i? eeneioeAoaeaoeaaee neaeao aee?ieo eeneioAi?no, %1.Eai??eiaa
eeneioaN81,50162.Eao??iiaa eeneioaN121,77963.I??enoeiiaa
eeneioaN141,22584.Iaioaaeaeaiiaa eeneioaN150, 43375.Iaeuei?oeiiaa
eeneioaN1630,91276.Iaeuei?oiea?iiaa eeneioaN161,82947.Aaioaaeaeaiiaa
eeneioaN171,16598.Noaa?eiiaa eeneioaN183,79689.Iea?iiaa
eeneioaN183,563710.E?iieaaa eeneioaN1816,271111.E?iieaiiaa
eeneioaN1835,182712.A?ao?iiaa eeneioaN200,8896

Ia iniia? e?iio?eueii? o?aeoe?? ?ic?iaeaia iacue, oiiaii iacaaia
“Eioon”, yea ia?aaeaia ia aeiee?i?/i? aeine?aeaeaiiy.

4. ?ic?iaea oaoiieia?? iaea?aeaiiy oa?iaeieia?/ieo cania?a “Eiei?ei”

? “Eioon”.

Ia i?aenoaa? i?iaaaeaieo aeine?aeaeaiue iaie ?ic?iaeaii oaoiieia?th
eiiieaenii? ia?a?iaee o?aae eyaeaaioey ?iaaoiai, yea neeaaea?oueny c
iine?aeiaiiai iaea?aeaiiy nooiai aeno?aeoo “Eiei?ei” oa e?iio?eueiiai
aeno?aeoo “Eioon”. A iniiao aeaii? oaoiieia?? eyaee aenia?aiaioaeueii
i?ae?a?ai? oiiae aeno?aaoaaiiy aeine?aeaeoaaii? ne?iaeie. Anoaiiaeaii
iioeiaeueiee ?aaeei aeno?aeoe?? noie a?ieia?/ii aeoeaieo ?a/iaei, yea
aeeth/a? oae? oaeoi?e: aeno?aaaio – 70 % nie?o (aeey oaiieueieo niieoe),
oei?ioi?i (aeey e?iio?eueieo niieoe), nooi?iue iiae??aiaiiy ne?iaeie –
1-3 ii, ni?aa?aeiioaiiy ne?iaeia-aeno?aaaio 1:10. Aeaia oaoiieia?y
ii?iaoaaia a oiiaao aeine?aeiiai caaiaeo AeIOeEC.

Oa?iaeieia?/i? aeine?aeaeaiiy, ye? i?iaaaeai? ia eaoaae?? a?io?i?? Oe?OA
i?io. Ai?ii?iith E.I. oa eaiae. a?ie. iaoe Iaaiea I.?., iieacaee, ui
“Eiei?ei” ia? ae?aaeaio i?ioecaiaeueio ? ae?o?aoe/io aeoeai?noue. Iac?
(1 % oa 3 %) c e?iio?eueiei aeno?aeoii “Eioon” iathoue ae?aaeaio
?aiicaaithaaeueio aeoeai?noue ? ia?aaeuothoue ii ae?? i?aia?ao
ii??aiyiiy iacue “Eaeaiaeoea”.

A ?acoeueoao? aea/aiiy aino?i? oiene/iino? “Eiei?eio” anoaiiaeaii, ui
i?e aioo?e/a?aaiiio aaaaeaii? LD50 neeaaea? 4660 57,3 ia/ea, ui
aeicaiey? a?aeianoe eiai aei i?aeoe/ii iaoiene/ieo niieoe.

5. Aiaoii?/ia aoaeiaa iaaecaiieo i?aai?a eyaeaaioey ?iaaoiai

Aea/aia aiaoii?/ia aoaeiaa iaaecaiieo i?aai?a eyaeaaioey ?iaaoiai ?
anoaiiaeai? iniiai? ae?aaiinoe/i? iciaee ne?iaeie: iayai?noue
eooioaeeynoi? ieaeiuei? ai?aea?ie eenoea c oa?aeoa?ieie iioiauaiiyie ii
eooao; i?inoeo i?eoeneeo iaeii- /e aeaiee?oeiieo o?eoii c aino?ith
aa?o?aeith ia noaaeao, eenoeao, /aoa/oe?; i?iaeeoiaiai aia?aoo
ai?cioeeoiiai oeio; eooeeoee ia ai?aea?i? iaethnoie oa noaaea;
nini/eiaeaeii? ai?aea?ie iaethnoie; e?enoae?a ienaeaoo eaeueoe?th a
oeaieiao /aoa/ee oa aiaeiaea?i? noaaea; oai?iiiinieo nae?aoi?ieo ee?oei
iaaeiei i?ia?aeieo oeaiei oa i?ae ai?aea?iith.

?acoeueoaoe aeine?aeaeaiue aeei?enoai? i?e ?ic?iaoe? i?iaeo?a OON ia
“O?aao eyaeaaioey ?iaaoiai”, “Eiei?ei” oa “Eioon”, a oaeiae
ai?iaaaeaeai? a o/aiaee i?ioean Oe?a?inueei? oa?iaoeaaoe/ii? aeaaeai??
oa Caii??cueeiai iaaee/iiai oi?aa?neoaoo.

Ae?-1. I?iaaaeaiiy aeiiii?aeieo ?ia?o

Ne?iaeia c? neeaaeoAe?-2. Iiae??aiaiiy ne?iaeieIiae??aiaia ne?iaeia ia
OI.4.

Ao?aoe

Nie?o aoeeiaeeOI.3. I?eaiooaaiiy 70 % nie?oo

Aeno?aaaio ia OI.4.Aiaea

Iiae??aiaia ne?iaeiaOI.4.1. Aeno?aeoe?y ne?iaeieNie?oiaee aeno?aeo ia
OI.4.2.

Aeno?aaaioO?io

Nie?oiaee aeno?aeoOI.4.2. Eiioeaio?oaaiiy aeno?aeooEiiaeainao nie?oo

Aiaeiee aeno?aeo ia OI.4.3.

Aiaeiee aeno?aeoOI.4.3. Aeno?aeoe?y aiaeiiai aeno?aeooOei?ioi?i-iee
aeoya ia OI.4.4.

Oei?ioi?iAiaeiee caeeoie ia OI.5.

Oei?ioi?i-iee aeoyaOI.4.4. Oia?thaaiiyA?aeaii oei?ioi?io

Aonoee aeno?aeo

Aiaeiee caeeoieOI.5. Noo?iiyOII-6. Oanoaaiiy ? iaeoaaiiy “Eioono”Nooee
aeno?aeo

IIA-7. Oanoaaiiy ? iaeoaaiiy “Eiei?eio”

?en. 5.1. Oaoiieia?/ia noaia iaea?aeaiiy oa?iaeieia?/ieo cania?a

“Eiei?eio” ? “Eioono”.

AENIIAEE

1. Aia?oa i?iaaaeaii eiiieaenia o?oio?i?/ia aeine?aeaeaiiy iaaecaiii?
/anoeie eyaeaaioey ?iaaoiai (Lotus corniculatus). Anoaiiaeaii iayai?noue
??ciiiai?oieo a?oi a?ieia?/ii aeoeaieo ?a/iaei: oeaaiii?ae?a,
ieneei?e/ieo eeneio, eoia?ei?a, aeoaeeueieo ?a/iaei, anei?a?iiai?
eeneioe, oinoie?i?ae?a, noa?i?ae?a, e?iio?eueieo ?a/iaei. Aecia/aii ?o
e?euee?niee ai?no: oeaaiii?ae?a – 1,75 %, ieneei?e/ieo eeneio – 1,35 %,
aeoaeeueieo ?a/iaei – 0,49 %, anei?a?iiai? eeneioe – 0,08 %.

2. C aeei?enoaiiyi iaoiae?a ??aeeiii? aeno?aeoe??, eieiieiai?
o?iiaoia?ao?? ia iie?ai?ae? oa nee?eaaae?, i?aia?aoeaii? o?iiaoia?ao??
ia iaia?? oa o oiieiio oa?? ni?aaioo c iaaecaiii? /anoeie eyaeaaioey
?iaaoiai aeae?eaii a ?iaeea?aeoaeueiiio noai? 24 ?a/iaeie: 5
ieneei?e/ieo eeneio, 4 ieneeoia?eia, 13 oeaaiii?ae?a, 1 ?a/iaeio
oinoie?i?aeii? oa 1 noa?i?aeii? i?e?iaee.

Ia iniia? o?ceei-o?i?/ieo aeanoeainoae aeo?aeieo ?a/iaei oa i?iaeoeo?a
?o o?i?/ieo ia?aoai?aiue, aeaieo OO-, ?*-, II?-niaeo?ineii??,
ii??aiyiiyi c a??ia?aeieie c?aceaie aeae?eai? niieoee ?aeaioeo?eiaai? ye
ieneei?e/i? eeneioe: n-eoia?iaa (2.21), eioaeia (2.22), oa?oeiaa (2.23),
oei?iaaiiaa (2.24), iaioei?iaaiiaa (2.25); ieneeoia?eie: ?cineiiieaoei
(2.03), neiiieaoei (2.04), oiaae?oa?ii (2.05), aneoeaoei (2.06);
oeaaiii?aee: ?ci?aiiaoei (2.07), 3-iaoeeeaa?oeaoei (2.08), eaiioa?ie
(2.09), eaa?oeaoei (2.10), iiioe?i (2.11), ano?aaae?i (2.12), o?eoie?i
(2.13), ?cieaa?oeeo?ei (2.14), eaa?oeeo?ei (2.15), a?ia?iceae (2.16),
ii??i (2.17), ii??i-3-I–D-aaeaeoiceae (2.18),
eaiioa?ie-3-I–D-aetheii??aiic?e-7-I–D-aetheii??aiiceae (2.19);
oinoie?i?aee: eaoeaoei (2.01); noa?i?aee: -neoinoa?ei (2.02).

Aia?oa aeae?eai? c o?aae Lotus corniculatus oei?iaaiiaa (2.24),
iaioei?iaaiiaa (2.25), eioaeia (2.22) eeneioe; neiiieaoei (2.04),
oiaae?oa?ii (2.05), aneoeaoei (2.06), ?cineiiieaoei (2.03); ano?aaae?i
(2.12), iiioe?i (2.11), o?eoie?i (2.13), ?cieaa?oeeo?ei (2.14), ii??i
(2.17), ii??i-3-I–D-aaeaeoiceae (2.18), ?ci?aiiaoei (2.07); eaoeaoei
(2.01). Ii??i (2.17) oa ii??i-3-I–D-aaeaeoiceae (2.18) ? iiaeie
?a/iaeiaie aeey ?iaeo Lotus. Ano?aaae?i (2.12) – iiaa ?a/iaeia aeey
aeaeo Lotus corniculatus. E??i oiai, ii??i aia?oa aeyaeaiee a ?iaei?
aiaiaeo, a ii??i-3-I–D-aaeaeoiceae ? iiaith i?e?iaeiith niieoeith.

3. Iaea?aeaia e?iio?eueia o?aeoe?y c o?aae eyaeaaioey ?iaaoiai. Aea/aii
i?aaiieaioe/i? oa aeaye? o?ceei-o?i?/i? aeanoeaino? e?iio?eueii?
o?aeoe??, a oaeiae aecia/aii e?euee?niee ai?no ??, yeee neeaaea? 7,23 %.
Aecia/aii ai?no oei?io?e?a – 1,22 0,03 %, ea?ioeii?ae?a – 28,4 0,58
ia%. Aaci??aeeiiith o?iiaoia?ao??th aeyaeaii 12 aee?ieo eeneio, c yeeo 8
iane/aieo e 4 iaiane/aieo, c ieo ia?aaaaeathoue iaiane/ai? e?iieaiiaa
(35,18 %), e?iieaaa (16,27 %), iea?iiaa (3,56 %) oa iane/ai?
iaeuei?oeiiaa (30,91 %) ? noaa?eiiaa (3,8 %) eeneioe.

4. ?ic?iaeaia eiiieaenia oaoiieia?y iaea?aeaiiy oa?iaeieia?/ieo cania?a
c o?aae eyaeaaioey ?iaaoiai nooiai aeno?aeoo “Eiei?ei” oa e?iio?eueiiai
aeno?aeoo “Eioon”. Oaoiieia?y ii?iaoaaia a oiiaao aeine?aeiiai caaiaeo
AeIOeEC.

5. Oa?iaeieia?/i? aeine?aeaeaiiy iieacaee, ui “Eiei?ei” ia? ae?aaeaio
i?ioecaiaeueio oa ae?o?aoe/io aeoeai?noue, a “Eioon” ?aiicaaithaaeueio
aeoeai?noue ? ia?aaeuo? ii ae?? i?aia?ao ii??aiyiiy iacue “Eaeaiaeoea”.
Iacue “Eioon” ia?aaeaii ia aeiee?i?/i? aeine?aeaeaiiy. Ia niin?a
iaea?aeaiiy e?iio?eueiiai aeno?aeoo c o?aae eyaeaaioey ?iaaoiai iiaeaia
cayaa ia io?eiaiiy iaoaioo Oe?a?ie.

6. Aia?oa aeyaeai? aiaoii?/i? ae?aaiinoe/i? iciaee o?aae eyaeaaioey
?iaaoiai, a naia: iayai?noue eooiaioaeeynoi? ieaeiuei? ai?aea?ie eenoea
c oa?aeoa?ieie iioiauaiiyie ii eooao; i?inoeo i?eoeniooeo iaeii- /e
aeaiee?oeiieo o?eoii c aino?ith aa?o?aeith ia noaaeao, eenoeao,
/aoa/oe?; i?iaeeoiaiai aia?aoo ai?cioeeoiiai oeio; eooeeoee ia ai?aea?i?
iaethnoie oa noaaea; nini/eiaeaeii? ai?aea?ie iaethnoie; e?enoae?a
ienaeaoo eaeueoe?th a oeaieiao /aoa/ee oa aiaeiaea?i? noaaea;
oaii?iiiinieo nae?aoi?ieo ee?oei iaaeiei i?ia?aeieo oeaiei oa i?ae
ai?aea?iith. Anoaiiaeaia eieae?caoe?y oaiieueieo niieoe, ye? i?noyoueny
o an?o iaaecaiieo i?aaiao eyaeaaioey ?iaaoiai, a?eueoith /anoeiith a
nae?aoi?ieo ee?oeiao – ?ae?iaeanoao, ?icoaoiaaieo oyaeaie iaaeiei
i?ia?aeieo oeaiei aai oa?ii i?ae ai?aea?iith.

7. ?ic?iaeaia AIAe ia o?aao eyaeaaioey ?iaaoiai, nooee aeno?aeo
“Eiei?ei” ? e?iio?eueiee aeno?aeo “Eioon”. ?acoeueoaoe ?iaioe
ai?iaaaeaeai? a iaa/aeueiee i?ioean Oe?a?inueei? oa?iaoeaaoe/ii?
aeaaeai?? oa Caii??cueeiai iaaee/iiai oi?aa?neoaoo.

Nienie iioae?eiaaieo i?aoeue ca oaiith aeena?oaoe??.

1. Aiaoii?/ia aoaeiaa iaaecaiii? /anoeie eyaeaaioey ?iaaoiai /
A.I.Eiceiaa, A.A.Ei?ieue, A.I.Eiaaeueia, E.N.Ea?oiaciaa // A?niee
oa?iaoe??. – 1997. – ? 1. – N. 71.

2. Ia?niaeoeaiua iai?aaeaiey a iaeanoe eco/aiey eaea?noaaiiuo ?anoaiee e
nicaeaiey ioa/anoaaiiuo oeoii?aia?aoia / Eiaaeaa A.I., Eenee/aiei A.N.,
AEo?aaaeue E.A., Oia?aaaa E.Y., Caaieioiue A.A., Nooiaeiaa Y.A.,
E?anieeiaa O.A., Ei?ieue A.A. // I?iaeci?. – 1998. – ? 22. – N. 39-40.

3. Aeine?aeaeaiiy a?ieia?/ii? aeoeaiino? eyaeaaioey ?iaaoiai / Ei?ieue
A.A., Iaaiea I.?., Naoa?iaa O.N., Ai?ii?ia E.I., Eiaaeueia A.I., Eaiei
A.?. // A?niee oa?iaoe??. – 1998. – ? 2(18). – N. 100-102.

4. Ei?ieue A.A., Eiaaeueia A.I. Aeine?aeaeaiiy oeaaiii?ae?a o o?aa?
Lotus corniiculatus L. // O?c?ieia?/ii aeoeai? ?a/iaeie. – 1999. – ? 1
(27). – N. 99-101.

5. Oaiieueiua niaaeeiaiey – enoi/ieee iieo/aiey eaea?noaaiiuo n?aaenoa /
Eiaaeaa A.I., Ei?ieue A.A., Oneiaa N.E. e ae?. // na. oac. iaaeaocianeie
49-e iao/.-i?aeo. eiio. i?io.-i?aiiae. ninoaaa, 19-23 ai?aey. – Ia?iue.
– 1993. – N. 7.

6. Ei?ieue A.A., Nai?ee?ia N.N. Aiae?c a?ieia?/ii aeoeaieo ?a/iaei
eyaeaaioey ?iaaoiai // Oac. aeii. “Aeinyaiaiiy no/anii? oa?iaoe?? – a
iaaee/io i?aeoeeo”. – Oa?e?a, 1996. – N. 215-216.

7. Aeaye? aniaeoe a?ieia?/ii? aeoeaiino? oeaaiii?aeiiai eiiieaeno
eyaeaaioey ?iaaoiai / E.A.Naa/aiei, I.?.Iaaiea, A.A.Ei?ieue,
A.I.O?eaoiaa // Oac. aeii. iaoe.-i?aeo. eiio. – Oa?e?a, 1996. – N. 337.

Ei?ieue A.A. “Oa?iaeiaiinoe/ia aea/aiiy Lotus corniculatus”. – ?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa oa?iaoeaaoe/ieo
iaoe ca niaoe?aeuei?noth 15.00.02 – oa?iaoeaaoe/ia o?i?y ?
oa?iaeiaiic?e. – Oe?a?inueea oa?iaoeaaoe/ia aeaaeai?y, Oa?e?a, 1999.

I?iaaaeaii o?oio?i?/ia aeine?aeaeaiiy o?aae eyaeaaioey ?iaaoiai. Ca
aeine?aeaeoaaii? ne?iaeie aeae?eaii ? anoaiiaeaii aoaeiao 24
?iaeea?aeoaeueieo niieoe: 5 ieneei?e/ieo eeneio, 4 eoia?eia, 13
oeaaiii?ae?a, 1 oinoie?i?ae ? 1 noa?i?ae. ?ic?iaeaia oaoiieia?y
eiiieaenii? ia?a?iaee o?aae eyaeaaioey ?iaaoiai, a iniia? yei? eaaeeoue
iine?aeiaia io?eiaiiy nooiai aeno?aeoo (oiiaia iacaa “Eiei?ei”), yeee
ia? ae?o?aoe/io oa i?ioecaiaeueio ae?th, ? e?iio?eueiiai aeno?aeoo
(oiiaia iacaa “Eioon”), yeee ia? ?aiicaaithaaeueio aeoeai?noue.
I?iaaaeaii e?euee?nia aecia/aiiy oeaaiii?ae?a, ieneei?e/ieo eeneio,
anei?a?iiai? eeneioe, aeoaeeueieo ?a/iaei a o?aa? eyaeaaioey ?iaaoiai ?
ea?ioeii?ae?a, oei?io?e?a, aee?ieo eeneio a e?iio?eueiiio aeno?aeo?.
Aea/aii aiaoii?/io aoaeiao iaaecaiieo i?aai?a eyaeaaioey ?iaaoiai,
anoaiiaeai? iniiai? ae?aaiinoe/i? iciaee ne?iaeie.

?ic?iaeai? i?iaeoe OON ia “O?aao eyaeaaioey ?iaaoiai”, “Nooee aeno?aeo
“Eiei?ei” ? “E?iio?eueiee aeno?aeo “Eioon”.

Eeth/ia? neiaa: eyaeaaiaoeue ?iaaoee, Lotus corniculatus,
oa?iaeiaiinoe/ia aea/aiiy, a?ieia?/ii aeoeai? ?a/iaeie, oaoiieia?y,
e?iio?eueiee aeno?aeo, ae?o?aoe/ia, i?ioecaiaeueia, ?aiicaaithaaeueia
aeoeai?noue.

Ei?ieue A.A. “Oa?iaeiaiinoe/aneia eco/aiea Lotus corniculatus”. –
?oeiienue.

Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa oa?iaoeaaoe/aneeo
iaoe ii niaoeeaeueiinoe 15.00.02 – oa?iaoeaaoe/aneay oeiey e
oa?iaeiaiicey. – Oe?aeineay oa?iaoeaaoe/aneay aeaaeaiey, Oa?ueeia, 1999
a.

Aia?aua i?iaaaeaii eiiieaeniia oeoioeie/aneia enneaaeiaaiea iaaecaiiuo
i?aaiia eyaeaaioea ?iaaoiai (Lotus corniculatus). Onoaiiaeaii iaee/ea
?acee/iuo a?oii aeieiae/anee aeoeaiuo aauanoa: oeaaiiieaeia,
ieneei?e/iuo eeneio, eoia?eiia, aeoaeeueiuo aauanoa, anei?aeiiaie
eeneiou, oinoieeieaeia, noa?ieaeia. Onoaiiaeaii eiee/anoaaiiia
niaea?aeaiea oeaaiiieaeia – 1,75 %, ieneei?e/iuo eeneio – 1,35 %,
aeoaeeueiuo aauanoa – 0,49 %, anei?aeiiaie eeneiou – 0,08 %.

N eniieueciaaieai iaoiaeia aeeaeeinoiie yeno?aeoeee, eieiii/iie
o?iiaoia?aoee ia iieeaieaea e neeeeaaaea, i?aia?aoeaiie o?iiaoia?aoee ia
aoiaaa e a oiieii neia ni?aaioa ec iaaecaiiie /anoe eyaeaeioea ?iaaoiai
auaeaeaii 24 eiaeeaeaeoaeueiuo aauanoaa: 5 ieneei?e/iuo eeneio, 4
ieneeoia?eia, 13 oeaaiiieaeia, 1 aauanoai oinoieeieaeiie e 1 noa?ieaeiie
i?e?iaeu. Ia iniiaa oeceei-oeie/aneeo naienoa enoiaeiuo aauanoa e
i?iaeoeoia eo oeie/aneeo i?aa?auaiee, aeaiiuo OO- EE-,
II?-niaeo?ieniiee, n?aaiaieai n aeinoiaa?iuie ia?acoeaie auaeaeaiiua
niaaeeiaiey eaeaioeoeoee?iaaiu eae ieneei?e/iua eeneiou: n-eoia?iaay
(2.21), eioaeiay (2.22), oa?oeiaay (2.23), oei?iaaiiaay (2.24),
iaioei?iaaiiaay (2.25); ieneeoia?eiu: ecineiiieaoei (2.03), neiiieaoei
(2.04), oiaaeeeoa?ii (2.05), yneoeaoei (2.06); oeaaiiieaeu: eci?aiiaoei
(2.07), 3-iaoeeeaa?oeaoei (2.08), eaiioa?ie (2.09), eaa?oeaoei (2.10),
iiioeei (2.11), ano?aaaeei (2.12), o?eoieei (2.13), ecieaa?oeeo?ei
(2.14), eaa?oeeo?ei (2.15), aeia?iceae (2.16), ii?ei (2.17),
ii?ei-3-I–D-aaeaeoiie?aiiceae (2.18),
eaiioa?ie-3-I–D-aaeaeoiie?aiicee-7-I–D-aetheiie?aiiceae (2.19);
oinoieeieaeu: eaoeaoei (2.01); noa?ieaeu: -neoinoa?ei (2.02). Aia?aua
auaeaeaiu ec o?aau Lotus corniculatus oei?iaaiiaay (2.24),
iaioei?iaaiiaay (2.25), eioaeiay (2.22) eeneiou; neiiieaoei (2.04),
oiaaeeeoa?ii (2.05), yneoeaoei (2.06), ecneiiieaoei (2.03); ano?aaaeei
(2.12), iiioeei (2.11), o?eoieei (2.13), ecieaa?oeeo?ei (2.14), ii?ei
(2.17), ii?ei-3-I–D-aaeaeoiie?aiiceae (2.18), eci?aiiaoei (2.07);
eaoeaoei (2.01). Ii?ei (2.17) e ii?ei-3-I–D-aaeaeoiie?aiiceae (2.18)
yaeythony iiauie aauanoaaie aeey ?iaea Lotus. Ano?aaaeei (2.12) – iiaia
aauanoai aeey aeaea Lotus corniculatus. E?iia oiai, ii?ei aia?aua
auyaeai a naiaenoaa aiaiauo, a ii?ei-3-I–D-aaeaeoiie?aiiceae yaeyaony
iiaui i?e?iaeiui niaaeeiaieai.

Iieo/aia eeiioeeueiay o?aeoeey ec o?aau eyaeaaioea ?iaaoiai. Eco/aiu
i?aaiieaioe/aneea e iaeioi?ua oeceei-oeie/aneea naienoaa eeiioeeueiie
o?aeoeee, a oaeaea ii?aaeaeaii eiee/anoaaiiia niaea?aeaiea aa, eioi?ia
ninoaaeyao 7,23 %. Ii?aaeaeaii niaea?aeaiea oei?ioeeeia – 1,22 0,03 %,
ea?ioeiieaeia – 28,4 0,58 ia%. Aaciaeeaeeinoiie o?iiaoia?aoeae
iaia?oaeaii 12 aee?iuo eeneio, ec eioi?uo 8 ianuuaiuo e 4 iaianuuaiuo,
ec ieo i?aiaeaaeatho iaianuuaiua eeiieaiiaay (35,18 %), eeiieaaay (16,27
%), ieaeiiaay (3,56 %) e ianuuaiua iaeueieoeiiaay (30,91 %) e
noaa?eiiaay (3,8 %) eeneiou.

?ac?aaioaia eiiieaeniay oaoiieiaey iieo/aiey oa?iaeieiae/aneeo n?aaenoa
ec o?aau eyaeaaioea ?iaaoiai nooiai yeno?aeoa “Eie?ei” e eeiioeeueiiai
yeno?aeoa “Eioon”. Oaoiieiaey ii?iae?iaaia a oneiaeyo iiuoiiai caaiaea
AIOeEN. Oa?iaeieiau/aneea enneaaeiaaiey iieacaee, /oi “Eiei?ei” eiaao
au?aaeaiioth i?ioeaiainiaeeoaeueioth e aeeo?aoe/aneoth aeoeaiinoue, a
“Eioon” – ?aiicaaeeaeythuoth aeoeaiinoue e i?aauoaao ii aeaenoaeth
i?aia?ao n?aaiaiey iacue “Eaeaiaeoea”. Iacue “Eioon” ia?aaeaii ia
aeieeeie/aneea eniuoaiey. Ia niinia iieo/aiey eeiioeeueiiai yeno?aeoa ec
o?aau eyaeaaioea ?iaaoiai iiaeaia cayaea ia iieo/aiea iaoaioa Oe?aeiu.

Aia?aua auyaeaiu aiaoiie/aneea aeeaaiinoe/aneea i?eciaee o?aau
eyaeaaioea ?iaaoiai, a eiaiii: iaee/ea ecaeeenoay oaeiaay ieaeiyy
yieaea?ia eenoa n oa?aeoa?iuie ooieuaieyie ii oaeao; i?inoua i?eaeaoua
iaeii- eee aeaooeeaoi/iua o?eoiiu n ino?ie aa?oooeie ia noaaeyo,
eenoueyo, /aoa/ea; onouee/iue aiia?ao aiecioeeoiiai oeia; eooeeoea ia
yieaea?ia eaianoeia e noaaey; nini/eiaeaeiie yieaea?iu eaianoeia;
e?enoaeeia ienaeaoa eaeueoeey a /aoa/ea e yieaea?ia noaaey;
oaiieiiiiniua nae?aoi?iua eeaoee aie?oa i?iaiaeyueo oeaiae e iiae
yieaea?iie. Onoaiiaeaia eieaeecaoeey oaiieueiuo niaaeeiaiee, eioi?ua
niaea?aeaony ai anao iaaecaiiuo i?aaiao eyaeaaioea ?iaaoiai, aieueoae
/anoueth a nae?aoi?iuo eeaoeao – eaeeiaeanoao, ?aniieiaeaiiuo oyaeaie
aie?oa i?iaiaeyueo oeaiae eee neiai iiae yieaea?iie. ?ac?aaioaia AIAe ia
o?aao eyaeaaioea ?iaaoiai, nooie yeno?aeo “Eiei?ei” e eeiioeeueiue
yeno?aeo “Eioon”. ?acoeueoaou ?aaiou aiaae?aiu a o/aaiue i?ioeann
Oe?aeineie oa?iaoeaaoe/aneie aeaaeaiee e Caii?iaeneiai iaaeeoeeineiai
oieaa?neoaoa.

Eeth/aaua neiaa: eyaeaaiaoe ?iaaoue (Lotus corniculatus),
oa?iaeiaiinoe/aneia eco/aiea, aeieiae/anee aeoeaiua aauanoaa,
oaoiieiaey, eeiioeeueiue yeno?aeo, aeeo?aoe/aneay,
i?ioeaiainiaeeoaeueiay, ?aiicaaeeaeythuay aeoeaiinoue.

Korol V.V. “Pharmacognosy study of Lotus corniculatus”. – Manuscript.

Thesis on the Candidate of Pharmaceutical Sciences Degree on speciality
15.00.02 – Pharmaceutical chemistry and Pharmacognosy. – Ukrainian
Academy of Pharmacy, Kharkov, 1999.

Phytochemical studiyng of the Lotus corniculatus herb has been carried
out. From the investigated raw material the structure of 24 individual
substances has been isolated and obtained: 5 benzoic acids derivatives,
4 coumarins, 13 flavonoles, 1 phospholipid and 1 steroid.

Technology of the complex processing of the herb, which includes the
consecutive obtaining of the dry extract (code name “Lokorin”), which
possesses diuretic and anti-inflammatory action and lypophylic extract
(code name “Lotus”), which possesses wound-healing activity, has been
worked out. Quantitative identifying of flavonoles, benzoic acids
derivatives, ascorbinic acid, tannins in the herb and carotinoids,
chlorophylls, fatty acids in lypophylic extract. Anatomic structure of
overground organs of Lotus corniculatus has been studied the main
diagnostic features of the raw material have been identified.

Temporary Pharmacopoeia Articls projects have been worked out on “Lotus
corniculatus herb”, “Dry extract “Lokorin” and “Lypophylic extract
“Lotus”.

Key words: Lotus corniculatus, pharmacognosy study, biologically active
matters, technology, lypophylic extract, diuretic, anti-inflammatory,
wound-healing activity.

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